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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Steroid hormone receptor ERR1 (Homo sapiens (Human)) | BDBM22420 ((cyclohexylmethyl)({[1-(4-methylphenyl)-1H-indol-3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet  | DrugBank MMDB PC cid PC sid PDB UniChem Similars | DrugBank MMDB PDB Article PubMed | n/a | n/a | 190 | n/a | n/a | n/a | n/a | 7.5 | 20 |
Novartis | Assay Description The IC50s of compounds were determined in the FRET assay, which was conducted as time-resolved measurement (TR-FRET) in a 1536 well plate format. The... | J Biol Chem 282: 23231-9 (2007) Article DOI: 10.1074/jbc.M703337200 BindingDB Entry DOI: 10.7270/Q21N7ZFJ | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| Steroid hormone receptor ERR1 (Homo sapiens (Human)) | BDBM22421 ((cyclohexylmethyl)[(1-phenyl-1H-indol-3-yl)methyl]...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 700 | n/a | n/a | n/a | n/a | 7.5 | 20 |
Novartis | Assay Description The IC50s of compounds were determined in the FRET assay, which was conducted as time-resolved measurement (TR-FRET) in a 1536 well plate format. The... | J Biol Chem 282: 23231-9 (2007) Article DOI: 10.1074/jbc.M703337200 BindingDB Entry DOI: 10.7270/Q21N7ZFJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cell (A) | Syringe (B) | Cell Links | Syringe Links | Cell + Syr Links | ΔG° kJ/mole | -TΔS° kJ/mole | ΔH° kJ/mole | log K | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|
| Estrogen-Related Receptor, alpha Mutant (C325S) (Homo sapiens (Human)) | BDBM22421 ((cyclohexylmethyl)[(1-phenyl-1H-indol-3-yl)methyl]...) | GoogleScholar PDB | PC cid PC sid | n/a | 19.6 | -54.3 | 6.03 | 7.5 | 25 | |
Novartis | J Biol Chem 282: 23231-9 (2007) | |||||||||
| Estrogen-Related Receptor, alpha (Homo sapiens (Human)) | BDBM22421 ((cyclohexylmethyl)[(1-phenyl-1H-indol-3-yl)methyl]...) | GoogleScholar PDB | PC cid PC sid | n/a | 18.0 | -53.1 | 6.11 | 7.5 | 25 | |
Novartis | J Biol Chem 282: 23231-9 (2007) | |||||||||
