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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Glycogen synthase kinase-3 beta (Rattus norvegicus (rat)) | BDBM17149 (2-imino-thiazolidin-4-one analog, 11 | 4-(5-{[(5Z)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet  | DrugBank PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Vernalis (R&D) Ltd | Assay Description In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g... | Bioorg Med Chem Lett 17: 3880-5 (2007) Article DOI: 10.1016/j.bmcl.2007.04.110 BindingDB Entry DOI: 10.7270/Q28G8HZQ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen synthase kinase-3 beta (Rattus norvegicus (rat)) | BDBM17150 (2-chloro-4-(5-{[(5Z)-2-imino-4-oxo-1,3-thiazolidin...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Vernalis (R&D) Ltd | Assay Description In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g... | Bioorg Med Chem Lett 17: 3880-5 (2007) Article DOI: 10.1016/j.bmcl.2007.04.110 BindingDB Entry DOI: 10.7270/Q28G8HZQ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM17151 (2-imino-thiazolidin-4-one analog, 13 | 4-(5-{1-[(5...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | DrugBank PC cid PC sid PDB UniChem Similars | DrugBank PDB Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Vernalis (R&D) Ltd | Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP... | Bioorg Med Chem Lett 17: 3880-5 (2007) Article DOI: 10.1016/j.bmcl.2007.04.110 BindingDB Entry DOI: 10.7270/Q28G8HZQ | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| Glycogen synthase kinase-3 beta (Rattus norvegicus (rat)) | BDBM17144 (2-imino-thiazolidin-4-one analog, 6 | 4-(5-{[(5Z)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | DrugBank PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 80 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Vernalis (R&D) Ltd | Assay Description In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g... | Bioorg Med Chem Lett 17: 3880-5 (2007) Article DOI: 10.1016/j.bmcl.2007.04.110 BindingDB Entry DOI: 10.7270/Q28G8HZQ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM17144 (2-imino-thiazolidin-4-one analog, 6 | 4-(5-{[(5Z)-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | DrugBank PC cid PC sid PDB UniChem Similars | DrugBank PDB Article PubMed | n/a | n/a | 120 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Vernalis (R&D) Ltd | Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP... | Bioorg Med Chem Lett 17: 3880-5 (2007) Article DOI: 10.1016/j.bmcl.2007.04.110 BindingDB Entry DOI: 10.7270/Q28G8HZQ | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM17141 (2-imino-thiazolidin-4-one analog, 1 | 4-(5-{[(5Z)-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid PDB UniChem Similars | DrugBank PDB Article PubMed | n/a | n/a | 180 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Vernalis (R&D) Ltd | Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP... | Bioorg Med Chem Lett 17: 3880-5 (2007) Article DOI: 10.1016/j.bmcl.2007.04.110 BindingDB Entry DOI: 10.7270/Q28G8HZQ | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Glycogen synthase kinase-3 beta (Rattus norvegicus (rat)) | BDBM17141 (2-imino-thiazolidin-4-one analog, 1 | 4-(5-{[(5Z)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 250 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Vernalis (R&D) Ltd | Assay Description In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g... | Bioorg Med Chem Lett 17: 3880-5 (2007) Article DOI: 10.1016/j.bmcl.2007.04.110 BindingDB Entry DOI: 10.7270/Q28G8HZQ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen synthase kinase-3 beta (Rattus norvegicus (rat)) | BDBM17151 (2-imino-thiazolidin-4-one analog, 13 | 4-(5-{1-[(5...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | DrugBank PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 430 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Vernalis (R&D) Ltd | Assay Description In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g... | Bioorg Med Chem Lett 17: 3880-5 (2007) Article DOI: 10.1016/j.bmcl.2007.04.110 BindingDB Entry DOI: 10.7270/Q28G8HZQ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen synthase kinase-3 beta (Rattus norvegicus (rat)) | BDBM17145 (2-imino-thiazolidin-4-one analog, 7 | N-[2-(dimeth...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 510 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Vernalis (R&D) Ltd | Assay Description In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g... | Bioorg Med Chem Lett 17: 3880-5 (2007) Article DOI: 10.1016/j.bmcl.2007.04.110 BindingDB Entry DOI: 10.7270/Q28G8HZQ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM17145 (2-imino-thiazolidin-4-one analog, 7 | N-[2-(dimeth...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 570 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Vernalis (R&D) Ltd | Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP... | Bioorg Med Chem Lett 17: 3880-5 (2007) Article DOI: 10.1016/j.bmcl.2007.04.110 BindingDB Entry DOI: 10.7270/Q28G8HZQ | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
| Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM17150 (2-chloro-4-(5-{[(5Z)-2-imino-4-oxo-1,3-thiazolidin...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 570 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Vernalis (R&D) Ltd | Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP... | Bioorg Med Chem Lett 17: 3880-5 (2007) Article DOI: 10.1016/j.bmcl.2007.04.110 BindingDB Entry DOI: 10.7270/Q28G8HZQ | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
| Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM17149 (2-imino-thiazolidin-4-one analog, 11 | 4-(5-{[(5Z)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | DrugBank PC cid PC sid PDB UniChem Similars | DrugBank PDB Article PubMed | n/a | n/a | 610 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Vernalis (R&D) Ltd | Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP... | Bioorg Med Chem Lett 17: 3880-5 (2007) Article DOI: 10.1016/j.bmcl.2007.04.110 BindingDB Entry DOI: 10.7270/Q28G8HZQ | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM17153 (4-(5-{[(4Z)-3-oxo-5-thia-2,7-diazatricyclo[6.4.0.0...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 760 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Vernalis (R&D) Ltd | Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP... | Bioorg Med Chem Lett 17: 3880-5 (2007) Article DOI: 10.1016/j.bmcl.2007.04.110 BindingDB Entry DOI: 10.7270/Q28G8HZQ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM17146 ((5Z)-2-imino-5-({5-[4-(piperazine-1-sulfonyl)pheny...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Vernalis (R&D) Ltd | Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP... | Bioorg Med Chem Lett 17: 3880-5 (2007) Article DOI: 10.1016/j.bmcl.2007.04.110 BindingDB Entry DOI: 10.7270/Q28G8HZQ | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
| Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM17148 (2-imino-thiazolidin-4-one analog, 10 | 4-(5-{[(5Z)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.30E+3 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Vernalis (R&D) Ltd | Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP... | Bioorg Med Chem Lett 17: 3880-5 (2007) Article DOI: 10.1016/j.bmcl.2007.04.110 BindingDB Entry DOI: 10.7270/Q28G8HZQ | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
| Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM17142 ((5Z)-2-imino-5-{[5-(2-nitrophenyl)furan-2-yl]methy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.90E+4 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Vernalis (R&D) Ltd | Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP... | Bioorg Med Chem Lett 17: 3880-5 (2007) Article DOI: 10.1016/j.bmcl.2007.04.110 BindingDB Entry DOI: 10.7270/Q28G8HZQ | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
| Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM17152 (4-(5-{[(5Z)-2,4-dioxo-1,3-thiazolidin-5-ylidene]me...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | 2.70E+4 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Vernalis (R&D) Ltd | Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP... | Bioorg Med Chem Lett 17: 3880-5 (2007) Article DOI: 10.1016/j.bmcl.2007.04.110 BindingDB Entry DOI: 10.7270/Q28G8HZQ | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM17143 (2-imino-thiazolidin-4-one analog, 4 | 4-(5-{[(5Z)-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid PDB UniChem Similars | DrugBank PDB Article PubMed | n/a | n/a | 4.70E+4 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Vernalis (R&D) Ltd | Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP... | Bioorg Med Chem Lett 17: 3880-5 (2007) Article DOI: 10.1016/j.bmcl.2007.04.110 BindingDB Entry DOI: 10.7270/Q28G8HZQ | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM17147 ((5Z)-2-imino-5-({5-[4-(morpholine-4-sulfonyl)pheny...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.50E+5 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Vernalis (R&D) Ltd | Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP... | Bioorg Med Chem Lett 17: 3880-5 (2007) Article DOI: 10.1016/j.bmcl.2007.04.110 BindingDB Entry DOI: 10.7270/Q28G8HZQ | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
