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PubMed code 19487123

Compile data set for download or QSAR
Found 31 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50296002
PNG
(CHEMBL564536 | isopropyl 3-chloro-5-(1-(6-(2-(5-et...)
Show SMILES CCc1sc(CCc2cc(cc(NC(C)c3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C29H38ClN5O3S/c1-6-26-20(5)32-28(39-26)8-7-23-16-25(35-9-11-37-12-10-35)17-27(33-23)31-19(4)21-13-22(30)15-24(14-21)34-29(36)38-18(2)3/h13-19H,6-12H2,1-5H3,(H,31,33)(H,34,36)
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n/an/a 1.40n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scinitill...

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50296002
PNG
(CHEMBL564536 | isopropyl 3-chloro-5-(1-(6-(2-(5-et...)
Show SMILES CCc1sc(CCc2cc(cc(NC(C)c3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C29H38ClN5O3S/c1-6-26-20(5)32-28(39-26)8-7-23-16-25(35-9-11-37-12-10-35)17-27(33-23)31-19(4)21-13-22(30)15-24(14-21)34-29(36)38-18(2)3/h13-19H,6-12H2,1-5H3,(H,31,33)(H,34,36)
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n/an/a 36n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]MK499 from human ERG channel in HEK293 cells

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50295987
PNG
(CHEMBL564513 | N-ethyl-6-(2-(5-ethyl-4-methyloxazo...)
Show SMILES CCNc1cc(cc(CCc2nc(C)c(CC)o2)n1)N1CCOCC1
Show InChI InChI=1S/C19H28N4O2/c1-4-17-14(3)21-19(25-17)7-6-15-12-16(13-18(22-15)20-5-2)23-8-10-24-11-9-23/h12-13H,4-11H2,1-3H3,(H,20,22)
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n/an/a 400n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]MK499 from human ERG channel in HEK293 cells

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50295989
PNG
(6-(2-(5-ethyl-4-methyloxazol-2-yl)ethyl)-4-morphol...)
Show SMILES CCCNc1cc(cc(CCc2nc(C)c(CC)o2)n1)N1CCOCC1
Show InChI InChI=1S/C20H30N4O2/c1-4-8-21-19-14-17(24-9-11-25-12-10-24)13-16(23-19)6-7-20-22-15(3)18(5-2)26-20/h13-14H,4-12H2,1-3H3,(H,21,23)
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n/an/a 480n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]MK499 from human ERG channel in HEK293 cells

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50295990
PNG
(6-(2-(5-ethyl-4-methyloxazol-2-yl)ethyl)-N-isoprop...)
Show SMILES CCc1oc(CCc2cc(cc(NC(C)C)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C20H30N4O2/c1-5-18-15(4)22-20(26-18)7-6-16-12-17(24-8-10-25-11-9-24)13-19(23-16)21-14(2)3/h12-14H,5-11H2,1-4H3,(H,21,23)
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n/an/a 540n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]MK499 from human ERG channel in HEK293 cells

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50295988
PNG
(6-(2-(5-ethyl-4-methyloxazol-2-yl)ethyl)-N-methyl-...)
Show SMILES CCc1oc(CCc2cc(cc(NC)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C18H26N4O2/c1-4-16-13(2)20-18(24-16)6-5-14-11-15(12-17(19-3)21-14)22-7-9-23-10-8-22/h11-12H,4-10H2,1-3H3,(H,19,21)
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n/an/a 830n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]MK499 from human ERG channel in HEK293 cells

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50295991
PNG
(6-(2-(5-ethyl-4-methyloxazol-2-yl)ethyl)-N-(2-meth...)
Show SMILES CCc1oc(CCc2cc(cc(NCCOC)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C20H30N4O3/c1-4-18-15(2)22-20(27-18)6-5-16-13-17(24-8-11-26-12-9-24)14-19(23-16)21-7-10-25-3/h13-14H,4-12H2,1-3H3,(H,21,23)
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n/an/a 900n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]MK499 from human ERG channel in HEK293 cells

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50295994
PNG
(CHEMBL562831 | ethyl 2-(6-(2-(5-ethyl-4-methyloxaz...)
Show SMILES CCOC(=O)CNc1cc(cc(CCc2nc(C)c(CC)o2)n1)N1CCOCC1
Show InChI InChI=1S/C21H30N4O4/c1-4-18-15(3)23-20(29-18)7-6-16-12-17(25-8-10-27-11-9-25)13-19(24-16)22-14-21(26)28-5-2/h12-13H,4-11,14H2,1-3H3,(H,22,24)
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n/an/a 910n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]MK499 from human ERG channel in HEK293 cells

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50295993
PNG
(3-(6-(2-(5-ethyl-4-methyloxazol-2-yl)ethyl)-4-morp...)
Show SMILES CCc1oc(CCc2cc(cc(NCCC#N)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C20H27N5O2/c1-3-18-15(2)23-20(27-18)6-5-16-13-17(25-9-11-26-12-10-25)14-19(24-16)22-8-4-7-21/h13-14H,3-6,8-12H2,1-2H3,(H,22,24)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]MK499 from human ERG channel in HEK293 cells

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50295996
PNG
(6-(2-(5-ethyl-4-methyloxazol-2-yl)ethyl)-4-morphol...)
Show SMILES CCc1oc(CCc2cc(cc(NCC(F)(F)F)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C19H25F3N4O2/c1-3-16-13(2)24-18(28-16)5-4-14-10-15(26-6-8-27-9-7-26)11-17(25-14)23-12-19(20,21)22/h10-11H,3-9,12H2,1-2H3,(H,23,25)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]MK499 from human ERG channel in HEK293 cells

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50295992
PNG
(2-(6-(2-(5-ethyl-4-methyloxazol-2-yl)ethyl)-4-morp...)
Show SMILES CCc1oc(CCc2cc(cc(NCC#N)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C19H25N5O2/c1-3-17-14(2)22-19(26-17)5-4-15-12-16(24-8-10-25-11-9-24)13-18(23-15)21-7-6-20/h12-13H,3-5,7-11H2,1-2H3,(H,21,23)
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n/an/a 4.30E+3n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]MK499 from human ERG channel in HEK293 cells

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50295996
PNG
(6-(2-(5-ethyl-4-methyloxazol-2-yl)ethyl)-4-morphol...)
Show SMILES CCc1oc(CCc2cc(cc(NCC(F)(F)F)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C19H25F3N4O2/c1-3-16-13(2)24-18(28-16)5-4-14-10-15(26-6-8-27-9-7-26)11-17(25-14)23-12-19(20,21)22/h10-11H,3-9,12H2,1-2H3,(H,23,25)
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n/an/a 4.30E+3n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scinitill...

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50295995
PNG
(CHEMBL559987 | N-(6-(2-(5-ethyl-4-methyloxazol-2-y...)
Show SMILES CCc1oc(CCc2cc(cc(NC(C)=O)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C19H26N4O3/c1-4-17-13(2)20-19(26-17)6-5-15-11-16(23-7-9-25-10-8-23)12-18(22-15)21-14(3)24/h11-12H,4-10H2,1-3H3,(H,21,22,24)
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n/an/a 7.00E+3n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]MK499 from human ERG channel in HEK293 cells

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50295997
PNG
(2-(6-((5-ethyl-4-methyloxazol-2-ylthio)methyl)-4-m...)
Show SMILES CCc1oc(SCc2cc(cc(NCC#N)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C18H23N5O2S/c1-3-16-13(2)21-18(25-16)26-12-14-10-15(23-6-8-24-9-7-23)11-17(22-14)20-5-4-19/h10-11H,3,5-9,12H2,1-2H3,(H,20,22)
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n/an/a 8.30E+3n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]MK499 from human ERG channel in HEK293 cells

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50295989
PNG
(6-(2-(5-ethyl-4-methyloxazol-2-yl)ethyl)-4-morphol...)
Show SMILES CCCNc1cc(cc(CCc2nc(C)c(CC)o2)n1)N1CCOCC1
Show InChI InChI=1S/C20H30N4O2/c1-4-8-21-19-14-17(24-9-11-25-12-10-24)13-16(23-19)6-7-20-22-15(3)18(5-2)26-20/h13-14H,4-12H2,1-3H3,(H,21,23)
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n/an/a 9.00E+3n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scinitill...

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50296000
PNG
(2-(4-morpholino-6-((1,4,5-trimethyl-1H-imidazol-2-...)
Show SMILES Cc1nc(SCc2cc(cc(NCC#N)n2)N2CCOCC2)n(C)c1C
Show InChI InChI=1S/C18H24N6OS/c1-13-14(2)23(3)18(21-13)26-12-15-10-16(24-6-8-25-9-7-24)11-17(22-15)20-5-4-19/h10-11H,5-9,12H2,1-3H3,(H,20,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]MK499 from human ERG channel in HEK293 cells

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50295998
PNG
(2-(6-((4,5-dimethyloxazol-2-ylthio)methyl)-4-morph...)
Show SMILES Cc1nc(SCc2cc(cc(NCC#N)n2)N2CCOCC2)oc1C
Show InChI InChI=1S/C17H21N5O2S/c1-12-13(2)24-17(20-12)25-11-14-9-15(22-5-7-23-8-6-22)10-16(21-14)19-4-3-18/h9-10H,4-8,11H2,1-2H3,(H,19,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]MK499 from human ERG channel in HEK293 cells

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50296001
PNG
(2-(6-((4,5-dimethylthiazol-2-ylthio)methyl)-4-morp...)
Show SMILES Cc1nc(SCc2cc(cc(NCC#N)n2)N2CCOCC2)sc1C
Show InChI InChI=1S/C17H21N5OS2/c1-12-13(2)25-17(20-12)24-11-14-9-15(22-5-7-23-8-6-22)10-16(21-14)19-4-3-18/h9-10H,4-8,11H2,1-2H3,(H,19,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]MK499 from human ERG channel in HEK293 cells

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50295991
PNG
(6-(2-(5-ethyl-4-methyloxazol-2-yl)ethyl)-N-(2-meth...)
Show SMILES CCc1oc(CCc2cc(cc(NCCOC)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C20H30N4O3/c1-4-18-15(2)22-20(27-18)6-5-16-13-17(24-8-11-26-12-9-24)14-19(23-16)21-7-10-25-3/h13-14H,4-12H2,1-3H3,(H,21,23)
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n/an/a 1.30E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scinitill...

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50295994
PNG
(CHEMBL562831 | ethyl 2-(6-(2-(5-ethyl-4-methyloxaz...)
Show SMILES CCOC(=O)CNc1cc(cc(CCc2nc(C)c(CC)o2)n1)N1CCOCC1
Show InChI InChI=1S/C21H30N4O4/c1-4-18-15(3)23-20(29-18)7-6-16-12-17(25-8-10-27-11-9-25)13-19(24-16)22-14-21(26)28-5-2/h12-13H,4-11,14H2,1-3H3,(H,22,24)
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n/an/a 1.50E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scinitill...

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50296001
PNG
(2-(6-((4,5-dimethylthiazol-2-ylthio)methyl)-4-morp...)
Show SMILES Cc1nc(SCc2cc(cc(NCC#N)n2)N2CCOCC2)sc1C
Show InChI InChI=1S/C17H21N5OS2/c1-12-13(2)25-17(20-12)24-11-14-9-15(22-5-7-23-8-6-22)10-16(21-14)19-4-3-18/h9-10H,4-8,11H2,1-2H3,(H,19,21)
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n/an/a 1.50E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scinitill...

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50295987
PNG
(CHEMBL564513 | N-ethyl-6-(2-(5-ethyl-4-methyloxazo...)
Show SMILES CCNc1cc(cc(CCc2nc(C)c(CC)o2)n1)N1CCOCC1
Show InChI InChI=1S/C19H28N4O2/c1-4-17-14(3)21-19(25-17)7-6-15-12-16(13-18(22-15)20-5-2)23-8-10-24-11-9-23/h12-13H,4-11H2,1-3H3,(H,20,22)
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n/an/a 1.60E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scinitill...

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50295997
PNG
(2-(6-((5-ethyl-4-methyloxazol-2-ylthio)methyl)-4-m...)
Show SMILES CCc1oc(SCc2cc(cc(NCC#N)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C18H23N5O2S/c1-3-16-13(2)21-18(25-16)26-12-14-10-15(23-6-8-24-9-7-23)11-17(22-14)20-5-4-19/h10-11H,3,5-9,12H2,1-2H3,(H,20,22)
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n/an/a 2.10E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scinitill...

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50295992
PNG
(2-(6-(2-(5-ethyl-4-methyloxazol-2-yl)ethyl)-4-morp...)
Show SMILES CCc1oc(CCc2cc(cc(NCC#N)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C19H25N5O2/c1-3-17-14(2)22-19(26-17)5-4-15-12-16(24-8-10-25-11-9-24)13-18(23-15)21-7-6-20/h12-13H,3-5,7-11H2,1-2H3,(H,21,23)
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n/an/a 2.10E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scinitill...

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50295993
PNG
(3-(6-(2-(5-ethyl-4-methyloxazol-2-yl)ethyl)-4-morp...)
Show SMILES CCc1oc(CCc2cc(cc(NCCC#N)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C20H27N5O2/c1-3-18-15(2)23-20(27-18)6-5-16-13-17(25-9-11-26-12-10-25)14-19(24-16)22-8-4-7-21/h13-14H,3-6,8-12H2,1-2H3,(H,22,24)
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n/an/a 2.20E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scinitill...

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50295990
PNG
(6-(2-(5-ethyl-4-methyloxazol-2-yl)ethyl)-N-isoprop...)
Show SMILES CCc1oc(CCc2cc(cc(NC(C)C)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C20H30N4O2/c1-5-18-15(4)22-20(26-18)7-6-16-12-17(24-8-10-25-11-9-24)13-19(23-16)21-14(2)3/h12-14H,5-11H2,1-4H3,(H,21,23)
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n/an/a 2.50E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scinitill...

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50295988
PNG
(6-(2-(5-ethyl-4-methyloxazol-2-yl)ethyl)-N-methyl-...)
Show SMILES CCc1oc(CCc2cc(cc(NC)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C18H26N4O2/c1-4-16-13(2)20-18(24-16)6-5-14-11-15(12-17(19-3)21-14)22-7-9-23-10-8-22/h11-12H,4-10H2,1-3H3,(H,19,21)
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n/an/a 3.20E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scinitill...

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50296000
PNG
(2-(4-morpholino-6-((1,4,5-trimethyl-1H-imidazol-2-...)
Show SMILES Cc1nc(SCc2cc(cc(NCC#N)n2)N2CCOCC2)n(C)c1C
Show InChI InChI=1S/C18H24N6OS/c1-13-14(2)23(3)18(21-13)26-12-15-10-16(24-6-8-25-9-7-24)11-17(22-15)20-5-4-19/h10-11H,5-9,12H2,1-3H3,(H,20,22)
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n/an/a 3.80E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scinitill...

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50295998
PNG
(2-(6-((4,5-dimethyloxazol-2-ylthio)methyl)-4-morph...)
Show SMILES Cc1nc(SCc2cc(cc(NCC#N)n2)N2CCOCC2)oc1C
Show InChI InChI=1S/C17H21N5O2S/c1-12-13(2)24-17(20-12)25-11-14-9-15(22-5-7-23-8-6-22)10-16(21-14)19-4-3-18/h9-10H,4-8,11H2,1-2H3,(H,19,21)
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n/an/a 7.00E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scinitill...

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50295995
PNG
(CHEMBL559987 | N-(6-(2-(5-ethyl-4-methyloxazol-2-y...)
Show SMILES CCc1oc(CCc2cc(cc(NC(C)=O)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C19H26N4O3/c1-4-17-13(2)20-19(26-17)6-5-15-11-16(23-7-9-25-10-8-23)12-18(22-15)21-14(3)24/h11-12H,4-10H2,1-3H3,(H,21,22,24)
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n/an/a 3.20E+5n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scinitill...

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))		BDBM50295999
PNG
(2-(6-((4,5-dimethyloxazol-2-yloxy)methyl)-4-morpho...)
Show SMILES Cc1nc(OCc2cc(cc(NCC#N)n2)N2CCOCC2)oc1C
Show InChI InChI=1S/C17H21N5O3/c1-12-13(2)25-17(20-12)24-11-14-9-15(22-5-7-23-8-6-22)10-16(21-14)19-4-3-18/h9-10H,4-8,11H2,1-2H3,(H,19,21)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scinitill...

Bioorg Med Chem Lett 19: 4325-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.069
BindingDB Entry DOI: 10.7270/Q21G0M97
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%