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PubMed code 18694645

Compile data set for download or QSAR
Found 25 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
C-C chemokine receptor type 4


(Homo sapiens (Human))		BDBM50245036
PNG
(CHEMBL486840 | N-(4-Chlorophenyl)-6,7-dimethoxy-2-...)
Show SMILES COc1cc2nc(nc(Nc3ccc(Cl)cc3)c2cc1OC)N1CCC(CC1)N1CCCC1
Show InChI InChI=1S/C25H30ClN5O2/c1-32-22-15-20-21(16-23(22)33-2)28-25(29-24(20)27-18-7-5-17(26)6-8-18)31-13-9-19(10-14-31)30-11-3-4-12-30/h5-8,15-16,19H,3-4,9-14H2,1-2H3,(H,27,28,29)
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n/an/a 24n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay

Bioorg Med Chem 16: 7968-74 (2008)


Article DOI: 10.1016/j.bmc.2008.07.062
BindingDB Entry DOI: 10.7270/Q2QJ7H49
More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))		BDBM50245034
PNG
(CHEMBL488018 | N-(3,4-Difluorophenyl)-6,7-dimethox...)
Show SMILES COc1cc2nc(nc(Nc3ccc(F)c(F)c3)c2cc1OC)N1CCC(CC1)N1CCCC1
Show InChI InChI=1S/C25H29F2N5O2/c1-33-22-14-18-21(15-23(22)34-2)29-25(30-24(18)28-16-5-6-19(26)20(27)13-16)32-11-7-17(8-12-32)31-9-3-4-10-31/h5-6,13-15,17H,3-4,7-12H2,1-2H3,(H,28,29,30)
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n/an/a 25n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay

Bioorg Med Chem 16: 7968-74 (2008)


Article DOI: 10.1016/j.bmc.2008.07.062
BindingDB Entry DOI: 10.7270/Q2QJ7H49
More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))		BDBM50245069
PNG
(CHEMBL487835 | N-(4-Fluorophenyl)-6,7-dimethoxy-2-...)
Show SMILES COc1cc2nc(nc(Nc3ccc(F)cc3)c2cc1OC)N1CCC(CC1)N1CCCC1
Show InChI InChI=1S/C25H30FN5O2/c1-32-22-15-20-21(16-23(22)33-2)28-25(29-24(20)27-18-7-5-17(26)6-8-18)31-13-9-19(10-14-31)30-11-3-4-12-30/h5-8,15-16,19H,3-4,9-14H2,1-2H3,(H,27,28,29)
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n/an/a 31n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay

Bioorg Med Chem 16: 7968-74 (2008)


Article DOI: 10.1016/j.bmc.2008.07.062
BindingDB Entry DOI: 10.7270/Q2QJ7H49
More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))		BDBM50245071
PNG
(3-[(1-{4-[(4-Chlorophenyl)amino]-6,7-dimethoxyquin...)
Show SMILES COc1cc2nc(nc(Nc3ccc(Cl)cc3)c2cc1OC)N1CCC(CC1)N(C)CCCO
Show InChI InChI=1S/C25H32ClN5O3/c1-30(11-4-14-32)19-9-12-31(13-10-19)25-28-21-16-23(34-3)22(33-2)15-20(21)24(29-25)27-18-7-5-17(26)6-8-18/h5-8,15-16,19,32H,4,9-14H2,1-3H3,(H,27,28,29)
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n/an/a 43n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay

Bioorg Med Chem 16: 7968-74 (2008)


Article DOI: 10.1016/j.bmc.2008.07.062
BindingDB Entry DOI: 10.7270/Q2QJ7H49
More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))		BDBM50245072
PNG
(4-[(1-{4-[(4-Chlorophenyl)amino]-6,7-dimethoxyquin...)
Show SMILES COc1cc2nc(nc(Nc3ccc(Cl)cc3)c2cc1OC)N1CCC(CC1)N(C)CCCCO
Show InChI InChI=1S/C26H34ClN5O3/c1-31(12-4-5-15-33)20-10-13-32(14-11-20)26-29-22-17-24(35-3)23(34-2)16-21(22)25(30-26)28-19-8-6-18(27)7-9-19/h6-9,16-17,20,33H,4-5,10-15H2,1-3H3,(H,28,29,30)
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n/an/a 61n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay

Bioorg Med Chem 16: 7968-74 (2008)


Article DOI: 10.1016/j.bmc.2008.07.062
BindingDB Entry DOI: 10.7270/Q2QJ7H49
More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))		BDBM50245034
PNG
(CHEMBL488018 | N-(3,4-Difluorophenyl)-6,7-dimethox...)
Show SMILES COc1cc2nc(nc(Nc3ccc(F)c(F)c3)c2cc1OC)N1CCC(CC1)N1CCCC1
Show InChI InChI=1S/C25H29F2N5O2/c1-33-22-14-18-21(15-23(22)34-2)29-25(30-24(18)28-16-5-6-19(26)20(27)13-16)32-11-7-17(8-12-32)31-9-3-4-10-31/h5-6,13-15,17H,3-4,7-12H2,1-2H3,(H,28,29,30)
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n/an/a 69n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay

Bioorg Med Chem 16: 7968-74 (2008)


Article DOI: 10.1016/j.bmc.2008.07.062
BindingDB Entry DOI: 10.7270/Q2QJ7H49
More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))		BDBM50244380
PNG
(CHEMBL487635 | N-Cycloheptyl-6,7-dimethoxy-2-(4-py...)
Show SMILES COc1cc2nc(nc(NC3CCCCCC3)c2cc1OC)N1CCC(CC1)N1CCCC1
Show InChI InChI=1S/C26H39N5O2/c1-32-23-17-21-22(18-24(23)33-2)28-26(29-25(21)27-19-9-5-3-4-6-10-19)31-15-11-20(12-16-31)30-13-7-8-14-30/h17-20H,3-16H2,1-2H3,(H,27,28,29)
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n/an/a 70n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Displacement of [121I]CCL22 from human CCR4 receptor by scintillation proximity assay

Bioorg Med Chem 16: 7968-74 (2008)


Article DOI: 10.1016/j.bmc.2008.07.062
BindingDB Entry DOI: 10.7270/Q2QJ7H49
More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))		BDBM50245112
PNG
(CHEMBL488690 | N-(4-Chlorophenyl)-2-{4-[2-(diethyl...)
Show SMILES CCN(CC)CCN1CCCN(CC1)c1nc(Nc2ccc(Cl)cc2)c2cc(OC)c(OC)cc2n1
Show InChI InChI=1S/C27H37ClN6O2/c1-5-32(6-2)14-15-33-12-7-13-34(17-16-33)27-30-23-19-25(36-4)24(35-3)18-22(23)26(31-27)29-21-10-8-20(28)9-11-21/h8-11,18-19H,5-7,12-17H2,1-4H3,(H,29,30,31)
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n/an/a 92n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay

Bioorg Med Chem 16: 7968-74 (2008)


Article DOI: 10.1016/j.bmc.2008.07.062
BindingDB Entry DOI: 10.7270/Q2QJ7H49
More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))		BDBM50245070
PNG
(2-[(1-{4-[(4-Chlorophenyl)amino]-6,7-dimethoxyquin...)
Show SMILES COc1cc2nc(nc(Nc3ccc(Cl)cc3)c2cc1OC)N1CCC(CC1)N(C)CCO
Show InChI InChI=1S/C24H30ClN5O3/c1-29(12-13-31)18-8-10-30(11-9-18)24-27-20-15-22(33-3)21(32-2)14-19(20)23(28-24)26-17-6-4-16(25)5-7-17/h4-7,14-15,18,31H,8-13H2,1-3H3,(H,26,27,28)
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n/an/a 98n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay

Bioorg Med Chem 16: 7968-74 (2008)


Article DOI: 10.1016/j.bmc.2008.07.062
BindingDB Entry DOI: 10.7270/Q2QJ7H49
More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))		BDBM50245036
PNG
(CHEMBL486840 | N-(4-Chlorophenyl)-6,7-dimethoxy-2-...)
Show SMILES COc1cc2nc(nc(Nc3ccc(Cl)cc3)c2cc1OC)N1CCC(CC1)N1CCCC1
Show InChI InChI=1S/C25H30ClN5O2/c1-32-22-15-20-21(16-23(22)33-2)28-25(29-24(20)27-18-7-5-17(26)6-8-18)31-13-9-19(10-14-31)30-11-3-4-12-30/h5-8,15-16,19H,3-4,9-14H2,1-2H3,(H,27,28,29)
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n/an/a 110n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay

Bioorg Med Chem 16: 7968-74 (2008)


Article DOI: 10.1016/j.bmc.2008.07.062
BindingDB Entry DOI: 10.7270/Q2QJ7H49
More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))		BDBM50245114
PNG
(CHEMBL488855 | N-(4-Chlorophenyl)-6,7-dimethoxy-2-...)
Show SMILES COc1cc2nc(nc(Nc3ccc(Cl)cc3)c2cc1OC)N1CCCN(CCN2CCCCC2)CC1
Show InChI InChI=1S/C28H37ClN6O2/c1-36-25-19-23-24(20-26(25)37-2)31-28(32-27(23)30-22-9-7-21(29)8-10-22)35-14-6-13-34(17-18-35)16-15-33-11-4-3-5-12-33/h7-10,19-20H,3-6,11-18H2,1-2H3,(H,30,31,32)
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n/an/a 130n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay

Bioorg Med Chem 16: 7968-74 (2008)


Article DOI: 10.1016/j.bmc.2008.07.062
BindingDB Entry DOI: 10.7270/Q2QJ7H49
More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Mus musculus)		BDBM50244380
PNG
(CHEMBL487635 | N-Cycloheptyl-6,7-dimethoxy-2-(4-py...)
Show SMILES COc1cc2nc(nc(NC3CCCCCC3)c2cc1OC)N1CCC(CC1)N1CCCC1
Show InChI InChI=1S/C26H39N5O2/c1-32-23-17-21-22(18-24(23)33-2)28-26(29-25(21)27-19-9-5-3-4-6-10-19)31-15-11-20(12-16-31)30-13-7-8-14-30/h17-20H,3-16H2,1-2H3,(H,27,28,29)
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n/an/a 130n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay

Bioorg Med Chem 16: 7968-74 (2008)


Article DOI: 10.1016/j.bmc.2008.07.062
BindingDB Entry DOI: 10.7270/Q2QJ7H49
More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Mus musculus)		BDBM50245036
PNG
(CHEMBL486840 | N-(4-Chlorophenyl)-6,7-dimethoxy-2-...)
Show SMILES COc1cc2nc(nc(Nc3ccc(Cl)cc3)c2cc1OC)N1CCC(CC1)N1CCCC1
Show InChI InChI=1S/C25H30ClN5O2/c1-32-22-15-20-21(16-23(22)33-2)28-25(29-24(20)27-18-7-5-17(26)6-8-18)31-13-9-19(10-14-31)30-11-3-4-12-30/h5-8,15-16,19H,3-4,9-14H2,1-2H3,(H,27,28,29)
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n/an/a 130n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay

Bioorg Med Chem 16: 7968-74 (2008)


Article DOI: 10.1016/j.bmc.2008.07.062
BindingDB Entry DOI: 10.7270/Q2QJ7H49
More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))		BDBM50245036
PNG
(CHEMBL486840 | N-(4-Chlorophenyl)-6,7-dimethoxy-2-...)
Show SMILES COc1cc2nc(nc(Nc3ccc(Cl)cc3)c2cc1OC)N1CCC(CC1)N1CCCC1
Show InChI InChI=1S/C25H30ClN5O2/c1-32-22-15-20-21(16-23(22)33-2)28-25(29-24(20)27-18-7-5-17(26)6-8-18)31-13-9-19(10-14-31)30-11-3-4-12-30/h5-8,15-16,19H,3-4,9-14H2,1-2H3,(H,27,28,29)
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n/an/a 150n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Displacement of [121I]CCL22 from human CCR4 receptor by scintillation proximity assay

Bioorg Med Chem 16: 7968-74 (2008)


Article DOI: 10.1016/j.bmc.2008.07.062
BindingDB Entry DOI: 10.7270/Q2QJ7H49
More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))		BDBM50245113
PNG
(CHEMBL488691 | N-(4-Chlorophenyl)-6,7-dimethoxy-2-...)
Show SMILES COc1cc2nc(nc(Nc3ccc(Cl)cc3)c2cc1OC)N1CCCN(CCN2CCCC2)CC1
Show InChI InChI=1S/C27H35ClN6O2/c1-35-24-18-22-23(19-25(24)36-2)30-27(31-26(22)29-21-8-6-20(28)7-9-21)34-13-5-12-33(16-17-34)15-14-32-10-3-4-11-32/h6-9,18-19H,3-5,10-17H2,1-2H3,(H,29,30,31)
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Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay

Bioorg Med Chem 16: 7968-74 (2008)


Article DOI: 10.1016/j.bmc.2008.07.062
BindingDB Entry DOI: 10.7270/Q2QJ7H49
More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))		BDBM50244380
PNG
(CHEMBL487635 | N-Cycloheptyl-6,7-dimethoxy-2-(4-py...)
Show SMILES COc1cc2nc(nc(NC3CCCCCC3)c2cc1OC)N1CCC(CC1)N1CCCC1
Show InChI InChI=1S/C26H39N5O2/c1-32-23-17-21-22(18-24(23)33-2)28-26(29-25(21)27-19-9-5-3-4-6-10-19)31-15-11-20(12-16-31)30-13-7-8-14-30/h17-20H,3-16H2,1-2H3,(H,27,28,29)
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Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Displacement of [121I]CCL22 from human CCR4 receptor by scintillation proximity assay

Bioorg Med Chem 16: 7968-74 (2008)


Article DOI: 10.1016/j.bmc.2008.07.062
BindingDB Entry DOI: 10.7270/Q2QJ7H49
More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))		BDBM50244380
PNG
(CHEMBL487635 | N-Cycloheptyl-6,7-dimethoxy-2-(4-py...)
Show SMILES COc1cc2nc(nc(NC3CCCCCC3)c2cc1OC)N1CCC(CC1)N1CCCC1
Show InChI InChI=1S/C26H39N5O2/c1-32-23-17-21-22(18-24(23)33-2)28-26(29-25(21)27-19-9-5-3-4-6-10-19)31-15-11-20(12-16-31)30-13-7-8-14-30/h17-20H,3-16H2,1-2H3,(H,27,28,29)
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Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay

Bioorg Med Chem 16: 7968-74 (2008)


Article DOI: 10.1016/j.bmc.2008.07.062
BindingDB Entry DOI: 10.7270/Q2QJ7H49
More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))		BDBM50245035
PNG
(CHEMBL488704 | N-(3-Bromophenyl)-6,7-dimethoxy-2-(...)
Show SMILES COc1cc2nc(nc(Nc3cccc(Br)c3)c2cc1OC)N1CCC(CC1)N1CCCC1
Show InChI InChI=1S/C25H30BrN5O2/c1-32-22-15-20-21(16-23(22)33-2)28-25(29-24(20)27-18-7-5-6-17(26)14-18)31-12-8-19(9-13-31)30-10-3-4-11-30/h5-7,14-16,19H,3-4,8-13H2,1-2H3,(H,27,28,29)
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n/an/a 220n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay

Bioorg Med Chem 16: 7968-74 (2008)


Article DOI: 10.1016/j.bmc.2008.07.062
BindingDB Entry DOI: 10.7270/Q2QJ7H49
More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))		BDBM50245071
PNG
(3-[(1-{4-[(4-Chlorophenyl)amino]-6,7-dimethoxyquin...)
Show SMILES COc1cc2nc(nc(Nc3ccc(Cl)cc3)c2cc1OC)N1CCC(CC1)N(C)CCCO
Show InChI InChI=1S/C25H32ClN5O3/c1-30(11-4-14-32)19-9-12-31(13-10-19)25-28-21-16-23(34-3)22(33-2)15-20(21)24(29-25)27-18-7-5-17(26)6-8-18/h5-8,15-16,19,32H,4,9-14H2,1-3H3,(H,27,28,29)
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Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay

Bioorg Med Chem 16: 7968-74 (2008)


Article DOI: 10.1016/j.bmc.2008.07.062
BindingDB Entry DOI: 10.7270/Q2QJ7H49
More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))		BDBM50245069
PNG
(CHEMBL487835 | N-(4-Fluorophenyl)-6,7-dimethoxy-2-...)
Show SMILES COc1cc2nc(nc(Nc3ccc(F)cc3)c2cc1OC)N1CCC(CC1)N1CCCC1
Show InChI InChI=1S/C25H30FN5O2/c1-32-22-15-20-21(16-23(22)33-2)28-25(29-24(20)27-18-7-5-17(26)6-8-18)31-13-9-19(10-14-31)30-11-3-4-12-30/h5-8,15-16,19H,3-4,9-14H2,1-2H3,(H,27,28,29)
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n/an/a 320n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay

Bioorg Med Chem 16: 7968-74 (2008)


Article DOI: 10.1016/j.bmc.2008.07.062
BindingDB Entry DOI: 10.7270/Q2QJ7H49
More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))		BDBM50245072
PNG
(4-[(1-{4-[(4-Chlorophenyl)amino]-6,7-dimethoxyquin...)
Show SMILES COc1cc2nc(nc(Nc3ccc(Cl)cc3)c2cc1OC)N1CCC(CC1)N(C)CCCCO
Show InChI InChI=1S/C26H34ClN5O3/c1-31(12-4-5-15-33)20-10-13-32(14-11-20)26-29-22-17-24(35-3)23(34-2)16-21(22)25(30-26)28-19-8-6-18(27)7-9-19/h6-9,16-17,20,33H,4-5,10-15H2,1-3H3,(H,28,29,30)
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n/an/a 360n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay

Bioorg Med Chem 16: 7968-74 (2008)


Article DOI: 10.1016/j.bmc.2008.07.062
BindingDB Entry DOI: 10.7270/Q2QJ7H49
More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))		BDBM50245035
PNG
(CHEMBL488704 | N-(3-Bromophenyl)-6,7-dimethoxy-2-(...)
Show SMILES COc1cc2nc(nc(Nc3cccc(Br)c3)c2cc1OC)N1CCC(CC1)N1CCCC1
Show InChI InChI=1S/C25H30BrN5O2/c1-32-22-15-20-21(16-23(22)33-2)28-25(29-24(20)27-18-7-5-6-17(26)14-18)31-12-8-19(9-13-31)30-10-3-4-11-30/h5-7,14-16,19H,3-4,8-13H2,1-2H3,(H,27,28,29)
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n/an/a 510n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Displacement of [121I]CCL22 from human CCR4 receptor by scintillation proximity assay

Bioorg Med Chem 16: 7968-74 (2008)


Article DOI: 10.1016/j.bmc.2008.07.062
BindingDB Entry DOI: 10.7270/Q2QJ7H49
More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))		BDBM50245111
PNG
(CHEMBL487665 | N-(4-Chlorophenyl)-2-(4-cyclohexyl-...)
Show SMILES COc1cc2nc(nc(Nc3ccc(Cl)cc3)c2cc1OC)N1CCCN(CC1)C1CCCCC1
Show InChI InChI=1S/C27H34ClN5O2/c1-34-24-17-22-23(18-25(24)35-2)30-27(31-26(22)29-20-11-9-19(28)10-12-20)33-14-6-13-32(15-16-33)21-7-4-3-5-8-21/h9-12,17-18,21H,3-8,13-16H2,1-2H3,(H,29,30,31)
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n/an/a 550n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay

Bioorg Med Chem 16: 7968-74 (2008)


Article DOI: 10.1016/j.bmc.2008.07.062
BindingDB Entry DOI: 10.7270/Q2QJ7H49
More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Mus musculus)		BDBM50245069
PNG
(CHEMBL487835 | N-(4-Fluorophenyl)-6,7-dimethoxy-2-...)
Show SMILES COc1cc2nc(nc(Nc3ccc(F)cc3)c2cc1OC)N1CCC(CC1)N1CCCC1
Show InChI InChI=1S/C25H30FN5O2/c1-32-22-15-20-21(16-23(22)33-2)28-25(29-24(20)27-18-7-5-17(26)6-8-18)31-13-9-19(10-14-31)30-11-3-4-12-30/h5-8,15-16,19H,3-4,9-14H2,1-2H3,(H,27,28,29)
KEGG

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n/an/a 710n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay

Bioorg Med Chem 16: 7968-74 (2008)


Article DOI: 10.1016/j.bmc.2008.07.062
BindingDB Entry DOI: 10.7270/Q2QJ7H49
More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Mus musculus)		BDBM50245034
PNG
(CHEMBL488018 | N-(3,4-Difluorophenyl)-6,7-dimethox...)
Show SMILES COc1cc2nc(nc(Nc3ccc(F)c(F)c3)c2cc1OC)N1CCC(CC1)N1CCCC1
Show InChI InChI=1S/C25H29F2N5O2/c1-33-22-14-18-21(15-23(22)34-2)29-25(30-24(18)28-16-5-6-19(26)20(27)13-16)32-11-7-17(8-12-32)31-9-3-4-10-31/h5-6,13-15,17H,3-4,7-12H2,1-2H3,(H,28,29,30)
KEGG

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n/an/a 820n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay

Bioorg Med Chem 16: 7968-74 (2008)


Article DOI: 10.1016/j.bmc.2008.07.062
BindingDB Entry DOI: 10.7270/Q2QJ7H49
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%