Found 3 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50223445
(CHEMBL410408 | c[homoPhe-Hca-Glu-Gly-Leu-Glu-Glu]-...)Show SMILES CC(C)C[C@@H]1NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc2cc(=O)oc3cc(O)ccc23)NC(=O)[C@H](CCc2ccccc2)NC(=O)CC[C@@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC1=O Show InChI InChI=1S/C46H58N8O15/c1-24(2)18-33-45(67)53-32(14-17-40(61)62)43(65)49-27(21-36(47)56)9-15-37(57)50-31(12-8-25-6-4-3-5-7-25)44(66)54-34(19-26-20-41(63)69-35-22-28(55)10-11-29(26)35)46(68)52-30(13-16-39(59)60)42(64)48-23-38(58)51-33/h3-7,10-11,20,22,24,27,30-34,55H,8-9,12-19,21,23H2,1-2H3,(H2,47,56)(H,48,64)(H,49,65)(H,50,57)(H,51,58)(H,52,68)(H,53,67)(H,54,66)(H,59,60)(H,61,62)/t27-,30-,31-,32-,33-,34-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.93E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Université Paris Descartes
Curated by ChEMBL
| Assay Description
Displacement of biotinylated VEGF165 from human recombinant VEGFR1 by chemiluminescent assay |
J Med Chem 50: 5135-46 (2007)
Article DOI: 10.1021/jm0706970
BindingDB Entry DOI: 10.7270/Q2125SDD |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50223447
(CHEMBL438299 | NGYEIEWYSWVTHGMY-NH2)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@H](C)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C96H124N22O26S/c1-7-49(4)81(117-88(136)66(29-31-79(129)130)108-89(137)69(35-52-18-24-58(122)25-19-52)107-77(126)44-103-84(132)62(97)40-75(98)124)95(143)109-65(28-30-78(127)128)86(134)112-71(37-54-41-101-63-14-10-8-12-60(54)63)91(139)111-70(36-53-20-26-59(123)27-21-53)90(138)115-74(46-119)93(141)113-72(38-55-42-102-64-15-11-9-13-61(55)64)92(140)116-80(48(2)3)94(142)118-82(50(5)120)96(144)114-73(39-56-43-100-47-105-56)85(133)104-45-76(125)106-67(32-33-145-6)87(135)110-68(83(99)131)34-51-16-22-57(121)23-17-51/h8-27,41-43,47-50,62,65-74,80-82,101-102,119-123H,7,28-40,44-46,97H2,1-6H3,(H2,98,124)(H2,99,131)(H,100,105)(H,103,132)(H,104,133)(H,106,125)(H,107,126)(H,108,137)(H,109,143)(H,110,135)(H,111,139)(H,112,134)(H,113,141)(H,114,144)(H,115,138)(H,116,140)(H,117,136)(H,118,142)(H,127,128)(H,129,130)/t49-,50-,62-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,80-,81-,82-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Université Paris Descartes
Curated by ChEMBL
| Assay Description
Displacement of biotinylated VEGF165 from human recombinant VEGFR1 by chemiluminescent assay |
J Med Chem 50: 5135-46 (2007)
Article DOI: 10.1021/jm0706970
BindingDB Entry DOI: 10.7270/Q2125SDD |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50223446
(CHEMBL389147 | c[Tyr-Tyr-Asp-Glu-Gly-Leu-Glu-Glu]-...)Show SMILES CC(C)C[C@@H]1NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC[C@H](NC(=O)[C@H](CCC(O)=O)NC1=O)C(N)=O Show InChI InChI=1S/C45H59N9O17/c1-22(2)17-30-42(68)52-29(13-16-37(61)62)41(67)50-27(39(46)65)11-14-34(57)48-31(18-23-3-7-25(55)8-4-23)43(69)53-32(19-24-5-9-26(56)10-6-24)44(70)54-33(20-38(63)64)45(71)51-28(12-15-36(59)60)40(66)47-21-35(58)49-30/h3-10,22,27-33,55-56H,11-21H2,1-2H3,(H2,46,65)(H,47,66)(H,48,57)(H,49,58)(H,50,67)(H,51,71)(H,52,68)(H,53,69)(H,54,70)(H,59,60)(H,61,62)(H,63,64)/t27-,28-,29-,30-,31-,32-,33-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.99E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Université Paris Descartes
Curated by ChEMBL
| Assay Description
Displacement of biotinylated VEGF165 from human recombinant VEGFR1 by chemiluminescent assay |
J Med Chem 50: 5135-46 (2007)
Article DOI: 10.1021/jm0706970
BindingDB Entry DOI: 10.7270/Q2125SDD |
More data for this
Ligand-Target Pair | |
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