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PubMed code 17291750

Compile data set for download or QSAR
Found 93 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM15553
PNG
((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@@H]1CCN([C@H](Cc2ccccc2C)C(=O)N1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C24H28F3N3O2/c1-14-5-3-4-6-16(14)11-22-24(32)29-15(2)7-8-30(22)23(31)12-18(28)9-17-10-20(26)21(27)13-19(17)25/h3-6,10,13,15,18,22H,7-9,11-12,28H2,1-2H3,(H,29,32)/t15-,18-,22-/m1/s1
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n/an/a 1.49n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM15554
PNG
((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@@H]1CCN([C@H](Cc2ccccc2F)C(=O)N1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C23H25F4N3O2/c1-13-6-7-30(21(23(32)29-13)10-14-4-2-3-5-17(14)24)22(31)11-16(28)8-15-9-19(26)20(27)12-18(15)25/h2-5,9,12-13,16,21H,6-8,10-11,28H2,1H3,(H,29,32)/t13-,16-,21-/m1/s1
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n/an/a 2.77n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM13519
PNG
((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Show SMILES C[C@H]1N(CCCNC1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C16H20F3N3O2/c1-9-16(24)21-3-2-4-22(9)15(23)7-11(20)5-10-6-13(18)14(19)8-12(10)17/h6,8-9,11H,2-5,7,20H2,1H3,(H,21,24)/t9-,11-/m1/s1
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Article
PubMed
n/an/a 6.60n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM15534
PNG
((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Show SMILES C[C@H]1N(CCCN(C)C1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C17H22F3N3O2/c1-10-17(25)22(2)4-3-5-23(10)16(24)8-12(21)6-11-7-14(19)15(20)9-13(11)18/h7,9-10,12H,3-6,8,21H2,1-2H3/t10-,12-/m1/s1
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n/an/a 6.60n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM15538
PNG
((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Show SMILES C[C@H]1N(CCCN(C2CC2)C1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C19H24F3N3O2/c1-11-19(27)25(14-3-4-14)6-2-5-24(11)18(26)9-13(23)7-12-8-16(21)17(22)10-15(12)20/h8,10-11,13-14H,2-7,9,23H2,1H3/t11-,13-/m1/s1
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n/an/a 8n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM15532
PNG
((3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoy...)
Show SMILES C[C@H]1N(CCCN(C2CC2)C1=O)C(=O)C[C@H](N)Cc1cc(F)ccc1F |r|
Show InChI InChI=1S/C19H25F2N3O2/c1-12-19(26)24(16-4-5-16)8-2-7-23(12)18(25)11-15(22)10-13-9-14(20)3-6-17(13)21/h3,6,9,12,15-16H,2,4-5,7-8,10-11,22H2,1H3/t12-,15-/m1/s1
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n/an/a 9n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM15539
PNG
((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Show SMILES C[C@H]1N(CCCN(C1=O)C(C)(C)C)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H28F3N3O2/c1-12-19(28)26(20(2,3)4)7-5-6-25(12)18(27)10-14(24)8-13-9-16(22)17(23)11-15(13)21/h9,11-12,14H,5-8,10,24H2,1-4H3/t12-,14-/m1/s1
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n/an/a 9.60n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM15543
PNG
((3R,6S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@H]1CNC(=O)[C@@H](C)N(C1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C17H22F3N3O2/c1-9-7-22-17(25)10(2)23(8-9)16(24)5-12(21)3-11-4-14(19)15(20)6-13(11)18/h4,6,9-10,12H,3,5,7-8,21H2,1-2H3,(H,22,25)/t9-,10+,12+/m0/s1
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n/an/a 9.70n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM15536
PNG
((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Show SMILES C[C@H]1N(CCCN(CCOCc2ccccc2)C1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C25H30F3N3O3/c1-17-25(33)30(10-11-34-16-18-6-3-2-4-7-18)8-5-9-31(17)24(32)14-20(29)12-19-13-22(27)23(28)15-21(19)26/h2-4,6-7,13,15,17,20H,5,8-12,14,16,29H2,1H3/t17-,20-/m1/s1
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n/an/a 10.5n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM15555
PNG
((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@@H]1CCN([C@H](Cc2ccccn2)C(=O)N1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C22H25F3N4O2/c1-13-5-7-29(20(22(31)28-13)11-16-4-2-3-6-27-16)21(30)10-15(26)8-14-9-18(24)19(25)12-17(14)23/h2-4,6,9,12-13,15,20H,5,7-8,10-11,26H2,1H3,(H,28,31)/t13-,15-,20-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM13518
PNG
((3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoy...)
Show SMILES C[C@H]1N(CCCNC1=O)C(=O)C[C@H](N)Cc1cc(F)ccc1F |r|
Show InChI InChI=1S/C16H21F2N3O2/c1-10-16(23)20-5-2-6-21(10)15(22)9-13(19)8-11-7-12(17)3-4-14(11)18/h3-4,7,10,13H,2,5-6,8-9,19H2,1H3,(H,20,23)/t10-,13-/m1/s1
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n/an/a 11.5n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM15530
PNG
(1-substituted diazepanone 9b | methyl 2-[(3R)-4-[(...)
Show SMILES COC(=O)CN1CCCN([C@H](C)C1=O)C(=O)C[C@H](N)Cc1cc(F)ccc1F |r|
Show InChI InChI=1S/C19H25F2N3O4/c1-12-19(27)23(11-18(26)28-2)6-3-7-24(12)17(25)10-15(22)9-13-8-14(20)4-5-16(13)21/h4-5,8,12,15H,3,6-7,9-11,22H2,1-2H3/t12-,15-/m1/s1
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n/an/a 11.6n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM15545
PNG
((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@@H]1CCN([C@H](C)C(=O)N1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C17H22F3N3O2/c1-9-3-4-23(10(2)17(25)22-9)16(24)7-12(21)5-11-6-14(19)15(20)8-13(11)18/h6,8-10,12H,3-5,7,21H2,1-2H3,(H,22,25)/t9-,10-,12-/m1/s1
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n/an/a 15.1n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM15535
PNG
((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Show SMILES C[C@H]1N(CCCN(CCO)C1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C18H24F3N3O3/c1-11-18(27)23(5-6-25)3-2-4-24(11)17(26)9-13(22)7-12-8-15(20)16(21)10-14(12)19/h8,10-11,13,25H,2-7,9,22H2,1H3/t11-,13-/m1/s1
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n/an/a 15.1n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM15537
PNG
((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Show SMILES C[C@H]1N(CCCN(CC(F)(F)F)C1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C18H21F6N3O2/c1-10-17(29)26(9-18(22,23)24)3-2-4-27(10)16(28)7-12(25)5-11-6-14(20)15(21)8-13(11)19/h6,8,10,12H,2-5,7,9,25H2,1H3/t10-,12-/m1/s1
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n/an/a 19.2n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM15529
PNG
((3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoy...)
Show SMILES CCN1CCCN([C@H](C)C1=O)C(=O)C[C@H](N)Cc1cc(F)ccc1F |r|
Show InChI InChI=1S/C18H25F2N3O2/c1-3-22-7-4-8-23(12(2)18(22)25)17(24)11-15(21)10-13-9-14(19)5-6-16(13)20/h5-6,9,12,15H,3-4,7-8,10-11,21H2,1-2H3/t12-,15-/m1/s1
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n/an/a 20.7n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM15549
PNG
((3R,6S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@H]1CNC(=O)[C@@H](CC(F)(F)F)N(C1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C18H21F6N3O2/c1-9-7-26-17(29)15(6-18(22,23)24)27(8-9)16(28)4-11(25)2-10-3-13(20)14(21)5-12(10)19/h3,5,9,11,15H,2,4,6-8,25H2,1H3,(H,26,29)/t9-,11+,15+/m0/s1
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n/an/a 24.6n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM15557
PNG
((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES CC[C@@H]1CCN([C@H](C)C(=O)N1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C18H24F3N3O2/c1-3-13-4-5-24(10(2)18(26)23-13)17(25)8-12(22)6-11-7-15(20)16(21)9-14(11)19/h7,9-10,12-13H,3-6,8,22H2,1-2H3,(H,23,26)/t10-,12-,13-/m1/s1
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n/an/a 29.6n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM15544
PNG
((3R,6R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@@H]1CNC(=O)[C@@H](C)N(C1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C17H22F3N3O2/c1-9-7-22-17(25)10(2)23(8-9)16(24)5-12(21)3-11-4-14(19)15(20)6-13(11)18/h4,6,9-10,12H,3,5,7-8,21H2,1-2H3,(H,22,25)/t9-,10-,12-/m1/s1
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n/an/a 33n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM15552
PNG
((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@@H]1CCN([C@H](CC(F)(F)F)C(=O)N1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C18H21F6N3O2/c1-9-2-3-27(15(17(29)26-9)8-18(22,23)24)16(28)6-11(25)4-10-5-13(20)14(21)7-12(10)19/h5,7,9,11,15H,2-4,6,8,25H2,1H3,(H,26,29)/t9-,11-,15-/m1/s1
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n/an/a 34.3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM15547
PNG
((3R,6S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES CC[C@H]1N(C[C@@H](C)CNC1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C18H24F3N3O2/c1-3-16-18(26)23-8-10(2)9-24(16)17(25)6-12(22)4-11-5-14(20)15(21)7-13(11)19/h5,7,10,12,16H,3-4,6,8-9,22H2,1-2H3,(H,23,26)/t10-,12+,16+/m0/s1
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n/an/a 37.3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM15548
PNG
((3R,6R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES CC[C@H]1N(C[C@H](C)CNC1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C18H24F3N3O2/c1-3-16-18(26)23-8-10(2)9-24(16)17(25)6-12(22)4-11-5-14(20)15(21)7-13(11)19/h5,7,10,12,16H,3-4,6,8-9,22H2,1-2H3,(H,23,26)/t10-,12-,16-/m1/s1
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n/an/a 60.3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM15531
PNG
(1-substituted diazepanone 9c | 2-[(3R)-4-[(3R)-3-a...)
Show SMILES C[C@H]1N(CCCN(CC(O)=O)C1=O)C(=O)C[C@H](N)Cc1cc(F)ccc1F |r|
Show InChI InChI=1S/C18H23F2N3O4/c1-11-18(27)22(10-17(25)26)5-2-6-23(11)16(24)9-14(21)8-12-7-13(19)3-4-15(12)20/h3-4,7,11,14H,2,5-6,8-10,21H2,1H3,(H,25,26)/t11-,14-/m1/s1
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n/an/a 69.9n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM15558
PNG
((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@H]1N(CC[C@@H](Cc2ccccc2F)NC1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C23H25F4N3O2/c1-13-23(32)29-17(9-14-4-2-3-5-18(14)24)6-7-30(13)22(31)11-16(28)8-15-10-20(26)21(27)12-19(15)25/h2-5,10,12-13,16-17H,6-9,11,28H2,1H3,(H,29,32)/t13-,16-,17+/m1/s1
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n/an/a 126n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM15556
PNG
((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@H]1N(CC[C@@H](NC1=O)C(F)(F)F)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C17H19F6N3O2/c1-8-16(28)25-14(17(21,22)23)2-3-26(8)15(27)6-10(24)4-9-5-12(19)13(20)7-11(9)18/h5,7-8,10,14H,2-4,6,24H2,1H3,(H,25,28)/t8-,10-,14-/m1/s1
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n/an/a 139n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM13523
PNG
(1,4-diazepan-2-one 2c | 4-[(3R)-3-amino-4-(2,4,5-t...)
Show SMILES N[C@@H](CC(=O)N1CCCNC(=O)C1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C15H18F3N3O2/c16-11-7-13(18)12(17)5-9(11)4-10(19)6-15(23)21-3-1-2-20-14(22)8-21/h5,7,10H,1-4,6,8,19H2,(H,20,22)/t10-/m1/s1
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n/an/a 142n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM15551
PNG
((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Show SMILES C[C@H]1N(CC(C)(C)CNC1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C18H24F3N3O2/c1-10-17(26)23-8-18(2,3)9-24(10)16(25)6-12(22)4-11-5-14(20)15(21)7-13(11)19/h5,7,10,12H,4,6,8-9,22H2,1-3H3,(H,23,26)/t10-,12-/m1/s1
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n/an/a 142n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM15550
PNG
((3R,6R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@@H]1CNC(=O)[C@@H](CC(F)(F)F)N(C1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C18H21F6N3O2/c1-9-7-26-17(29)15(6-18(22,23)24)27(8-9)16(28)4-11(25)2-10-3-13(20)14(21)5-12(10)19/h3,5,9,11,15H,2,4,6-8,25H2,1H3,(H,26,29)/t9-,11-,15-/m1/s1
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n/an/a 143n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM15546
PNG
((3R,7S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@H]1CCN([C@H](C)C(=O)N1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C17H22F3N3O2/c1-9-3-4-23(10(2)17(25)22-9)16(24)7-12(21)5-11-6-14(19)15(20)8-13(11)18/h6,8-10,12H,3-5,7,21H2,1-2H3,(H,22,25)/t9-,10+,12+/m0/s1
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n/an/a 397n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM15541
PNG
(4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]...)
Show SMILES CC1CCNC(=O)CN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C16H20F3N3O2/c1-9-2-3-21-15(23)8-22(9)16(24)6-11(20)4-10-5-13(18)14(19)7-12(10)17/h5,7,9,11H,2-4,6,8,20H2,1H3,(H,21,23)/t9?,11-/m1/s1
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n/an/a 765n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM15541
PNG
(4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]...)
Show SMILES CC1CCNC(=O)CN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C16H20F3N3O2/c1-9-2-3-21-15(23)8-22(9)16(24)6-11(20)4-10-5-13(18)14(19)7-12(10)17/h5,7,9,11H,2-4,6,8,20H2,1H3,(H,21,23)/t9?,11-/m1/s1
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n/an/a 1.05E+3n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM15554
PNG
((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@@H]1CCN([C@H](Cc2ccccc2F)C(=O)N1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C23H25F4N3O2/c1-13-6-7-30(21(23(32)29-13)10-14-4-2-3-5-17(14)24)22(31)11-16(28)8-15-9-19(26)20(27)12-18(15)25/h2-5,9,12-13,16,21H,6-8,10-11,28H2,1H3,(H,29,32)/t13-,16-,21-/m1/s1
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n/an/a 5.30E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM15553
PNG
((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@@H]1CCN([C@H](Cc2ccccc2C)C(=O)N1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C24H28F3N3O2/c1-14-5-3-4-6-16(14)11-22-24(32)29-15(2)7-8-30(22)23(31)12-18(28)9-17-10-20(26)21(27)13-19(17)25/h3-6,10,13,15,18,22H,7-9,11-12,28H2,1-2H3,(H,29,32)/t15-,18-,22-/m1/s1
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n/an/a 6.80E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM15558
PNG
((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@H]1N(CC[C@@H](Cc2ccccc2F)NC1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C23H25F4N3O2/c1-13-23(32)29-17(9-14-4-2-3-5-18(14)24)6-7-30(13)22(31)11-16(28)8-15-10-20(26)21(27)12-19(15)25/h2-5,10,12-13,16-17H,6-9,11,28H2,1H3,(H,29,32)/t13-,16-,17+/m1/s1
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n/an/a 8.70E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM15552
PNG
((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@@H]1CCN([C@H](CC(F)(F)F)C(=O)N1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C18H21F6N3O2/c1-9-2-3-27(15(17(29)26-9)8-18(22,23)24)16(28)6-11(25)4-10-5-13(20)14(21)7-12(10)19/h5,7,9,11,15H,2-4,6,8,25H2,1H3,(H,26,29)/t9-,11-,15-/m1/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM15536
PNG
((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Show SMILES C[C@H]1N(CCCN(CCOCc2ccccc2)C1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C25H30F3N3O3/c1-17-25(33)30(10-11-34-16-18-6-3-2-4-7-18)8-5-9-31(17)24(32)14-20(29)12-19-13-22(27)23(28)15-21(19)26/h2-4,6-7,13,15,17,20H,5,8-12,14,16,29H2,1H3/t17-,20-/m1/s1
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n/an/a 1.50E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM15549
PNG
((3R,6S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@H]1CNC(=O)[C@@H](CC(F)(F)F)N(C1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C18H21F6N3O2/c1-9-7-26-17(29)15(6-18(22,23)24)27(8-9)16(28)4-11(25)2-10-3-13(20)14(21)5-12(10)19/h3,5,9,11,15H,2,4,6-8,25H2,1H3,(H,26,29)/t9-,11+,15+/m0/s1
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n/an/a 1.60E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM15551
PNG
((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Show SMILES C[C@H]1N(CC(C)(C)CNC1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C18H24F3N3O2/c1-10-17(26)23-8-18(2,3)9-24(10)16(25)6-12(22)4-11-5-14(20)15(21)7-13(11)19/h5,7,10,12H,4,6,8-9,22H2,1-3H3,(H,23,26)/t10-,12-/m1/s1
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n/an/a 1.70E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM15536
PNG
((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Show SMILES C[C@H]1N(CCCN(CCOCc2ccccc2)C1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C25H30F3N3O3/c1-17-25(33)30(10-11-34-16-18-6-3-2-4-7-18)8-5-9-31(17)24(32)14-20(29)12-19-13-22(27)23(28)15-21(19)26/h2-4,6-7,13,15,17,20H,5,8-12,14,16,29H2,1H3/t17-,20-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM15554
PNG
((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@@H]1CCN([C@H](Cc2ccccc2F)C(=O)N1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C23H25F4N3O2/c1-13-6-7-30(21(23(32)29-13)10-14-4-2-3-5-17(14)24)22(31)11-16(28)8-15-9-19(26)20(27)12-18(15)25/h2-5,9,12-13,16,21H,6-8,10-11,28H2,1H3,(H,29,32)/t13-,16-,21-/m1/s1
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n/an/a 1.80E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM15558
PNG
((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@H]1N(CC[C@@H](Cc2ccccc2F)NC1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C23H25F4N3O2/c1-13-23(32)29-17(9-14-4-2-3-5-18(14)24)6-7-30(13)22(31)11-16(28)8-15-10-20(26)21(27)12-19(15)25/h2-5,10,12-13,16-17H,6-9,11,28H2,1H3,(H,29,32)/t13-,16-,17+/m1/s1
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n/an/a 1.90E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM15553
PNG
((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@@H]1CCN([C@H](Cc2ccccc2C)C(=O)N1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C24H28F3N3O2/c1-14-5-3-4-6-16(14)11-22-24(32)29-15(2)7-8-30(22)23(31)12-18(28)9-17-10-20(26)21(27)13-19(17)25/h3-6,10,13,15,18,22H,7-9,11-12,28H2,1-2H3,(H,29,32)/t15-,18-,22-/m1/s1
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n/an/a 1.90E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM15557
PNG
((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES CC[C@@H]1CCN([C@H](C)C(=O)N1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C18H24F3N3O2/c1-3-13-4-5-24(10(2)18(26)23-13)17(25)8-12(22)6-11-7-15(20)16(21)9-14(11)19/h7,9-10,12-13H,3-6,8,22H2,1-2H3,(H,23,26)/t10-,12-,13-/m1/s1
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n/an/a 2.00E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM15534
PNG
((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Show SMILES C[C@H]1N(CCCN(C)C1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C17H22F3N3O2/c1-10-17(25)22(2)4-3-5-23(10)16(24)8-12(21)6-11-7-14(19)15(20)9-13(11)18/h7,9-10,12H,3-6,8,21H2,1-2H3/t10-,12-/m1/s1
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n/an/a 2.10E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM15543
PNG
((3R,6S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@H]1CNC(=O)[C@@H](C)N(C1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C17H22F3N3O2/c1-9-7-22-17(25)10(2)23(8-9)16(24)5-12(21)3-11-4-14(19)15(20)6-13(11)18/h4,6,9-10,12H,3,5,7-8,21H2,1-2H3,(H,22,25)/t9-,10+,12+/m0/s1
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n/an/a 2.10E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM15538
PNG
((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Show SMILES C[C@H]1N(CCCN(C2CC2)C1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C19H24F3N3O2/c1-11-19(27)25(14-3-4-14)6-2-5-24(11)18(26)9-13(23)7-12-8-16(21)17(22)10-15(12)20/h8,10-11,13-14H,2-7,9,23H2,1H3/t11-,13-/m1/s1
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n/an/a 2.20E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM15551
PNG
((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Show SMILES C[C@H]1N(CC(C)(C)CNC1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C18H24F3N3O2/c1-10-17(26)23-8-18(2,3)9-24(10)16(25)6-12(22)4-11-5-14(20)15(21)7-13(11)19/h5,7,10,12H,4,6,8-9,22H2,1-3H3,(H,23,26)/t10-,12-/m1/s1
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n/an/a 2.60E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM15555
PNG
((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@@H]1CCN([C@H](Cc2ccccn2)C(=O)N1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C22H25F3N4O2/c1-13-5-7-29(20(22(31)28-13)11-16-4-2-3-6-27-16)21(30)10-15(26)8-14-9-18(24)19(25)12-17(14)23/h2-4,6,9,12-13,15,20H,5,7-8,10-11,26H2,1H3,(H,28,31)/t13-,15-,20-/m1/s1
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n/an/a 2.70E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM15530
PNG
(1-substituted diazepanone 9b | methyl 2-[(3R)-4-[(...)
Show SMILES COC(=O)CN1CCCN([C@H](C)C1=O)C(=O)C[C@H](N)Cc1cc(F)ccc1F |r|
Show InChI InChI=1S/C19H25F2N3O4/c1-12-19(27)23(11-18(26)28-2)6-3-7-24(12)17(25)10-15(22)9-13-8-14(20)4-5-16(13)21/h4-5,8,12,15H,3,6-7,9-11,22H2,1-2H3/t12-,15-/m1/s1
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n/an/a 2.90E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM15549
PNG
((3R,6S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@H]1CNC(=O)[C@@H](CC(F)(F)F)N(C1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C18H21F6N3O2/c1-9-7-26-17(29)15(6-18(22,23)24)27(8-9)16(28)4-11(25)2-10-3-13(20)14(21)5-12(10)19/h3,5,9,11,15H,2,4,6-8,25H2,1H3,(H,26,29)/t9-,11+,15+/m0/s1
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n/an/a 3.10E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM15555
PNG
((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@@H]1CCN([C@H](Cc2ccccn2)C(=O)N1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C22H25F3N4O2/c1-13-5-7-29(20(22(31)28-13)11-16-4-2-3-6-27-16)21(30)10-15(26)8-14-9-18(24)19(25)12-17(14)23/h2-4,6,9,12-13,15,20H,5,7-8,10-11,26H2,1H3,(H,28,31)/t13-,15-,20-/m1/s1
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n/an/a 3.40E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM15539
PNG
((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Show SMILES C[C@H]1N(CCCN(C1=O)C(C)(C)C)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H28F3N3O2/c1-12-19(28)26(20(2,3)4)7-5-6-25(12)18(27)10-14(24)8-13-9-16(22)17(23)11-15(13)21/h9,11-12,14H,5-8,10,24H2,1-4H3/t12-,14-/m1/s1
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n/an/a 3.50E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM15545
PNG
((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@@H]1CCN([C@H](C)C(=O)N1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C17H22F3N3O2/c1-9-3-4-23(10(2)17(25)22-9)16(24)7-12(21)5-11-6-14(19)15(20)8-13(11)18/h6,8-10,12H,3-5,7,21H2,1-2H3,(H,22,25)/t9-,10-,12-/m1/s1
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n/an/a 3.80E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM15543
PNG
((3R,6S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@H]1CNC(=O)[C@@H](C)N(C1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C17H22F3N3O2/c1-9-7-22-17(25)10(2)23(8-9)16(24)5-12(21)3-11-4-14(19)15(20)6-13(11)18/h4,6,9-10,12H,3,5,7-8,21H2,1-2H3,(H,22,25)/t9-,10+,12+/m0/s1
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n/an/a 3.80E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM15529
PNG
((3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoy...)
Show SMILES CCN1CCCN([C@H](C)C1=O)C(=O)C[C@H](N)Cc1cc(F)ccc1F |r|
Show InChI InChI=1S/C18H25F2N3O2/c1-3-22-7-4-8-23(12(2)18(22)25)17(24)11-15(21)10-13-9-14(19)5-6-16(13)20/h5-6,9,12,15H,3-4,7-8,10-11,21H2,1-2H3/t12-,15-/m1/s1
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n/an/a 3.80E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM15547
PNG
((3R,6S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES CC[C@H]1N(C[C@@H](C)CNC1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C18H24F3N3O2/c1-3-16-18(26)23-8-10(2)9-24(16)17(25)6-12(22)4-11-5-14(20)15(21)7-13(11)19/h5,7,10,12,16H,3-4,6,8-9,22H2,1-2H3,(H,23,26)/t10-,12+,16+/m0/s1
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n/an/a 4.10E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM15552
PNG
((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@@H]1CCN([C@H](CC(F)(F)F)C(=O)N1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C18H21F6N3O2/c1-9-2-3-27(15(17(29)26-9)8-18(22,23)24)16(28)6-11(25)4-10-5-13(20)14(21)7-12(10)19/h5,7,9,11,15H,2-4,6,8,25H2,1H3,(H,26,29)/t9-,11-,15-/m1/s1
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n/an/a 4.20E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM13523
PNG
(1,4-diazepan-2-one 2c | 4-[(3R)-3-amino-4-(2,4,5-t...)
Show SMILES N[C@@H](CC(=O)N1CCCNC(=O)C1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C15H18F3N3O2/c16-11-7-13(18)12(17)5-9(11)4-10(19)6-15(23)21-3-1-2-20-14(22)8-21/h5,7,10H,1-4,6,8,19H2,(H,20,22)/t10-/m1/s1
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n/an/a 4.20E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM15537
PNG
((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Show SMILES C[C@H]1N(CCCN(CC(F)(F)F)C1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C18H21F6N3O2/c1-10-17(29)26(9-18(22,23)24)3-2-4-27(10)16(28)7-12(25)5-11-6-14(20)15(21)8-13(11)19/h6,8,10,12H,2-5,7,9,25H2,1H3/t10-,12-/m1/s1
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n/an/a 4.20E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM15550
PNG
((3R,6R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@@H]1CNC(=O)[C@@H](CC(F)(F)F)N(C1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C18H21F6N3O2/c1-9-7-26-17(29)15(6-18(22,23)24)27(8-9)16(28)4-11(25)2-10-3-13(20)14(21)5-12(10)19/h3,5,9,11,15H,2,4,6-8,25H2,1H3,(H,26,29)/t9-,11-,15-/m1/s1
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n/an/a 4.20E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM15541
PNG
(4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]...)
Show SMILES CC1CCNC(=O)CN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C16H20F3N3O2/c1-9-2-3-21-15(23)8-22(9)16(24)6-11(20)4-10-5-13(18)14(19)7-12(10)17/h5,7,9,11H,2-4,6,8,20H2,1H3,(H,21,23)/t9?,11-/m1/s1
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n/an/a 4.40E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM15532
PNG
((3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoy...)
Show SMILES C[C@H]1N(CCCN(C2CC2)C1=O)C(=O)C[C@H](N)Cc1cc(F)ccc1F |r|
Show InChI InChI=1S/C19H25F2N3O2/c1-12-19(26)24(16-4-5-16)8-2-7-23(12)18(25)11-15(22)10-13-9-14(20)3-6-17(13)21/h3,6,9,12,15-16H,2,4-5,7-8,10-11,22H2,1H3/t12-,15-/m1/s1
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n/an/a 4.50E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM15538
PNG
((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Show SMILES C[C@H]1N(CCCN(C2CC2)C1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C19H24F3N3O2/c1-11-19(27)25(14-3-4-14)6-2-5-24(11)18(26)9-13(23)7-12-8-16(21)17(22)10-15(12)20/h8,10-11,13-14H,2-7,9,23H2,1H3/t11-,13-/m1/s1
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n/an/a 4.60E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM13519
PNG
((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Show SMILES C[C@H]1N(CCCNC1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C16H20F3N3O2/c1-9-16(24)21-3-2-4-22(9)15(23)7-11(20)5-10-6-13(18)14(19)8-12(10)17/h6,8-9,11H,2-5,7,20H2,1H3,(H,21,24)/t9-,11-/m1/s1
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n/an/a 4.60E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM15557
PNG
((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES CC[C@@H]1CCN([C@H](C)C(=O)N1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C18H24F3N3O2/c1-3-13-4-5-24(10(2)18(26)23-13)17(25)8-12(22)6-11-7-15(20)16(21)9-14(11)19/h7,9-10,12-13H,3-6,8,22H2,1-2H3,(H,23,26)/t10-,12-,13-/m1/s1
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n/an/a 4.90E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM15535
PNG
((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Show SMILES C[C@H]1N(CCCN(CCO)C1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C18H24F3N3O3/c1-11-18(27)23(5-6-25)3-2-4-24(11)17(26)9-13(22)7-12-8-15(20)16(21)10-14(12)19/h8,10-11,13,25H,2-7,9,22H2,1H3/t11-,13-/m1/s1
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n/an/a 5.30E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM15539
PNG
((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Show SMILES C[C@H]1N(CCCN(C1=O)C(C)(C)C)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H28F3N3O2/c1-12-19(28)26(20(2,3)4)7-5-6-25(12)18(27)10-14(24)8-13-9-16(22)17(23)11-15(13)21/h9,11-12,14H,5-8,10,24H2,1-4H3/t12-,14-/m1/s1
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n/an/a 5.50E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM15537
PNG
((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Show SMILES C[C@H]1N(CCCN(CC(F)(F)F)C1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C18H21F6N3O2/c1-10-17(29)26(9-18(22,23)24)3-2-4-27(10)16(28)7-12(25)5-11-6-14(20)15(21)8-13(11)19/h6,8,10,12H,2-5,7,9,25H2,1H3/t10-,12-/m1/s1
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n/an/a 5.60E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM13518
PNG
((3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoy...)
Show SMILES C[C@H]1N(CCCNC1=O)C(=O)C[C@H](N)Cc1cc(F)ccc1F |r|
Show InChI InChI=1S/C16H21F2N3O2/c1-10-16(23)20-5-2-6-21(10)15(22)9-13(19)8-11-7-12(17)3-4-14(11)18/h3-4,7,10,13H,2,5-6,8-9,19H2,1H3,(H,20,23)/t10-,13-/m1/s1
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n/an/a 5.80E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM13519
PNG
((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Show SMILES C[C@H]1N(CCCNC1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C16H20F3N3O2/c1-9-16(24)21-3-2-4-22(9)15(23)7-11(20)5-10-6-13(18)14(19)8-12(10)17/h6,8-9,11H,2-5,7,20H2,1H3,(H,21,24)/t9-,11-/m1/s1
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n/an/a 5.90E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM15547
PNG
((3R,6S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES CC[C@H]1N(C[C@@H](C)CNC1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C18H24F3N3O2/c1-3-16-18(26)23-8-10(2)9-24(16)17(25)6-12(22)4-11-5-14(20)15(21)7-13(11)19/h5,7,10,12,16H,3-4,6,8-9,22H2,1-2H3,(H,23,26)/t10-,12+,16+/m0/s1
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n/an/a 6.10E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM15546
PNG
((3R,7S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@H]1CCN([C@H](C)C(=O)N1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C17H22F3N3O2/c1-9-3-4-23(10(2)17(25)22-9)16(24)7-12(21)5-11-6-14(19)15(20)8-13(11)18/h6,8-10,12H,3-5,7,21H2,1-2H3,(H,22,25)/t9-,10+,12+/m0/s1
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n/an/a 7.00E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM15544
PNG
((3R,6R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@@H]1CNC(=O)[C@@H](C)N(C1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C17H22F3N3O2/c1-9-7-22-17(25)10(2)23(8-9)16(24)5-12(21)3-11-4-14(19)15(20)6-13(11)18/h4,6,9-10,12H,3,5,7-8,21H2,1-2H3,(H,22,25)/t9-,10-,12-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM15545
PNG
((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@@H]1CCN([C@H](C)C(=O)N1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C17H22F3N3O2/c1-9-3-4-23(10(2)17(25)22-9)16(24)7-12(21)5-11-6-14(19)15(20)8-13(11)18/h6,8-10,12H,3-5,7,21H2,1-2H3,(H,22,25)/t9-,10-,12-/m1/s1
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n/an/a 7.20E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM15546
PNG
((3R,7S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@H]1CCN([C@H](C)C(=O)N1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C17H22F3N3O2/c1-9-3-4-23(10(2)17(25)22-9)16(24)7-12(21)5-11-6-14(19)15(20)8-13(11)18/h6,8-10,12H,3-5,7,21H2,1-2H3,(H,22,25)/t9-,10+,12+/m0/s1
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n/an/a 7.30E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM15556
PNG
((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@H]1N(CC[C@@H](NC1=O)C(F)(F)F)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C17H19F6N3O2/c1-8-16(28)25-14(17(21,22)23)2-3-26(8)15(27)6-10(24)4-9-5-12(19)13(20)7-11(9)18/h5,7-8,10,14H,2-4,6,24H2,1H3,(H,25,28)/t8-,10-,14-/m1/s1
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n/an/a 7.60E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM15535
PNG
((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Show SMILES C[C@H]1N(CCCN(CCO)C1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C18H24F3N3O3/c1-11-18(27)23(5-6-25)3-2-4-24(11)17(26)9-13(22)7-12-8-15(20)16(21)10-14(12)19/h8,10-11,13,25H,2-7,9,22H2,1H3/t11-,13-/m1/s1
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n/an/a 7.80E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM15550
PNG
((3R,6R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@@H]1CNC(=O)[C@@H](CC(F)(F)F)N(C1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C18H21F6N3O2/c1-9-7-26-17(29)15(6-18(22,23)24)27(8-9)16(28)4-11(25)2-10-3-13(20)14(21)5-12(10)19/h3,5,9,11,15H,2,4,6-8,25H2,1H3,(H,26,29)/t9-,11-,15-/m1/s1
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n/an/a 8.90E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM15548
PNG
((3R,6R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES CC[C@H]1N(C[C@H](C)CNC1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C18H24F3N3O2/c1-3-16-18(26)23-8-10(2)9-24(16)17(25)6-12(22)4-11-5-14(20)15(21)7-13(11)19/h5,7,10,12,16H,3-4,6,8-9,22H2,1-2H3,(H,23,26)/t10-,12-,16-/m1/s1
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n/an/a 9.00E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM15544
PNG
((3R,6R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@@H]1CNC(=O)[C@@H](C)N(C1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C17H22F3N3O2/c1-9-7-22-17(25)10(2)23(8-9)16(24)5-12(21)3-11-4-14(19)15(20)6-13(11)18/h4,6,9-10,12H,3,5,7-8,21H2,1-2H3,(H,22,25)/t9-,10-,12-/m1/s1
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n/an/a 9.30E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM15532
PNG
((3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoy...)
Show SMILES C[C@H]1N(CCCN(C2CC2)C1=O)C(=O)C[C@H](N)Cc1cc(F)ccc1F |r|
Show InChI InChI=1S/C19H25F2N3O2/c1-12-19(26)24(16-4-5-16)8-2-7-23(12)18(25)11-15(22)10-13-9-14(20)3-6-17(13)21/h3,6,9,12,15-16H,2,4-5,7-8,10-11,22H2,1H3/t12-,15-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM15531
PNG
(1-substituted diazepanone 9c | 2-[(3R)-4-[(3R)-3-a...)
Show SMILES C[C@H]1N(CCCN(CC(O)=O)C1=O)C(=O)C[C@H](N)Cc1cc(F)ccc1F |r|
Show InChI InChI=1S/C18H23F2N3O4/c1-11-18(27)22(10-17(25)26)5-2-6-23(11)16(24)9-14(21)8-12-7-13(19)3-4-15(12)20/h3-4,7,11,14H,2,5-6,8-10,21H2,1H3,(H,25,26)/t11-,14-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM15556
PNG
((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@H]1N(CC[C@@H](NC1=O)C(F)(F)F)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C17H19F6N3O2/c1-8-16(28)25-14(17(21,22)23)2-3-26(8)15(27)6-10(24)4-9-5-12(19)13(20)7-11(9)18/h5,7-8,10,14H,2-4,6,24H2,1H3,(H,25,28)/t8-,10-,14-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM15534
PNG
((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Show SMILES C[C@H]1N(CCCN(C)C1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C17H22F3N3O2/c1-10-17(25)22(2)4-3-5-23(10)16(24)8-12(21)6-11-7-14(19)15(20)9-13(11)18/h7,9-10,12H,3-6,8,21H2,1-2H3/t10-,12-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM13523
PNG
(1,4-diazepan-2-one 2c | 4-[(3R)-3-amino-4-(2,4,5-t...)
Show SMILES N[C@@H](CC(=O)N1CCCNC(=O)C1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C15H18F3N3O2/c16-11-7-13(18)12(17)5-9(11)4-10(19)6-15(23)21-3-1-2-20-14(22)8-21/h5,7,10H,1-4,6,8,19H2,(H,20,22)/t10-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM15530
PNG
(1-substituted diazepanone 9b | methyl 2-[(3R)-4-[(...)
Show SMILES COC(=O)CN1CCCN([C@H](C)C1=O)C(=O)C[C@H](N)Cc1cc(F)ccc1F |r|
Show InChI InChI=1S/C19H25F2N3O4/c1-12-19(27)23(11-18(26)28-2)6-3-7-24(12)17(25)10-15(22)9-13-8-14(20)4-5-16(13)21/h4-5,8,12,15H,3,6-7,9-11,22H2,1-2H3/t12-,15-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM15529
PNG
((3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoy...)
Show SMILES CCN1CCCN([C@H](C)C1=O)C(=O)C[C@H](N)Cc1cc(F)ccc1F |r|
Show InChI InChI=1S/C18H25F2N3O2/c1-3-22-7-4-8-23(12(2)18(22)25)17(24)11-15(21)10-13-9-14(19)5-6-16(13)20/h5-6,9,12,15H,3-4,7-8,10-11,21H2,1-2H3/t12-,15-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM15548
PNG
((3R,6R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES CC[C@H]1N(C[C@H](C)CNC1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C18H24F3N3O2/c1-3-16-18(26)23-8-10(2)9-24(16)17(25)6-12(22)4-11-5-14(20)15(21)7-13(11)19/h5,7,10,12,16H,3-4,6,8-9,22H2,1-2H3,(H,23,26)/t10-,12-,16-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM13518
PNG
((3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoy...)
Show SMILES C[C@H]1N(CCCNC1=O)C(=O)C[C@H](N)Cc1cc(F)ccc1F |r|
Show InChI InChI=1S/C16H21F2N3O2/c1-10-16(23)20-5-2-6-21(10)15(22)9-13(19)8-11-7-12(17)3-4-14(11)18/h3-4,7,10,13H,2,5-6,8-9,19H2,1H3,(H,20,23)/t10-,13-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM15531
PNG
(1-substituted diazepanone 9c | 2-[(3R)-4-[(3R)-3-a...)
Show SMILES C[C@H]1N(CCCN(CC(O)=O)C1=O)C(=O)C[C@H](N)Cc1cc(F)ccc1F |r|
Show InChI InChI=1S/C18H23F2N3O4/c1-11-18(27)22(10-17(25)26)5-2-6-23(11)16(24)9-14(21)8-12-7-13(19)3-4-15(12)20/h3-4,7,11,14H,2,5-6,8-10,21H2,1H3,(H,25,26)/t11-,14-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM15541
PNG
(4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]...)
Show SMILES CC1CCNC(=O)CN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C16H20F3N3O2/c1-9-2-3-21-15(23)8-22(9)16(24)6-11(20)4-10-5-13(18)14(19)7-12(10)17/h5,7,9,11H,2-4,6,8,20H2,1H3,(H,21,23)/t9?,11-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM15541
PNG
(4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]...)
Show SMILES CC1CCNC(=O)CN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C16H20F3N3O2/c1-9-2-3-21-15(23)8-22(9)16(24)6-11(20)4-10-5-13(18)14(19)7-12(10)17/h5,7,9,11H,2-4,6,8,20H2,1H3,(H,21,23)/t9?,11-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM15541
PNG
(4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]...)
Show SMILES CC1CCNC(=O)CN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C16H20F3N3O2/c1-9-2-3-21-15(23)8-22(9)16(24)6-11(20)4-10-5-13(18)14(19)7-12(10)17/h5,7,9,11H,2-4,6,8,20H2,1H3,(H,21,23)/t9?,11-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%