BindingDB logo
myBDB logout

PubMed code 18504132

Compile data set for download or QSAR
Found 51 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Progesterone receptor


(Homo sapiens (Human))		BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES [H][C@@]12CC[C@@](O)(C#CC)[C@@]1(C)C[C@@H](C1=C3CCC(=O)C=C3CC[C@@]21[H])c1ccc(cc1)N(C)C |r,c:14,20|
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
DrugBank
PDB
Article
PubMed
n/an/a 0.200n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES [H][C@@]12CC[C@@](O)(C#CC)[C@@]1(C)C[C@@H](C1=C3CCC(=O)C=C3CC[C@@]21[H])c1ccc(cc1)N(C)C |r,c:14,20|
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
DrugBank
PDB
Article
PubMed
n/an/a 0.600n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at cloned glucocorticoid receptor-ligand binding domain expressed in african green monkey COS7 cells by GAL4 luciferase reporter ...

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Androgen receptor


(Homo sapiens (Human))		BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES [H][C@@]12CC[C@@](O)(C#CC)[C@@]1(C)C[C@@H](C1=C3CCC(=O)C=C3CC[C@@]21[H])c1ccc(cc1)N(C)C |r,c:14,20|
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
Article
PubMed
n/an/a 6.90n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at cloned androgen receptor-ligand binding domain expressed in african green monkey COS7 cells by two hybrid luciferase assay

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270630
PNG
(3-[5-Ethyl-5-(2-furyl)-2-oxo-1,2,3,5-tetrahydro-4,...)
Show SMILES CCC1(OCC(=O)Nc2ccc(cc12)-c1cc(F)cc(c1)C#N)c1ccco1
Show InChI InChI=1S/C22H17FN2O3/c1-2-22(20-4-3-7-27-20)18-11-15(5-6-19(18)25-21(26)13-28-22)16-8-14(12-24)9-17(23)10-16/h3-11H,2,13H2,1H3,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 11.8n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121165
PNG
(3-(3,3-Dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-5...)
Show SMILES CC1(C)C(=O)Nc2ccc(cc12)-c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C17H13FN2O/c1-17(2)14-8-11(3-4-15(14)20-16(17)21)12-5-10(9-19)6-13(18)7-12/h3-8H,1-2H3,(H,20,21)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 13n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270631
PNG
(3-[5,5-Di(2-furyl)-2-oxo-1,2,3,5-tetrahydro-4,1-be...)
Show SMILES Fc1cc(cc(c1)-c1ccc2NC(=O)COC(c3ccco3)(c3ccco3)c2c1)C#N
Show InChI InChI=1S/C24H15FN2O4/c25-18-10-15(13-26)9-17(11-18)16-5-6-20-19(12-16)24(21-3-1-7-29-21,22-4-2-8-30-22)31-14-23(28)27-20/h1-12H,14H2,(H,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 13.3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270622
PNG
(7-(3-Fluorophenyl)-5,5-dimethyl-1,5-dihydro-4,1-be...)
Show SMILES CC1(C)OCC(=O)Nc2ccc(cc12)-c1cccc(F)c1
Show InChI InChI=1S/C17H16FNO2/c1-17(2)14-9-12(11-4-3-5-13(18)8-11)6-7-15(14)19-16(20)10-21-17/h3-9H,10H2,1-2H3,(H,19,20)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 14.9n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270573
PNG
(7-(3-Chloro-5-fluorophenyl)-5,5-dimethyl-1,5-dihyd...)
Show SMILES CC1(C)OCC(=O)Nc2ccc(cc12)-c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C17H15ClFNO2/c1-17(2)14-7-10(11-5-12(18)8-13(19)6-11)3-4-15(14)20-16(21)9-22-17/h3-8H,9H2,1-2H3,(H,20,21)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 15n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270624
PNG
(7-(2,3-Difluorophenyl)-5,5-dimethyl-1,5-dihydro-4,...)
Show SMILES CC1(C)OCC(=O)Nc2ccc(cc12)-c1cccc(F)c1F
Show InChI InChI=1S/C17H15F2NO2/c1-17(2)12-8-10(11-4-3-5-13(18)16(11)19)6-7-14(12)20-15(21)9-22-17/h3-8H,9H2,1-2H3,(H,20,21)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 15.7n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270632
PNG
(7-(3-Chloro-4-fluorophenyl)-5,5-di(2-furyl)-1,5-di...)
Show SMILES Fc1ccc(cc1Cl)-c1ccc2NC(=O)COC(c3ccco3)(c3ccco3)c2c1
Show InChI InChI=1S/C23H15ClFNO4/c24-17-12-15(5-7-18(17)25)14-6-8-19-16(11-14)23(20-3-1-9-28-20,21-4-2-10-29-21)30-13-22(27)26-19/h1-12H,13H2,(H,26,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 22.5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270575
PNG
(3-(5,5-Dimethyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzo...)
Show SMILES CC1(C)OCC(=O)Nc2ccc(cc12)-c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C18H15FN2O2/c1-18(2)15-8-12(3-4-16(15)21-17(22)10-23-18)13-5-11(9-20)6-14(19)7-13/h3-8H,10H2,1-2H3,(H,21,22)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 25n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270580
PNG
(3-Fluoro-5-(2-oxo-5,5-dithien-2-yl-1,2,3,5-tetrahy...)
Show SMILES Fc1cc(cc(c1)-c1ccc2NC(=O)COC(c3cccs3)(c3cccs3)c2c1)C#N
Show InChI InChI=1S/C24H15FN2O2S2/c25-18-10-15(13-26)9-17(11-18)16-5-6-20-19(12-16)24(21-3-1-7-30-21,22-4-2-8-31-22)29-14-23(28)27-20/h1-12H,14H2,(H,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 26.6n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270574
PNG
(7-(3,5-Dichlorophenyl)-5,5-dimethyl-1,5-dihydro-4,...)
Show SMILES CC1(C)OCC(=O)Nc2ccc(cc12)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C17H15Cl2NO2/c1-17(2)14-7-10(11-5-12(18)8-13(19)6-11)3-4-15(14)20-16(21)9-22-17/h3-8H,9H2,1-2H3,(H,20,21)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 29.1n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270625
PNG
(7-(3,4-Difluorophenyl)-5-ethyl-5-(2-furyl)-1,5-dih...)
Show SMILES CC1(C)OCC(=O)Nc2ccc(cc12)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C17H15F2NO2/c1-17(2)12-7-10(11-3-5-13(18)14(19)8-11)4-6-15(12)20-16(21)9-22-17/h3-8H,9H2,1-2H3,(H,20,21)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 29.3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270606
PNG
(4-[5-ethyl-5-(furan-2-yl)-2-oxo-1,2,3,5-tetrahydro...)
Show SMILES CCC1(OCC(=O)Nc2ccc(cc12)-c1coc(c1)C#N)c1ccco1
Show InChI InChI=1S/C20H16N2O4/c1-2-20(18-4-3-7-24-18)16-9-13(14-8-15(10-21)25-11-14)5-6-17(16)22-19(23)12-26-20/h3-9,11H,2,12H2,1H3,(H,22,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 29.9n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270626
PNG
(7-(3,5-Difluorophenyl)-5,5-dimethyl-1,5-dihydro-4,...)
Show SMILES CC1(C)OCC(=O)Nc2ccc(cc12)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C17H15F2NO2/c1-17(2)14-7-10(11-5-12(18)8-13(19)6-11)3-4-15(14)20-16(21)9-22-17/h3-8H,9H2,1-2H3,(H,20,21)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 30n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270627
PNG
(7-(3-Chloro-4-fluorophenyl)-5,5-dimethyl-1,5-dihyd...)
Show SMILES CC1(C)OCC(=O)Nc2ccc(cc12)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C17H15ClFNO2/c1-17(2)12-7-10(11-3-5-14(19)13(18)8-11)4-6-15(12)20-16(21)9-22-17/h3-8H,9H2,1-2H3,(H,20,21)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 30.1n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270634
PNG
(7-(3-Chloro-4-fluorophenyl)-5-(2-furyl)-5-(pentafl...)
Show SMILES Fc1cc(cc(c1)-c1ccc2NC(=O)COC(c3ccco3)(c2c1)C(F)(F)C(F)(F)F)C#N
Show InChI InChI=1S/C22H12F6N2O3/c23-15-7-12(10-29)6-14(8-15)13-3-4-17-16(9-13)20(18-2-1-5-32-18,33-11-19(31)30-17)21(24,25)22(26,27)28/h1-9H,11H2,(H,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 34.1n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270576
PNG
(3-Chloro-5-(5,5-dimethyl-2-oxo-1,2,3,5-tetrahydro-...)
Show SMILES CC1(C)OCC(=O)Nc2ccc(cc12)-c1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C18H15ClN2O2/c1-18(2)15-8-12(3-4-16(15)21-17(22)10-23-18)13-5-11(9-20)6-14(19)7-13/h3-8H,10H2,1-2H3,(H,21,22)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 34.6n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270628
PNG
(3-(5-Ethyl-2-oxo-5-thien-3-yl-1,2,3,5-tetrahydro-4...)
Show SMILES CCC1(OCC(=O)Nc2ccc(cc12)-c1cc(F)cc(c1)C#N)c1ccsc1
Show InChI InChI=1S/C22H17FN2O2S/c1-2-22(17-5-6-28-13-17)19-10-15(3-4-20(19)25-21(26)12-27-22)16-7-14(11-24)8-18(23)9-16/h3-10,13H,2,12H2,1H3,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 59.2n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270598
PNG
(7-(2-Fluorophenyl)-5,5-dimethyl-1,5-dihydro-4,1-be...)
Show SMILES CC1(C)OCC(=O)Nc2ccc(cc12)-c1ccccc1F
Show InChI InChI=1S/C17H16FNO2/c1-17(2)13-9-11(12-5-3-4-6-14(12)18)7-8-15(13)19-16(20)10-21-17/h3-9H,10H2,1-2H3,(H,19,20)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 62.1n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270629
PNG
(7-(3-Chloro-4-fluorophenyl)-5-ethyl-5-(2-furyl)-1,...)
Show SMILES CCC1(OCC(=O)Nc2ccc(cc12)-c1ccc(F)c(Cl)c1)c1ccco1
Show InChI InChI=1S/C21H17ClFNO3/c1-2-21(19-4-3-9-26-19)15-10-13(14-5-7-17(23)16(22)11-14)6-8-18(15)24-20(25)12-27-21/h3-11H,2,12H2,1H3,(H,24,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 62.5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270581
PNG
(7-(3-Chloro-4-fluorophenyl)-5,5-dithien-2-yl-1,5-d...)
Show SMILES Fc1ccc(cc1Cl)-c1ccc2NC(=O)COC(c3cccs3)(c3cccs3)c2c1
Show InChI InChI=1S/C23H15ClFNO2S2/c24-17-12-15(5-7-18(17)25)14-6-8-19-16(11-14)23(20-3-1-9-29-20,21-4-2-10-30-21)28-13-22(27)26-19/h1-12H,13H2,(H,26,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 65.2n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270577
PNG
(7-(3-Chloro-4-fluorophenyl)-5-methyl-5-thien-2-yl-...)
Show SMILES CC1(OCC(=O)Nc2ccc(cc12)-c1ccc(F)c(Cl)c1)c1cccs1
Show InChI InChI=1S/C20H15ClFNO2S/c1-20(18-3-2-8-26-18)14-9-12(13-4-6-16(22)15(21)10-13)5-7-17(14)23-19(24)11-25-20/h2-10H,11H2,1H3,(H,23,24)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 65.5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270636
PNG
(3-Fluoro-5-(5-isopropyl-5-thien-2-yl-2-thioxo-1,2,...)
Show SMILES CC(C)C1(OCC(=S)Nc2ccc(cc12)-c1cc(F)cc(c1)C#N)c1cccs1
Show InChI InChI=1S/C23H19FN2OS2/c1-14(2)23(21-4-3-7-29-21)19-11-16(5-6-20(19)26-22(28)13-27-23)17-8-15(12-25)9-18(24)10-17/h3-11,14H,13H2,1-2H3,(H,26,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 78.2n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270633
PNG
(7-(3-Chloro-4-fluorophenyl)-5-(2-furyl)-5-(pentafl...)
Show SMILES Fc1ccc(cc1Cl)-c1ccc2NC(=O)COC(c3ccco3)(c2c1)C(F)(F)C(F)(F)F
Show InChI InChI=1S/C21H12ClF6NO3/c22-14-9-12(3-5-15(14)23)11-4-6-16-13(8-11)19(17-2-1-7-31-17,32-10-18(30)29-16)20(24,25)21(26,27)28/h1-9H,10H2,(H,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 82.4n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270582
PNG
(7-(3-Chloro-4-fluorophenyl)-5,5-diphenyl-1,5-dihyd...)
Show SMILES Fc1ccc(cc1Cl)-c1ccc2NC(=O)COC(c3ccccc3)(c3ccccc3)c2c1
Show InChI InChI=1S/C27H19ClFNO2/c28-23-16-19(11-13-24(23)29)18-12-14-25-22(15-18)27(32-17-26(31)30-25,20-7-3-1-4-8-20)21-9-5-2-6-10-21/h1-16H,17H2,(H,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 88n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50118690
PNG
(3-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]...)
Show SMILES CC1(C)OC(=O)Nc2ccc(cc12)-c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C17H13FN2O2/c1-17(2)14-8-11(3-4-15(14)20-16(21)22-17)12-5-10(9-19)6-13(18)7-12/h3-8H,1-2H3,(H,20,21)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 90n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor assessed as alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270599
PNG
(3-(5-Ethyl-2-oxo-5-thiophen-2-yl-1,2,3,5-tetrahydr...)
Show SMILES CCC1(OCC(=O)Nc2ccc(cc12)-c1cc(F)cc(c1)C#N)c1cccs1
Show InChI InChI=1S/C22H17FN2O2S/c1-2-22(20-4-3-7-28-20)18-11-15(5-6-19(18)25-21(26)13-27-22)16-8-14(12-24)9-17(23)10-16/h3-11H,2,13H2,1H3,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270623
PNG
(7-(4-Fluorophenyl)-5,5-dimethyl-1,5-dihydro-4,1-be...)
Show SMILES CC1(C)OCC(=O)Nc2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C17H16FNO2/c1-17(2)14-9-12(11-3-6-13(18)7-4-11)5-8-15(14)19-16(20)10-21-17/h3-9H,10H2,1-2H3,(H,19,20)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50243849
PNG
(7-(3-Chloro-4-fluorophenyl)-4,5,5-trimethyl-1,3,4,...)
Show SMILES CN1CC(=O)Nc2ccc(cc2C1(C)C)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C18H18ClFN2O/c1-18(2)13-8-11(12-4-6-15(20)14(19)9-12)5-7-16(13)21-17(23)10-22(18)3/h4-9H,10H2,1-3H3,(H,21,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 105n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270607
PNG
(4-(5-Ethyl-2-oxo-5-thien-2-yl-1,2,3,5-tetrahydro-4...)
Show SMILES CCC1(OCC(=O)Nc2ccc(cc12)-c1csc(c1)C#N)c1cccs1
Show InChI InChI=1S/C20H16N2O2S2/c1-2-20(18-4-3-7-25-18)16-9-13(14-8-15(10-21)26-12-14)5-6-17(16)22-19(23)11-24-20/h3-9,12H,2,11H2,1H3,(H,22,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 108n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270603
PNG
(7-(3-Chloro-4-fluorophenyl)-5-ethyl-5-thien-3-yl-1...)
Show SMILES CCC1(OCC(=O)Nc2ccc(cc12)-c1ccc(F)c(Cl)c1)c1ccsc1
Show InChI InChI=1S/C21H17ClFNO2S/c1-2-21(15-7-8-27-12-15)16-9-13(14-3-5-18(23)17(22)10-14)4-6-19(16)24-20(25)11-26-21/h3-10,12H,2,11H2,1H3,(H,24,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 117n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270602
PNG
(3-Fluoro-5-(5-isopropyl-2-oxo-5-thien-2-yl-1,2,3,5...)
Show SMILES CC(C)C1(OCC(=O)Nc2ccc(cc12)-c1cc(F)cc(c1)C#N)c1cccs1
Show InChI InChI=1S/C23H19FN2O2S/c1-14(2)23(21-4-3-7-29-21)19-11-16(5-6-20(19)26-22(27)13-28-23)17-8-15(12-25)9-18(24)10-17/h3-11,14H,13H2,1-2H3,(H,26,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 138n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50270630
PNG
(3-[5-Ethyl-5-(2-furyl)-2-oxo-1,2,3,5-tetrahydro-4,...)
Show SMILES CCC1(OCC(=O)Nc2ccc(cc12)-c1cc(F)cc(c1)C#N)c1ccco1
Show InChI InChI=1S/C22H17FN2O3/c1-2-22(20-4-3-7-27-20)18-11-15(5-6-19(18)25-21(26)13-28-22)16-8-14(12-24)9-17(23)10-16/h3-11H,2,13H2,1H3,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 190n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at cloned glucocorticoid receptor-ligand binding domain expressed in african green monkey COS7 cells by GAL4 luciferase reporter ...

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270578
PNG
(7-(3-Chloro-4-fluoro-phenyl)-5-ethyl-5-thiophen-2-...)
Show SMILES CCC1(OCC(=O)Nc2ccc(cc12)-c1ccc(F)c(Cl)c1)c1cccs1
Show InChI InChI=1S/C21H17ClFNO2S/c1-2-21(19-4-3-9-27-19)15-10-13(14-5-7-17(23)16(22)11-14)6-8-18(15)24-20(25)12-26-21/h3-11H,2,12H2,1H3,(H,24,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 208n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270600
PNG
(7-(3-Chloro-4-fluorophenyl)-5-propyl-5-thien-2-yl-...)
Show SMILES CCCC1(OCC(=O)Nc2ccc(cc12)-c1ccc(F)c(Cl)c1)c1cccs1
Show InChI InChI=1S/C22H19ClFNO2S/c1-2-9-22(20-4-3-10-28-20)16-11-14(15-5-7-18(24)17(23)12-15)6-8-19(16)25-21(26)13-27-22/h3-8,10-12H,2,9,13H2,1H3,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 349n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270601
PNG
(7-(3-Chloro-4-fluorophenyl)-5-isopropyl-5-thien-2-...)
Show SMILES CC(C)C1(OCC(=O)Nc2ccc(cc12)-c1ccc(F)c(Cl)c1)c1cccs1
Show InChI InChI=1S/C22H19ClFNO2S/c1-13(2)22(20-4-3-9-28-20)16-10-14(15-5-7-18(24)17(23)11-15)6-8-19(16)25-21(26)12-27-22/h3-11,13H,12H2,1-2H3,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 366n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Mineralocorticoid receptor


(Homo sapiens (Human))		BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES [H][C@@]12CC[C@@](O)(C#CC)[C@@]1(C)C[C@@H](C1=C3CCC(=O)C=C3CC[C@@]21[H])c1ccc(cc1)N(C)C |r,c:14,20|
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
Article
PubMed
n/an/a 590n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at cloned mineralocorticoid receptor-ligand binding domain expressed in african green monkey COS7 cells by GAL4 luciferase report...

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270637
PNG
(7-(3-Chloro-4-fluorophenyl)-5-methyl-1,3-dihydro-H...)
Show SMILES CC1=NCC(=O)Nc2ccc(cc12)-c1ccc(F)c(Cl)c1 |t:1|
Show InChI InChI=1S/C16H12ClFN2O/c1-9-12-6-10(11-2-4-14(18)13(17)7-11)3-5-15(12)20-16(21)8-19-9/h2-7H,8H2,1H3,(H,20,21)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 677n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))		BDBM50270630
PNG
(3-[5-Ethyl-5-(2-furyl)-2-oxo-1,2,3,5-tetrahydro-4,...)
Show SMILES CCC1(OCC(=O)Nc2ccc(cc12)-c1cc(F)cc(c1)C#N)c1ccco1
Show InChI InChI=1S/C22H17FN2O3/c1-2-22(20-4-3-7-27-20)18-11-15(5-6-19(18)25-21(26)13-28-22)16-8-14(12-24)9-17(23)10-16/h3-11H,2,13H2,1H3,(H,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 690n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at cloned androgen receptor-ligand binding domain expressed in african green monkey COS7 cells by two hybrid luciferase assay

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270604
PNG
(7-(3-Chloro-4-fluorophenyl)-5,5-bis(4-chlorophenyl...)
Show SMILES Fc1ccc(cc1Cl)-c1ccc2NC(=O)COC(c3ccc(Cl)s3)(c3ccc(Cl)s3)c2c1
Show InChI InChI=1S/C23H13Cl3FNO2S2/c24-15-10-13(1-3-16(15)27)12-2-4-17-14(9-12)23(30-11-22(29)28-17,18-5-7-20(25)31-18)19-6-8-21(26)32-19/h1-10H,11H2,(H,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270605
PNG
(3-[5,5-bis(5-chlorothiophen-2-yl)-2-oxo-1,2,3,5-te...)
Show SMILES Fc1cc(cc(c1)-c1ccc2NC(=O)COC(c3ccc(Cl)s3)(c3ccc(Cl)s3)c2c1)C#N
Show InChI InChI=1S/C24H13Cl2FN2O2S2/c25-21-5-3-19(32-21)24(20-4-6-22(26)33-20)17-10-14(1-2-18(17)29-23(30)12-31-24)15-7-13(11-28)8-16(27)9-15/h1-10H,12H2,(H,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50270631
PNG
(3-[5,5-Di(2-furyl)-2-oxo-1,2,3,5-tetrahydro-4,1-be...)
Show SMILES Fc1cc(cc(c1)-c1ccc2NC(=O)COC(c3ccco3)(c3ccco3)c2c1)C#N
Show InChI InChI=1S/C24H15FN2O4/c25-18-10-15(13-26)9-17(11-18)16-5-6-20-19(12-16)24(21-3-1-7-29-21,22-4-2-8-30-22)31-14-23(28)27-20/h1-12H,14H2,(H,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.30E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at cloned glucocorticoid receptor-ligand binding domain expressed in african green monkey COS7 cells by GAL4 luciferase reporter ...

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50270575
PNG
(3-(5,5-Dimethyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzo...)
Show SMILES CC1(C)OCC(=O)Nc2ccc(cc12)-c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C18H15FN2O2/c1-18(2)15-8-12(3-4-16(15)21-17(22)10-23-18)13-5-11(9-20)6-14(19)7-13/h3-8H,10H2,1-2H3,(H,21,22)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>3.00E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at cloned glucocorticoid receptor-ligand binding domain expressed in african green monkey COS7 cells by GAL4 luciferase reporter ...

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))		BDBM50270575
PNG
(3-(5,5-Dimethyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzo...)
Show SMILES CC1(C)OCC(=O)Nc2ccc(cc12)-c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C18H15FN2O2/c1-18(2)15-8-12(3-4-16(15)21-17(22)10-23-18)13-5-11(9-20)6-14(19)7-13/h3-8H,10H2,1-2H3,(H,21,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>3.00E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at cloned androgen receptor-ligand binding domain expressed in african green monkey COS7 cells by two hybrid luciferase assay

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Mineralocorticoid receptor


(Homo sapiens (Human))		BDBM50270631
PNG
(3-[5,5-Di(2-furyl)-2-oxo-1,2,3,5-tetrahydro-4,1-be...)
Show SMILES Fc1cc(cc(c1)-c1ccc2NC(=O)COC(c3ccco3)(c3ccco3)c2c1)C#N
Show InChI InChI=1S/C24H15FN2O4/c25-18-10-15(13-26)9-17(11-18)16-5-6-20-19(12-16)24(21-3-1-7-29-21,22-4-2-8-30-22)31-14-23(28)27-20/h1-12H,14H2,(H,27,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>3.00E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at cloned mineralocorticoid receptor-ligand binding domain expressed in african green monkey COS7 cells by GAL4 luciferase report...

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Mineralocorticoid receptor


(Homo sapiens (Human))		BDBM50270630
PNG
(3-[5-Ethyl-5-(2-furyl)-2-oxo-1,2,3,5-tetrahydro-4,...)
Show SMILES CCC1(OCC(=O)Nc2ccc(cc12)-c1cc(F)cc(c1)C#N)c1ccco1
Show InChI InChI=1S/C22H17FN2O3/c1-2-22(20-4-3-7-27-20)18-11-15(5-6-19(18)25-21(26)13-28-22)16-8-14(12-24)9-17(23)10-16/h3-11H,2,13H2,1H3,(H,25,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>3.00E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at cloned mineralocorticoid receptor-ligand binding domain expressed in african green monkey COS7 cells by GAL4 luciferase report...

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))		BDBM50270631
PNG
(3-[5,5-Di(2-furyl)-2-oxo-1,2,3,5-tetrahydro-4,1-be...)
Show SMILES Fc1cc(cc(c1)-c1ccc2NC(=O)COC(c3ccco3)(c3ccco3)c2c1)C#N
Show InChI InChI=1S/C24H15FN2O4/c25-18-10-15(13-26)9-17(11-18)16-5-6-20-19(12-16)24(21-3-1-7-29-21,22-4-2-8-30-22)31-14-23(28)27-20/h1-12H,14H2,(H,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>3.00E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at cloned androgen receptor-ligand binding domain expressed in african green monkey COS7 cells by two hybrid luciferase assay

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Mineralocorticoid receptor


(Homo sapiens (Human))		BDBM50270575
PNG
(3-(5,5-Dimethyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzo...)
Show SMILES CC1(C)OCC(=O)Nc2ccc(cc12)-c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C18H15FN2O2/c1-18(2)15-8-12(3-4-16(15)21-17(22)10-23-18)13-5-11(9-20)6-14(19)7-13/h3-8H,10H2,1-2H3,(H,21,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>3.00E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at cloned mineralocorticoid receptor-ligand binding domain expressed in african green monkey COS7 cells by GAL4 luciferase report...

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50270635
PNG
(7-(3,5-Difluorophenyl)-5,5-dimethyl-1,5-dihydro-4,...)
Show SMILES CC1(C)OCC(=S)Nc2ccc(cc12)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C17H15F2NOS/c1-17(2)14-7-10(11-5-12(18)8-13(19)6-11)3-4-15(14)20-16(22)9-21-17/h3-8H,9H2,1-2H3,(H,20,22)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 35.8n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor assessed as alkaline phosphatase activity in human T47D cells

Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%