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PubMed code 18789706

Compile data set for download or QSAR
Found 37 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479331
PNG
(CHEMBL514703)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2ccc3oc(=O)cc(C)c3c2)CC1
Show InChI InChI=1S/C24H28N2O5/c1-17-13-24(28)31-22-8-7-19(14-20(17)22)30-16-18(27)15-25-9-11-26(12-10-25)21-5-3-4-6-23(21)29-2/h3-8,13-14,18,27H,9-12,15-16H2,1-2H3
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n/an/an/an/a 1.36E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 0.1 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479337
PNG
(CHEMBL447858)
Show SMILES CCN(CC)CC(O)COc1ccc2oc(=O)cc(C)c2c1
Show InChI InChI=1S/C17H23NO4/c1-4-18(5-2)10-13(19)11-21-14-6-7-16-15(9-14)12(3)8-17(20)22-16/h6-9,13,19H,4-5,10-11H2,1-3H3
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n/an/an/an/a 1.70E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 0.1 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479331
PNG
(CHEMBL514703)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2ccc3oc(=O)cc(C)c3c2)CC1
Show InChI InChI=1S/C24H28N2O5/c1-17-13-24(28)31-22-8-7-19(14-20(17)22)30-16-18(27)15-25-9-11-26(12-10-25)21-5-3-4-6-23(21)29-2/h3-8,13-14,18,27H,9-12,15-16H2,1-2H3
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n/an/an/an/a 1.46E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 0.5 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479328
PNG
(CHEMBL477411)
Show SMILES OC(COc1ccc2c(cc(=O)oc2c1)-c1ccccc1)CN1CCCCC1
Show InChI InChI=1S/C23H25NO4/c25-18(15-24-11-5-2-6-12-24)16-27-19-9-10-20-21(17-7-3-1-4-8-17)14-23(26)28-22(20)13-19/h1,3-4,7-10,13-14,18,25H,2,5-6,11-12,15-16H2
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n/an/an/an/a 2.34E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 1.0 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479335
PNG
(CHEMBL478660)
Show SMILES Cc1cc(=O)oc2ccc(OCC(O)CN3CCN(CC3)c3ccccc3)cc12
Show InChI InChI=1S/C23H26N2O4/c1-17-13-23(27)29-22-8-7-20(14-21(17)22)28-16-19(26)15-24-9-11-25(12-10-24)18-5-3-2-4-6-18/h2-8,13-14,19,26H,9-12,15-16H2,1H3
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n/an/an/an/a 1.31E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 0.1 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479328
PNG
(CHEMBL477411)
Show SMILES OC(COc1ccc2c(cc(=O)oc2c1)-c1ccccc1)CN1CCCCC1
Show InChI InChI=1S/C23H25NO4/c25-18(15-24-11-5-2-6-12-24)16-27-19-9-10-20-21(17-7-3-1-4-8-17)14-23(26)28-22(20)13-19/h1,3-4,7-10,13-14,18,25H,2,5-6,11-12,15-16H2
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n/an/an/an/a 1.58E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 0.5 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479334
PNG
(CHEMBL477410)
Show SMILES OC(COc1ccc2c(cc(=O)oc2c1)-c1ccccc1)CN1CCOCC1
Show InChI InChI=1S/C22H23NO5/c24-17(14-23-8-10-26-11-9-23)15-27-18-6-7-19-20(16-4-2-1-3-5-16)13-22(25)28-21(19)12-18/h1-7,12-13,17,24H,8-11,14-15H2
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n/an/an/an/a 2.17E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 1.0 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479327
PNG
(CHEMBL477799)
Show SMILES OC(COc1ccc2c(cc(=O)oc2c1)-c1ccccc1)CN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C28H28N2O4/c31-23(19-29-13-15-30(16-14-29)22-9-5-2-6-10-22)20-33-24-11-12-25-26(21-7-3-1-4-8-21)18-28(32)34-27(25)17-24/h1-12,17-18,23,31H,13-16,19-20H2
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n/an/an/an/a 1.18E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 0.1 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479333
PNG
(CHEMBL477800)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2ccc3c(cc(=O)oc3c2)-c2ccccc2)CC1
Show InChI InChI=1S/C29H30N2O5/c1-34-27-10-6-5-9-26(27)31-15-13-30(14-16-31)19-22(32)20-35-23-11-12-24-25(21-7-3-2-4-8-21)18-29(33)36-28(24)17-23/h2-12,17-18,22,32H,13-16,19-20H2,1H3
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n/an/an/an/a 1.82E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 1.0 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479330
PNG
(CHEMBL478247)
Show SMILES CCCNCC(O)COc1ccc2c(cc(=O)oc2c1)-c1ccccc1
Show InChI InChI=1S/C21H23NO4/c1-2-10-22-13-16(23)14-25-17-8-9-18-19(15-6-4-3-5-7-15)12-21(24)26-20(18)11-17/h3-9,11-12,16,22-23H,2,10,13-14H2,1H3
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n/an/an/an/a 2.40E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 1.0 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479327
PNG
(CHEMBL477799)
Show SMILES OC(COc1ccc2c(cc(=O)oc2c1)-c1ccccc1)CN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C28H28N2O4/c31-23(19-29-13-15-30(16-14-29)22-9-5-2-6-10-22)20-33-24-11-12-25-26(21-7-3-1-4-8-21)18-28(32)34-27(25)17-24/h1-12,17-18,23,31H,13-16,19-20H2
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n/an/an/an/a 1.81E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 1.0 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479337
PNG
(CHEMBL447858)
Show SMILES CCN(CC)CC(O)COc1ccc2oc(=O)cc(C)c2c1
Show InChI InChI=1S/C17H23NO4/c1-4-18(5-2)10-13(19)11-21-14-6-7-16-15(9-14)12(3)8-17(20)22-16/h6-9,13,19H,4-5,10-11H2,1-3H3
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n/an/an/an/a 1.96E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 0.5 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479334
PNG
(CHEMBL477410)
Show SMILES OC(COc1ccc2c(cc(=O)oc2c1)-c1ccccc1)CN1CCOCC1
Show InChI InChI=1S/C22H23NO5/c24-17(14-23-8-10-26-11-9-23)15-27-18-6-7-19-20(16-4-2-1-3-5-16)13-22(25)28-21(19)12-18/h1-7,12-13,17,24H,8-11,14-15H2
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n/an/an/an/a 1.44E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 0.1 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479338
PNG
(CHEMBL513910)
Show SMILES OC(COc1ccc2c(cc(=O)oc2c1)-c1ccccc1)CN1CCNCC1
Show InChI InChI=1S/C22H24N2O4/c25-17(14-24-10-8-23-9-11-24)15-27-18-6-7-19-20(16-4-2-1-3-5-16)13-22(26)28-21(19)12-18/h1-7,12-13,17,23,25H,8-11,14-15H2
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n/an/an/an/a 2.26E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 1.0 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479336
PNG
(CHEMBL517509)
Show SMILES CN1CCN(CC(O)COc2ccc3oc(=O)cc(C)c3c2)CC1
Show InChI InChI=1S/C18H24N2O4/c1-13-9-18(22)24-17-4-3-15(10-16(13)17)23-12-14(21)11-20-7-5-19(2)6-8-20/h3-4,9-10,14,21H,5-8,11-12H2,1-2H3
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n/an/an/an/a 2.43E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 1.0 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479333
PNG
(CHEMBL477800)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2ccc3c(cc(=O)oc3c2)-c2ccccc2)CC1
Show InChI InChI=1S/C29H30N2O5/c1-34-27-10-6-5-9-26(27)31-15-13-30(14-16-31)19-22(32)20-35-23-11-12-24-25(21-7-3-2-4-8-21)18-29(33)36-28(24)17-23/h2-12,17-18,22,32H,13-16,19-20H2,1H3
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n/an/an/an/a 1.17E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 0.1 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479338
PNG
(CHEMBL513910)
Show SMILES OC(COc1ccc2c(cc(=O)oc2c1)-c1ccccc1)CN1CCNCC1
Show InChI InChI=1S/C22H24N2O4/c25-17(14-24-10-8-23-9-11-24)15-27-18-6-7-19-20(16-4-2-1-3-5-16)13-22(26)28-21(19)12-18/h1-7,12-13,17,23,25H,8-11,14-15H2
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n/an/an/an/a 1.65E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 0.5 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479330
PNG
(CHEMBL478247)
Show SMILES CCCNCC(O)COc1ccc2c(cc(=O)oc2c1)-c1ccccc1
Show InChI InChI=1S/C21H23NO4/c1-2-10-22-13-16(23)14-25-17-8-9-18-19(15-6-4-3-5-7-15)12-21(24)26-20(18)11-17/h3-9,11-12,16,22-23H,2,10,13-14H2,1H3
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n/an/an/an/a 1.58E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 0.1 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479335
PNG
(CHEMBL478660)
Show SMILES Cc1cc(=O)oc2ccc(OCC(O)CN3CCN(CC3)c3ccccc3)cc12
Show InChI InChI=1S/C23H26N2O4/c1-17-13-23(27)29-22-8-7-20(14-21(17)22)28-16-19(26)15-24-9-11-25(12-10-24)18-5-3-2-4-6-18/h2-8,13-14,19,26H,9-12,15-16H2,1H3
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n/an/an/an/a 1.59E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 0.5 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479332
PNG
(CHEMBL518264)
Show SMILES Cc1cc(=O)oc2ccc(OCC(O)CN3CCCCC3)cc12
Show InChI InChI=1S/C18H23NO4/c1-13-9-18(21)23-17-6-5-15(10-16(13)17)22-12-14(20)11-19-7-3-2-4-8-19/h5-6,9-10,14,20H,2-4,7-8,11-12H2,1H3
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n/an/an/an/a 2.61E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 1.0 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479336
PNG
(CHEMBL517509)
Show SMILES CN1CCN(CC(O)COc2ccc3oc(=O)cc(C)c3c2)CC1
Show InChI InChI=1S/C18H24N2O4/c1-13-9-18(22)24-17-4-3-15(10-16(13)17)23-12-14(21)11-20-7-5-19(2)6-8-20/h3-4,9-10,14,21H,5-8,11-12H2,1-2H3
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n/an/an/an/a 1.80E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 0.5 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479329
PNG
(CHEMBL478248)
Show SMILES CCN(CC)CC(O)COc1ccc2c(cc(=O)oc2c1)-c1ccccc1
Show InChI InChI=1S/C22H25NO4/c1-3-23(4-2)14-17(24)15-26-18-10-11-19-20(16-8-6-5-7-9-16)13-22(25)27-21(19)12-18/h5-13,17,24H,3-4,14-15H2,1-2H3
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n/an/an/an/a 1.60E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 0.1 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479332
PNG
(CHEMBL518264)
Show SMILES Cc1cc(=O)oc2ccc(OCC(O)CN3CCCCC3)cc12
Show InChI InChI=1S/C18H23NO4/c1-13-9-18(21)23-17-6-5-15(10-16(13)17)22-12-14(20)11-19-7-3-2-4-8-19/h5-6,9-10,14,20H,2-4,7-8,11-12H2,1H3
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n/an/an/an/a 1.73E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 0.1 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479329
PNG
(CHEMBL478248)
Show SMILES CCN(CC)CC(O)COc1ccc2c(cc(=O)oc2c1)-c1ccccc1
Show InChI InChI=1S/C22H25NO4/c1-3-23(4-2)14-17(24)15-26-18-10-11-19-20(16-8-6-5-7-9-16)13-22(25)27-21(19)12-18/h5-13,17,24H,3-4,14-15H2,1-2H3
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n/an/an/an/a 1.74E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 0.5 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479335
PNG
(CHEMBL478660)
Show SMILES Cc1cc(=O)oc2ccc(OCC(O)CN3CCN(CC3)c3ccccc3)cc12
Show InChI InChI=1S/C23H26N2O4/c1-17-13-23(27)29-22-8-7-20(14-21(17)22)28-16-19(26)15-24-9-11-25(12-10-24)18-5-3-2-4-6-18/h2-8,13-14,19,26H,9-12,15-16H2,1H3
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n/an/an/an/a 2.15E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 1.0 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479338
PNG
(CHEMBL513910)
Show SMILES OC(COc1ccc2c(cc(=O)oc2c1)-c1ccccc1)CN1CCNCC1
Show InChI InChI=1S/C22H24N2O4/c25-17(14-24-10-8-23-9-11-24)15-27-18-6-7-19-20(16-4-2-1-3-5-16)13-22(26)28-21(19)12-18/h1-7,12-13,17,23,25H,8-11,14-15H2
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n/an/an/an/a 1.52E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 0.1 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479328
PNG
(CHEMBL477411)
Show SMILES OC(COc1ccc2c(cc(=O)oc2c1)-c1ccccc1)CN1CCCCC1
Show InChI InChI=1S/C23H25NO4/c25-18(15-24-11-5-2-6-12-24)16-27-19-9-10-20-21(17-7-3-1-4-8-17)14-23(26)28-22(20)13-19/h1,3-4,7-10,13-14,18,25H,2,5-6,11-12,15-16H2
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n/an/an/an/a 1.47E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 0.1 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479327
PNG
(CHEMBL477799)
Show SMILES OC(COc1ccc2c(cc(=O)oc2c1)-c1ccccc1)CN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C28H28N2O4/c31-23(19-29-13-15-30(16-14-29)22-9-5-2-6-10-22)20-33-24-11-12-25-26(21-7-3-1-4-8-21)18-28(32)34-27(25)17-24/h1-12,17-18,23,31H,13-16,19-20H2
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n/an/an/an/a 1.37E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 0.5 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479330
PNG
(CHEMBL478247)
Show SMILES CCCNCC(O)COc1ccc2c(cc(=O)oc2c1)-c1ccccc1
Show InChI InChI=1S/C21H23NO4/c1-2-10-22-13-16(23)14-25-17-8-9-18-19(15-6-4-3-5-7-15)12-21(24)26-20(18)11-17/h3-9,11-12,16,22-23H,2,10,13-14H2,1H3
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n/an/an/an/a 1.78E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 0.5 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479329
PNG
(CHEMBL478248)
Show SMILES CCN(CC)CC(O)COc1ccc2c(cc(=O)oc2c1)-c1ccccc1
Show InChI InChI=1S/C22H25NO4/c1-3-23(4-2)14-17(24)15-26-18-10-11-19-20(16-8-6-5-7-9-16)13-22(25)27-21(19)12-18/h5-13,17,24H,3-4,14-15H2,1-2H3
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n/an/an/an/a 2.42E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 1.0 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479332
PNG
(CHEMBL518264)
Show SMILES Cc1cc(=O)oc2ccc(OCC(O)CN3CCCCC3)cc12
Show InChI InChI=1S/C18H23NO4/c1-13-9-18(21)23-17-6-5-15(10-16(13)17)22-12-14(20)11-19-7-3-2-4-8-19/h5-6,9-10,14,20H,2-4,7-8,11-12H2,1H3
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n/an/an/an/a 2.04E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 0.5 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479334
PNG
(CHEMBL477410)
Show SMILES OC(COc1ccc2c(cc(=O)oc2c1)-c1ccccc1)CN1CCOCC1
Show InChI InChI=1S/C22H23NO5/c24-17(14-23-8-10-26-11-9-23)15-27-18-6-7-19-20(16-4-2-1-3-5-16)13-22(25)28-21(19)12-18/h1-7,12-13,17,24H,8-11,14-15H2
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n/an/an/an/a 1.62E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 0.5 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479331
PNG
(CHEMBL514703)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2ccc3oc(=O)cc(C)c3c2)CC1
Show InChI InChI=1S/C24H28N2O5/c1-17-13-24(28)31-22-8-7-19(14-20(17)22)30-16-18(27)15-25-9-11-26(12-10-25)21-5-3-4-6-23(21)29-2/h3-8,13-14,18,27H,9-12,15-16H2,1-2H3
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n/an/an/an/a 2.00E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 1.0 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479337
PNG
(CHEMBL447858)
Show SMILES CCN(CC)CC(O)COc1ccc2oc(=O)cc(C)c2c1
Show InChI InChI=1S/C17H23NO4/c1-4-18(5-2)10-13(19)11-21-14-6-7-16-15(9-14)12(3)8-17(20)22-16/h6-9,13,19H,4-5,10-11H2,1-3H3
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n/an/an/an/a 2.78E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 1.0 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479336
PNG
(CHEMBL517509)
Show SMILES CN1CCN(CC(O)COc2ccc3oc(=O)cc(C)c3c2)CC1
Show InChI InChI=1S/C18H24N2O4/c1-13-9-18(22)24-17-4-3-15(10-16(13)17)23-12-14(21)11-20-7-5-19(2)6-8-20/h3-4,9-10,14,21H,5-8,11-12H2,1-2H3
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n/an/an/an/a 1.74E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 0.1 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50017656
PNG
(CHEMBL1193 | Dimethyl-(3-phenyl-3-pyridin-2-yl-pro...)
Show SMILES CN(C)CCC(c1ccccc1)c1ccccn1
Show InChI InChI=1S/C16H20N2/c1-18(2)13-11-15(14-8-4-3-5-9-14)16-10-6-7-12-17-16/h3-10,12,15H,11,13H2,1-2H3
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n/an/an/an/a 2.82E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 5 ug/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50479333
PNG
(CHEMBL477800)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2ccc3c(cc(=O)oc3c2)-c2ccccc2)CC1
Show InChI InChI=1S/C29H30N2O5/c1-34-27-10-6-5-9-26(27)31-15-13-30(14-16-31)19-22(32)20-35-23-11-12-24-25(21-7-3-2-4-8-21)18-29(33)36-28(24)17-23/h2-12,17-18,22,32H,13-16,19-20H2,1H3
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n/an/an/an/a 1.27E+4n/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions at 0.5 mg/ml

Bioorg Med Chem 16: 9009-17 (2008)


Article DOI: 10.1016/j.bmc.2008.08.039
BindingDB Entry DOI: 10.7270/Q2PR7ZSZ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%