Affinity Data by PubMed id=19572549

PubMed code 19572549

Found 30 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM33214 (pyrazolopyridine, 13) Show SMILES NCC1CN(CCO1)c1c(cnc2[nH]ncc12)-c1ccsc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	7.5	23
The Institute of Cancer Research					Assay Description CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
The Institute of Cancer Research					More data for this Ligand-Target Pair				3D Structure (docked)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM33213 (pyrazolopyridine, 12) Show SMILES NCC1CN(CCO1)c1c(Br)cnc2[nH]ncc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	390	n/a	n/a	n/a	n/a	7.5	23
The Institute of Cancer Research					Assay Description CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
The Institute of Cancer Research					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM33216 (pyrazolopyridine, (R)-14) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	7.5	23
The Institute of Cancer Research					Assay Description CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
The Institute of Cancer Research					More data for this Ligand-Target Pair				3D Structure (docked)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM33217 (pyrazolopyridine, (S)-14) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	n/a	n/a	860	n/a	n/a	n/a	n/a	7.5	23
The Institute of Cancer Research					Assay Description CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
The Institute of Cancer Research					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM33215 (pyrazolopyridine, (Rac)-14 \| racemic) Show SMILES NCC1CN(CCO1)c1c(cnc2[nH]ncc12)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	890	n/a	n/a	n/a	n/a	7.5	23
The Institute of Cancer Research					Assay Description CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
The Institute of Cancer Research					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM33212 (pyrazolo pyridine, 11) Show SMILES CCOC(=O)c1cnc2[nH]ncc2c1N1CCOC(CN)C1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	7.5	23
The Institute of Cancer Research					Assay Description CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
The Institute of Cancer Research					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase Chk2 (Homo sapiens (Human))	BDBM33214 (pyrazolopyridine, 13) Show SMILES NCC1CN(CCO1)c1c(cnc2[nH]ncc12)-c1ccsc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.60E+3	n/a	n/a	n/a	n/a	7.4	23
The Institute of Cancer Research					Assay Description CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
The Institute of Cancer Research					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk2 (Homo sapiens (Human))	BDBM33216 (pyrazolopyridine, (R)-14) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.90E+3	n/a	n/a	n/a	n/a	7.4	23
The Institute of Cancer Research					Assay Description CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
The Institute of Cancer Research					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk2 (Homo sapiens (Human))	BDBM33213 (pyrazolopyridine, 12) Show SMILES NCC1CN(CCO1)c1c(Br)cnc2[nH]ncc12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	7.40E+3	n/a	n/a	n/a	n/a	7.4	23
The Institute of Cancer Research					Assay Description CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
The Institute of Cancer Research					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM33211 (purine, 10) Show SMILES NCC1CN(CCO1)c1ncnc2nc[nH]c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	9.20E+3	n/a	n/a	n/a	n/a	7.5	23
The Institute of Cancer Research					Assay Description CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
The Institute of Cancer Research					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM33210 (4-(7H-purin-6-yl)morpholine \| purine, 9) Show SMILES C1CN(CCO1)c1ncnc2nc[nH]c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	4.20E+4	n/a	n/a	n/a	n/a	7.5	23
The Institute of Cancer Research					Assay Description CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
The Institute of Cancer Research					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM33207 (benzothienopyrimidinone, 6) Show SMILES O=c1[nH]cnc2sc3CCCCc3c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	5.20E+4	n/a	n/a	n/a	n/a	7.5	23
The Institute of Cancer Research					Assay Description CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
The Institute of Cancer Research					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase Chk2 (Homo sapiens (Human))	BDBM33212 (pyrazolo pyridine, 11) Show SMILES CCOC(=O)c1cnc2[nH]ncc2c1N1CCOC(CN)C1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	7.40E+4	n/a	n/a	n/a	n/a	7.4	23
The Institute of Cancer Research					Assay Description CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
The Institute of Cancer Research					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM33210 (4-(7H-purin-6-yl)morpholine \| purine, 9) Show SMILES C1CN(CCO1)c1ncnc2nc[nH]c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	7.5	23
The Institute of Cancer Research					Assay Description AlphaScreen (PerkinElmer Life Sciences, Inc) was performed in opaque 384-well polypropylene plates. The assay relies on hydrogel coated Donor and Acc...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
The Institute of Cancer Research					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM33203 (quinazolinone, 2) Show SMILES CCCNc1nc2ccccc2c(=O)[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	7.5	23
The Institute of Cancer Research					Assay Description AlphaScreen (PerkinElmer Life Sciences, Inc) was performed in opaque 384-well polypropylene plates. The assay relies on hydrogel coated Donor and Acc...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
The Institute of Cancer Research					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM33208 (thiazole, 7) Show SMILES CC(C)(C)Nc1nc(N)c(s1)C(=O)c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase DrugBank MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	7.5	23
The Institute of Cancer Research					Assay Description CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
The Institute of Cancer Research					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM33208 (thiazole, 7) Show SMILES CC(C)(C)Nc1nc(N)c(s1)C(=O)c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase DrugBank MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	7.5	23
The Institute of Cancer Research					Assay Description AlphaScreen (PerkinElmer Life Sciences, Inc) was performed in opaque 384-well polypropylene plates. The assay relies on hydrogel coated Donor and Acc...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
The Institute of Cancer Research					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM33207 (benzothienopyrimidinone, 6) Show SMILES O=c1[nH]cnc2sc3CCCCc3c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	7.5	23
The Institute of Cancer Research					Assay Description AlphaScreen (PerkinElmer Life Sciences, Inc) was performed in opaque 384-well polypropylene plates. The assay relies on hydrogel coated Donor and Acc...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
The Institute of Cancer Research					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM33206 (thiazoloazepinyl acetamide, 5) Show SMILES CC(=O)Nc1nc2CCCNC(=O)c2s1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	7.5	23
The Institute of Cancer Research					Assay Description CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
The Institute of Cancer Research					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM33209 (2-methylsulfanyl imidazol-4-one, 8) Show SMILES CSC1=N\C(=C/c2cccs2)C(=O)N1 \|t:2\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	7.5	23
The Institute of Cancer Research					Assay Description CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
The Institute of Cancer Research					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM33206 (thiazoloazepinyl acetamide, 5) Show SMILES CC(=O)Nc1nc2CCCNC(=O)c2s1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	7.5	23
The Institute of Cancer Research					Assay Description AlphaScreen (PerkinElmer Life Sciences, Inc) was performed in opaque 384-well polypropylene plates. The assay relies on hydrogel coated Donor and Acc...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
The Institute of Cancer Research					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human))	BDBM33212 (pyrazolo pyridine, 11) Show SMILES CCOC(=O)c1cnc2[nH]ncc2c1N1CCOC(CN)C1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	7.5	23
The Institute of Cancer Research					Assay Description CDK1 kinase activity was measured in a DELFIA based HTScan CDK1/CycB kinase assay kit (Cell Signalling Technology) that monitors biotinylated substra...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
The Institute of Cancer Research					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM33209 (2-methylsulfanyl imidazol-4-one, 8) Show SMILES CSC1=N\C(=C/c2cccs2)C(=O)N1 \|t:2\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	7.5	23
The Institute of Cancer Research					Assay Description AlphaScreen (PerkinElmer Life Sciences, Inc) was performed in opaque 384-well polypropylene plates. The assay relies on hydrogel coated Donor and Acc...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
The Institute of Cancer Research					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM33204 (N-phenylquinazolin-4-amine, 3) Show SMILES Clc1ccc2c(Nc3ccccc3)ncnc2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	7.5	23
The Institute of Cancer Research					Assay Description AlphaScreen (PerkinElmer Life Sciences, Inc) was performed in opaque 384-well polypropylene plates. The assay relies on hydrogel coated Donor and Acc...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
The Institute of Cancer Research					More data for this Ligand-Target Pair
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human))	BDBM33214 (pyrazolopyridine, 13) Show SMILES NCC1CN(CCO1)c1c(cnc2[nH]ncc12)-c1ccsc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	7.5	23
The Institute of Cancer Research					Assay Description CDK1 kinase activity was measured in a DELFIA based HTScan CDK1/CycB kinase assay kit (Cell Signalling Technology) that monitors biotinylated substra...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
The Institute of Cancer Research					More data for this Ligand-Target Pair
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human))	BDBM33213 (pyrazolopyridine, 12) Show SMILES NCC1CN(CCO1)c1c(Br)cnc2[nH]ncc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	7.5	23
The Institute of Cancer Research					Assay Description CDK1 kinase activity was measured in a DELFIA based HTScan CDK1/CycB kinase assay kit (Cell Signalling Technology) that monitors biotinylated substra...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
The Institute of Cancer Research					More data for this Ligand-Target Pair
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human))	BDBM33216 (pyrazolopyridine, (R)-14) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	7.5	23
The Institute of Cancer Research					Assay Description CDK1 kinase activity was measured in a DELFIA based HTScan CDK1/CycB kinase assay kit (Cell Signalling Technology) that monitors biotinylated substra...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
The Institute of Cancer Research					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM33203 (quinazolinone, 2) Show SMILES CCCNc1nc2ccccc2c(=O)[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	7.5	23
The Institute of Cancer Research					Assay Description CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
The Institute of Cancer Research					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM33202 (benzisoxazole, 1) Show SMILES Fc1ccc(cc1)-c1onc2ccc(cc12)-c1cc[nH]n1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	7.5	23
The Institute of Cancer Research					Assay Description AlphaScreen (PerkinElmer Life Sciences, Inc) was performed in opaque 384-well polypropylene plates. The assay relies on hydrogel coated Donor and Acc...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
The Institute of Cancer Research					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM33205 (N-(3-methoxybenzyl)quinazolin-4-amine, 4) Show SMILES COc1cccc(CNc2ncnc3cc(OC)c(OC)cc23)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	7.5	23
The Institute of Cancer Research					Assay Description AlphaScreen (PerkinElmer Life Sciences, Inc) was performed in opaque 384-well polypropylene plates. The assay relies on hydrogel coated Donor and Acc...				J Med Chem 52: 4810-9 (2009) Article DOI: 10.1021/jm900314j BindingDB Entry DOI: 10.7270/Q27W69KC
The Institute of Cancer Research					More data for this Ligand-Target Pair

* indicates data uncertainty>20%