Affinity Data by PubMed id=18778098

PubMed code 18778098

Found 12 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50272529 (3,7-Bis(2-hydroxyethyl)icaritin \| CHEMBL498486) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
University of Milan Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5A1 expressed in COS7 cells				J Nat Prod 71: 1513-7 (2008) Article DOI: 10.1021/np800049y BindingDB Entry DOI: 10.7270/Q2R78G4G
University of Milan Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM14390 (5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
University of Milan Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5A1 expressed in COS7 cells				J Nat Prod 71: 1513-7 (2008) Article DOI: 10.1021/np800049y BindingDB Entry DOI: 10.7270/Q2R78G4G
University of Milan Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (Homo sapiens (Human))	BDBM14390 (5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
University of Milan Curated by ChEMBL					Assay Description Inhibition of human PDE6C				J Nat Prod 71: 1513-7 (2008) Article DOI: 10.1021/np800049y BindingDB Entry DOI: 10.7270/Q2R78G4G
University of Milan Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50272526 (CHEMBL497293 \| Icariside II) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
University of Milan Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5A1 expressed in COS7 cells				J Nat Prod 71: 1513-7 (2008) Article DOI: 10.1021/np800049y BindingDB Entry DOI: 10.7270/Q2R78G4G
University of Milan Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50272528 (7-(2-Hydroxyethyl)-3-O-rhamnosylicariin \| CHEMBL50...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
University of Milan Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5A1 expressed in COS7 cells				J Nat Prod 71: 1513-7 (2008) Article DOI: 10.1021/np800049y BindingDB Entry DOI: 10.7270/Q2R78G4G
University of Milan Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50240974 (2-(3,4-Dihydroxy-phenyl)-3,5,7-trihydroxy-8-(3-met...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
University of Milan Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5A1 expressed in COS7 cells				J Nat Prod 71: 1513-7 (2008) Article DOI: 10.1021/np800049y BindingDB Entry DOI: 10.7270/Q2R78G4G
University of Milan Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50240972 (5,7-Dihydroxy-2-(4-hydroxy-phenyl)-8-(3-methyl-but...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.29E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Milan Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5A1 expressed in COS7 cells				J Nat Prod 71: 1513-7 (2008) Article DOI: 10.1021/np800049y BindingDB Entry DOI: 10.7270/Q2R78G4G
University of Milan Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50272527 (3-hydroxy-7-o-beta-glucose-8-prenyl-4'-methoxy Chr...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Milan Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5A1 expressed in COS7 cells				J Nat Prod 71: 1513-7 (2008) Article DOI: 10.1021/np800049y BindingDB Entry DOI: 10.7270/Q2R78G4G
University of Milan Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50027363 (CHEBI:78420 \| Icariin) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Milan Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5A1 expressed in COS7 cells				J Nat Prod 71: 1513-7 (2008) Article DOI: 10.1021/np800049y BindingDB Entry DOI: 10.7270/Q2R78G4G
University of Milan Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM19460 ((2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.62E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Milan Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5A1 expressed in COS7 cells				J Nat Prod 71: 1513-7 (2008) Article DOI: 10.1021/np800049y BindingDB Entry DOI: 10.7270/Q2R78G4G
University of Milan Curated by ChEMBL					More data for this Ligand-Target Pair
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (Homo sapiens (Human))	BDBM50272529 (3,7-Bis(2-hydroxyethyl)icaritin \| CHEMBL498486) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.09E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Milan Curated by ChEMBL					Assay Description Inhibition of human PDE6C				J Nat Prod 71: 1513-7 (2008) Article DOI: 10.1021/np800049y BindingDB Entry DOI: 10.7270/Q2R78G4G
University of Milan Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50272557 (3,7-dimethanesulfonyl-8-prenyl-4'-methoxy Chrysin ...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.55E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Milan Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5A1 expressed in COS7 cells				J Nat Prod 71: 1513-7 (2008) Article DOI: 10.1021/np800049y BindingDB Entry DOI: 10.7270/Q2R78G4G
University of Milan Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%