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PubMed code 18661965

Compile data set for download or QSAR
Found 12 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nischarin


(RAT)		BDBM50138499
PNG
(2-Phenethyl-4,5-dihydro-1H-imidazole | CHEMBL14210)
Show SMILES C(Cc1ccccc1)C1=NCCN1 |t:9|
Show InChI InChI=1S/C11H14N2/c1-2-4-10(5-3-1)6-7-11-12-8-9-13-11/h1-5H,6-9H2,(H,12,13)
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PubMed
 3.70E+3n/an/an/an/an/an/an/an/a



Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from Imidazoline receptor 1 rat PC-12 cells

J Med Chem 51: 5130-4 (2008)


Article DOI: 10.1021/jm800400k
BindingDB Entry DOI: 10.7270/Q2DF6R1N
More data for this
Ligand-Target Pair
Nischarin


(RAT)		BDBM50272773
PNG
(2-(2-Biphenyl-2-yl-ethyl)-4,5-dihydro-1H-imidazole...)
Show SMILES C(Cc1ccccc1-c1ccccc1)C1=NCCN1 |t:16|
Show InChI InChI=1S/C17H18N2/c1-2-6-14(7-3-1)16-9-5-4-8-15(16)10-11-17-18-12-13-19-17/h1-9H,10-13H2,(H,18,19)
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 6.34E+3n/an/an/an/an/an/an/an/a



Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from Imidazoline receptor 1 rat PC-12 cells

J Med Chem 51: 5130-4 (2008)


Article DOI: 10.1021/jm800400k
BindingDB Entry DOI: 10.7270/Q2DF6R1N
More data for this
Ligand-Target Pair
Nischarin


(RAT)		BDBM50272774
PNG
(2-(2-(thiophen-2-yl)ethyl)-4,5-dihydro-1H-imidazol...)
Show SMILES C(Cc1cccs1)C1=NCCN1 |t:8|
Show InChI InChI=1S/C9H12N2S/c1-2-8(12-7-1)3-4-9-10-5-6-11-9/h1-2,7H,3-6H2,(H,10,11)
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n/an/a 2.88E+3n/an/an/an/an/an/a



Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from Imidazoline receptor 1 in Sprague-Dawley rat kidney membrane

J Med Chem 51: 5130-4 (2008)


Article DOI: 10.1021/jm800400k
BindingDB Entry DOI: 10.7270/Q2DF6R1N
More data for this
Ligand-Target Pair
Nischarin


(RAT)		BDBM50272777
PNG
(2-(2-Cyclohexyl-ethyl)-4,5-dihydro-1H-imidazole | ...)
Show SMILES C(CC1=NCCN1)C1CCCCC1 |t:2|
Show InChI InChI=1S/C11H20N2/c1-2-4-10(5-3-1)6-7-11-12-8-9-13-11/h10H,1-9H2,(H,12,13)
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n/an/a 3.57E+3n/an/an/an/an/an/a



Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from Imidazoline receptor 1 in Sprague-Dawley rat kidney membrane

J Med Chem 51: 5130-4 (2008)


Article DOI: 10.1021/jm800400k
BindingDB Entry DOI: 10.7270/Q2DF6R1N
More data for this
Ligand-Target Pair
Nischarin


(RAT)		BDBM50272779
PNG
(2-[2-(3-Nitro-biphenyl-2-yl)-ethyl]-4,5-dihydro-1H...)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1ccccc1CCC1=NCCN1 |t:19|
Show InChI InChI=1S/C17H17N3O2/c21-20(22)15-6-3-5-14(12-15)16-7-2-1-4-13(16)8-9-17-18-10-11-19-17/h1-7,12H,8-11H2,(H,18,19)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from Imidazoline receptor 1 in Sprague-Dawley rat kidney membrane

J Med Chem 51: 5130-4 (2008)


Article DOI: 10.1021/jm800400k
BindingDB Entry DOI: 10.7270/Q2DF6R1N
More data for this
Ligand-Target Pair
Nischarin


(RAT)		BDBM50272781
PNG
(2-[2-(2-Chloro-phenyl)-ethyl]-4,5-dihydro-1H-imida...)
Show SMILES Clc1ccccc1CCC1=NCCN1 |t:10|
Show InChI InChI=1S/C11H13ClN2/c12-10-4-2-1-3-9(10)5-6-11-13-7-8-14-11/h1-4H,5-8H2,(H,13,14)
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n/an/a 4.26E+3n/an/an/an/an/an/a



Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from Imidazoline receptor 1 in Sprague-Dawley rat kidney membrane

J Med Chem 51: 5130-4 (2008)


Article DOI: 10.1021/jm800400k
BindingDB Entry DOI: 10.7270/Q2DF6R1N
More data for this
Ligand-Target Pair
Nischarin


(RAT)		BDBM50272811
PNG
(2-[2-(2-Thiophen-3-yl-phenyl)-ethyl]-4,5-dihydro-1...)
Show SMILES C(Cc1ccccc1-c1ccsc1)C1=NCCN1 |t:15|
Show InChI InChI=1S/C15H16N2S/c1-2-4-14(13-7-10-18-11-13)12(3-1)5-6-15-16-8-9-17-15/h1-4,7,10-11H,5-6,8-9H2,(H,16,17)
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n/an/a 6.89E+3n/an/an/an/an/an/a



Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from Imidazoline receptor 1 in Sprague-Dawley rat kidney membrane

J Med Chem 51: 5130-4 (2008)


Article DOI: 10.1021/jm800400k
BindingDB Entry DOI: 10.7270/Q2DF6R1N
More data for this
Ligand-Target Pair
Nischarin


(RAT)		BDBM50272810
PNG
(2-(2-(4,5-dihydro-1H-imidazol-2-yl)ethyl)phenol | ...)
Show SMILES Oc1ccccc1CCC1=NCCN1 |t:10|
Show InChI InChI=1S/C11H14N2O/c14-10-4-2-1-3-9(10)5-6-11-12-7-8-13-11/h1-4,14H,5-8H2,(H,12,13)
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n/an/a 7.30E+3n/an/an/an/an/an/a



Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from Imidazoline receptor 1 in Sprague-Dawley rat kidney membrane

J Med Chem 51: 5130-4 (2008)


Article DOI: 10.1021/jm800400k
BindingDB Entry DOI: 10.7270/Q2DF6R1N
More data for this
Ligand-Target Pair
Nischarin


(RAT)		BDBM50272780
PNG
(2-(2-o-Tolyl-ethyl)-4,5-dihydro-1H-imidazole | CHE...)
Show SMILES Cc1ccccc1CCC1=NCCN1 |t:10|
Show InChI InChI=1S/C12H16N2/c1-10-4-2-3-5-11(10)6-7-12-13-8-9-14-12/h2-5H,6-9H2,1H3,(H,13,14)
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n/an/a 7.36E+3n/an/an/an/an/an/a



Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from Imidazoline receptor 1 in Sprague-Dawley rat kidney membrane

J Med Chem 51: 5130-4 (2008)


Article DOI: 10.1021/jm800400k
BindingDB Entry DOI: 10.7270/Q2DF6R1N
More data for this
Ligand-Target Pair
Nischarin


(RAT)		BDBM50272775
PNG
(2-[2-(1H-Pyrrol-2-yl)-ethyl]-4,5-dihydro-1H-imidaz...)
Show SMILES C(Cc1ccc[nH]1)C1=NCCN1 |t:8|
Show InChI InChI=1S/C9H13N3/c1-2-8(10-5-1)3-4-9-11-6-7-12-9/h1-2,5,10H,3-4,6-7H2,(H,11,12)
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n/an/a 2.39E+4n/an/an/an/an/an/a



Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from Imidazoline receptor 1 in Sprague-Dawley rat kidney membrane

J Med Chem 51: 5130-4 (2008)


Article DOI: 10.1021/jm800400k
BindingDB Entry DOI: 10.7270/Q2DF6R1N
More data for this
Ligand-Target Pair
Nischarin


(RAT)		BDBM50272776
PNG
(2-(2-(naphthalen-1-yl)ethyl)-4,5-dihydro-1H-imidaz...)
Show SMILES C(Cc1cccc2ccccc12)C1=NCCN1 |t:14|
Show InChI InChI=1S/C15H16N2/c1-2-7-14-12(4-1)5-3-6-13(14)8-9-15-16-10-11-17-15/h1-7H,8-11H2,(H,16,17)
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n/an/a 2.58E+4n/an/an/an/an/an/a



Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from Imidazoline receptor 1 in Sprague-Dawley rat kidney membrane

J Med Chem 51: 5130-4 (2008)


Article DOI: 10.1021/jm800400k
BindingDB Entry DOI: 10.7270/Q2DF6R1N
More data for this
Ligand-Target Pair
Nischarin


(RAT)		BDBM50272778
PNG
(3-[2-(4,5-Dihydro-1H-imidazol-2-yl)-ethyl]-pyridin...)
Show SMILES C(Cc1cccnc1)C1=NCCN1 |t:9|
Show InChI InChI=1S/C10H13N3/c1-2-9(8-11-5-1)3-4-10-12-6-7-13-10/h1-2,5,8H,3-4,6-7H2,(H,12,13)
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n/an/a 2.12E+5n/an/an/an/an/an/a



Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from Imidazoline receptor 1 in Sprague-Dawley rat kidney membrane

J Med Chem 51: 5130-4 (2008)


Article DOI: 10.1021/jm800400k
BindingDB Entry DOI: 10.7270/Q2DF6R1N
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%