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PubMed code 17407275

Compile data set for download or QSAR
Found 12 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
P2Y purinoceptor 14


(Homo sapiens (Human))		BDBM50209667
PNG
(CHEMBL387520 | diphosphoric acid 1-alpha-D-glucopy...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)O[C@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=S
Show InChI InChI=1S/C15H22N2O17P2S/c18-5-1-2-17(15(37)16-5)12-9(22)6(19)4(31-12)3-30-35(26,27)34-36(28,29)33-14-10(23)7(20)8(21)11(32-14)13(24)25/h1-2,4,6-12,14,19-23H,3H2,(H,24,25)(H,26,27)(H,28,29)(H,16,18,37)/t4-,6-,7+,8+,9-,10-,11+,12-,14-/m1/s1
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n/an/an/an/a 420n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y14 expressed in COS7 cells assessed as stimulation of PLC-mediated [3H]inositol hydrolsis

J Med Chem 50: 2030-9 (2007)


Article DOI: 10.1021/jm061222w
BindingDB Entry DOI: 10.7270/Q24Q7TPN
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))		BDBM50209659
PNG
(UDP-alpha-D-glucose | uridine 5'-[3-alpha-D-glucop...)
Show SMILES OC[C@H]1O[C@H](OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/t5-,6-,8-,9-,10+,11-,12-,13-,14-/m1/s1
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n/an/an/an/a 350n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y14 expressed in COS7 cells assessed as stimulation of PLC-mediated [3H]inositol hydrolsis

J Med Chem 50: 2030-9 (2007)


Article DOI: 10.1021/jm061222w
BindingDB Entry DOI: 10.7270/Q24Q7TPN
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))		BDBM50209661
PNG
(CHEMBL226713 | [({[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,...)
Show SMILES OC[C@H]1O[C@](O)(COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C15H24N2O17P2/c18-3-6-10(21)12(23)15(25,33-6)5-31-36(28,29)34-35(26,27)30-4-7-9(20)11(22)13(32-7)17-2-1-8(19)16-14(17)24/h1-2,6-7,9-13,18,20-23,25H,3-5H2,(H,26,27)(H,28,29)(H,16,19,24)/t6-,7-,9-,10-,11-,12+,13-,15-/m1/s1
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n/an/an/an/a 880n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y14 expressed in COS7 cells assessed as stimulation of PLC-mediated [3H]inositol hydrolsis

J Med Chem 50: 2030-9 (2007)


Article DOI: 10.1021/jm061222w
BindingDB Entry DOI: 10.7270/Q24Q7TPN
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))		BDBM50209663
PNG
(CHEMBL374384 | MRS-2670 | diphosphoric acid 1-alph...)
Show SMILES OC[C@H]1O[C@H](OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=S)[nH]c2=O)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C15H24N2O16P2S/c18-3-5-8(19)10(21)12(23)14(31-5)32-35(27,28)33-34(25,26)29-4-6-9(20)11(22)13(30-6)17-2-1-7(36)16-15(17)24/h1-2,5-6,8-14,18-23H,3-4H2,(H,25,26)(H,27,28)(H,16,24,36)/t5-,6-,8-,9-,10+,11-,12-,13-,14-/m1/s1
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n/an/an/an/a 350n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y14 expressed in COS7 cells assessed as stimulation of PLC-mediated [3H]inositol hydrolsis

J Med Chem 50: 2030-9 (2007)


Article DOI: 10.1021/jm061222w
BindingDB Entry DOI: 10.7270/Q24Q7TPN
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))		BDBM50197974
PNG
(udp-N-acetyl-glucosamine)
Show SMILES CC(=O)N[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1OP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8+,10-,11-,12+,13-,14+,15+,16-/m0/s1
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n/an/an/an/a 810n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y14 expressed in COS7 cells assessed as stimulation of PLC-mediated [3H]inositol hydrolsis

J Med Chem 50: 2030-9 (2007)


Article DOI: 10.1021/jm061222w
BindingDB Entry DOI: 10.7270/Q24Q7TPN
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))		BDBM50209668
PNG
(CHEMBL439009 | Galactose-Uridine-5'-Diphosphate)
Show SMILES OC[C@H]1O[C@H](OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)[C@H](O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/t5-,6-,8+,9-,10+,11-,12-,13-,14-/m1/s1
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n/an/an/an/a 670n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y14 expressed in COS7 cells assessed as stimulation of PLC-mediated [3H]inositol hydrolsis

J Med Chem 50: 2030-9 (2007)


Article DOI: 10.1021/jm061222w
BindingDB Entry DOI: 10.7270/Q24Q7TPN
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))		BDBM50209658
PNG
(CHEMBL390160 | [({[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)O[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C15H24N2O17P2/c18-5-1-2-17(15(26)16-5)14-12(25)6(19)4(32-14)3-31-35(27,28)34-36(29,30)33-13-10(23)8(21)7(20)9(22)11(13)24/h1-2,4,6-14,19-25H,3H2,(H,27,28)(H,29,30)(H,16,18,26)/t4-,6-,7-,8-,9+,10+,11-,12-,13-,14-/m1/s1
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n/an/an/an/a 1.88E+3n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y14 expressed in COS7 cells assessed as stimulation of PLC-mediated [3H]inositol hydrolsis

J Med Chem 50: 2030-9 (2007)


Article DOI: 10.1021/jm061222w
BindingDB Entry DOI: 10.7270/Q24Q7TPN
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))		BDBM50209665
PNG
(CHEMBL228057 | UDP-alpha-D-glucuronic acid | uridi...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)O[C@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C15H22N2O18P2/c18-5-1-2-17(15(26)16-5)12-9(22)6(19)4(32-12)3-31-36(27,28)35-37(29,30)34-14-10(23)7(20)8(21)11(33-14)13(24)25/h1-2,4,6-12,14,19-23H,3H2,(H,24,25)(H,27,28)(H,29,30)(H,16,18,26)/t4-,6-,7+,8+,9-,10-,11+,12-,14-/m1/s1
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n/an/an/an/a 370n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y14 expressed in COS7 cells assessed as stimulation of PLC-mediated [3H]inositol hydrolsis

J Med Chem 50: 2030-9 (2007)


Article DOI: 10.1021/jm061222w
BindingDB Entry DOI: 10.7270/Q24Q7TPN
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))		BDBM50197974
PNG
(udp-N-acetyl-glucosamine)
Show SMILES CC(=O)N[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1OP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8+,10-,11-,12+,13-,14+,15+,16-/m0/s1
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n/an/an/an/a 810n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y14 expressed in COS7 cells assessed as stimulation of PLC-mediated [3H]inositol hydrolsis

J Med Chem 50: 2030-9 (2007)


Article DOI: 10.1021/jm061222w
BindingDB Entry DOI: 10.7270/Q24Q7TPN
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))		BDBM50209666
PNG
(CHEMBL227711 | URIDINE-5'-DIPHOSPHATE-MANNOSE)
Show SMILES OC[C@H]1O[C@H](OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)[C@@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/t5-,6-,8-,9-,10+,11-,12+,13-,14-/m1/s1
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n/an/an/an/a 910n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y14 expressed in COS7 cells assessed as stimulation of PLC-mediated [3H]inositol hydrolsis

J Med Chem 50: 2030-9 (2007)


Article DOI: 10.1021/jm061222w
BindingDB Entry DOI: 10.7270/Q24Q7TPN
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))		BDBM50209669
PNG
(CHEMBL228111 | MRS-2670 | diphosphoric acid 1-alph...)
Show SMILES OC[C@H]1O[C@H](OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=S)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C15H24N2O16P2S/c18-3-5-8(20)10(22)12(24)14(31-5)32-35(27,28)33-34(25,26)29-4-6-9(21)11(23)13(30-6)17-2-1-7(19)16-15(17)36/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,25,26)(H,27,28)(H,16,19,36)/t5-,6-,8-,9-,10+,11-,12-,13-,14-/m1/s1
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n/an/an/an/a 49n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y14 expressed in COS7 cells assessed as stimulation of PLC-mediated [3H]inositol hydrolsis

J Med Chem 50: 2030-9 (2007)


Article DOI: 10.1021/jm061222w
BindingDB Entry DOI: 10.7270/Q24Q7TPN
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))		BDBM50209664
PNG
(CHEMBL439378 | diphosphoric acid 1-alpha-D-glucopy...)
Show SMILES CSC1NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@H]1O |c:7|
Show InChI InChI=1S/C16H28N2O16P2S/c1-37-8-2-3-18(16(25)17-8)14-12(23)10(21)7(31-14)5-30-35(26,27)34-36(28,29)33-15-13(24)11(22)9(20)6(4-19)32-15/h2-3,6-15,19-24H,4-5H2,1H3,(H,17,25)(H,26,27)(H,28,29)/t6-,7-,8?,9-,10-,11+,12-,13-,14-,15-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y14 expressed in COS7 cells assessed as stimulation of PLC-mediated [3H]inositol hydrolsis

J Med Chem 50: 2030-9 (2007)


Article DOI: 10.1021/jm061222w
BindingDB Entry DOI: 10.7270/Q24Q7TPN
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%