Found 10 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Acetylcholinesterase
(Homo sapiens (Human)) | BDBM8963
(CHEMBL32823 | Homodimeric Tacrine Analog 3b | N-[7...)Show SMILES C(CCCNc1c2CCCCc2nc2ccccc12)CCCNc1c2CCCCc2nc2ccccc12 Show InChI InChI=1S/C33H40N4/c1(2-12-22-34-32-24-14-4-8-18-28(24)36-29-19-9-5-15-25(29)32)3-13-23-35-33-26-16-6-10-20-30(26)37-31-21-11-7-17-27(31)33/h4,6,8,10,14,16,18,20H,1-3,5,7,9,11-13,15,17,19,21-23H2,(H,34,36)(H,35,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 0.810 | n/a | n/a | n/a | n/a | n/a | n/a |
Bologna University
Curated by ChEMBL
| Assay Description Inhibition of human serum recombinant AChE by Ellman's method |
J Med Chem 50: 6446-9 (2007)
Article DOI: 10.1021/jm701225u BindingDB Entry DOI: 10.7270/Q2FN15Z6 |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Homo sapiens (Human)) | BDBM50228383
(1,7-bis(5,6,7,8-tetrahydroacridin-9-ylamino)heptan...)Show SMILES O=C(CCCNc1c2CCCCc2nc2ccccc12)CCCNc1c2CCCCc2nc2ccccc12 Show InChI InChI=1S/C33H38N4O/c38-23(11-9-21-34-32-24-13-1-5-17-28(24)36-29-18-6-2-14-25(29)32)12-10-22-35-33-26-15-3-7-19-30(26)37-31-20-8-4-16-27(31)33/h1,3,5,7,13,15,17,19H,2,4,6,8-12,14,16,18,20-22H2,(H,34,36)(H,35,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.83 | n/a | n/a | n/a | n/a | n/a | n/a |
Bologna University
Curated by ChEMBL
| Assay Description Inhibition of human serum recombinant AChE by Ellman's method |
J Med Chem 50: 6446-9 (2007)
Article DOI: 10.1021/jm701225u BindingDB Entry DOI: 10.7270/Q2FN15Z6 |
More data for this Ligand-Target Pair | |
Cholinesterase
(Homo sapiens (Human)) | BDBM50228384
(CHEMBL440983 | N1,N2-bis(2-(5,6,7,8-tetrahydroacri...)Show SMILES O=C(NCCNc1c2CCCCc2nc2ccccc12)C(=O)NCCNc1c2CCCCc2nc2ccccc12 Show InChI InChI=1S/C32H36N6O2/c39-31(35-19-17-33-29-21-9-1-5-13-25(21)37-26-14-6-2-10-22(26)29)32(40)36-20-18-34-30-23-11-3-7-15-27(23)38-28-16-8-4-12-24(28)30/h1,3,5,7,9,11,13,15H,2,4,6,8,10,12,14,16-20H2,(H,33,37)(H,34,38)(H,35,39)(H,36,40) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.44 | n/a | n/a | n/a | n/a | n/a | n/a |
Bologna University
Curated by ChEMBL
| Assay Description Inhibition of human serum recombinant BChE by Ellman's method |
J Med Chem 50: 6446-9 (2007)
Article DOI: 10.1021/jm701225u BindingDB Entry DOI: 10.7270/Q2FN15Z6 |
More data for this Ligand-Target Pair | |
Cholinesterase
(Homo sapiens (Human)) | BDBM8963
(CHEMBL32823 | Homodimeric Tacrine Analog 3b | N-[7...)Show SMILES C(CCCNc1c2CCCCc2nc2ccccc12)CCCNc1c2CCCCc2nc2ccccc12 Show InChI InChI=1S/C33H40N4/c1(2-12-22-34-32-24-14-4-8-18-28(24)36-29-19-9-5-15-25(29)32)3-13-23-35-33-26-16-6-10-20-30(26)37-31-21-11-7-17-27(31)33/h4,6,8,10,14,16,18,20H,1-3,5,7,9,11-13,15,17,19,21-23H2,(H,34,36)(H,35,37) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 5.66 | n/a | n/a | n/a | n/a | n/a | n/a |
Bologna University
Curated by ChEMBL
| Assay Description Inhibition of human serum recombinant BChE by Ellman's method |
J Med Chem 50: 6446-9 (2007)
Article DOI: 10.1021/jm701225u BindingDB Entry DOI: 10.7270/Q2FN15Z6 |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Homo sapiens (Human)) | BDBM50228384
(CHEMBL440983 | N1,N2-bis(2-(5,6,7,8-tetrahydroacri...)Show SMILES O=C(NCCNc1c2CCCCc2nc2ccccc12)C(=O)NCCNc1c2CCCCc2nc2ccccc12 Show InChI InChI=1S/C32H36N6O2/c39-31(35-19-17-33-29-21-9-1-5-13-25(21)37-26-14-6-2-10-22(26)29)32(40)36-20-18-34-30-23-11-3-7-15-27(23)38-28-16-8-4-12-24(28)30/h1,3,5,7,9,11,13,15H,2,4,6,8,10,12,14,16-20H2,(H,33,37)(H,34,38)(H,35,39)(H,36,40) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.65 | n/a | n/a | n/a | n/a | n/a | n/a |
Bologna University
Curated by ChEMBL
| Assay Description Inhibition of human serum recombinant AChE by Ellman's method |
J Med Chem 50: 6446-9 (2007)
Article DOI: 10.1021/jm701225u BindingDB Entry DOI: 10.7270/Q2FN15Z6 |
More data for this Ligand-Target Pair | |
Cholinesterase
(Homo sapiens (Human)) | BDBM50228383
(1,7-bis(5,6,7,8-tetrahydroacridin-9-ylamino)heptan...)Show SMILES O=C(CCCNc1c2CCCCc2nc2ccccc12)CCCNc1c2CCCCc2nc2ccccc12 Show InChI InChI=1S/C33H38N4O/c38-23(11-9-21-34-32-24-13-1-5-17-28(24)36-29-18-6-2-14-25(29)32)12-10-22-35-33-26-15-3-7-19-30(26)37-31-20-8-4-16-27(31)33/h1,3,5,7,13,15,17,19H,2,4,6,8-12,14,16,18,20-22H2,(H,34,36)(H,35,37) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bologna University
Curated by ChEMBL
| Assay Description Inhibition of human serum recombinant BChE by Ellman's method |
J Med Chem 50: 6446-9 (2007)
Article DOI: 10.1021/jm701225u BindingDB Entry DOI: 10.7270/Q2FN15Z6 |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Homo sapiens (Human)) | BDBM50228385
(CHEMBL235014 | N-(2-(2-(2-(5,6,7,8-tetrahydroacrid...)Show SMILES C(COCCOCCNc1c2CCCCc2nc2ccccc12)Nc1c2CCCCc2nc2ccccc12 Show InChI InChI=1S/C32H38N4O2/c1-5-13-27-23(9-1)31(24-10-2-6-14-28(24)35-27)33-17-19-37-21-22-38-20-18-34-32-25-11-3-7-15-29(25)36-30-16-8-4-12-26(30)32/h1,3,5,7,9,11,13,15H,2,4,6,8,10,12,14,16-22H2,(H,33,35)(H,34,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Bologna University
Curated by ChEMBL
| Assay Description Inhibition of human serum recombinant AChE by Ellman's method |
J Med Chem 50: 6446-9 (2007)
Article DOI: 10.1021/jm701225u BindingDB Entry DOI: 10.7270/Q2FN15Z6 |
More data for this Ligand-Target Pair | |
Cholinesterase
(Homo sapiens (Human)) | BDBM50228385
(CHEMBL235014 | N-(2-(2-(2-(5,6,7,8-tetrahydroacrid...)Show SMILES C(COCCOCCNc1c2CCCCc2nc2ccccc12)Nc1c2CCCCc2nc2ccccc12 Show InChI InChI=1S/C32H38N4O2/c1-5-13-27-23(9-1)31(24-10-2-6-14-28(24)35-27)33-17-19-37-21-22-38-20-18-34-32-25-11-3-7-15-29(25)36-30-16-8-4-12-26(30)32/h1,3,5,7,9,11,13,15H,2,4,6,8,10,12,14,16-22H2,(H,33,35)(H,34,36) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 35.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Bologna University
Curated by ChEMBL
| Assay Description Inhibition of human serum recombinant BChE by Ellman's method |
J Med Chem 50: 6446-9 (2007)
Article DOI: 10.1021/jm701225u BindingDB Entry DOI: 10.7270/Q2FN15Z6 |
More data for this Ligand-Target Pair | |
Cholinesterase
(Homo sapiens (Human)) | BDBM8961
(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)Show InChI InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 45.8 | n/a | n/a | n/a | n/a | n/a | n/a |
Bologna University
Curated by ChEMBL
| Assay Description Inhibition of human serum recombinant BChE by Ellman's method |
J Med Chem 50: 6446-9 (2007)
Article DOI: 10.1021/jm701225u BindingDB Entry DOI: 10.7270/Q2FN15Z6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Acetylcholinesterase
(Homo sapiens (Human)) | BDBM8961
(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)Show InChI InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 424 | n/a | n/a | n/a | n/a | n/a | n/a |
Bologna University
Curated by ChEMBL
| Assay Description Inhibition of human serum recombinant AChE by Ellman's method |
J Med Chem 50: 6446-9 (2007)
Article DOI: 10.1021/jm701225u BindingDB Entry DOI: 10.7270/Q2FN15Z6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |