Found 22 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Coagulation factor X
(Homo sapiens (Human)) | BDBM50373933
(CHEMBL258328)Show SMILES CCOC(=O)N1CCC(NC(=O)c2cc3cc(Cl)ccc3[nH]2)C(C1)NC(=O)c1nc2CCN(C)Cc2s1 |w:22.26,8.8| Show InChI InChI=1S/C25H29ClN6O4S/c1-3-36-25(35)32-9-7-17(28-22(33)19-11-14-10-15(26)4-5-16(14)27-19)20(12-32)29-23(34)24-30-18-6-8-31(2)13-21(18)37-24/h4-5,10-11,17,20,27H,3,6-9,12-13H2,1-2H3,(H,28,33)(H,29,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem Lett 18: 782-7 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.037
BindingDB Entry DOI: 10.7270/Q20P10WJ |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50373927
(CHEMBL271011)Show SMILES CN1CCc2nc(sc2C1)C(=O)N[C@@H]1CN(CC[C@@H]1NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)NC(C)(C)C Show InChI InChI=1S/C27H34ClN7O3S/c1-27(2,3)33-26(38)35-10-8-18(30-23(36)20-12-15-11-16(28)5-6-17(15)29-20)21(13-35)31-24(37)25-32-19-7-9-34(4)14-22(19)39-25/h5-6,11-12,18,21,29H,7-10,13-14H2,1-4H3,(H,30,36)(H,31,37)(H,33,38)/t18-,21+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem Lett 18: 782-7 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.037
BindingDB Entry DOI: 10.7270/Q20P10WJ |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50373929
(CHEMBL256814)Show SMILES CC(C)C(=O)N1CC[C@H](NC(=O)c2cc3cc(Cl)ccc3[nH]2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 Show InChI InChI=1S/C26H31ClN6O3S/c1-14(2)26(36)33-9-7-18(29-23(34)20-11-15-10-16(27)4-5-17(15)28-20)21(12-33)30-24(35)25-31-19-6-8-32(3)13-22(19)37-25/h4-5,10-11,14,18,21,28H,6-9,12-13H2,1-3H3,(H,29,34)(H,30,35)/t18-,21+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem Lett 18: 782-7 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.037
BindingDB Entry DOI: 10.7270/Q20P10WJ |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50373931
(CHEMBL402343)Show SMILES COCC(=O)N1CC[C@H](NC(=O)c2cc3cc(Cl)ccc3[nH]2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 Show InChI InChI=1S/C25H29ClN6O4S/c1-31-7-5-18-21(12-31)37-25(30-18)24(35)29-20-11-32(22(33)13-36-2)8-6-17(20)28-23(34)19-10-14-9-15(26)3-4-16(14)27-19/h3-4,9-10,17,20,27H,5-8,11-13H2,1-2H3,(H,28,34)(H,29,35)/t17-,20+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem Lett 18: 782-7 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.037
BindingDB Entry DOI: 10.7270/Q20P10WJ |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50373928
(CHEMBL403904)Show SMILES CCNC(=O)N1CC[C@H](NC(=O)c2cc3cc(Cl)ccc3[nH]2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 Show InChI InChI=1S/C25H30ClN7O3S/c1-3-27-25(36)33-9-7-17(29-22(34)19-11-14-10-15(26)4-5-16(14)28-19)20(12-33)30-23(35)24-31-18-6-8-32(2)13-21(18)37-24/h4-5,10-11,17,20,28H,3,6-9,12-13H2,1-2H3,(H,27,36)(H,29,34)(H,30,35)/t17-,20+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem Lett 18: 782-7 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.037
BindingDB Entry DOI: 10.7270/Q20P10WJ |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50328730
(CHEMBL430037 | N-((3R,4S)-4-(5-chloro-1H-indole-2-...)Show SMILES CN(C)C(=O)N1CC[C@H](NC(=O)c2cc3cc(Cl)ccc3[nH]2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 Show InChI InChI=1S/C25H30ClN7O3S/c1-31(2)25(36)33-9-7-17(28-22(34)19-11-14-10-15(26)4-5-16(14)27-19)20(12-33)29-23(35)24-30-18-6-8-32(3)13-21(18)37-24/h4-5,10-11,17,20,27H,6-9,12-13H2,1-3H3,(H,28,34)(H,29,35)/t17-,20+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem Lett 18: 782-7 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.037
BindingDB Entry DOI: 10.7270/Q20P10WJ |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50328729
(CHEMBL1270159 | N-((3R,4S)-1-acetyl-4-(5-chloro-1H...)Show SMILES CN1CCc2nc(sc2C1)C(=O)N[C@@H]1CN(CC[C@@H]1NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(C)=O |r| Show InChI InChI=1S/C24H27ClN6O3S/c1-13(32)31-8-6-17(27-22(33)19-10-14-9-15(25)3-4-16(14)26-19)20(11-31)28-23(34)24-29-18-5-7-30(2)12-21(18)35-24/h3-4,9-10,17,20,26H,5-8,11-12H2,1-2H3,(H,27,33)(H,28,34)/t17-,20+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem Lett 18: 782-7 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.037
BindingDB Entry DOI: 10.7270/Q20P10WJ |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50373930
(CHEMBL271895)Show SMILES CCC(=O)N1CC[C@H](NC(=O)c2cc3cc(Cl)ccc3[nH]2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 Show InChI InChI=1S/C25H29ClN6O3S/c1-3-22(33)32-9-7-17(28-23(34)19-11-14-10-15(26)4-5-16(14)27-19)20(12-32)29-24(35)25-30-18-6-8-31(2)13-21(18)36-25/h4-5,10-11,17,20,27H,3,6-9,12-13H2,1-2H3,(H,28,34)(H,29,35)/t17-,20+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem Lett 18: 782-7 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.037
BindingDB Entry DOI: 10.7270/Q20P10WJ |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50373921
(CHEMBL257080)Show SMILES CN1CCc2nc(sc2C1)C(=O)N[C@@H]1CN(CC[C@@H]1NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)CO Show InChI InChI=1S/C24H27ClN6O4S/c1-30-6-4-17-20(11-30)36-24(29-17)23(35)28-19-10-31(21(33)12-32)7-5-16(19)27-22(34)18-9-13-8-14(25)2-3-15(13)26-18/h2-3,8-9,16,19,26,32H,4-7,10-12H2,1H3,(H,27,34)(H,28,35)/t16-,19+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem Lett 18: 782-7 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.037
BindingDB Entry DOI: 10.7270/Q20P10WJ |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50373938
(CHEMBL271316)Show SMILES CN1CCc2nc(sc2C1)C(=O)NC1CN(CCC1NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)OC(C)(C)C |w:13.14,18.21| Show InChI InChI=1S/C27H33ClN6O4S/c1-27(2,3)38-26(37)34-10-8-18(30-23(35)20-12-15-11-16(28)5-6-17(15)29-20)21(13-34)31-24(36)25-32-19-7-9-33(4)14-22(19)39-25/h5-6,11-12,18,21,29H,7-10,13-14H2,1-4H3,(H,30,35)(H,31,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem Lett 18: 782-7 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.037
BindingDB Entry DOI: 10.7270/Q20P10WJ |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50214995
(CHEMBL245678 | N-((1R,2S)-2-(5-CHLORO-1H-INDOLE-2-...)Show SMILES CN1CCc2nc(sc2C1)C(=O)N[C@@H]1CCCC[C@@H]1NC(=O)c1cc2cc(Cl)ccc2[nH]1 |r| Show InChI InChI=1S/C23H26ClN5O2S/c1-29-9-8-18-20(12-29)32-23(28-18)22(31)27-17-5-3-2-4-16(17)26-21(30)19-11-13-10-14(24)6-7-15(13)25-19/h6-7,10-11,16-17,25H,2-5,8-9,12H2,1H3,(H,26,30)(H,27,31)/t16-,17+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| MMDB
PDB
Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem Lett 18: 782-7 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.037
BindingDB Entry DOI: 10.7270/Q20P10WJ |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50373924
(CHEMBL437213)Show SMILES CN1CCc2nc(sc2C1)C(=O)N[C@@H]1CN(CC(O)=O)CC[C@@H]1NC(=O)c1cc2cc(Cl)ccc2[nH]1 Show InChI InChI=1S/C24H27ClN6O4S/c1-30-6-4-17-20(11-30)36-24(29-17)23(35)28-19-10-31(12-21(32)33)7-5-16(19)27-22(34)18-9-13-8-14(25)2-3-15(13)26-18/h2-3,8-9,16,19,26H,4-7,10-12H2,1H3,(H,27,34)(H,28,35)(H,32,33)/t16-,19+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem Lett 18: 782-7 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.037
BindingDB Entry DOI: 10.7270/Q20P10WJ |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50373934
(CHEMBL444898)Show SMILES CN1CCc2nc(sc2C1)C(=O)NC1CN(CCC1NC(=O)c1cc2cc(Cl)ccc2[nH]1)S(C)(=O)=O |w:13.14,18.21| Show InChI InChI=1S/C23H27ClN6O4S2/c1-29-7-5-17-20(12-29)35-23(28-17)22(32)27-19-11-30(36(2,33)34)8-6-16(19)26-21(31)18-10-13-9-14(24)3-4-15(13)25-18/h3-4,9-10,16,19,25H,5-8,11-12H2,1-2H3,(H,26,31)(H,27,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem Lett 18: 782-7 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.037
BindingDB Entry DOI: 10.7270/Q20P10WJ |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50214983
(CHEMBL391805 | N-((1R,2R)-2-(5-CHLORO-1H-INDOLE-2-...)Show SMILES CN1CCc2nc(sc2C1)C(=O)N[C@@H]1CCCC[C@H]1NC(=O)c1cc2cc(Cl)ccc2[nH]1 Show InChI InChI=1S/C23H26ClN5O2S/c1-29-9-8-18-20(12-29)32-23(28-18)22(31)27-17-5-3-2-4-16(17)26-21(30)19-11-13-10-14(24)6-7-15(13)25-19/h6-7,10-11,16-17,25H,2-5,8-9,12H2,1H3,(H,26,30)(H,27,31)/t16-,17-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| MMDB
PDB
Article
PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem Lett 18: 782-7 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.037
BindingDB Entry DOI: 10.7270/Q20P10WJ |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50373922
(CHEMBL401661)Show SMILES CN1CCc2nc(sc2C1)C(=O)NC1CCN(CC1NC(=O)c1cc2cc(Cl)ccc2[nH]1)S(C)(=O)=O |w:13.14,18.21| Show InChI InChI=1S/C23H27ClN6O4S2/c1-29-7-5-17-20(12-29)35-23(28-17)22(32)26-16-6-8-30(36(2,33)34)11-19(16)27-21(31)18-10-13-9-14(24)3-4-15(13)25-18/h3-4,9-10,16,19,25H,5-8,11-12H2,1-2H3,(H,26,32)(H,27,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem Lett 18: 782-7 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.037
BindingDB Entry DOI: 10.7270/Q20P10WJ |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50373926
(CHEMBL270797)Show SMILES COCCN1CC[C@H](NC(=O)c2cc3cc(Cl)ccc3[nH]2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 Show InChI InChI=1S/C25H31ClN6O3S/c1-31-7-5-19-22(14-31)36-25(30-19)24(34)29-21-13-32(9-10-35-2)8-6-18(21)28-23(33)20-12-15-11-16(26)3-4-17(15)27-20/h3-4,11-12,18,21,27H,5-10,13-14H2,1-2H3,(H,28,33)(H,29,34)/t18-,21+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem Lett 18: 782-7 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.037
BindingDB Entry DOI: 10.7270/Q20P10WJ |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50373935
(CHEMBL257903)Show SMILES CN1CCc2nc(sc2C1)C(=O)NC1CCN(CC1NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(C)=O |w:13.14,18.21| Show InChI InChI=1S/C24H27ClN6O3S/c1-13(32)31-8-6-17(27-23(34)24-29-18-5-7-30(2)12-21(18)35-24)20(11-31)28-22(33)19-10-14-9-15(25)3-4-16(14)26-19/h3-4,9-10,17,20,26H,5-8,11-12H2,1-2H3,(H,27,34)(H,28,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem Lett 18: 782-7 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.037
BindingDB Entry DOI: 10.7270/Q20P10WJ |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50373925
(CHEMBL257284)Show SMILES COC(=O)CN1CC[C@H](NC(=O)c2cc3cc(Cl)ccc3[nH]2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 Show InChI InChI=1S/C25H29ClN6O4S/c1-31-7-5-18-21(12-31)37-25(30-18)24(35)29-20-11-32(13-22(33)36-2)8-6-17(20)28-23(34)19-10-14-9-15(26)3-4-16(14)27-19/h3-4,9-10,17,20,27H,5-8,11-13H2,1-2H3,(H,28,34)(H,29,35)/t17-,20+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem Lett 18: 782-7 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.037
BindingDB Entry DOI: 10.7270/Q20P10WJ |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50373936
(CHEMBL270391)Show SMILES CN1CCc2nc(sc2C1)C(=O)NC1CNCCC1NC(=O)c1cc2cc(Cl)ccc2[nH]1 |w:13.14,18.21| Show InChI InChI=1S/C22H25ClN6O2S/c1-29-7-5-16-19(11-29)32-22(28-16)21(31)27-18-10-24-6-4-15(18)26-20(30)17-9-12-8-13(23)2-3-14(12)25-17/h2-3,8-9,15,18,24-25H,4-7,10-11H2,1H3,(H,26,30)(H,27,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem Lett 18: 782-7 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.037
BindingDB Entry DOI: 10.7270/Q20P10WJ |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50373932
(CHEMBL257268)Show SMILES CCOC(=O)N1CCC(NC(=O)c2nc3CCN(C)Cc3s2)C(C1)NC(=O)c1cc2cc(Cl)ccc2[nH]1 |w:8.8,22.26| Show InChI InChI=1S/C25H29ClN6O4S/c1-3-36-25(35)32-9-7-17(28-23(34)24-30-18-6-8-31(2)13-21(18)37-24)20(12-32)29-22(33)19-11-14-10-15(26)4-5-16(14)27-19/h4-5,10-11,17,20,27H,3,6-9,12-13H2,1-2H3,(H,28,34)(H,29,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem Lett 18: 782-7 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.037
BindingDB Entry DOI: 10.7270/Q20P10WJ |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50373937
(CHEMBL270604)Show SMILES CN1CCc2nc(sc2C1)C(=O)NC1CCN(CC1NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)OC(C)(C)C |w:13.14,18.21| Show InChI InChI=1S/C27H33ClN6O4S/c1-27(2,3)38-26(37)34-10-8-18(30-24(36)25-32-19-7-9-33(4)14-22(19)39-25)21(13-34)31-23(35)20-12-15-11-16(28)5-6-17(15)29-20/h5-6,11-12,18,21,29H,7-10,13-14H2,1-4H3,(H,30,36)(H,31,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem Lett 18: 782-7 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.037
BindingDB Entry DOI: 10.7270/Q20P10WJ |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50373923
(CHEMBL401680)Show SMILES CN1CCc2nc(sc2C1)C(=O)NC1CCNCC1NC(=O)c1cc2cc(Cl)ccc2[nH]1 |w:13.14,18.21| Show InChI InChI=1S/C22H25ClN6O2S/c1-29-7-5-16-19(11-29)32-22(28-16)21(31)26-15-4-6-24-10-18(15)27-20(30)17-9-12-8-13(23)2-3-14(12)25-17/h2-3,8-9,15,18,24-25H,4-7,10-11H2,1H3,(H,26,31)(H,27,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem Lett 18: 782-7 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.037
BindingDB Entry DOI: 10.7270/Q20P10WJ |
More data for this
Ligand-Target Pair | |
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