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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Glycogen phosphorylase, liver form (Homo sapiens (Human)) | BDBM35353 (indole-2-carboxamide derivative, 25e (R-isomer)) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet  | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc. | Assay Description The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... | Bioorg Med Chem 16: 10001-12 (2008) Article DOI: 10.1016/j.bmc.2008.10.021 BindingDB Entry DOI: 10.7270/Q2K072MF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen phosphorylase, liver form (Homo sapiens (Human)) | BDBM35351 (indole-2-carboxamide derivative, 25e) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 36 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc. | Assay Description The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... | Bioorg Med Chem 16: 10001-12 (2008) Article DOI: 10.1016/j.bmc.2008.10.021 BindingDB Entry DOI: 10.7270/Q2K072MF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen phosphorylase, liver form (Homo sapiens (Human)) | BDBM35350 (indole-2-carboxamide derivative, 25d) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 48 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc. | Assay Description The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... | Bioorg Med Chem 16: 10001-12 (2008) Article DOI: 10.1016/j.bmc.2008.10.021 BindingDB Entry DOI: 10.7270/Q2K072MF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen phosphorylase, liver form (Homo sapiens (Human)) | BDBM35349 (indole-2-carboxamide derivative, 25c) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 63 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc. | Assay Description The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... | Bioorg Med Chem 16: 10001-12 (2008) Article DOI: 10.1016/j.bmc.2008.10.021 BindingDB Entry DOI: 10.7270/Q2K072MF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen phosphorylase, liver form (Homo sapiens (Human)) | BDBM35345 (indole-2-carboxamide derivative, 15) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 68 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc. | Assay Description The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... | Bioorg Med Chem 16: 10001-12 (2008) Article DOI: 10.1016/j.bmc.2008.10.021 BindingDB Entry DOI: 10.7270/Q2K072MF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen phosphorylase, liver form (Homo sapiens (Human)) | BDBM35352 (indole-2-carboxamide derivative, 25e (S-isomer)) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 160 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc. | Assay Description The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... | Bioorg Med Chem 16: 10001-12 (2008) Article DOI: 10.1016/j.bmc.2008.10.021 BindingDB Entry DOI: 10.7270/Q2K072MF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen phosphorylase, liver form (Homo sapiens (Human)) | BDBM35339 (indole-2-carboxamide derivative, 5b) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 320 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc. | Assay Description The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... | Bioorg Med Chem 16: 10001-12 (2008) Article DOI: 10.1016/j.bmc.2008.10.021 BindingDB Entry DOI: 10.7270/Q2K072MF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen phosphorylase, liver form (Homo sapiens (Human)) | BDBM35338 (indole-2-carboxamide derivative, 3) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 440 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc. | Assay Description The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... | Bioorg Med Chem 16: 10001-12 (2008) Article DOI: 10.1016/j.bmc.2008.10.021 BindingDB Entry DOI: 10.7270/Q2K072MF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen phosphorylase, liver form (Homo sapiens (Human)) | BDBM35348 (indole-2-carboxamide derivative, 25b) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 590 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc. | Assay Description The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... | Bioorg Med Chem 16: 10001-12 (2008) Article DOI: 10.1016/j.bmc.2008.10.021 BindingDB Entry DOI: 10.7270/Q2K072MF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen phosphorylase, liver form (Homo sapiens (Human)) | BDBM35343 (indole-2-carboxamide derivative, 9b | trans-isomer...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 800 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc. | Assay Description The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... | Bioorg Med Chem 16: 10001-12 (2008) Article DOI: 10.1016/j.bmc.2008.10.021 BindingDB Entry DOI: 10.7270/Q2K072MF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen phosphorylase, liver form (Homo sapiens (Human)) | BDBM35347 (indole-2-carboxamide derivative, 25a) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 810 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc. | Assay Description The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... | Bioorg Med Chem 16: 10001-12 (2008) Article DOI: 10.1016/j.bmc.2008.10.021 BindingDB Entry DOI: 10.7270/Q2K072MF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen phosphorylase, liver form (Homo sapiens (Human)) | BDBM35341 (indole-2-carboxamide derivative, 7) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 900 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc. | Assay Description The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... | Bioorg Med Chem 16: 10001-12 (2008) Article DOI: 10.1016/j.bmc.2008.10.021 BindingDB Entry DOI: 10.7270/Q2K072MF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen phosphorylase, liver form (Homo sapiens (Human)) | BDBM35346 ((S)-5-chloro-N-(3-(4-fluorophenyl)-1-(4-hydroxypip...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 920 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc. | Assay Description The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... | Bioorg Med Chem 16: 10001-12 (2008) Article DOI: 10.1016/j.bmc.2008.10.021 BindingDB Entry DOI: 10.7270/Q2K072MF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen phosphorylase, liver form (Homo sapiens (Human)) | BDBM35340 (indole-2-carboxamide derivative, 5c) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc. | Assay Description The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... | Bioorg Med Chem 16: 10001-12 (2008) Article DOI: 10.1016/j.bmc.2008.10.021 BindingDB Entry DOI: 10.7270/Q2K072MF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen phosphorylase, liver form (Homo sapiens (Human)) | BDBM35342 (cis-isomers | indole-2-carboxamide derivative, 9a) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.50E+3 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc. | Assay Description The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... | Bioorg Med Chem 16: 10001-12 (2008) Article DOI: 10.1016/j.bmc.2008.10.021 BindingDB Entry DOI: 10.7270/Q2K072MF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen phosphorylase, liver form (Homo sapiens (Human)) | BDBM35344 (indole-2-carboxamide derivative, 12) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc. | Assay Description The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... | Bioorg Med Chem 16: 10001-12 (2008) Article DOI: 10.1016/j.bmc.2008.10.021 BindingDB Entry DOI: 10.7270/Q2K072MF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
