Found 9 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Prolyl endopeptidase
(Rattus norvegicus) | BDBM50274983
(2-{3-[(2S)-4,4-Difluoro-2-(pyrrolidinocarbonyl)pyr...)Show SMILES FC1(F)C[C@H](N(C1)C(=O)CCN1C(=O)c2ccccc2C1=O)C(=O)N1CCCC1 |r| Show InChI InChI=1S/C20H21F2N3O4/c21-20(22)11-15(19(29)23-8-3-4-9-23)25(12-20)16(26)7-10-24-17(27)13-5-1-2-6-14(13)18(24)28/h1-2,5-6,15H,3-4,7-12H2/t15-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
| MMDB PDB Article PubMed
| n/a | n/a | 0.810 | n/a | n/a | n/a | n/a | n/a | n/a |
CHINOIN, Ltd
Curated by ChEMBL
| Assay Description Inhibition of POP in Sprague-Dawley rat brain homogenates |
J Med Chem 51: 7514-22 (2009)
Article DOI: 10.1021/jm800944x BindingDB Entry DOI: 10.7270/Q2NG4QFC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Prolyl endopeptidase
(Rattus norvegicus) | BDBM50274985
(1-{3-Oxo-3-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin...)Show SMILES O=C(CCn1c2ccccc2nc(-c2ccccc2)c1=O)N1CCC[C@H]1C(=O)N1CCCC1 |r| Show InChI InChI=1S/C26H28N4O3/c31-23(29-17-8-13-22(29)25(32)28-15-6-7-16-28)14-18-30-21-12-5-4-11-20(21)27-24(26(30)33)19-9-2-1-3-10-19/h1-5,9-12,22H,6-8,13-18H2/t22-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 0.880 | n/a | n/a | n/a | n/a | n/a | n/a |
CHINOIN, Ltd
Curated by ChEMBL
| Assay Description Inhibition of POP in Sprague-Dawley rat brain homogenates |
J Med Chem 51: 7514-22 (2009)
Article DOI: 10.1021/jm800944x BindingDB Entry DOI: 10.7270/Q2NG4QFC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Prolyl endopeptidase
(Rattus norvegicus) | BDBM50274959
((S)-2-(3-oxo-3-(2-(pyrrolidine-1-carbonyl)pyrrolid...)Show SMILES O=C(CCN1C(=O)c2ccccc2C1=O)N1CCC[C@H]1C(=O)N1CCCC1 |r| Show InChI InChI=1S/C20H23N3O4/c24-17(22-12-5-8-16(22)20(27)21-10-3-4-11-21)9-13-23-18(25)14-6-1-2-7-15(14)19(23)26/h1-2,6-7,16H,3-5,8-13H2/t16-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
CHINOIN, Ltd
Curated by ChEMBL
| Assay Description Inhibition of POP in Sprague-Dawley rat brain homogenates |
J Med Chem 51: 7514-22 (2009)
Article DOI: 10.1021/jm800944x BindingDB Entry DOI: 10.7270/Q2NG4QFC |
More data for this Ligand-Target Pair | |
Prolyl endopeptidase
(Rattus norvegicus) | BDBM50240495
((R)-1-(4-(pyrrolidine-1-carbonyl)thiazolidin-3-yl)...)Show InChI InChI=1S/C16H28N2O2S/c1-2-3-4-5-6-9-15(19)18-13-21-12-14(18)16(20)17-10-7-8-11-17/h14H,2-13H2,1H3/t14-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
CHINOIN, Ltd
Curated by ChEMBL
| Assay Description Inhibition of POP in Sprague-Dawley rat brain homogenates |
J Med Chem 51: 7514-22 (2009)
Article DOI: 10.1021/jm800944x BindingDB Entry DOI: 10.7270/Q2NG4QFC |
More data for this Ligand-Target Pair | |
Prolyl endopeptidase
(Rattus norvegicus) | BDBM50051539
((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)Show SMILES O=C(CCCc1ccccc1)N1CCC[C@H]1C(=O)N1CCCC1 |r| Show InChI InChI=1S/C19H26N2O2/c22-18(12-6-10-16-8-2-1-3-9-16)21-15-7-11-17(21)19(23)20-13-4-5-14-20/h1-3,8-9,17H,4-7,10-15H2/t17-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
CHINOIN, Ltd
Curated by ChEMBL
| Assay Description Inhibition of POP in Sprague-Dawley rat brain homogenates |
J Med Chem 51: 7514-22 (2009)
Article DOI: 10.1021/jm800944x BindingDB Entry DOI: 10.7270/Q2NG4QFC |
More data for this Ligand-Target Pair | |
Prolyl endopeptidase
(Rattus norvegicus) | BDBM50274984
(2-{4-Oxo-4-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin...)Show SMILES O=C(CCCN1C(=O)c2ccccc2C1=O)N1CCC[C@H]1C(=O)N1CCCC1 |r| Show InChI InChI=1S/C21H25N3O4/c25-18(23-13-5-9-17(23)21(28)22-11-3-4-12-22)10-6-14-24-19(26)15-7-1-2-8-16(15)20(24)27/h1-2,7-8,17H,3-6,9-14H2/t17-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
CHINOIN, Ltd
Curated by ChEMBL
| Assay Description Inhibition of POP in Sprague-Dawley rat brain homogenates |
J Med Chem 51: 7514-22 (2009)
Article DOI: 10.1021/jm800944x BindingDB Entry DOI: 10.7270/Q2NG4QFC |
More data for this Ligand-Target Pair | |
Prolyl endopeptidase
(Rattus norvegicus) | BDBM50275012
(3-{4-Oxo-4-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin...)Show SMILES O=C(CCCN1C(=O)NC(C1=O)(c1ccccc1)c1ccccc1)N1CCC[C@H]1C(=O)N1CCCC1 |r| Show InChI InChI=1S/C28H32N4O4/c33-24(31-19-9-15-23(31)25(34)30-17-7-8-18-30)16-10-20-32-26(35)28(29-27(32)36,21-11-3-1-4-12-21)22-13-5-2-6-14-22/h1-6,11-14,23H,7-10,15-20H2,(H,29,36)/t23-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
CHINOIN, Ltd
Curated by ChEMBL
| Assay Description Inhibition of POP in Sprague-Dawley rat brain homogenates |
J Med Chem 51: 7514-22 (2009)
Article DOI: 10.1021/jm800944x BindingDB Entry DOI: 10.7270/Q2NG4QFC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Prolyl endopeptidase
(Rattus norvegicus) | BDBM50240498
((S)-1-(2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl)o...)Show InChI InChI=1S/C17H30N2O2/c1-2-3-4-5-6-11-16(20)19-14-9-10-15(19)17(21)18-12-7-8-13-18/h15H,2-14H2,1H3/t15-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
CHINOIN, Ltd
Curated by ChEMBL
| Assay Description Inhibition of POP in Sprague-Dawley rat brain homogenates |
J Med Chem 51: 7514-22 (2009)
Article DOI: 10.1021/jm800944x BindingDB Entry DOI: 10.7270/Q2NG4QFC |
More data for this Ligand-Target Pair | |
Prolyl endopeptidase
(Rattus norvegicus) | BDBM50274986
(1-{4-Oxo-4-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin...)Show SMILES O=C(CCCn1c2ccccc2nc(-c2ccccc2)c1=O)N1CCC[C@H]1C(=O)N1CCCC1 |r| Show InChI InChI=1S/C27H30N4O3/c32-24(30-18-8-14-23(30)26(33)29-16-6-7-17-29)15-9-19-31-22-13-5-4-12-21(22)28-25(27(31)34)20-10-2-1-3-11-20/h1-5,10-13,23H,6-9,14-19H2/t23-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
CHINOIN, Ltd
Curated by ChEMBL
| Assay Description Inhibition of POP in Sprague-Dawley rat brain homogenates |
J Med Chem 51: 7514-22 (2009)
Article DOI: 10.1021/jm800944x BindingDB Entry DOI: 10.7270/Q2NG4QFC |
More data for this Ligand-Target Pair | |