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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Glucagon receptor (Homo sapiens (Human)) | BDBM50324714 (CHEMBL1222088) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:178.191,168.175,148.161,133.142,113.120,96.104,76.86,62.70,43.53,30.37,8.12,232.238,206.214,wD:197.208,189.195,220.228,174.179,223.231,160.169,142.148,121.133,105.112,87.95,71.74,54.61,39.41,16.28,4.4,240.246,241.249,210.215,(49.7,-5.19,;48.4,-4.39,;48.4,-2.8,;47.09,-2.01,;47.09,-.42,;45.78,.38,;44.48,-.41,;44.48,-2.01,;43.16,.38,;43.16,1.97,;44.48,2.77,;44.48,4.36,;45.79,1.97,;41.85,-.41,;40.54,.39,;40.54,1.97,;39.24,-.41,;39.24,-2,;40.54,-2.79,;41.92,-2.15,;42.94,-3.33,;42.18,-4.72,;42.64,-6.22,;41.62,-7.4,;40.15,-7.06,;39.68,-5.55,;40.7,-4.38,;37.93,.39,;36.62,-.4,;36.62,-2,;35.31,.39,;35.31,1.98,;36.62,2.78,;36.62,4.37,;35.31,5.17,;37.93,5.16,;33.99,-.4,;32.69,.39,;32.69,1.98,;31.38,-.4,;30.07,.4,;28.76,-.39,;28.76,-1.99,;27.45,.4,;27.45,1.99,;28.76,2.79,;30.07,1.98,;31.38,2.78,;31.38,4.37,;30.07,5.17,;28.77,4.38,;26.15,-.39,;24.82,.4,;24.82,1.99,;23.52,-.39,;23.52,-1.98,;24.86,-2.75,;26.2,-1.98,;24.86,-4.29,;22.21,.41,;20.9,-.39,;20.9,-1.98,;19.59,.41,;19.59,2,;20.9,2.8,;20.9,4.39,;19.57,5.16,;19.57,6.7,;18.27,-.38,;16.97,.41,;16.97,2,;15.65,-.38,;15.65,-1.97,;14.36,.42,;13.04,-.37,;13.04,-1.97,;11.74,.42,;11.74,2,;13.07,2.78,;13.07,4.32,;14.39,5.09,;14.39,6.63,;15.74,7.4,;13.07,7.4,;10.43,-.37,;9.11,.42,;9.11,2.02,;7.8,-.36,;7.8,-1.96,;9.11,-2.76,;9.11,-4.35,;10.42,-5.14,;7.76,-5.11,;6.48,.43,;5.19,-.35,;5.19,-1.96,;3.87,.44,;3.87,2.02,;5.22,2.79,;5.22,4.34,;3.87,5.12,;6.55,5.12,;2.58,-.35,;1.25,.44,;1.25,2.03,;-.06,-.35,;-.06,-1.95,;1.25,-2.74,;2.56,-1.95,;1.25,-4.33,;-1.36,.44,;-2.67,-.34,;-2.67,-1.94,;-3.98,.45,;-3.98,2.03,;-2.67,2.83,;-2.67,4.42,;-1.36,2.03,;-5.29,-.34,;-6.6,.45,;-6.6,2.03,;-7.9,-.34,;-7.9,-1.94,;-6.6,-2.73,;-5.29,-1.94,;-3.98,-2.74,;-3.99,-4.33,;-2.68,-5.12,;-5.3,-5.12,;-6.6,-4.32,;-9.24,.45,;-10.53,-.33,;-10.53,-1.93,;-11.83,.45,;-11.83,2.04,;-10.53,2.84,;-10.53,4.43,;-9.23,5.24,;-9.23,6.83,;-13.14,-.33,;-14.45,.46,;-14.45,2.04,;-15.77,-.33,;-15.77,-1.93,;-14.45,-2.72,;-17.08,.46,;-18.38,-.32,;-18.38,-1.92,;-19.7,.46,;-19.7,2.05,;-18.38,2.85,;-17.07,2.05,;-15.77,2.85,;-15.76,4.44,;-14.44,5.24,;-17.08,5.25,;-18.38,4.44,;-21,-.32,;-22.31,.47,;-22.31,2.05,;-23.63,-.32,;-23.63,-1.91,;-22.31,-2.71,;-21.01,-1.91,;-22.31,-4.3,;-24.93,.47,;-26.25,-.32,;-26.25,-1.91,;-27.55,.47,;-27.55,2.06,;-26.25,2.86,;-28.86,-.31,;-30.18,.48,;-30.18,2.06,;-31.47,-.31,;-32.81,.48,;-34.09,-.31,;-34.09,-1.9,;-35.41,.48,;-35.41,2.07,;-34.09,2.87,;-32.79,2.06,;-31.47,2.87,;-31.47,4.45,;-32.8,5.26,;-34.1,4.46,;-36.71,-.3,;-38.02,.48,;-38.02,2.07,;-39.35,-.3,;-40.65,.49,;-41.95,-.3,;-41.95,-1.89,;-43.26,.49,;-44.58,-.29,;-45.88,.49,;-45.88,2.08,;-47.19,-.29,;-47.19,-1.88,;-45.88,-2.68,;-45.88,-4.28,;-47.2,-5.07,;-44.59,-5.07,;-48.5,.5,;-49.81,-.29,;-49.81,-1.88,;-51.13,.5,;-51.13,2.09,;-49.81,2.89,;-52.43,-.29,;-53.77,.49,;-53.77,2.01,;-55.09,2.77,;-56.34,1.91,;-57.57,2.83,;-57.07,4.29,;-55.53,4.26,;-55.1,-.28,;-56.42,.49,;-55.1,-1.82,;-39.35,-1.89,;-40.65,-2.7,;-38.02,-2.69,;-31.47,-1.9,;-32.81,-2.7,;-30.18,-2.7,;31.38,-1.99,;32.69,-2.78,;30.07,-2.79,;48.4,.38,;48.4,1.96,;49.72,-.42,;51.01,.37,;51.01,1.96,;52.33,2.76,;53.64,1.96,;52.33,4.35,;52.33,-.42,;52.33,-2.01,;53.64,.37,;54.95,-.43,;54.95,-2.02,;53.64,-2.81,;56.26,-2.81,;56.26,.37,;57.57,-.43,;56.26,1.95,)| Show InChI InChI=1S/C155H227N41O50S/c1-74(2)55-99(137(228)178-98(50-54-247-11)136(227)186-106(63-117(161)208)147(238)195-124(78(8)200)127(162)218)181-141(232)105(61-85-67-167-90-30-19-18-29-89(85)90)185-135(226)96(44-48-116(160)207)179-151(242)123(76(5)6)194-145(236)103(57-81-25-14-12-15-26-81)184-143(234)108(65-121(214)215)187-131(222)91(31-20-22-51-156)172-128(219)77(7)170-130(221)93(33-24-53-166-155(163)164)173-133(224)95(43-47-115(159)206)176-134(225)97(45-49-119(210)211)177-142(233)107(64-120(212)213)188-138(229)100(56-75(3)4)180-139(230)101(59-83-34-38-87(203)39-35-83)182-132(223)92(32-21-23-52-157)174-149(240)112(71-198)191-140(231)102(60-84-36-40-88(204)41-37-84)183-144(235)109(66-122(216)217)189-150(241)113(72-199)192-153(244)126(80(10)202)196-146(237)104(58-82-27-16-13-17-28-82)190-152(243)125(79(9)201)193-118(209)69-168-129(220)94(42-46-114(158)205)175-148(239)111(70-197)171-110(154(245)246)62-86-68-165-73-169-86/h12-19,25-30,34-41,67-68,73-80,91-113,123-126,167,171,197-204H,20-24,31-33,42-66,69-72,156-157H2,1-11H3,(H2,158,205)(H2,159,206)(H2,160,207)(H2,161,208)(H2,162,218)(H,165,169)(H,168,220)(H,170,221)(H,172,219)(H,173,224)(H,174,240)(H,175,239)(H,176,225)(H,177,233)(H,178,228)(H,179,242)(H,180,230)(H,181,232)(H,182,223)(H,183,235)(H,184,234)(H,185,226)(H,186,227)(H,187,222)(H,188,229)(H,189,241)(H,190,243)(H,191,231)(H,192,244)(H,193,209)(H,194,236)(H,195,238)(H,196,237)(H,210,211)(H,212,213)(H,214,215)(H,216,217)(H,245,246)(H4,163,164,166)/t77-,78+,79+,80+,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,123-,124-,125-,126-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet  | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0480 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon receptor (Homo sapiens (Human)) | BDBM50324705 (CHEMBL1222079) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:208.216,180.193,170.177,150.163,135.144,115.122,98.106,76.86,62.70,43.53,30.37,8.12,234.240,wD:199.210,191.197,222.230,176.181,225.233,162.171,144.150,123.135,107.114,87.97,71.74,54.61,39.41,16.28,4.4,242.248,243.251,212.217,(49.72,-5.28,;48.42,-4.48,;48.42,-2.89,;47.11,-2.1,;47.11,-.51,;45.8,.29,;44.5,-.5,;44.5,-2.1,;43.18,.29,;43.18,1.88,;44.5,2.68,;44.5,4.27,;45.81,1.88,;41.87,-.5,;40.55,.3,;40.55,1.88,;39.26,-.5,;39.26,-2.09,;40.55,-2.88,;41.94,-2.24,;42.96,-3.42,;42.19,-4.81,;42.63,-6.25,;41.6,-7.35,;40.12,-7.01,;39.69,-5.56,;40.72,-4.46,;37.95,.3,;36.63,-.49,;36.63,-2.09,;35.32,.3,;35.32,1.89,;36.63,2.69,;36.63,4.28,;35.33,5.06,;37.95,5.07,;34.01,-.49,;32.71,.31,;32.71,1.89,;31.39,-.49,;30.08,.31,;28.78,-.48,;28.78,-2.08,;27.46,.31,;27.46,1.9,;28.78,2.7,;30.09,1.89,;31.39,2.7,;31.39,4.28,;30.09,5.07,;28.78,4.29,;26.16,-.48,;24.84,.31,;24.84,1.9,;23.54,-.48,;23.54,-2.07,;24.84,-2.86,;26.16,-2.07,;24.84,-4.46,;22.23,.32,;20.91,-.48,;20.91,-2.07,;19.6,.32,;19.6,1.91,;20.91,2.71,;20.91,4.3,;19.61,5.08,;22.23,5.08,;18.29,-.47,;16.98,.32,;16.98,1.91,;15.67,-.47,;15.67,-2.06,;14.37,.33,;13.05,-.46,;13.05,-2.06,;11.75,.33,;11.75,1.92,;13.05,2.73,;13.05,4.31,;14.37,5.09,;14.37,6.69,;13.06,7.48,;15.67,7.48,;10.44,-.46,;9.12,.33,;9.12,1.93,;7.81,-.45,;7.81,-2.05,;9.16,-2.83,;9.16,-4.38,;10.5,-5.15,;10.5,-6.7,;11.85,-7.48,;9.16,-7.48,;6.49,.34,;5.21,-.44,;5.21,-2.05,;3.88,.35,;3.88,1.93,;5.23,2.71,;5.23,4.26,;3.88,5.03,;6.56,5.03,;2.59,-.44,;1.27,.35,;1.27,1.94,;-.05,-.44,;-.05,-2.04,;1.27,-2.83,;2.57,-2.04,;1.27,-4.42,;-1.36,.35,;-2.67,-.43,;-2.67,-2.03,;-3.98,.36,;-3.98,1.94,;-2.67,2.75,;-2.67,4.33,;-1.34,1.94,;-5.27,-.43,;-6.6,.36,;-6.6,1.94,;-7.89,-.43,;-7.89,-2.03,;-6.6,-2.82,;-5.28,-2.03,;-3.97,-2.83,;-3.97,-4.42,;-2.66,-5.21,;-5.28,-5.21,;-6.59,-4.41,;-9.21,.36,;-10.53,-.42,;-10.53,-2.02,;-11.83,.36,;-11.83,1.95,;-10.53,2.75,;-10.53,4.34,;-9.22,5.14,;-9.22,6.73,;-13.14,-.42,;-14.45,.37,;-14.45,1.95,;-15.75,-.42,;-15.75,-2.02,;-14.45,-2.81,;-17.08,.37,;-18.38,-.41,;-18.38,-2.01,;-19.68,.37,;-19.68,1.96,;-18.38,2.76,;-17.07,1.96,;-15.75,2.76,;-15.75,4.35,;-14.44,5.14,;-17.07,5.14,;-18.38,4.35,;-21,-.41,;-22.3,.38,;-22.3,1.96,;-23.62,-.41,;-23.62,-2,;-22.3,-2.8,;-21.01,-2,;-22.3,-4.39,;-24.92,.38,;-26.24,-.41,;-26.24,-2,;-27.55,.38,;-27.55,1.97,;-26.24,2.77,;-28.85,-.4,;-30.18,.39,;-30.18,1.97,;-31.46,-.4,;-32.79,.39,;-34.09,-.4,;-34.09,-1.99,;-35.41,.39,;-35.41,1.98,;-34.09,2.78,;-32.79,1.98,;-31.47,2.78,;-31.47,4.37,;-32.78,5.16,;-34.08,4.37,;-36.71,-.39,;-38.03,.4,;-38.03,1.98,;-39.33,-.39,;-40.65,.4,;-41.95,-.39,;-41.95,-1.98,;-43.25,.4,;-44.58,-.38,;-45.88,.4,;-45.88,1.99,;-47.19,-.38,;-47.19,-1.97,;-45.88,-2.77,;-45.88,-4.37,;-47.18,-5.16,;-44.59,-5.16,;-48.5,.41,;-49.81,-.38,;-49.81,-1.97,;-51.13,.41,;-51.13,2,;-49.79,2.8,;-52.42,-.38,;-53.77,.39,;-53.77,1.92,;-55.09,2.69,;-56.35,1.82,;-57.58,2.75,;-57.09,4.22,;-55.54,4.18,;-55.1,-.38,;-56.43,.39,;-55.1,-1.93,;-39.33,-1.98,;-40.65,-2.79,;-38.03,-2.78,;-31.46,-1.99,;-32.79,-2.8,;-30.18,-2.79,;31.39,-2.08,;32.71,-2.87,;30.08,-2.88,;48.42,.29,;48.42,1.87,;49.74,-.51,;51.03,.28,;51.03,1.87,;52.35,2.67,;53.66,1.87,;52.35,4.26,;52.35,-.51,;52.35,-2.1,;53.66,.28,;54.97,-.52,;54.97,-2.11,;53.66,-2.9,;56.28,-2.9,;56.28,.28,;57.58,-.52,;56.28,1.86,)| Show InChI InChI=1S/C155H228N44O49S/c1-73(2)54-98(136(230)181-97(49-53-249-11)135(229)189-105(62-117(161)212)146(240)198-123(77(8)203)126(162)220)184-140(234)104(60-84-66-170-89-29-19-18-28-88(84)89)188-134(228)96(44-48-116(160)211)182-150(244)122(75(5)6)197-144(238)102(56-80-24-14-12-15-25-80)187-142(236)107(64-120(216)217)190-133(227)94(42-46-114(158)209)175-127(221)76(7)173-129(223)91(31-22-51-168-154(163)164)176-130(224)92(32-23-52-169-155(165)166)177-132(226)95(43-47-115(159)210)180-141(235)106(63-119(214)215)191-137(231)99(55-74(3)4)183-138(232)100(58-82-33-37-86(206)38-34-82)185-131(225)90(30-20-21-50-156)178-148(242)111(70-201)194-139(233)101(59-83-35-39-87(207)40-36-83)186-143(237)108(65-121(218)219)192-149(243)112(71-202)195-152(246)125(79(10)205)199-145(239)103(57-81-26-16-13-17-27-81)193-151(245)124(78(9)204)196-118(213)68-171-128(222)93(41-45-113(157)208)179-147(241)110(69-200)174-109(153(247)248)61-85-67-167-72-172-85/h12-19,24-29,33-40,66-67,72-79,90-112,122-125,170,174,200-207H,20-23,30-32,41-65,68-71,156H2,1-11H3,(H2,157,208)(H2,158,209)(H2,159,210)(H2,160,211)(H2,161,212)(H2,162,220)(H,167,172)(H,171,222)(H,173,223)(H,175,221)(H,176,224)(H,177,226)(H,178,242)(H,179,241)(H,180,235)(H,181,230)(H,182,244)(H,183,232)(H,184,234)(H,185,225)(H,186,237)(H,187,236)(H,188,228)(H,189,229)(H,190,227)(H,191,231)(H,192,243)(H,193,245)(H,194,233)(H,195,246)(H,196,213)(H,197,238)(H,198,240)(H,199,239)(H,214,215)(H,216,217)(H,218,219)(H,247,248)(H4,163,164,168)(H4,165,166,169)/t76-,77+,78+,79+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0710 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon receptor (Homo sapiens (Human)) | BDBM50324720 (CHEMBL1222094) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:208.216,180.193,170.177,150.163,135.144,115.122,98.106,76.86,62.70,43.53,30.37,8.12,234.240,wD:199.210,191.197,222.230,176.181,225.233,162.171,144.150,123.135,107.114,87.97,71.74,54.61,39.41,16.28,4.4,242.248,243.251,212.217,(49.7,-5.26,;48.39,-4.46,;48.39,-2.87,;47.08,-2.08,;47.08,-.49,;45.77,.31,;44.47,-.48,;44.47,-2.07,;43.15,.31,;43.15,1.9,;44.47,2.7,;44.47,4.29,;45.78,1.9,;41.85,-.48,;40.54,.32,;40.54,1.9,;39.23,-.48,;39.23,-2.07,;40.54,-2.86,;41.91,-2.22,;42.93,-3.4,;42.17,-4.79,;42.63,-6.29,;41.61,-7.47,;40.14,-7.14,;39.67,-5.63,;40.69,-4.45,;37.92,.32,;36.61,-.47,;36.61,-2.07,;35.3,.32,;35.3,1.91,;36.61,2.71,;36.61,4.3,;35.3,5.08,;37.93,5.09,;33.98,-.47,;32.68,.33,;32.68,1.91,;31.37,-.47,;30.06,.33,;28.75,-.46,;28.75,-2.06,;27.44,.33,;27.44,1.92,;28.75,2.72,;30.06,1.92,;31.37,2.72,;31.37,4.3,;30.07,5.09,;28.76,4.31,;26.14,-.46,;24.81,.34,;24.81,1.92,;23.51,-.46,;23.51,-2.05,;24.81,-2.84,;26.13,-2.05,;24.81,-4.44,;22.2,.34,;20.9,-.45,;20.9,-2.05,;19.58,.34,;19.58,1.93,;20.9,2.73,;20.9,4.32,;19.59,5.1,;22.21,5.11,;18.27,-.45,;16.97,.34,;16.97,1.93,;15.65,-.45,;15.65,-2.04,;14.36,.35,;13.03,-.44,;13.03,-2.04,;11.72,.35,;11.72,1.94,;13.03,2.75,;13.03,4.33,;14.36,5.11,;14.36,6.71,;13.04,7.5,;15.66,7.5,;10.41,-.43,;9.1,.35,;9.1,1.95,;7.78,-.43,;7.78,-2.03,;9.1,-2.82,;9.1,-4.42,;10.43,-5.19,;10.44,-6.73,;11.79,-7.5,;9.11,-7.5,;6.47,.36,;5.19,-.42,;5.19,-2.03,;3.86,.37,;3.86,1.95,;5.19,2.76,;5.15,4.3,;3.79,5.04,;6.46,5.1,;2.56,-.42,;1.25,.37,;1.25,1.96,;-.07,-.41,;-.07,-2.01,;1.25,-2.81,;2.54,-2.01,;1.25,-4.4,;-1.38,.37,;-2.68,-.41,;-2.68,-2.01,;-4,.38,;-4,1.96,;-2.68,2.77,;-2.68,4.35,;-1.36,1.96,;-5.3,-.41,;-6.62,.38,;-6.62,1.97,;-7.92,-.41,;-7.92,-2.01,;-6.62,-2.8,;-5.31,-2.01,;-4,-2.8,;-4,-4.39,;-2.68,-5.19,;-5.3,-5.19,;-6.61,-4.39,;-9.24,.38,;-10.55,-.4,;-10.55,-2,;-11.85,.39,;-11.85,1.97,;-10.55,2.78,;-10.55,4.36,;-9.24,5.16,;-9.24,6.74,;-13.16,-.4,;-14.47,.39,;-14.47,1.97,;-15.77,-.4,;-15.77,-2,;-14.47,-2.79,;-17.1,.39,;-18.4,-.39,;-18.4,-1.99,;-19.71,.39,;-19.71,1.98,;-18.4,2.78,;-17.09,1.98,;-15.77,2.78,;-15.78,4.37,;-14.46,5.16,;-17.09,5.16,;-18.4,4.37,;-21.02,-.39,;-22.33,.4,;-22.33,1.98,;-23.65,-.39,;-23.65,-1.98,;-22.33,-2.78,;-21.03,-1.98,;-22.33,-4.37,;-24.94,.4,;-26.26,-.38,;-26.26,-1.98,;-27.57,.4,;-27.57,1.99,;-26.26,2.79,;-28.87,-.38,;-30.2,.41,;-30.2,1.99,;-31.49,-.38,;-32.81,.41,;-34.11,-.37,;-34.11,-1.97,;-35.43,.41,;-35.43,2,;-34.11,2.8,;-32.81,2,;-31.49,2.8,;-31.49,4.39,;-32.8,5.18,;-34.1,4.39,;-36.73,-.37,;-38.04,.42,;-38.04,2,;-39.35,-.37,;-40.67,.42,;-41.97,-.37,;-41.97,-1.96,;-43.27,.42,;-44.6,-.36,;-45.91,.43,;-45.91,2.01,;-47.21,-.36,;-47.21,-1.95,;-45.9,-2.75,;-45.9,-4.34,;-47.2,-5.14,;-44.61,-5.14,;-48.52,.43,;-49.83,-.36,;-49.83,-1.95,;-51.15,.43,;-51.15,2.02,;-49.81,2.82,;-52.44,-.36,;-53.79,.42,;-53.79,1.94,;-55.11,2.7,;-56.36,1.84,;-57.59,2.76,;-57.1,4.22,;-55.55,4.19,;-55.12,-.35,;-56.45,.42,;-55.12,-1.89,;-39.35,-1.96,;-40.67,-2.76,;-38.04,-2.76,;-31.49,-1.97,;-32.81,-2.77,;-30.2,-2.77,;31.37,-2.06,;32.68,-2.85,;30.06,-2.86,;48.39,.31,;48.39,1.89,;49.71,-.49,;51.01,.3,;51.01,1.89,;52.32,2.69,;53.63,1.89,;52.32,4.28,;52.32,-.49,;52.32,-2.08,;53.63,.3,;54.94,-.49,;54.94,-2.09,;53.63,-2.88,;56.25,-2.88,;56.25,.3,;57.59,-.46,;56.25,1.88,)| Show InChI InChI=1S/C155H226N42O51S/c1-73(2)54-98(136(230)179-97(49-53-249-11)135(229)187-105(62-115(159)208)146(240)196-123(77(8)201)126(160)220)182-140(234)104(60-84-66-168-89-29-19-18-28-88(84)89)186-134(228)95(42-46-114(158)207)180-150(244)122(75(5)6)195-144(238)102(56-80-24-14-12-15-25-80)185-142(236)107(64-120(216)217)188-133(227)94(41-45-113(157)206)173-127(221)76(7)171-129(223)91(31-22-51-166-154(161)162)174-130(224)92(32-23-52-167-155(163)164)175-132(226)96(44-48-118(212)213)178-141(235)106(63-119(214)215)189-137(231)99(55-74(3)4)181-138(232)100(58-82-33-37-86(204)38-34-82)183-131(225)90(30-20-21-50-156)176-148(242)111(70-199)192-139(233)101(59-83-35-39-87(205)40-36-83)184-143(237)108(65-121(218)219)190-149(243)112(71-200)193-152(246)125(79(10)203)197-145(239)103(57-81-26-16-13-17-27-81)191-151(245)124(78(9)202)194-116(209)68-169-128(222)93(43-47-117(210)211)177-147(241)110(69-198)172-109(153(247)248)61-85-67-165-72-170-85/h12-19,24-29,33-40,66-67,72-79,90-112,122-125,168,172,198-205H,20-23,30-32,41-65,68-71,156H2,1-11H3,(H2,157,206)(H2,158,207)(H2,159,208)(H2,160,220)(H,165,170)(H,169,222)(H,171,223)(H,173,221)(H,174,224)(H,175,226)(H,176,242)(H,177,241)(H,178,235)(H,179,230)(H,180,244)(H,181,232)(H,182,234)(H,183,225)(H,184,237)(H,185,236)(H,186,228)(H,187,229)(H,188,227)(H,189,231)(H,190,243)(H,191,245)(H,192,233)(H,193,246)(H,194,209)(H,195,238)(H,196,240)(H,197,239)(H,210,211)(H,212,213)(H,214,215)(H,216,217)(H,218,219)(H,247,248)(H4,161,162,166)(H4,163,164,167)/t76-,77+,78+,79+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.70 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50324704 (CHEMBL1222078) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:209.218,181.195,171.179,151.165,136.146,116.124,98.108,76.86,62.70,43.53,30.37,8.12,235.242,wD:200.212,192.199,223.232,177.183,226.235,163.173,145.152,124.137,108.116,87.97,71.74,54.61,39.41,16.28,4.4,243.250,244.253,213.219,(49.7,-5.27,;48.4,-4.48,;48.4,-2.88,;47.09,-2.09,;47.09,-.5,;45.78,.29,;44.48,-.5,;44.48,-2.09,;43.16,.3,;43.16,1.88,;44.48,2.69,;44.48,4.27,;45.79,1.88,;41.86,-.49,;40.54,.3,;40.54,1.89,;39.24,-.49,;39.24,-2.08,;40.54,-2.88,;41.92,-2.23,;42.94,-3.42,;42.17,-4.8,;42.64,-6.3,;41.62,-7.48,;40.15,-7.15,;39.68,-5.64,;40.7,-4.46,;37.93,.3,;36.62,-.49,;36.62,-2.08,;35.31,.31,;35.31,1.89,;36.62,2.7,;36.62,4.28,;35.32,5.07,;37.94,5.07,;34,-.49,;32.7,.31,;32.7,1.9,;31.36,-.48,;30.06,.31,;28.77,-.48,;28.77,-2.07,;27.44,.32,;27.44,1.9,;28.77,2.7,;30.08,1.9,;31.38,2.7,;31.37,4.29,;30.07,5.07,;28.76,4.29,;26.15,-.48,;24.83,.32,;24.83,1.9,;23.53,-.47,;23.53,-2.06,;24.83,-2.86,;26.14,-2.06,;24.83,-4.45,;22.22,.32,;20.91,-.47,;20.91,-2.06,;19.59,.33,;19.59,1.91,;20.91,2.71,;20.88,4.25,;19.53,4.99,;22.2,5.06,;18.29,-.47,;16.98,.33,;16.98,1.91,;15.67,-.46,;15.67,-2.06,;14.37,.33,;13.05,-.45,;13.05,-2.05,;11.75,.33,;11.75,1.92,;13.05,2.73,;13.05,4.31,;14.37,5.1,;14.37,6.69,;13.06,7.48,;15.67,7.48,;10.44,-.45,;9.12,.34,;9.12,1.93,;7.81,-.45,;7.81,-1.99,;9.16,-2.76,;9.14,-4.3,;10.49,-5.07,;10.49,-6.62,;11.82,-7.39,;9.14,-7.39,;6.5,.35,;5.22,-.44,;5.22,-2.04,;3.89,.35,;3.9,1.93,;5.25,2.71,;5.22,4.26,;6.68,4.76,;7.63,3.52,;6.73,2.26,;2.59,-.43,;1.28,.35,;1.28,1.94,;-.04,-.43,;-.04,-2.03,;1.28,-2.82,;2.57,-2.03,;1.28,-4.41,;-1.35,.36,;-2.66,-.43,;-2.66,-2.03,;-3.97,.36,;-3.97,1.95,;-2.66,2.75,;-2.66,4.33,;-1.33,1.95,;-5.26,-.42,;-6.58,.36,;-6.58,1.95,;-7.88,-.42,;-7.88,-2.02,;-6.58,-2.81,;-5.27,-2.02,;-3.96,-2.82,;-3.96,-4.41,;-2.65,-5.2,;-5.27,-5.2,;-6.58,-4.4,;-9.2,.37,;-10.51,-.42,;-10.51,-2.02,;-11.82,.37,;-11.82,1.95,;-10.51,2.76,;-10.51,4.34,;-9.21,5.14,;-9.21,6.72,;-13.12,-.42,;-14.43,.37,;-14.43,1.96,;-15.73,-.41,;-15.73,-2.01,;-14.43,-2.8,;-17.06,.38,;-18.36,-.41,;-18.36,-2,;-19.66,.38,;-19.66,1.96,;-18.36,2.77,;-17.05,1.96,;-15.73,2.76,;-15.74,4.35,;-14.42,5.14,;-17.05,5.14,;-18.36,4.35,;-20.98,-.41,;-22.28,.38,;-22.28,1.97,;-23.6,-.4,;-23.6,-1.99,;-22.28,-2.79,;-20.99,-1.99,;-22.28,-4.39,;-24.9,.38,;-26.22,-.4,;-26.22,-1.99,;-27.52,.39,;-27.52,1.97,;-26.22,2.78,;-28.83,-.4,;-30.15,.39,;-30.15,1.98,;-31.44,-.39,;-32.76,.39,;-34.06,-.39,;-34.06,-1.98,;-35.38,.4,;-35.38,1.98,;-34.06,2.79,;-32.76,1.98,;-31.44,2.78,;-31.44,4.37,;-32.75,5.16,;-34.05,4.37,;-36.68,-.39,;-38,.4,;-38,1.99,;-39.3,-.38,;-40.61,.4,;-41.92,-.38,;-41.92,-1.97,;-43.21,.41,;-44.54,-.38,;-45.85,.41,;-45.85,1.99,;-47.15,-.38,;-47.15,-1.97,;-45.85,-2.77,;-45.85,-4.36,;-47.15,-5.15,;-44.55,-5.15,;-48.46,.41,;-49.77,-.38,;-49.77,-1.96,;-51.09,.41,;-51.09,2,;-49.75,2.8,;-52.38,-.38,;-53.73,.4,;-53.73,1.93,;-55.05,2.7,;-56.32,1.83,;-57.56,2.76,;-57.05,4.23,;-55.51,4.2,;-55.07,-.38,;-56.41,.4,;-55.07,-1.93,;-39.3,-1.98,;-40.61,-2.78,;-38,-2.78,;-31.44,-1.99,;-32.76,-2.79,;-30.15,-2.79,;31.36,-2.07,;32.7,-2.87,;30.06,-2.87,;48.4,.29,;48.4,1.88,;49.71,-.5,;51.01,.29,;51.01,1.87,;52.33,2.68,;53.64,1.87,;52.33,4.26,;52.33,-.51,;52.33,-2.1,;53.63,.29,;54.94,-.51,;54.94,-2.1,;53.63,-2.9,;56.25,-2.89,;56.25,.28,;57.56,-.52,;56.25,1.87,)| Show InChI InChI=1S/C156H227N45O48S/c1-74(2)52-99(136(230)182-98(47-51-250-11)135(229)191-107(61-118(161)213)147(241)200-124(78(8)205)127(162)221)185-140(234)105(58-85-65-171-91-29-19-18-28-90(85)91)189-134(228)97(43-46-117(160)212)183-151(245)123(76(5)6)199-145(239)103(54-81-24-14-12-15-25-81)188-142(236)108(62-120(215)216)192-133(227)96(42-45-116(159)211)177-128(222)77(7)175-130(224)93(31-22-49-169-155(163)164)178-131(225)94(32-23-50-170-156(165)166)179-141(235)106(59-86-66-167-72-173-86)190-144(238)109(63-121(217)218)193-137(231)100(53-75(3)4)184-138(232)101(56-83-33-37-88(208)38-34-83)186-132(226)92(30-20-21-48-157)180-149(243)113(70-203)196-139(233)102(57-84-35-39-89(209)40-36-84)187-143(237)110(64-122(219)220)194-150(244)114(71-204)197-153(247)126(80(10)207)201-146(240)104(55-82-26-16-13-17-27-82)195-152(246)125(79(9)206)198-119(214)68-172-129(223)95(41-44-115(158)210)181-148(242)112(69-202)176-111(154(248)249)60-87-67-168-73-174-87/h12-19,24-29,33-40,65-67,72-80,92-114,123-126,171,176,202-209H,20-23,30-32,41-64,68-71,157H2,1-11H3,(H2,158,210)(H2,159,211)(H2,160,212)(H2,161,213)(H2,162,221)(H,167,173)(H,168,174)(H,172,223)(H,175,224)(H,177,222)(H,178,225)(H,179,235)(H,180,243)(H,181,242)(H,182,230)(H,183,245)(H,184,232)(H,185,234)(H,186,226)(H,187,237)(H,188,236)(H,189,228)(H,190,238)(H,191,229)(H,192,227)(H,193,231)(H,194,244)(H,195,246)(H,196,233)(H,197,247)(H,198,214)(H,199,239)(H,200,241)(H,201,240)(H,215,216)(H,217,218)(H,219,220)(H,248,249)(H4,163,164,169)(H4,165,166,170)/t77-,78+,79+,80+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,123-,124-,125-,126-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.230 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50324727 (CHEMBL1222101) Show SMILES CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(=O)NCCCC[C@H](NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C |r| Show InChI InChI=1S/C155H227N41O49S/c1-75(2)56-100-135(225)178-99(50-55-246-11)133(223)173-93(134(224)196-125(81(10)203)153(244)245)33-21-23-52-164-117(208)49-46-98(132(222)185-106(139(229)181-100)62-86-67-167-91-31-19-18-30-90(86)91)179-149(239)122(77(5)6)194-143(233)104(58-82-26-14-12-15-27-82)184-140(230)107(64-119(210)211)186-131(221)97(45-48-116(158)207)172-126(216)78(7)170-128(218)94(34-24-53-165-154(159)160)174-129(219)95(35-25-54-166-155(161)162)176-147(237)113(72-199)191-142(232)109(66-121(214)215)187-136(226)101(57-76(3)4)180-137(227)102(60-84-36-40-88(204)41-37-84)182-130(220)92(32-20-22-51-156)175-146(236)112(71-198)190-138(228)103(61-85-38-42-89(205)43-39-85)183-141(231)108(65-120(212)213)188-148(238)114(73-200)192-151(241)124(80(9)202)195-144(234)105(59-83-28-16-13-17-29-83)189-150(240)123(79(8)201)193-118(209)69-168-127(217)96(44-47-115(157)206)177-145(235)111(70-197)171-110(152(242)243)63-87-68-163-74-169-87/h12-19,26-31,36-43,67-68,74-81,92-114,122-125,167,171,197-205H,20-25,32-35,44-66,69-73,156H2,1-11H3,(H2,157,206)(H2,158,207)(H,163,169)(H,164,208)(H,168,217)(H,170,218)(H,172,216)(H,173,223)(H,174,219)(H,175,236)(H,176,237)(H,177,235)(H,178,225)(H,179,239)(H,180,227)(H,181,229)(H,182,220)(H,183,231)(H,184,230)(H,185,222)(H,186,221)(H,187,226)(H,188,238)(H,189,240)(H,190,228)(H,191,232)(H,192,241)(H,193,209)(H,194,233)(H,195,234)(H,196,224)(H,210,211)(H,212,213)(H,214,215)(H,242,243)(H,244,245)(H4,159,160,165)(H4,161,162,166)/t78-,79+,80+,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,122-,123-,124-,125-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.180 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50324729 (CHEMBL1222174) Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)C(C)CN[C@@H](Cc2cnc[nH]2)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O |r| Show InChI InChI=1S/C153H220N36O48S/c1-15-76(6)122(149(231)166-80(10)129(211)174-107(62-88-68-161-93-33-23-22-32-92(88)93)141(223)176-101(56-74(2)3)137(219)173-100(52-55-238-14)136(218)180-108(64-116(157)199)146(228)189-125(83(13)194)153(236)237)187-144(226)105(58-84-28-18-16-19-29-84)178-135(217)99(47-51-119(202)203)171-132(214)94-35-25-27-54-159-117(200)50-46-98(134(216)170-97(45-49-115(156)198)131(213)165-78(8)127(209)164-79(9)128(210)168-94)172-142(224)109(65-120(204)205)181-138(220)102(57-75(4)5)175-139(221)103(60-86-36-40-90(195)41-37-86)177-133(215)95(34-24-26-53-154)169-147(229)112(71-190)184-140(222)104(61-87-38-42-91(196)43-39-87)179-143(225)110(66-121(206)207)182-148(230)113(72-191)185-151(233)124(82(12)193)188-145(227)106(59-85-30-20-17-21-31-85)183-150(232)123(81(11)192)186-118(201)70-162-130(212)96(44-48-114(155)197)167-126(208)77(7)67-160-111(152(234)235)63-89-69-158-73-163-89/h16-23,28-33,36-43,68-69,73-83,94-113,122-125,160-161,190-196H,15,24-27,34-35,44-67,70-72,154H2,1-14H3,(H2,155,197)(H2,156,198)(H2,157,199)(H,158,163)(H,159,200)(H,162,212)(H,164,209)(H,165,213)(H,166,231)(H,167,208)(H,168,210)(H,169,229)(H,170,216)(H,171,214)(H,172,224)(H,173,219)(H,174,211)(H,175,221)(H,176,223)(H,177,215)(H,178,217)(H,179,225)(H,180,218)(H,181,220)(H,182,230)(H,183,232)(H,184,222)(H,185,233)(H,186,201)(H,187,226)(H,188,227)(H,189,228)(H,202,203)(H,204,205)(H,206,207)(H,234,235)(H,236,237)/t76-,77?,78-,79-,80-,81+,82+,83+,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,122-,123-,124-,125-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0130 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon receptor (Homo sapiens (Human)) | BDBM50324709 (CHEMBL1222083) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:203.211,175.188,165.172,145.158,130.139,110.117,76.86,62.70,43.53,30.37,8.12,229.235,wD:207.212,194.205,186.192,217.225,171.176,220.228,157.166,139.145,118.130,102.109,87.97,71.74,54.61,39.41,16.28,4.4,237.243,238.246,(49.79,-5.31,;48.48,-4.51,;48.48,-2.92,;47.17,-2.13,;47.17,-.53,;45.86,.27,;44.55,-.53,;44.55,-2.13,;43.24,.27,;43.24,1.86,;44.55,2.66,;44.55,4.25,;45.87,1.86,;41.93,-.53,;40.61,.27,;40.61,1.86,;39.31,-.52,;39.31,-2.12,;40.61,-2.91,;41.99,-2.27,;43.02,-3.45,;42.25,-4.84,;42.69,-6.28,;41.66,-7.38,;40.18,-7.04,;39.74,-5.59,;40.77,-4.49,;38,.28,;36.68,-.52,;36.68,-2.12,;35.37,.28,;35.37,1.87,;36.68,2.67,;36.68,4.26,;35.38,5.05,;38,5.05,;34.06,-.52,;32.75,.28,;32.75,1.87,;31.43,-.52,;30.12,.29,;28.82,-.51,;28.82,-2.11,;27.5,.29,;27.5,1.88,;28.82,2.68,;30.13,1.87,;31.43,2.67,;31.44,4.26,;30.13,5.06,;28.82,4.27,;26.2,-.51,;24.87,.29,;24.87,1.88,;23.58,-.51,;23.58,-2.1,;24.87,-2.89,;26.19,-2.1,;24.87,-4.49,;22.26,.3,;20.95,-.5,;20.95,-2.1,;19.63,.3,;19.63,1.89,;20.95,2.69,;20.95,4.28,;19.64,5.07,;22.26,5.07,;18.32,-.5,;17,.3,;17,1.89,;15.7,-.5,;15.7,-2.09,;14.4,.3,;13.07,-.49,;13.07,-2.09,;11.76,.31,;11.76,1.9,;13.07,2.7,;13.07,4.28,;14.39,5.08,;14.39,6.67,;13.08,7.46,;15.69,7.47,;10.45,-.48,;9.14,.31,;9.14,1.91,;7.82,-.48,;7.82,-2.03,;9.18,-2.81,;9.18,-4.36,;10.52,-5.14,;10.52,-6.69,;11.85,-7.47,;9.17,-7.47,;6.51,.32,;5.22,-.47,;5.22,-2.08,;3.89,.32,;2.59,-.47,;1.28,.33,;1.28,1.92,;-.05,-.46,;-.05,-2.07,;1.28,-2.86,;2.57,-2.07,;1.28,-4.45,;-1.35,.33,;-2.67,-.46,;-2.67,-2.06,;-3.98,.33,;-3.98,1.92,;-2.67,2.72,;-2.67,4.31,;-1.33,1.92,;-5.28,-.46,;-6.6,.34,;-6.6,1.93,;-7.9,-.45,;-7.9,-2.06,;-6.6,-2.85,;-5.29,-2.06,;-3.98,-2.85,;-3.98,-4.44,;-2.66,-5.24,;-5.29,-5.24,;-6.6,-4.44,;-9.22,.34,;-10.53,-.45,;-10.53,-2.05,;-11.84,.34,;-11.84,1.93,;-10.53,2.73,;-10.53,4.32,;-9.23,5.12,;-9.23,6.71,;-13.15,-.45,;-14.46,.35,;-14.46,1.93,;-15.77,-.44,;-15.77,-2.05,;-14.46,-2.84,;-17.1,.35,;-18.39,-.44,;-18.39,-2.04,;-19.7,.35,;-19.7,1.94,;-18.39,2.74,;-17.08,1.94,;-15.77,2.74,;-15.77,4.33,;-14.45,5.13,;-17.09,5.13,;-18.4,4.33,;-21.02,-.44,;-22.33,.36,;-22.33,1.94,;-23.65,-.44,;-23.65,-2.03,;-22.33,-2.83,;-21.03,-2.03,;-22.33,-4.42,;-24.95,.36,;-26.27,-.43,;-26.27,-2.03,;-27.58,.36,;-27.58,1.95,;-26.27,2.75,;-28.88,-.43,;-30.21,.36,;-30.21,1.95,;-31.5,-.43,;-32.83,.37,;-34.13,-.42,;-34.13,-2.02,;-35.45,.37,;-35.45,1.96,;-34.13,2.76,;-32.83,1.96,;-31.5,2.75,;-31.51,4.35,;-32.82,5.15,;-34.12,4.35,;-36.75,-.42,;-38.07,.37,;-38.07,1.96,;-39.38,-.42,;-40.69,.38,;-42,-.41,;-42,-2.01,;-43.3,.38,;-44.63,-.41,;-45.93,.38,;-45.93,1.97,;-47.25,-.41,;-47.25,-2,;-45.93,-2.8,;-45.93,-4.39,;-47.24,-5.2,;-44.64,-5.19,;-48.56,.38,;-49.87,-.41,;-49.87,-2,;-51.19,.38,;-51.19,1.98,;-49.85,2.78,;-52.48,-.41,;-53.84,.38,;-53.84,1.91,;-55.17,2.67,;-56.42,1.81,;-57.66,2.73,;-57.16,4.2,;-55.61,4.17,;-55.18,-.4,;-56.51,.38,;-55.18,-1.95,;-39.38,-2.01,;-40.69,-2.81,;-38.07,-2.81,;-31.5,-2.02,;-32.83,-2.82,;-30.21,-2.82,;31.43,-2.11,;32.75,-2.9,;30.12,-2.9,;48.48,.26,;48.48,1.85,;49.8,-.54,;51.1,.26,;51.1,1.85,;52.42,2.65,;53.73,1.85,;52.42,4.24,;52.42,-.54,;52.42,-2.13,;53.73,.26,;55.04,-.54,;55.04,-2.14,;53.73,-2.93,;56.35,-2.93,;56.35,.25,;57.66,-.55,;56.35,1.84,)| Show InChI InChI=1S/C152H223N43O48S/c1-72(2)52-96(134(226)177-95(47-51-244-11)133(225)185-103(60-114(157)207)143(235)194-121(76(8)199)124(158)216)180-138(230)102(58-83-64-166-88-29-19-18-28-87(83)88)184-132(224)94(43-46-113(156)206)178-147(239)120(74(5)6)193-141(233)100(54-79-24-14-12-15-25-79)183-139(231)105(62-118(212)213)187-131(223)93(42-45-112(155)205)173-125(217)75(7)170-128(220)91(32-23-50-165-152(161)162)174-129(221)89(31-22-49-164-151(159)160)172-115(208)66-168-127(219)104(61-117(210)211)186-135(227)97(53-73(3)4)179-136(228)98(56-81-33-37-85(202)38-34-81)181-130(222)90(30-20-21-48-153)175-145(237)109(69-197)190-137(229)99(57-82-35-39-86(203)40-36-82)182-140(232)106(63-119(214)215)188-146(238)110(70-198)191-149(241)123(78(10)201)195-142(234)101(55-80-26-16-13-17-27-80)189-148(240)122(77(9)200)192-116(209)67-167-126(218)92(41-44-111(154)204)176-144(236)108(68-196)171-107(150(242)243)59-84-65-163-71-169-84/h12-19,24-29,33-40,64-65,71-78,89-110,120-123,166,171,196-203H,20-23,30-32,41-63,66-70,153H2,1-11H3,(H2,154,204)(H2,155,205)(H2,156,206)(H2,157,207)(H2,158,216)(H,163,169)(H,167,218)(H,168,219)(H,170,220)(H,172,208)(H,173,217)(H,174,221)(H,175,237)(H,176,236)(H,177,226)(H,178,239)(H,179,228)(H,180,230)(H,181,222)(H,182,232)(H,183,231)(H,184,224)(H,185,225)(H,186,227)(H,187,223)(H,188,238)(H,189,240)(H,190,229)(H,191,241)(H,192,209)(H,193,233)(H,194,235)(H,195,234)(H,210,211)(H,212,213)(H,214,215)(H,242,243)(H4,159,160,164)(H4,161,162,165)/t75-,76+,77+,78+,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,120-,121-,122-,123-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.130 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon receptor (Homo sapiens (Human)) | BDBM50324722 (CHEMBL1222096) Show SMILES [H][C@](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)([C@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@H](CCNC(N)=N)C(N)=O |r| Show InChI InChI=1S/C151H226N38O49/c1-17-76(10)120(147(234)166-80(14)127(214)175-104(61-86-64-159-90-35-25-24-34-89(86)90)137(224)177-100(57-73(4)5)138(225)186-118(74(6)7)145(232)174-92(36-26-28-53-152)128(215)160-66-110(196)167-91(123(154)210)52-55-158-151(155)156)188-139(226)102(58-83-30-20-18-21-31-83)178-134(221)98(46-51-116(206)207)171-131(218)93(37-27-29-54-153)168-126(213)79(13)164-124(211)78(12)165-130(217)95(43-48-113(200)201)170-132(219)96(44-49-114(202)203)172-133(220)97(45-50-115(204)205)173-135(222)99(56-72(2)3)176-136(223)101(60-85-38-40-88(195)41-39-85)179-142(229)107(68-190)182-144(231)109(70-192)183-146(233)119(75(8)9)187-141(228)105(63-117(208)209)180-143(230)108(69-191)184-149(236)122(82(16)194)189-140(227)103(59-84-32-22-19-23-33-84)181-148(235)121(81(15)193)185-111(197)67-161-129(216)94(42-47-112(198)199)169-125(212)77(11)163-106(150(237)238)62-87-65-157-71-162-87/h18-25,30-35,38-41,64-65,71-82,91-109,118-122,159,163,190-195H,17,26-29,36-37,42-63,66-70,152-153H2,1-16H3,(H2,154,210)(H,157,162)(H,160,215)(H,161,216)(H,164,211)(H,165,217)(H,166,234)(H,167,196)(H,168,213)(H,169,212)(H,170,219)(H,171,218)(H,172,220)(H,173,222)(H,174,232)(H,175,214)(H,176,223)(H,177,224)(H,178,221)(H,179,229)(H,180,230)(H,181,235)(H,182,231)(H,183,233)(H,184,236)(H,185,197)(H,186,225)(H,187,228)(H,188,226)(H,189,227)(H,198,199)(H,200,201)(H,202,203)(H,204,205)(H,206,207)(H,208,209)(H,237,238)(H4,155,156,158)/t76-,77-,78-,79-,80-,81+,82-,91+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,118-,119-,120-,121-,122-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon receptor (Homo sapiens (Human)) | BDBM50324723 (CHEMBL1222097) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:205.213,177.190,167.174,147.160,132.141,112.119,98.103,76.86,62.70,43.53,30.37,8.12,231.237,wD:196.207,188.194,219.227,173.178,222.230,159.168,141.147,120.132,104.111,87.97,71.74,54.61,39.41,16.28,4.4,239.245,240.248,209.214,(49.71,-5.2,;48.4,-4.41,;48.4,-2.82,;47.1,-2.03,;47.1,-.44,;45.79,.36,;44.49,-.43,;44.49,-2.02,;43.17,.37,;43.17,1.95,;44.49,2.75,;44.49,4.34,;45.79,1.95,;41.87,-.43,;40.55,.37,;40.55,1.95,;39.25,-.43,;39.25,-2.02,;40.55,-2.81,;41.93,-2.17,;42.95,-3.35,;42.18,-4.73,;42.65,-6.24,;41.63,-7.42,;40.16,-7.08,;39.69,-5.57,;40.7,-4.39,;37.94,.37,;36.63,-.42,;36.63,-2.02,;35.32,.38,;35.32,1.96,;36.63,2.76,;36.63,4.35,;35.32,5.13,;37.94,5.14,;34.01,-.42,;32.71,.38,;32.71,1.96,;31.39,-.42,;30.08,.38,;28.78,-.42,;28.78,-2.01,;27.46,.38,;27.46,1.97,;28.78,2.77,;30.08,1.97,;31.39,2.76,;31.39,4.35,;30.09,5.14,;28.78,4.35,;26.17,-.41,;24.84,.39,;24.84,1.97,;23.55,-.41,;23.55,-2,;24.84,-2.79,;26.2,-2.05,;24.81,-4.34,;22.23,.39,;20.93,-.41,;20.93,-2,;19.61,.39,;19.61,1.98,;20.95,2.75,;20.95,4.3,;22.29,5.08,;22.29,6.63,;18.3,-.4,;17,.4,;17,1.98,;15.69,-.4,;15.69,-1.99,;14.39,.4,;13.07,-.39,;13.07,-1.99,;11.76,.4,;11.76,1.99,;13.07,2.8,;13.07,4.37,;14.39,5.16,;14.39,6.76,;13.07,7.55,;15.69,7.55,;10.46,-.39,;9.13,.41,;9.13,2,;7.82,-.38,;7.82,-1.98,;9.13,-2.77,;9.13,-4.36,;10.45,-5.16,;10.45,-6.75,;9.12,-7.55,;11.76,-7.55,;6.51,.42,;5.22,-.37,;5.22,-1.98,;3.9,.42,;3.9,2.01,;5.22,2.8,;2.6,-.37,;1.29,.42,;1.29,2.01,;-.03,-.37,;-.03,-1.96,;1.29,-2.75,;2.58,-1.96,;1.29,-4.35,;-1.33,.43,;-2.64,-.36,;-2.64,-1.96,;-3.96,.43,;-3.96,2.01,;-2.64,2.81,;-2.64,4.4,;-1.32,2.01,;-5.25,-.36,;-6.57,.43,;-6.57,2.02,;-7.87,-.36,;-7.87,-1.96,;-6.57,-2.74,;-5.26,-1.96,;-3.96,-2.75,;-3.95,-4.34,;-2.64,-5.14,;-5.26,-5.14,;-6.57,-4.34,;-9.19,.44,;-10.5,-.35,;-10.5,-1.95,;-11.8,.44,;-11.8,2.02,;-10.5,2.82,;-10.5,4.41,;-9.19,5.21,;-9.19,6.79,;-13.11,-.35,;-14.42,.44,;-14.42,2.03,;-15.72,-.35,;-15.72,-1.95,;-14.42,-2.74,;-17.05,.44,;-18.34,-.34,;-18.34,-1.94,;-19.65,.45,;-19.65,2.03,;-18.34,2.83,;-17.04,2.03,;-15.72,2.83,;-15.72,4.41,;-14.41,5.21,;-17.04,5.21,;-18.35,4.42,;-20.97,-.34,;-22.27,.45,;-22.27,2.04,;-23.59,-.34,;-23.59,-1.93,;-22.27,-2.73,;-20.98,-1.93,;-22.27,-4.32,;-24.89,.45,;-26.2,-.33,;-26.2,-1.93,;-27.51,.46,;-27.51,2.04,;-26.2,2.84,;-28.81,-.33,;-30.14,.46,;-30.14,2.04,;-31.43,-.33,;-32.75,.46,;-34.05,-.33,;-34.05,-1.92,;-35.36,.47,;-35.36,2.05,;-34.05,2.85,;-32.75,2.05,;-31.43,2.84,;-31.43,4.43,;-32.74,5.23,;-34.04,4.44,;-36.66,-.32,;-37.98,.47,;-37.98,2.05,;-39.29,-.32,;-40.6,.47,;-41.9,-.32,;-41.9,-1.91,;-43.2,.47,;-44.53,-.31,;-45.83,.48,;-45.83,2.06,;-47.14,-.31,;-47.14,-1.9,;-45.83,-2.7,;-45.83,-4.29,;-47.14,-5.09,;-44.54,-5.09,;-48.45,.48,;-49.75,-.31,;-49.75,-1.9,;-51.08,.48,;-51.08,2.07,;-49.74,2.87,;-52.37,-.3,;-53.72,.48,;-53.72,2.02,;-55.06,2.8,;-56.32,1.92,;-57.57,2.86,;-57.06,4.34,;-55.49,4.31,;-55.06,-.3,;-56.41,.48,;-55.06,-1.86,;-39.29,-1.91,;-40.6,-2.71,;-37.98,-2.71,;-31.43,-1.92,;-32.75,-2.72,;-30.14,-2.72,;31.39,-2.01,;32.71,-2.8,;30.08,-2.8,;48.4,.36,;48.4,1.95,;49.72,-.44,;51.02,.36,;51.02,1.94,;52.34,2.74,;53.64,1.94,;52.34,4.33,;52.34,-.44,;52.34,-2.03,;53.64,.35,;54.95,-.45,;54.95,-2.04,;53.64,-2.83,;56.26,-2.83,;56.26,.35,;57.57,-.45,;56.26,1.94,)| Show InChI InChI=1S/C154H229N43O48S/c1-74(2)54-98(134(226)178-97(48-53-246-11)133(225)186-105(62-116(159)209)144(236)196-122(78(8)202)125(160)217)181-138(230)104(60-85-66-168-90-31-19-18-30-89(85)90)185-132(224)96(45-47-115(158)208)179-149(241)121(76(5)6)195-142(234)102(56-81-26-14-12-15-27-81)184-139(231)106(63-118(211)212)187-130(222)91(32-20-22-49-155)173-126(218)77(7)171-128(220)93(34-24-51-166-153(161)162)174-129(221)94(35-25-52-167-154(163)164)176-147(239)112(71-200)192-141(233)108(65-120(215)216)188-135(227)99(55-75(3)4)180-136(228)100(58-83-36-40-87(205)41-37-83)182-131(223)92(33-21-23-50-156)175-146(238)111(70-199)191-137(229)101(59-84-38-42-88(206)43-39-84)183-140(232)107(64-119(213)214)189-148(240)113(72-201)193-151(243)124(80(10)204)197-143(235)103(57-82-28-16-13-17-29-82)190-150(242)123(79(9)203)194-117(210)68-169-127(219)95(44-46-114(157)207)177-145(237)110(69-198)172-109(152(244)245)61-86-67-165-73-170-86/h12-19,26-31,36-43,66-67,73-80,91-113,121-124,168,172,198-206H,20-25,32-35,44-65,68-72,155-156H2,1-11H3,(H2,157,207)(H2,158,208)(H2,159,209)(H2,160,217)(H,165,170)(H,169,219)(H,171,220)(H,173,218)(H,174,221)(H,175,238)(H,176,239)(H,177,237)(H,178,226)(H,179,241)(H,180,228)(H,181,230)(H,182,223)(H,183,232)(H,184,231)(H,185,224)(H,186,225)(H,187,222)(H,188,227)(H,189,240)(H,190,242)(H,191,229)(H,192,233)(H,193,243)(H,194,210)(H,195,234)(H,196,236)(H,197,235)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,161,162,166)(H4,163,164,167)/t77-,78+,79+,80+,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,121-,122-,123-,124-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.120 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon receptor (Homo sapiens (Human)) | BDBM50324729 (CHEMBL1222174) Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)C(C)CN[C@@H](Cc2cnc[nH]2)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O |r| Show InChI InChI=1S/C153H220N36O48S/c1-15-76(6)122(149(231)166-80(10)129(211)174-107(62-88-68-161-93-33-23-22-32-92(88)93)141(223)176-101(56-74(2)3)137(219)173-100(52-55-238-14)136(218)180-108(64-116(157)199)146(228)189-125(83(13)194)153(236)237)187-144(226)105(58-84-28-18-16-19-29-84)178-135(217)99(47-51-119(202)203)171-132(214)94-35-25-27-54-159-117(200)50-46-98(134(216)170-97(45-49-115(156)198)131(213)165-78(8)127(209)164-79(9)128(210)168-94)172-142(224)109(65-120(204)205)181-138(220)102(57-75(4)5)175-139(221)103(60-86-36-40-90(195)41-37-86)177-133(215)95(34-24-26-53-154)169-147(229)112(71-190)184-140(222)104(61-87-38-42-91(196)43-39-87)179-143(225)110(66-121(206)207)182-148(230)113(72-191)185-151(233)124(82(12)193)188-145(227)106(59-85-30-20-17-21-31-85)183-150(232)123(81(11)192)186-118(201)70-162-130(212)96(44-48-114(155)197)167-126(208)77(7)67-160-111(152(234)235)63-89-69-158-73-163-89/h16-23,28-33,36-43,68-69,73-83,94-113,122-125,160-161,190-196H,15,24-27,34-35,44-67,70-72,154H2,1-14H3,(H2,155,197)(H2,156,198)(H2,157,199)(H,158,163)(H,159,200)(H,162,212)(H,164,209)(H,165,213)(H,166,231)(H,167,208)(H,168,210)(H,169,229)(H,170,216)(H,171,214)(H,172,224)(H,173,219)(H,174,211)(H,175,221)(H,176,223)(H,177,215)(H,178,217)(H,179,225)(H,180,218)(H,181,220)(H,182,230)(H,183,232)(H,184,222)(H,185,233)(H,186,201)(H,187,226)(H,188,227)(H,189,228)(H,202,203)(H,204,205)(H,206,207)(H,234,235)(H,236,237)/t76-,77?,78-,79-,80-,81+,82+,83+,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,122-,123-,124-,125-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0550 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50324703 (CHEMBL1222077) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O |r,wU:208.216,180.193,170.177,150.163,135.144,115.122,98.106,76.86,62.70,43.53,30.37,8.12,234.240,wD:199.210,191.197,222.230,176.181,225.233,162.171,144.150,123.135,107.114,87.97,71.74,54.61,39.41,16.28,4.4,242.248,243.251,212.217,(49.71,-5.26,;48.4,-4.46,;48.4,-2.87,;47.1,-2.08,;47.1,-.49,;45.79,.31,;44.48,-.48,;44.48,-2.08,;43.16,.31,;43.16,1.9,;44.48,2.7,;44.48,4.29,;45.79,1.9,;41.86,-.48,;40.55,.32,;40.55,1.9,;39.24,-.48,;39.24,-2.07,;40.55,-2.86,;41.92,-2.22,;42.95,-3.4,;42.18,-4.79,;42.64,-6.29,;41.63,-7.47,;40.15,-7.14,;39.68,-5.63,;40.7,-4.45,;37.93,.32,;36.62,-.47,;36.62,-2.07,;35.31,.32,;35.31,1.91,;36.62,2.71,;36.62,4.3,;35.32,5.08,;37.94,5.09,;34,-.47,;32.69,.32,;32.69,1.91,;31.38,-.47,;30.07,.33,;28.77,-.47,;28.77,-2.06,;27.45,.33,;27.45,1.92,;28.77,2.72,;30.07,1.91,;31.38,2.71,;31.39,4.3,;30.08,5.09,;28.77,4.31,;26.15,-.46,;24.82,.33,;24.82,1.92,;23.53,-.46,;23.53,-2.05,;24.82,-2.84,;26.15,-2.05,;24.82,-4.44,;22.22,.34,;20.91,-.46,;20.91,-2.05,;19.58,.34,;19.58,1.93,;20.91,2.73,;20.91,4.32,;19.59,5.1,;22.22,5.1,;18.28,-.45,;16.98,.34,;16.98,1.93,;15.66,-.45,;15.66,-2.04,;14.37,.35,;13.04,-.44,;13.04,-2.04,;11.73,.35,;11.73,1.93,;13.04,2.75,;13.04,4.32,;14.38,5.11,;14.38,6.71,;13.05,7.5,;15.67,7.5,;10.43,-.44,;9.1,.35,;9.1,1.95,;7.81,-.43,;7.81,-2.03,;9.1,-2.83,;9.1,-4.42,;10.45,-5.19,;10.45,-6.73,;11.78,-7.5,;9.1,-7.5,;6.49,.36,;5.2,-.42,;5.2,-2.03,;3.88,.37,;3.88,1.95,;5.21,2.72,;5.21,4.27,;3.88,5.04,;6.55,5.04,;2.57,-.42,;1.25,.37,;1.25,1.96,;-.07,-.42,;-.07,-2.02,;1.25,-2.81,;2.57,-2.02,;1.25,-4.4,;-1.37,.37,;-2.66,-.41,;-2.66,-2.01,;-3.99,.38,;-3.99,1.96,;-2.66,2.77,;-2.66,4.35,;-1.35,1.96,;-5.29,-.41,;-6.6,.38,;-6.6,1.96,;-7.91,-.41,;-7.91,-2.01,;-6.6,-2.8,;-5.3,-2.01,;-3.99,-2.81,;-3.99,-4.4,;-2.67,-5.19,;-5.3,-5.19,;-6.61,-4.39,;-9.23,.38,;-10.54,-.4,;-10.54,-2,;-11.84,.38,;-11.84,1.97,;-10.54,2.77,;-10.54,4.36,;-9.22,5.16,;-9.22,6.74,;-13.14,-.4,;-14.46,.39,;-14.46,1.97,;-15.77,-.4,;-15.77,-2,;-14.46,-2.79,;-17.08,.39,;-18.39,-.4,;-18.39,-1.99,;-19.7,.39,;-19.7,1.98,;-18.39,2.78,;-17.08,1.98,;-15.77,2.78,;-15.77,4.37,;-14.45,5.16,;-17.07,5.16,;-18.38,4.37,;-21.01,-.39,;-22.32,.4,;-22.32,1.98,;-23.62,-.39,;-23.62,-1.98,;-22.32,-2.78,;-21.01,-1.98,;-22.32,-4.37,;-24.94,.4,;-26.24,-.39,;-26.24,-1.98,;-27.55,.4,;-27.55,1.99,;-26.24,2.79,;-28.86,-.38,;-30.18,.41,;-30.18,1.99,;-31.48,-.38,;-32.8,.41,;-34.11,-.38,;-34.11,-1.97,;-35.42,.41,;-35.42,2,;-34.11,2.8,;-32.81,1.99,;-31.48,2.8,;-31.47,4.38,;-32.79,5.18,;-34.09,4.39,;-36.71,-.37,;-38.03,.41,;-38.03,2,;-39.35,-.37,;-40.64,.42,;-41.96,-.37,;-41.96,-1.96,;-43.26,.42,;-44.59,-.36,;-45.9,.42,;-45.9,2.01,;-47.19,-.36,;-47.19,-1.95,;-45.9,-2.75,;-45.9,-4.35,;-47.2,-5.14,;-44.59,-5.14,;-48.5,.42,;-49.81,-.36,;-49.81,-1.95,;-51.13,.43,;-51.13,2.02,;-49.81,2.82,;-52.43,-.36,;-53.78,.41,;-53.78,1.95,;-55.1,2.71,;-56.37,1.85,;-57.61,2.77,;-57.1,4.25,;-55.55,4.21,;-55.11,-.37,;-56.45,.41,;-55.11,-1.92,;-39.35,-1.96,;-40.64,-2.77,;-38.03,-2.76,;-31.48,-1.97,;-32.8,-2.78,;-30.18,-2.77,;31.38,-2.06,;32.69,-2.85,;30.07,-2.86,;48.4,.31,;48.4,1.89,;49.72,-.49,;51.02,.3,;51.02,1.89,;52.34,2.69,;53.65,1.89,;52.34,4.28,;52.34,-.49,;52.34,-2.09,;53.64,.3,;54.95,-.5,;54.95,-2.09,;53.64,-2.88,;56.27,-2.88,;56.27,.3,;57.61,-.46,;56.27,1.88,)| Show InChI InChI=1S/C155H226N42O51S/c1-73(2)54-98(135(228)179-97(49-53-249-11)134(227)187-105(62-116(160)209)145(238)197-125(79(10)203)153(247)248)182-139(232)104(60-84-66-168-89-29-19-18-28-88(84)89)186-133(226)95(43-47-115(159)208)180-149(242)122(75(5)6)195-143(236)102(56-80-24-14-12-15-25-80)185-141(234)107(64-120(215)216)188-132(225)94(42-46-114(158)207)173-126(219)76(7)171-128(221)91(31-22-51-166-154(161)162)174-129(222)92(32-23-52-167-155(163)164)175-131(224)96(44-48-118(211)212)178-140(233)106(63-119(213)214)189-136(229)99(55-74(3)4)181-137(230)100(58-82-33-37-86(204)38-34-82)183-130(223)90(30-20-21-50-156)176-147(240)111(70-199)192-138(231)101(59-83-35-39-87(205)40-36-83)184-142(235)108(65-121(217)218)190-148(241)112(71-200)193-151(244)124(78(9)202)196-144(237)103(57-81-26-16-13-17-27-81)191-150(243)123(77(8)201)194-117(210)68-169-127(220)93(41-45-113(157)206)177-146(239)110(69-198)172-109(152(245)246)61-85-67-165-72-170-85/h12-19,24-29,33-40,66-67,72-79,90-112,122-125,168,172,198-205H,20-23,30-32,41-65,68-71,156H2,1-11H3,(H2,157,206)(H2,158,207)(H2,159,208)(H2,160,209)(H,165,170)(H,169,220)(H,171,221)(H,173,219)(H,174,222)(H,175,224)(H,176,240)(H,177,239)(H,178,233)(H,179,228)(H,180,242)(H,181,230)(H,182,232)(H,183,223)(H,184,235)(H,185,234)(H,186,226)(H,187,227)(H,188,225)(H,189,229)(H,190,241)(H,191,243)(H,192,231)(H,193,244)(H,194,210)(H,195,236)(H,196,237)(H,197,238)(H,211,212)(H,213,214)(H,215,216)(H,217,218)(H,245,246)(H,247,248)(H4,161,162,166)(H4,163,164,167)/t76-,77+,78+,79+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50324713 (CHEMBL1222087 | HSQGTFTSDYSKYLDEQAAKEFIAWLMNT) Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O |r| Show InChI InChI=1S/C152H220N36O50S/c1-14-75(6)121(148(232)164-78(9)127(211)173-105(61-86-66-159-91-32-22-21-31-90(86)91)139(223)175-99(55-73(2)3)135(219)172-98(51-54-239-13)134(218)179-106(63-115(157)199)144(228)188-124(81(12)194)152(237)238)186-142(226)103(57-82-27-17-15-18-28-82)177-133(217)97(46-50-118(203)204)170-130(214)92(33-23-25-52-153)166-126(210)77(8)162-125(209)76(7)163-129(213)95(44-48-114(156)198)169-132(216)96(45-49-117(201)202)171-140(224)107(64-119(205)206)180-136(220)100(56-74(4)5)174-137(221)101(59-84-35-39-88(195)40-36-84)176-131(215)93(34-24-26-53-154)167-146(230)111(70-190)183-138(222)102(60-85-37-41-89(196)42-38-85)178-141(225)108(65-120(207)208)181-147(231)112(71-191)184-150(234)123(80(11)193)187-143(227)104(58-83-29-19-16-20-30-83)182-149(233)122(79(10)192)185-116(200)68-160-128(212)94(43-47-113(155)197)168-145(229)110(69-189)165-109(151(235)236)62-87-67-158-72-161-87/h15-22,27-32,35-42,66-67,72-81,92-112,121-124,159,165,189-196H,14,23-26,33-34,43-65,68-71,153-154H2,1-13H3,(H2,155,197)(H2,156,198)(H2,157,199)(H,158,161)(H,160,212)(H,162,209)(H,163,213)(H,164,232)(H,166,210)(H,167,230)(H,168,229)(H,169,216)(H,170,214)(H,171,224)(H,172,219)(H,173,211)(H,174,221)(H,175,223)(H,176,215)(H,177,217)(H,178,225)(H,179,218)(H,180,220)(H,181,231)(H,182,233)(H,183,222)(H,184,234)(H,185,200)(H,186,226)(H,187,227)(H,188,228)(H,201,202)(H,203,204)(H,205,206)(H,207,208)(H,235,236)(H,237,238)/t75-,76-,77-,78-,79+,80+,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,121-,122-,123-,124-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0260 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50324720 (CHEMBL1222094) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:208.216,180.193,170.177,150.163,135.144,115.122,98.106,76.86,62.70,43.53,30.37,8.12,234.240,wD:199.210,191.197,222.230,176.181,225.233,162.171,144.150,123.135,107.114,87.97,71.74,54.61,39.41,16.28,4.4,242.248,243.251,212.217,(49.7,-5.26,;48.39,-4.46,;48.39,-2.87,;47.08,-2.08,;47.08,-.49,;45.77,.31,;44.47,-.48,;44.47,-2.07,;43.15,.31,;43.15,1.9,;44.47,2.7,;44.47,4.29,;45.78,1.9,;41.85,-.48,;40.54,.32,;40.54,1.9,;39.23,-.48,;39.23,-2.07,;40.54,-2.86,;41.91,-2.22,;42.93,-3.4,;42.17,-4.79,;42.63,-6.29,;41.61,-7.47,;40.14,-7.14,;39.67,-5.63,;40.69,-4.45,;37.92,.32,;36.61,-.47,;36.61,-2.07,;35.3,.32,;35.3,1.91,;36.61,2.71,;36.61,4.3,;35.3,5.08,;37.93,5.09,;33.98,-.47,;32.68,.33,;32.68,1.91,;31.37,-.47,;30.06,.33,;28.75,-.46,;28.75,-2.06,;27.44,.33,;27.44,1.92,;28.75,2.72,;30.06,1.92,;31.37,2.72,;31.37,4.3,;30.07,5.09,;28.76,4.31,;26.14,-.46,;24.81,.34,;24.81,1.92,;23.51,-.46,;23.51,-2.05,;24.81,-2.84,;26.13,-2.05,;24.81,-4.44,;22.2,.34,;20.9,-.45,;20.9,-2.05,;19.58,.34,;19.58,1.93,;20.9,2.73,;20.9,4.32,;19.59,5.1,;22.21,5.11,;18.27,-.45,;16.97,.34,;16.97,1.93,;15.65,-.45,;15.65,-2.04,;14.36,.35,;13.03,-.44,;13.03,-2.04,;11.72,.35,;11.72,1.94,;13.03,2.75,;13.03,4.33,;14.36,5.11,;14.36,6.71,;13.04,7.5,;15.66,7.5,;10.41,-.43,;9.1,.35,;9.1,1.95,;7.78,-.43,;7.78,-2.03,;9.1,-2.82,;9.1,-4.42,;10.43,-5.19,;10.44,-6.73,;11.79,-7.5,;9.11,-7.5,;6.47,.36,;5.19,-.42,;5.19,-2.03,;3.86,.37,;3.86,1.95,;5.19,2.76,;5.15,4.3,;3.79,5.04,;6.46,5.1,;2.56,-.42,;1.25,.37,;1.25,1.96,;-.07,-.41,;-.07,-2.01,;1.25,-2.81,;2.54,-2.01,;1.25,-4.4,;-1.38,.37,;-2.68,-.41,;-2.68,-2.01,;-4,.38,;-4,1.96,;-2.68,2.77,;-2.68,4.35,;-1.36,1.96,;-5.3,-.41,;-6.62,.38,;-6.62,1.97,;-7.92,-.41,;-7.92,-2.01,;-6.62,-2.8,;-5.31,-2.01,;-4,-2.8,;-4,-4.39,;-2.68,-5.19,;-5.3,-5.19,;-6.61,-4.39,;-9.24,.38,;-10.55,-.4,;-10.55,-2,;-11.85,.39,;-11.85,1.97,;-10.55,2.78,;-10.55,4.36,;-9.24,5.16,;-9.24,6.74,;-13.16,-.4,;-14.47,.39,;-14.47,1.97,;-15.77,-.4,;-15.77,-2,;-14.47,-2.79,;-17.1,.39,;-18.4,-.39,;-18.4,-1.99,;-19.71,.39,;-19.71,1.98,;-18.4,2.78,;-17.09,1.98,;-15.77,2.78,;-15.78,4.37,;-14.46,5.16,;-17.09,5.16,;-18.4,4.37,;-21.02,-.39,;-22.33,.4,;-22.33,1.98,;-23.65,-.39,;-23.65,-1.98,;-22.33,-2.78,;-21.03,-1.98,;-22.33,-4.37,;-24.94,.4,;-26.26,-.38,;-26.26,-1.98,;-27.57,.4,;-27.57,1.99,;-26.26,2.79,;-28.87,-.38,;-30.2,.41,;-30.2,1.99,;-31.49,-.38,;-32.81,.41,;-34.11,-.37,;-34.11,-1.97,;-35.43,.41,;-35.43,2,;-34.11,2.8,;-32.81,2,;-31.49,2.8,;-31.49,4.39,;-32.8,5.18,;-34.1,4.39,;-36.73,-.37,;-38.04,.42,;-38.04,2,;-39.35,-.37,;-40.67,.42,;-41.97,-.37,;-41.97,-1.96,;-43.27,.42,;-44.6,-.36,;-45.91,.43,;-45.91,2.01,;-47.21,-.36,;-47.21,-1.95,;-45.9,-2.75,;-45.9,-4.34,;-47.2,-5.14,;-44.61,-5.14,;-48.52,.43,;-49.83,-.36,;-49.83,-1.95,;-51.15,.43,;-51.15,2.02,;-49.81,2.82,;-52.44,-.36,;-53.79,.42,;-53.79,1.94,;-55.11,2.7,;-56.36,1.84,;-57.59,2.76,;-57.1,4.22,;-55.55,4.19,;-55.12,-.35,;-56.45,.42,;-55.12,-1.89,;-39.35,-1.96,;-40.67,-2.76,;-38.04,-2.76,;-31.49,-1.97,;-32.81,-2.77,;-30.2,-2.77,;31.37,-2.06,;32.68,-2.85,;30.06,-2.86,;48.39,.31,;48.39,1.89,;49.71,-.49,;51.01,.3,;51.01,1.89,;52.32,2.69,;53.63,1.89,;52.32,4.28,;52.32,-.49,;52.32,-2.08,;53.63,.3,;54.94,-.49,;54.94,-2.09,;53.63,-2.88,;56.25,-2.88,;56.25,.3,;57.59,-.46,;56.25,1.88,)| Show InChI InChI=1S/C155H226N42O51S/c1-73(2)54-98(136(230)179-97(49-53-249-11)135(229)187-105(62-115(159)208)146(240)196-123(77(8)201)126(160)220)182-140(234)104(60-84-66-168-89-29-19-18-28-88(84)89)186-134(228)95(42-46-114(158)207)180-150(244)122(75(5)6)195-144(238)102(56-80-24-14-12-15-25-80)185-142(236)107(64-120(216)217)188-133(227)94(41-45-113(157)206)173-127(221)76(7)171-129(223)91(31-22-51-166-154(161)162)174-130(224)92(32-23-52-167-155(163)164)175-132(226)96(44-48-118(212)213)178-141(235)106(63-119(214)215)189-137(231)99(55-74(3)4)181-138(232)100(58-82-33-37-86(204)38-34-82)183-131(225)90(30-20-21-50-156)176-148(242)111(70-199)192-139(233)101(59-83-35-39-87(205)40-36-83)184-143(237)108(65-121(218)219)190-149(243)112(71-200)193-152(246)125(79(10)203)197-145(239)103(57-81-26-16-13-17-27-81)191-151(245)124(78(9)202)194-116(209)68-169-128(222)93(43-47-117(210)211)177-147(241)110(69-198)172-109(153(247)248)61-85-67-165-72-170-85/h12-19,24-29,33-40,66-67,72-79,90-112,122-125,168,172,198-205H,20-23,30-32,41-65,68-71,156H2,1-11H3,(H2,157,206)(H2,158,207)(H2,159,208)(H2,160,220)(H,165,170)(H,169,222)(H,171,223)(H,173,221)(H,174,224)(H,175,226)(H,176,242)(H,177,241)(H,178,235)(H,179,230)(H,180,244)(H,181,232)(H,182,234)(H,183,225)(H,184,237)(H,185,236)(H,186,228)(H,187,229)(H,188,227)(H,189,231)(H,190,243)(H,191,245)(H,192,233)(H,193,246)(H,194,209)(H,195,238)(H,196,240)(H,197,239)(H,210,211)(H,212,213)(H,214,215)(H,216,217)(H,218,219)(H,247,248)(H4,161,162,166)(H4,163,164,167)/t76-,77+,78+,79+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.110 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon receptor (Homo sapiens (Human)) | BDBM50324704 (CHEMBL1222078) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:209.218,181.195,171.179,151.165,136.146,116.124,98.108,76.86,62.70,43.53,30.37,8.12,235.242,wD:200.212,192.199,223.232,177.183,226.235,163.173,145.152,124.137,108.116,87.97,71.74,54.61,39.41,16.28,4.4,243.250,244.253,213.219,(49.7,-5.27,;48.4,-4.48,;48.4,-2.88,;47.09,-2.09,;47.09,-.5,;45.78,.29,;44.48,-.5,;44.48,-2.09,;43.16,.3,;43.16,1.88,;44.48,2.69,;44.48,4.27,;45.79,1.88,;41.86,-.49,;40.54,.3,;40.54,1.89,;39.24,-.49,;39.24,-2.08,;40.54,-2.88,;41.92,-2.23,;42.94,-3.42,;42.17,-4.8,;42.64,-6.3,;41.62,-7.48,;40.15,-7.15,;39.68,-5.64,;40.7,-4.46,;37.93,.3,;36.62,-.49,;36.62,-2.08,;35.31,.31,;35.31,1.89,;36.62,2.7,;36.62,4.28,;35.32,5.07,;37.94,5.07,;34,-.49,;32.7,.31,;32.7,1.9,;31.36,-.48,;30.06,.31,;28.77,-.48,;28.77,-2.07,;27.44,.32,;27.44,1.9,;28.77,2.7,;30.08,1.9,;31.38,2.7,;31.37,4.29,;30.07,5.07,;28.76,4.29,;26.15,-.48,;24.83,.32,;24.83,1.9,;23.53,-.47,;23.53,-2.06,;24.83,-2.86,;26.14,-2.06,;24.83,-4.45,;22.22,.32,;20.91,-.47,;20.91,-2.06,;19.59,.33,;19.59,1.91,;20.91,2.71,;20.88,4.25,;19.53,4.99,;22.2,5.06,;18.29,-.47,;16.98,.33,;16.98,1.91,;15.67,-.46,;15.67,-2.06,;14.37,.33,;13.05,-.45,;13.05,-2.05,;11.75,.33,;11.75,1.92,;13.05,2.73,;13.05,4.31,;14.37,5.1,;14.37,6.69,;13.06,7.48,;15.67,7.48,;10.44,-.45,;9.12,.34,;9.12,1.93,;7.81,-.45,;7.81,-1.99,;9.16,-2.76,;9.14,-4.3,;10.49,-5.07,;10.49,-6.62,;11.82,-7.39,;9.14,-7.39,;6.5,.35,;5.22,-.44,;5.22,-2.04,;3.89,.35,;3.9,1.93,;5.25,2.71,;5.22,4.26,;6.68,4.76,;7.63,3.52,;6.73,2.26,;2.59,-.43,;1.28,.35,;1.28,1.94,;-.04,-.43,;-.04,-2.03,;1.28,-2.82,;2.57,-2.03,;1.28,-4.41,;-1.35,.36,;-2.66,-.43,;-2.66,-2.03,;-3.97,.36,;-3.97,1.95,;-2.66,2.75,;-2.66,4.33,;-1.33,1.95,;-5.26,-.42,;-6.58,.36,;-6.58,1.95,;-7.88,-.42,;-7.88,-2.02,;-6.58,-2.81,;-5.27,-2.02,;-3.96,-2.82,;-3.96,-4.41,;-2.65,-5.2,;-5.27,-5.2,;-6.58,-4.4,;-9.2,.37,;-10.51,-.42,;-10.51,-2.02,;-11.82,.37,;-11.82,1.95,;-10.51,2.76,;-10.51,4.34,;-9.21,5.14,;-9.21,6.72,;-13.12,-.42,;-14.43,.37,;-14.43,1.96,;-15.73,-.41,;-15.73,-2.01,;-14.43,-2.8,;-17.06,.38,;-18.36,-.41,;-18.36,-2,;-19.66,.38,;-19.66,1.96,;-18.36,2.77,;-17.05,1.96,;-15.73,2.76,;-15.74,4.35,;-14.42,5.14,;-17.05,5.14,;-18.36,4.35,;-20.98,-.41,;-22.28,.38,;-22.28,1.97,;-23.6,-.4,;-23.6,-1.99,;-22.28,-2.79,;-20.99,-1.99,;-22.28,-4.39,;-24.9,.38,;-26.22,-.4,;-26.22,-1.99,;-27.52,.39,;-27.52,1.97,;-26.22,2.78,;-28.83,-.4,;-30.15,.39,;-30.15,1.98,;-31.44,-.39,;-32.76,.39,;-34.06,-.39,;-34.06,-1.98,;-35.38,.4,;-35.38,1.98,;-34.06,2.79,;-32.76,1.98,;-31.44,2.78,;-31.44,4.37,;-32.75,5.16,;-34.05,4.37,;-36.68,-.39,;-38,.4,;-38,1.99,;-39.3,-.38,;-40.61,.4,;-41.92,-.38,;-41.92,-1.97,;-43.21,.41,;-44.54,-.38,;-45.85,.41,;-45.85,1.99,;-47.15,-.38,;-47.15,-1.97,;-45.85,-2.77,;-45.85,-4.36,;-47.15,-5.15,;-44.55,-5.15,;-48.46,.41,;-49.77,-.38,;-49.77,-1.96,;-51.09,.41,;-51.09,2,;-49.75,2.8,;-52.38,-.38,;-53.73,.4,;-53.73,1.93,;-55.05,2.7,;-56.32,1.83,;-57.56,2.76,;-57.05,4.23,;-55.51,4.2,;-55.07,-.38,;-56.41,.4,;-55.07,-1.93,;-39.3,-1.98,;-40.61,-2.78,;-38,-2.78,;-31.44,-1.99,;-32.76,-2.79,;-30.15,-2.79,;31.36,-2.07,;32.7,-2.87,;30.06,-2.87,;48.4,.29,;48.4,1.88,;49.71,-.5,;51.01,.29,;51.01,1.87,;52.33,2.68,;53.64,1.87,;52.33,4.26,;52.33,-.51,;52.33,-2.1,;53.63,.29,;54.94,-.51,;54.94,-2.1,;53.63,-2.9,;56.25,-2.89,;56.25,.28,;57.56,-.52,;56.25,1.87,)| Show InChI InChI=1S/C156H227N45O48S/c1-74(2)52-99(136(230)182-98(47-51-250-11)135(229)191-107(61-118(161)213)147(241)200-124(78(8)205)127(162)221)185-140(234)105(58-85-65-171-91-29-19-18-28-90(85)91)189-134(228)97(43-46-117(160)212)183-151(245)123(76(5)6)199-145(239)103(54-81-24-14-12-15-25-81)188-142(236)108(62-120(215)216)192-133(227)96(42-45-116(159)211)177-128(222)77(7)175-130(224)93(31-22-49-169-155(163)164)178-131(225)94(32-23-50-170-156(165)166)179-141(235)106(59-86-66-167-72-173-86)190-144(238)109(63-121(217)218)193-137(231)100(53-75(3)4)184-138(232)101(56-83-33-37-88(208)38-34-83)186-132(226)92(30-20-21-48-157)180-149(243)113(70-203)196-139(233)102(57-84-35-39-89(209)40-36-84)187-143(237)110(64-122(219)220)194-150(244)114(71-204)197-153(247)126(80(10)207)201-146(240)104(55-82-26-16-13-17-27-82)195-152(246)125(79(9)206)198-119(214)68-172-129(223)95(41-44-115(158)210)181-148(242)112(69-202)176-111(154(248)249)60-87-67-168-73-174-87/h12-19,24-29,33-40,65-67,72-80,92-114,123-126,171,176,202-209H,20-23,30-32,41-64,68-71,157H2,1-11H3,(H2,158,210)(H2,159,211)(H2,160,212)(H2,161,213)(H2,162,221)(H,167,173)(H,168,174)(H,172,223)(H,175,224)(H,177,222)(H,178,225)(H,179,235)(H,180,243)(H,181,242)(H,182,230)(H,183,245)(H,184,232)(H,185,234)(H,186,226)(H,187,237)(H,188,236)(H,189,228)(H,190,238)(H,191,229)(H,192,227)(H,193,231)(H,194,244)(H,195,246)(H,196,233)(H,197,247)(H,198,214)(H,199,239)(H,200,241)(H,201,240)(H,215,216)(H,217,218)(H,219,220)(H,248,249)(H4,163,164,169)(H4,165,166,170)/t77-,78+,79+,80+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,123-,124-,125-,126-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon receptor (Homo sapiens (Human)) | BDBM50324710 (CHEMBL1222084) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:203.211,175.188,165.172,145.158,130.139,110.117,98.101,223.231,76.86,62.70,43.53,30.37,8.12,232.238,wD:194.205,186.192,217.225,171.176,220.228,157.166,139.145,118.130,102.109,87.97,71.74,54.61,39.41,16.28,4.4,240.246,241.249,207.212,(49.77,-5.31,;48.46,-4.51,;48.46,-2.92,;47.15,-2.13,;47.15,-.53,;45.84,.27,;44.54,-.53,;44.54,-2.12,;43.22,.27,;43.22,1.86,;44.54,2.66,;44.54,4.25,;45.85,1.86,;41.91,-.53,;40.59,.27,;40.59,1.86,;39.29,-.52,;39.29,-2.12,;40.59,-2.91,;41.98,-2.27,;43,-3.45,;42.23,-4.84,;42.67,-6.28,;41.64,-7.38,;40.16,-7.04,;39.72,-5.59,;40.75,-4.49,;37.98,.28,;36.66,-.52,;36.66,-2.12,;35.35,.28,;35.35,1.87,;36.66,2.67,;36.66,4.26,;35.36,5.05,;37.98,5.05,;34.04,-.52,;32.74,.28,;32.74,1.87,;31.42,-.52,;30.11,.29,;28.8,-.51,;28.8,-2.11,;27.47,.29,;27.47,1.88,;28.8,2.68,;30.11,1.87,;31.42,2.67,;31.42,4.26,;30.11,5.06,;28.8,4.27,;26.18,-.51,;24.86,.29,;24.86,1.88,;23.55,-.51,;23.55,-2.1,;24.86,-2.89,;26.17,-2.1,;24.86,-4.48,;22.24,.3,;20.92,-.5,;20.92,-2.1,;19.61,.3,;19.61,1.89,;20.92,2.69,;20.92,4.28,;19.62,5.07,;22.25,5.07,;18.3,-.5,;16.99,.3,;16.99,1.89,;15.68,-.5,;15.68,-2.09,;14.38,.3,;13.06,-.49,;13.06,-2.09,;11.75,.31,;11.75,1.9,;13.06,2.7,;13.06,4.28,;14.38,5.08,;14.38,6.67,;13.07,7.46,;15.68,7.47,;10.44,-.48,;9.12,.31,;9.12,1.91,;7.81,-.48,;7.81,-2.03,;9.16,-2.81,;9.16,-4.36,;10.5,-5.14,;10.5,-6.69,;11.84,-7.47,;9.15,-7.47,;6.49,.32,;5.2,-.47,;5.2,-2.08,;3.87,.32,;2.58,-.47,;1.26,.33,;1.26,1.92,;-.06,-.46,;-.06,-2.06,;1.26,-2.85,;2.56,-2.06,;1.26,-4.45,;-1.37,.33,;-2.68,-.46,;-2.68,-2.06,;-3.99,.33,;-3.99,1.92,;-2.68,2.72,;-2.68,4.31,;-1.35,1.92,;-5.29,-.46,;-6.61,.34,;-6.61,1.93,;-7.91,-.45,;-7.91,-2.06,;-6.61,-2.85,;-5.3,-2.06,;-3.99,-2.85,;-3.99,-4.44,;-2.67,-5.24,;-5.3,-5.24,;-6.61,-4.44,;-9.23,.34,;-10.55,-.45,;-10.55,-2.05,;-11.85,.34,;-11.85,1.93,;-10.55,2.73,;-10.55,4.32,;-9.24,5.12,;-9.24,6.71,;-13.17,-.45,;-14.47,.35,;-14.47,1.93,;-15.78,-.44,;-15.78,-2.05,;-14.47,-2.84,;-17.11,.35,;-18.41,-.44,;-18.41,-2.04,;-19.71,.35,;-19.71,1.94,;-18.41,2.74,;-17.1,1.94,;-15.78,2.74,;-15.78,4.33,;-14.47,5.13,;-17.1,5.13,;-18.41,4.33,;-21.03,-.44,;-22.34,.36,;-22.34,1.94,;-23.66,-.43,;-23.66,-2.03,;-22.34,-2.83,;-21.05,-2.03,;-22.34,-4.42,;-24.96,.36,;-26.28,-.43,;-26.28,-2.03,;-27.59,.36,;-27.59,1.95,;-26.28,2.75,;-28.89,-.43,;-30.23,.36,;-30.23,1.95,;-31.51,-.43,;-32.84,.37,;-34.14,-.42,;-34.14,-2.02,;-35.46,.37,;-35.46,1.96,;-34.14,2.76,;-32.84,1.96,;-31.52,2.75,;-31.52,4.34,;-32.83,5.15,;-34.13,4.35,;-36.76,-.42,;-38.08,.37,;-38.08,1.96,;-39.39,-.42,;-40.7,.38,;-42.01,-.41,;-42.01,-2.01,;-43.31,.38,;-44.64,-.41,;-45.95,.38,;-45.95,1.97,;-47.26,-.41,;-47.26,-2,;-45.94,-2.8,;-45.94,-4.39,;-47.25,-5.19,;-44.65,-5.19,;-48.57,.38,;-49.88,-.41,;-49.88,-2,;-51.2,.38,;-51.2,1.98,;-49.86,2.78,;-52.49,-.41,;-53.85,.37,;-53.85,1.9,;-55.17,2.67,;-56.43,1.8,;-57.67,2.73,;-57.17,4.19,;-55.62,4.16,;-55.19,-.41,;-56.52,.37,;-55.19,-1.96,;-39.39,-2.01,;-40.7,-2.81,;-38.08,-2.81,;-31.51,-2.02,;-32.84,-2.82,;-30.23,-2.82,;3.87,1.91,;2.53,2.67,;5.2,2.71,;31.42,-2.11,;32.74,-2.9,;30.11,-2.9,;48.46,.26,;48.46,1.85,;49.79,-.54,;51.08,.26,;51.08,1.85,;52.4,2.65,;53.71,1.85,;52.4,4.24,;52.4,-.54,;52.4,-2.13,;53.71,.26,;55.02,-.54,;55.02,-2.14,;53.71,-2.93,;56.33,-2.93,;56.33,.26,;57.67,-.5,;56.33,1.84,)| Show InChI InChI=1S/C154H227N43O49S/c1-72(2)53-97(134(227)177-96(48-52-247-12)133(226)186-104(61-115(159)210)143(236)195-121(76(8)201)125(160)218)181-138(231)103(59-84-65-168-89-30-20-19-29-88(84)89)185-132(225)95(44-47-114(158)209)179-148(241)120(74(5)6)194-141(234)101(55-80-25-15-13-16-26-80)184-139(232)105(62-117(212)213)187-131(224)94(43-46-113(157)208)173-126(219)75(7)171-128(221)91(32-23-50-166-153(161)162)174-129(222)92(33-24-51-167-154(163)164)178-150(243)123(78(10)203)197-144(237)107(64-119(216)217)188-135(228)98(54-73(3)4)180-136(229)99(57-82-34-38-86(205)39-35-82)182-130(223)90(31-21-22-49-155)175-146(239)110(69-199)191-137(230)100(58-83-36-40-87(206)41-37-83)183-140(233)106(63-118(214)215)189-147(240)111(70-200)192-151(244)124(79(11)204)196-142(235)102(56-81-27-17-14-18-28-81)190-149(242)122(77(9)202)193-116(211)67-169-127(220)93(42-45-112(156)207)176-145(238)109(68-198)172-108(152(245)246)60-85-66-165-71-170-85/h13-20,25-30,34-41,65-66,71-79,90-111,120-124,168,172,198-206H,21-24,31-33,42-64,67-70,155H2,1-12H3,(H2,156,207)(H2,157,208)(H2,158,209)(H2,159,210)(H2,160,218)(H,165,170)(H,169,220)(H,171,221)(H,173,219)(H,174,222)(H,175,239)(H,176,238)(H,177,227)(H,178,243)(H,179,241)(H,180,229)(H,181,231)(H,182,223)(H,183,233)(H,184,232)(H,185,225)(H,186,226)(H,187,224)(H,188,228)(H,189,240)(H,190,242)(H,191,230)(H,192,244)(H,193,211)(H,194,234)(H,195,236)(H,196,235)(H,197,237)(H,212,213)(H,214,215)(H,216,217)(H,245,246)(H4,161,162,166)(H4,163,164,167)/t75-,76+,77+,78+,79+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-,124-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.130 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon receptor (Homo sapiens (Human)) | BDBM50324728 (CHEMBL1222102) Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)C(C)CN[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O |r| Show InChI InChI=1S/C153H222N36O49S/c1-15-76(6)122(149(232)166-80(10)129(212)174-107(62-88-68-161-93-33-23-22-32-92(88)93)141(224)176-101(56-74(2)3)137(220)173-100(52-55-239-14)136(219)180-108(64-116(158)199)146(229)189-125(83(13)194)153(237)238)187-144(227)105(58-84-28-18-16-19-29-84)178-135(218)99(47-51-119(203)204)171-132(215)94(34-24-26-53-154)168-128(211)79(9)164-127(210)78(8)165-131(214)97(45-49-115(157)198)170-134(217)98(46-50-118(201)202)172-142(225)109(65-120(205)206)181-138(221)102(57-75(4)5)175-139(222)103(60-86-36-40-90(195)41-37-86)177-133(216)95(35-25-27-54-155)169-147(230)112(71-190)184-140(223)104(61-87-38-42-91(196)43-39-87)179-143(226)110(66-121(207)208)182-148(231)113(72-191)185-151(234)124(82(12)193)188-145(228)106(59-85-30-20-17-21-31-85)183-150(233)123(81(11)192)186-117(200)70-162-130(213)96(44-48-114(156)197)167-126(209)77(7)67-160-111(152(235)236)63-89-69-159-73-163-89/h16-23,28-33,36-43,68-69,73-83,94-113,122-125,160-161,190-196H,15,24-27,34-35,44-67,70-72,154-155H2,1-14H3,(H2,156,197)(H2,157,198)(H2,158,199)(H,159,163)(H,162,213)(H,164,210)(H,165,214)(H,166,232)(H,167,209)(H,168,211)(H,169,230)(H,170,217)(H,171,215)(H,172,225)(H,173,220)(H,174,212)(H,175,222)(H,176,224)(H,177,216)(H,178,218)(H,179,226)(H,180,219)(H,181,221)(H,182,231)(H,183,233)(H,184,223)(H,185,234)(H,186,200)(H,187,227)(H,188,228)(H,189,229)(H,201,202)(H,203,204)(H,205,206)(H,207,208)(H,235,236)(H,237,238)/t76-,77?,78-,79-,80-,81+,82+,83+,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,122-,123-,124-,125-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.590 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50324718 (CHEMBL1222092) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:204.212,176.189,166.173,146.159,131.140,111.118,94.102,72.82,58.66,39.49,30.32,8.12,230.236,wD:195.206,187.193,218.226,172.177,221.229,158.167,140.146,119.131,103.110,83.93,67.70,50.57,35.37,16.28,4.4,238.244,239.247,208.213,(49.68,-5.25,;48.36,-4.46,;48.36,-2.87,;47.06,-2.08,;47.06,-.49,;45.75,.31,;44.45,-.48,;44.45,-2.07,;43.13,.32,;43.13,1.9,;44.45,2.7,;44.45,4.28,;45.76,1.9,;41.83,-.48,;40.52,.32,;40.52,1.91,;39.21,-.48,;39.21,-2.07,;40.55,-2.84,;41.97,-2.22,;43.01,-3.37,;42.24,-4.71,;42.71,-6.18,;41.69,-7.33,;40.17,-7.01,;39.69,-5.54,;40.72,-4.39,;37.9,.32,;36.59,-.47,;36.59,-2.06,;35.28,.33,;35.28,1.91,;33.97,-.47,;32.67,.33,;32.67,1.91,;31.35,-.47,;30.05,.33,;28.74,-.46,;28.74,-2.06,;27.43,.34,;27.43,1.92,;28.74,2.72,;30.05,1.92,;31.36,2.71,;31.36,4.3,;30.05,5.11,;28.75,4.3,;26.13,-.46,;24.81,.34,;24.81,1.92,;23.51,-.46,;23.51,-2.05,;24.81,-2.84,;26.17,-2.09,;24.77,-4.39,;22.2,.34,;20.89,-.45,;20.89,-2.05,;19.58,.34,;19.58,1.93,;20.89,2.73,;20.89,4.31,;22.2,5.11,;23.56,4.36,;18.25,-.45,;16.96,.35,;16.96,1.93,;15.64,-.45,;15.64,-2.04,;14.34,.35,;13.03,-.44,;13.03,-2.04,;11.73,.35,;11.73,1.94,;13.03,2.75,;13.03,4.32,;14.35,5.12,;14.35,6.72,;13.03,7.51,;15.65,7.51,;10.42,-.43,;9.1,.36,;9.1,1.95,;7.79,-.43,;7.79,-2.03,;9.1,-2.82,;9.1,-4.41,;10.44,-5.19,;10.44,-6.73,;9.1,-7.51,;11.79,-7.51,;6.48,.37,;5.18,-.42,;5.18,-2.03,;3.87,.37,;3.87,1.96,;5.22,2.73,;5.22,4.28,;3.87,5.07,;6.55,5.07,;2.57,-.42,;1.24,.37,;1.24,1.96,;-.06,-.41,;-.06,-2.01,;1.24,-2.8,;2.55,-2.01,;1.24,-4.39,;-1.36,.38,;-2.67,-.41,;-2.67,-2.01,;-3.99,.38,;-3.99,1.97,;-2.67,2.76,;-2.67,4.35,;-1.36,1.97,;-5.3,-.41,;-6.6,.38,;-6.6,1.97,;-7.9,-.41,;-7.9,-2,;-6.6,-2.79,;-5.29,-2.01,;-3.98,-2.8,;-4,-4.39,;-2.68,-5.19,;-5.3,-5.18,;-6.6,-4.38,;-9.23,.39,;-10.53,-.4,;-10.53,-2,;-11.83,.39,;-11.83,1.97,;-10.53,2.77,;-10.53,4.36,;-9.22,5.17,;-9.22,6.74,;-13.14,-.4,;-14.45,.39,;-14.45,1.98,;-15.76,-.4,;-15.76,-2,;-14.45,-2.78,;-17.08,.4,;-18.37,-.39,;-18.37,-1.98,;-19.69,.4,;-19.69,1.98,;-18.37,2.78,;-17.06,1.98,;-15.77,2.78,;-15.75,4.36,;-14.44,5.16,;-17.07,5.18,;-18.37,4.37,;-20.99,-.39,;-22.3,.4,;-22.3,1.99,;-23.62,-.39,;-23.62,-1.98,;-22.3,-2.77,;-21,-1.98,;-22.3,-4.37,;-24.91,.4,;-26.23,-.38,;-26.23,-1.98,;-27.54,.41,;-27.54,1.99,;-26.23,2.79,;-28.85,-.38,;-30.17,.41,;-30.17,2,;-31.45,-.38,;-32.79,.41,;-34.08,-.37,;-34.08,-1.97,;-35.39,.42,;-35.39,2,;-34.08,2.8,;-32.78,2,;-31.46,2.8,;-31.46,4.38,;-32.78,5.19,;-34.08,4.38,;-36.69,-.37,;-38,.42,;-38,2.01,;-39.33,-.37,;-40.63,.42,;-41.93,-.37,;-41.93,-1.96,;-43.24,.43,;-44.55,-.36,;-45.86,.43,;-45.86,2.01,;-47.17,-.36,;-47.17,-1.95,;-45.86,-2.75,;-45.86,-4.34,;-47.18,-5.14,;-44.56,-5.14,;-48.47,.43,;-49.78,-.36,;-49.78,-1.95,;-51.1,.43,;-51.1,2.02,;-49.78,2.82,;-52.4,-.36,;-53.75,.42,;-53.75,1.95,;-55.07,2.72,;-56.33,1.85,;-57.56,2.78,;-57.06,4.24,;-55.51,4.21,;-55.08,-.35,;-56.41,.42,;-55.08,-1.9,;-39.33,-1.96,;-40.63,-2.76,;-38,-2.76,;-31.45,-1.97,;-32.79,-2.77,;-30.17,-2.77,;31.35,-2.06,;32.67,-2.85,;30.05,-2.85,;48.36,.31,;48.36,1.9,;49.69,-.49,;50.98,.31,;50.98,1.89,;52.3,2.69,;53.61,1.89,;52.3,4.28,;52.3,-.49,;52.3,-2.08,;53.6,.3,;54.91,-.49,;54.91,-2.09,;53.6,-2.88,;56.22,-2.87,;56.22,.3,;57.56,-.45,;56.22,1.89,)| Show InChI InChI=1S/C154H228N42O48S/c1-74(2)55-99(135(226)179-98(49-54-245-12)134(225)186-106(63-115(158)206)145(236)195-122(79(9)200)125(159)216)182-139(230)105(61-86-67-167-91-32-20-19-31-90(86)91)180-127(218)78(8)171-149(240)121(76(5)6)194-143(234)103(57-82-27-15-13-16-28-82)185-141(232)108(65-119(212)213)187-131(222)92(33-21-23-50-155)173-126(217)77(7)170-129(220)94(35-25-52-165-153(160)161)174-130(221)95(36-26-53-166-154(162)163)175-133(224)97(46-48-117(208)209)178-140(231)107(64-118(210)211)188-136(227)100(56-75(3)4)181-137(228)101(59-84-37-41-88(203)42-38-84)183-132(223)93(34-22-24-51-156)176-147(238)112(71-198)191-138(229)102(60-85-39-43-89(204)44-40-85)184-142(233)109(66-120(214)215)189-148(239)113(72-199)192-151(242)124(81(11)202)196-144(235)104(58-83-29-17-14-18-30-83)190-150(241)123(80(10)201)193-116(207)69-168-128(219)96(45-47-114(157)205)177-146(237)111(70-197)172-110(152(243)244)62-87-68-164-73-169-87/h13-20,27-32,37-44,67-68,73-81,92-113,121-124,167,172,197-204H,21-26,33-36,45-66,69-72,155-156H2,1-12H3,(H2,157,205)(H2,158,206)(H2,159,216)(H,164,169)(H,168,219)(H,170,220)(H,171,240)(H,173,217)(H,174,221)(H,175,224)(H,176,238)(H,177,237)(H,178,231)(H,179,226)(H,180,218)(H,181,228)(H,182,230)(H,183,223)(H,184,233)(H,185,232)(H,186,225)(H,187,222)(H,188,227)(H,189,239)(H,190,241)(H,191,229)(H,192,242)(H,193,207)(H,194,234)(H,195,236)(H,196,235)(H,208,209)(H,210,211)(H,212,213)(H,214,215)(H,243,244)(H4,160,161,165)(H4,162,163,166)/t77-,78-,79+,80+,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,121-,122-,123-,124-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0870 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50324719 (CHEMBL1222093 | HAEGTFTSDVSSYLEERRAQDFVQWLMNT) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O |r| Show InChI InChI=1S/C149H220N40O51S/c1-68(2)51-93(173-132(223)95(55-79-33-35-82(196)36-34-79)176-139(230)103(64-190)182-141(232)105(66-192)183-143(234)116(71(7)8)187-138(229)101(60-114(209)210)180-140(231)104(65-191)184-145(236)118(75(12)194)188-136(227)97(54-78-27-19-16-20-28-78)181-144(235)117(74(11)193)185-109(200)63-161-122(213)87(39-44-110(201)202)165-120(211)72(9)163-102(146(237)238)57-81-62-157-67-162-81)130(221)170-91(41-46-112(205)206)126(217)169-90(40-45-111(203)204)125(216)168-86(32-24-49-159-149(155)156)124(215)167-85(31-23-48-158-148(153)154)123(214)164-73(10)121(212)166-88(37-42-106(150)197)127(218)179-100(59-113(207)208)134(225)175-96(53-77-25-17-15-18-26-77)135(226)186-115(70(5)6)142(233)172-89(38-43-107(151)198)128(219)177-98(56-80-61-160-84-30-22-21-29-83(80)84)133(224)174-94(52-69(3)4)131(222)171-92(47-50-241-14)129(220)178-99(58-108(152)199)137(228)189-119(76(13)195)147(239)240/h15-22,25-30,33-36,61-62,67-76,85-105,115-119,160,163,190-196H,23-24,31-32,37-60,63-66H2,1-14H3,(H2,150,197)(H2,151,198)(H2,152,199)(H,157,162)(H,161,213)(H,164,214)(H,165,211)(H,166,212)(H,167,215)(H,168,216)(H,169,217)(H,170,221)(H,171,222)(H,172,233)(H,173,223)(H,174,224)(H,175,225)(H,176,230)(H,177,219)(H,178,220)(H,179,218)(H,180,231)(H,181,235)(H,182,232)(H,183,234)(H,184,236)(H,185,200)(H,186,226)(H,187,229)(H,188,227)(H,189,228)(H,201,202)(H,203,204)(H,205,206)(H,207,208)(H,209,210)(H,237,238)(H,239,240)(H4,153,154,158)(H4,155,156,159)/t72-,73-,74+,75+,76+,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,115-,116-,117-,118-,119-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.180 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50324725 (CHEMBL1222099) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc2cnc[nH]2)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O |r,wU:177.185,149.162,139.146,119.132,104.113,84.91,72.75,211.218,62.64,43.53,30.37,8.12,233.240,wD:181.186,168.179,160.166,191.199,145.150,194.202,131.140,113.119,92.104,76.83,200.207,222.229,54.61,39.41,16.28,4.4,241.248,242.251,(14.09,-1.66,;12.78,-.87,;12.78,.73,;11.47,1.51,;11.47,3.11,;10.17,3.91,;8.86,3.11,;8.86,1.52,;7.55,3.91,;7.55,5.49,;8.86,6.29,;8.86,7.88,;10.17,5.49,;6.24,3.11,;4.93,3.91,;4.93,5.5,;3.62,3.11,;3.62,1.52,;4.93,.73,;6.31,1.37,;7.33,.19,;6.56,-1.19,;7.02,-2.69,;6.01,-3.87,;4.54,-3.54,;4.06,-2.03,;5.08,-.85,;2.32,3.91,;1,3.12,;1,1.53,;-.3,3.92,;-.3,5.5,;1,6.3,;1,7.9,;-.3,8.68,;2.32,8.69,;-1.61,3.12,;-2.92,3.92,;-2.92,5.51,;-4.23,3.12,;-5.54,3.92,;-6.85,3.13,;-6.85,1.54,;-8.16,3.93,;-8.16,5.51,;-6.85,6.31,;-5.54,5.51,;-4.23,6.31,;-4.23,7.9,;-5.54,8.7,;-6.84,7.91,;-9.46,3.13,;-10.78,3.93,;-10.78,5.52,;-12.08,3.13,;-12.08,1.54,;-10.78,.75,;-9.46,1.54,;-10.78,-.84,;-13.4,3.93,;-14.71,3.14,;-14.71,1.54,;-16.02,3.94,;-16.02,5.52,;-14.71,6.32,;-14.71,7.91,;-16.04,8.69,;-23.81,11.77,;-30.38,7.89,;-31.73,8.66,;-30.38,6.32,;-31.73,5.55,;-31.73,3.96,;-33.02,3.17,;-34.33,3.97,;-34.33,5.55,;-35.65,3.18,;-35.65,1.58,;-34.33,.79,;-33.04,1.58,;-34.33,-.8,;-36.96,3.97,;-38.27,3.18,;-38.27,1.58,;-39.58,3.97,;-39.58,5.56,;-38.27,6.36,;-38.27,7.94,;-36.94,5.56,;-40.87,3.18,;-42.2,3.97,;-42.2,5.56,;-43.49,3.19,;-43.49,1.59,;-42.2,.8,;-40.89,1.58,;-39.58,.79,;-39.58,-.8,;-38.26,-1.6,;-40.88,-1.59,;-42.19,-.79,;-44.81,3.98,;-46.12,3.19,;-46.12,1.59,;-47.43,3.98,;-47.43,5.57,;-46.12,6.37,;-46.12,7.96,;-44.82,8.76,;-43.45,8.01,;-48.74,3.19,;-50.04,3.98,;-50.04,5.57,;-51.34,3.19,;-51.34,1.6,;-50.04,.81,;-52.67,3.99,;-53.97,3.2,;-53.97,1.61,;-55.27,3.99,;-55.27,5.57,;-53.97,6.37,;-52.66,5.57,;-51.34,6.37,;-51.35,7.96,;-50.03,8.76,;-52.66,8.77,;-53.97,7.97,;-56.59,3.2,;-57.89,3.99,;-57.89,5.58,;-59.21,3.2,;-59.21,1.61,;-57.89,.82,;-56.6,1.61,;-57.89,-.78,;-60.51,4,;-61.83,3.21,;-61.83,1.62,;-63.13,4,;-63.13,5.58,;-61.83,6.38,;-64.43,3.21,;-65.76,4,;-65.76,5.59,;-67.05,3.21,;-68.37,4.01,;-69.67,3.22,;-69.67,1.63,;-70.98,4.01,;-70.98,5.59,;-69.67,6.39,;-68.37,5.59,;-67.05,6.39,;-67.05,7.99,;-68.36,8.78,;-69.66,7.98,;-72.29,3.22,;-73.6,4.01,;-73.6,5.6,;-74.91,3.22,;-76.22,4.01,;-77.53,3.23,;-77.53,1.63,;-78.82,4.02,;-80.15,3.23,;-81.45,4.02,;-81.45,5.61,;-82.76,3.23,;-82.76,1.64,;-81.45,.84,;-81.45,-.75,;-82.76,-1.55,;-80.16,-1.54,;-84.07,4.02,;-85.38,3.23,;-85.38,1.64,;-86.7,4.02,;-86.7,5.61,;-85.36,6.41,;-88,3.23,;-89.35,4.01,;-89.35,5.56,;-90.69,6.33,;-91.96,5.47,;-93.2,6.42,;-92.68,7.9,;-91.11,7.85,;-90.69,3.24,;-92.04,4.01,;-90.69,1.68,;-74.91,1.63,;-76.22,.83,;-73.6,.83,;-67.05,1.62,;-68.37,.82,;-65.76,.83,;-30.4,3.17,;-30.4,1.56,;-29.11,3.96,;-27.8,3.16,;-27.8,1.56,;-26.49,.77,;-26.49,-.82,;-25.17,-1.62,;-25.17,-3.21,;-26.5,-4.01,;-23.88,-4,;-26.49,3.95,;-26.49,5.54,;-25.18,3.16,;-23.87,3.95,;-23.87,5.53,;-22.56,6.34,;-22.56,7.93,;-23.91,8.69,;-25.29,7.91,;-25.32,6.36,;-26.62,8.64,;-22.56,3.15,;-22.56,1.55,;-21.24,3.94,;-19.94,3.14,;-19.94,1.55,;-18.64,3.94,;-18.64,5.52,;-17.32,3.14,;-4.23,1.53,;-2.92,.74,;-5.54,.74,;12.78,3.9,;12.78,5.49,;14.1,3.1,;15.4,3.9,;15.4,5.48,;16.71,6.28,;18.02,5.48,;16.71,7.87,;16.71,3.1,;16.71,1.51,;18.02,3.9,;19.32,3.1,;19.32,1.51,;18.02,.71,;20.63,.72,;20.63,3.89,;21.94,3.09,;20.63,5.48,)| Show InChI InChI=1S/C156H228N42O49S/c1-75(2)56-100(136(227)180-99(50-55-248-11)135(226)188-107(64-117(160)209)146(237)198-126(81(10)204)154(246)247)183-140(231)106(62-86-68-169-91-31-19-18-30-90(86)91)187-134(225)97(45-48-116(159)208)181-150(241)123(77(5)6)196-144(235)104(58-82-26-14-12-15-27-82)186-142(233)109(66-121(214)215)189-131(222)92-33-21-23-52-166-118(210)49-46-98(133(224)176-95(35-25-54-168-156(163)164)130(221)175-94(34-24-53-167-155(161)162)129(220)172-78(7)127(218)174-92)179-141(232)108(65-120(212)213)190-137(228)101(57-76(3)4)182-138(229)102(60-84-36-40-88(205)41-37-84)184-132(223)93(32-20-22-51-157)177-148(239)113(72-200)193-139(230)103(61-85-38-42-89(206)43-39-85)185-143(234)110(67-122(216)217)191-149(240)114(73-201)194-152(243)125(80(9)203)197-145(236)105(59-83-28-16-13-17-29-83)192-151(242)124(79(8)202)195-119(211)70-170-128(219)96(44-47-115(158)207)178-147(238)112(71-199)173-111(153(244)245)63-87-69-165-74-171-87/h12-19,26-31,36-43,68-69,74-81,92-114,123-126,169,173,199-206H,20-25,32-35,44-67,70-73,157H2,1-11H3,(H2,158,207)(H2,159,208)(H2,160,209)(H,165,171)(H,166,210)(H,170,219)(H,172,220)(H,174,218)(H,175,221)(H,176,224)(H,177,239)(H,178,238)(H,179,232)(H,180,227)(H,181,241)(H,182,229)(H,183,231)(H,184,223)(H,185,234)(H,186,233)(H,187,225)(H,188,226)(H,189,222)(H,190,228)(H,191,240)(H,192,242)(H,193,230)(H,194,243)(H,195,211)(H,196,235)(H,197,236)(H,198,237)(H,212,213)(H,214,215)(H,216,217)(H,244,245)(H,246,247)(H4,161,162,167)(H4,163,164,168)/t78-,79+,80+,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,123-,124-,125-,126-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0490 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon receptor (Homo sapiens (Human)) | BDBM50324707 (CHEMBL1222081) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCS(O)(=O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:209.217,181.194,171.178,151.164,136.145,116.123,98.107,76.86,62.70,43.53,30.37,8.12,235.241,wD:200.211,192.198,223.231,177.182,226.234,163.172,145.151,124.136,108.115,87.97,71.74,54.61,39.41,16.28,4.4,243.249,244.252,213.218,(49.74,-5.28,;48.43,-4.49,;48.43,-2.89,;47.12,-2.1,;47.12,-.51,;45.81,.29,;44.51,-.51,;44.51,-2.1,;43.19,.29,;43.19,1.88,;44.51,2.68,;44.51,4.27,;45.82,1.88,;41.89,-.5,;40.57,.3,;40.57,1.88,;39.26,-.5,;39.26,-2.09,;40.57,-2.88,;41.95,-2.24,;42.97,-3.43,;42.2,-4.81,;42.64,-6.25,;41.62,-7.35,;40.14,-7.01,;39.7,-5.57,;40.73,-4.47,;37.95,.3,;36.64,-.5,;36.64,-2.09,;35.33,.3,;35.33,1.89,;36.64,2.69,;36.64,4.28,;35.34,5.07,;37.96,5.07,;34.02,-.49,;32.72,.31,;32.72,1.89,;31.4,-.49,;30.09,.31,;28.78,-.49,;28.78,-2.08,;27.46,.31,;27.46,1.9,;28.78,2.7,;30.09,1.9,;31.4,2.69,;31.4,4.28,;30.09,5.08,;28.79,4.29,;26.17,-.48,;24.84,.32,;24.84,1.9,;23.55,-.48,;23.55,-2.08,;24.84,-2.86,;26.16,-2.08,;24.84,-4.46,;22.23,.32,;20.92,-.48,;20.92,-2.07,;19.6,.32,;19.6,1.91,;20.92,2.71,;20.92,4.3,;19.61,5.09,;22.23,5.09,;18.29,-.48,;16.99,.33,;16.99,1.91,;15.68,-.47,;15.68,-2.07,;14.38,.33,;13.06,-.46,;13.06,-2.06,;11.75,.33,;11.75,1.92,;13.06,2.73,;13.06,4.31,;14.38,5.1,;14.38,6.69,;13.06,7.48,;15.68,7.49,;10.43,-.46,;9.11,.33,;9.11,1.93,;7.8,-.46,;7.8,-2.06,;9.16,-2.83,;9.16,-4.38,;10.49,-5.16,;10.49,-6.71,;11.85,-7.49,;9.16,-7.49,;6.49,.35,;5.2,-.44,;5.2,-2.05,;3.87,.35,;3.87,1.94,;5.22,2.71,;5.22,4.26,;4.44,5.62,;6.56,5.04,;3.67,4.28,;2.57,-.44,;1.26,.35,;1.26,1.94,;-.06,-.44,;-.06,-2.04,;1.26,-2.83,;2.56,-2.04,;1.26,-4.42,;-1.37,.35,;-2.68,-.44,;-2.68,-2.04,;-3.99,.36,;-3.99,1.94,;-2.68,2.75,;-2.68,4.33,;-1.35,1.94,;-5.29,-.43,;-6.61,.36,;-6.61,1.95,;-7.91,-.43,;-7.91,-2.03,;-6.61,-2.82,;-5.3,-2.03,;-3.99,-2.83,;-3.99,-4.42,;-2.67,-5.22,;-5.3,-5.21,;-6.61,-4.41,;-9.23,.36,;-10.54,-.43,;-10.54,-2.03,;-11.85,.37,;-11.85,1.95,;-10.54,2.75,;-10.54,4.34,;-9.23,5.14,;-9.23,6.73,;-13.16,-.42,;-14.47,.37,;-14.47,1.96,;-15.77,-.42,;-15.77,-2.02,;-14.47,-2.81,;-17.1,.37,;-18.4,-.42,;-18.4,-2.01,;-19.7,.38,;-19.7,1.96,;-18.4,2.76,;-17.09,1.96,;-15.77,2.76,;-15.77,4.35,;-14.46,5.15,;-17.09,5.15,;-18.4,4.35,;-21.02,-.41,;-22.33,.38,;-22.33,1.97,;-23.65,-.41,;-23.65,-2,;-22.33,-2.8,;-21.03,-2,;-22.33,-4.39,;-24.95,.38,;-26.27,-.41,;-26.27,-2,;-27.57,.39,;-27.57,1.97,;-26.27,2.77,;-28.88,-.4,;-30.21,.39,;-30.21,1.98,;-31.5,-.4,;-32.82,.39,;-34.12,-.4,;-34.12,-1.99,;-35.44,.39,;-35.44,1.98,;-34.12,2.78,;-32.82,1.98,;-31.5,2.78,;-31.5,4.37,;-32.81,5.17,;-34.11,4.37,;-36.74,-.4,;-38.05,.4,;-38.05,1.98,;-39.37,-.39,;-40.68,.4,;-41.98,-.39,;-41.98,-1.98,;-43.28,.4,;-44.61,-.39,;-45.92,.41,;-45.92,1.99,;-47.23,-.38,;-47.23,-1.98,;-45.92,-2.77,;-45.92,-4.37,;-47.22,-5.17,;-44.62,-5.16,;-48.54,.41,;-49.85,-.38,;-49.85,-1.97,;-51.17,.41,;-51.17,2,;-49.83,2.8,;-52.47,-.38,;-53.81,.4,;-53.81,1.93,;-55.14,2.7,;-56.4,1.83,;-57.64,2.76,;-57.14,4.22,;-55.59,4.19,;-55.16,-.37,;-56.48,.4,;-55.16,-1.92,;-39.37,-1.99,;-40.68,-2.79,;-38.05,-2.78,;-31.5,-1.99,;-32.82,-2.8,;-30.21,-2.79,;31.4,-2.08,;32.72,-2.87,;30.09,-2.88,;48.43,.29,;48.43,1.88,;49.76,-.51,;51.05,.29,;51.05,1.87,;52.37,2.67,;53.68,1.87,;52.37,4.26,;52.37,-.52,;52.37,-2.11,;53.67,.28,;54.98,-.52,;54.98,-2.11,;53.67,-2.9,;56.3,-2.9,;56.3,.28,;57.64,-.47,;56.3,1.87,)| Show InChI InChI=1S/C154H227N43O51S2/c1-73(2)54-98(135(227)178-96(47-52-249-11)133(225)187-105(62-116(159)209)145(237)196-122(77(8)201)125(160)217)182-139(231)104(60-84-66-168-89-29-19-18-28-88(84)89)186-132(224)95(43-46-115(158)208)180-149(241)121(75(5)6)195-143(235)102(56-80-24-14-12-15-25-80)185-141(233)107(64-119(213)214)188-131(223)94(42-45-114(157)207)173-126(218)76(7)171-128(220)91(31-22-50-166-153(161)162)174-129(221)92(32-23-51-167-154(163)164)175-134(226)97(48-53-250(246,247)248)179-140(232)106(63-118(211)212)189-136(228)99(55-74(3)4)181-137(229)100(58-82-33-37-86(204)38-34-82)183-130(222)90(30-20-21-49-155)176-147(239)111(70-199)192-138(230)101(59-83-35-39-87(205)40-36-83)184-142(234)108(65-120(215)216)190-148(240)112(71-200)193-151(243)124(79(10)203)197-144(236)103(57-81-26-16-13-17-27-81)191-150(242)123(78(9)202)194-117(210)68-169-127(219)93(41-44-113(156)206)177-146(238)110(69-198)172-109(152(244)245)61-85-67-165-72-170-85/h12-19,24-29,33-40,66-67,72-79,90-112,121-124,168,172,198-205H,20-23,30-32,41-65,68-71,155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H2,160,217)(H,165,170)(H,169,219)(H,171,220)(H,173,218)(H,174,221)(H,175,226)(H,176,239)(H,177,238)(H,178,227)(H,179,232)(H,180,241)(H,181,229)(H,182,231)(H,183,222)(H,184,234)(H,185,233)(H,186,224)(H,187,225)(H,188,223)(H,189,228)(H,190,240)(H,191,242)(H,192,230)(H,193,243)(H,194,210)(H,195,235)(H,196,237)(H,197,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,161,162,166)(H4,163,164,167)(H,246,247,248)/t76-,77+,78+,79+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,121-,122-,123-,124-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon receptor (Homo sapiens (Human)) | BDBM50324718 (CHEMBL1222092) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:204.212,176.189,166.173,146.159,131.140,111.118,94.102,72.82,58.66,39.49,30.32,8.12,230.236,wD:195.206,187.193,218.226,172.177,221.229,158.167,140.146,119.131,103.110,83.93,67.70,50.57,35.37,16.28,4.4,238.244,239.247,208.213,(49.68,-5.25,;48.36,-4.46,;48.36,-2.87,;47.06,-2.08,;47.06,-.49,;45.75,.31,;44.45,-.48,;44.45,-2.07,;43.13,.32,;43.13,1.9,;44.45,2.7,;44.45,4.28,;45.76,1.9,;41.83,-.48,;40.52,.32,;40.52,1.91,;39.21,-.48,;39.21,-2.07,;40.55,-2.84,;41.97,-2.22,;43.01,-3.37,;42.24,-4.71,;42.71,-6.18,;41.69,-7.33,;40.17,-7.01,;39.69,-5.54,;40.72,-4.39,;37.9,.32,;36.59,-.47,;36.59,-2.06,;35.28,.33,;35.28,1.91,;33.97,-.47,;32.67,.33,;32.67,1.91,;31.35,-.47,;30.05,.33,;28.74,-.46,;28.74,-2.06,;27.43,.34,;27.43,1.92,;28.74,2.72,;30.05,1.92,;31.36,2.71,;31.36,4.3,;30.05,5.11,;28.75,4.3,;26.13,-.46,;24.81,.34,;24.81,1.92,;23.51,-.46,;23.51,-2.05,;24.81,-2.84,;26.17,-2.09,;24.77,-4.39,;22.2,.34,;20.89,-.45,;20.89,-2.05,;19.58,.34,;19.58,1.93,;20.89,2.73,;20.89,4.31,;22.2,5.11,;23.56,4.36,;18.25,-.45,;16.96,.35,;16.96,1.93,;15.64,-.45,;15.64,-2.04,;14.34,.35,;13.03,-.44,;13.03,-2.04,;11.73,.35,;11.73,1.94,;13.03,2.75,;13.03,4.32,;14.35,5.12,;14.35,6.72,;13.03,7.51,;15.65,7.51,;10.42,-.43,;9.1,.36,;9.1,1.95,;7.79,-.43,;7.79,-2.03,;9.1,-2.82,;9.1,-4.41,;10.44,-5.19,;10.44,-6.73,;9.1,-7.51,;11.79,-7.51,;6.48,.37,;5.18,-.42,;5.18,-2.03,;3.87,.37,;3.87,1.96,;5.22,2.73,;5.22,4.28,;3.87,5.07,;6.55,5.07,;2.57,-.42,;1.24,.37,;1.24,1.96,;-.06,-.41,;-.06,-2.01,;1.24,-2.8,;2.55,-2.01,;1.24,-4.39,;-1.36,.38,;-2.67,-.41,;-2.67,-2.01,;-3.99,.38,;-3.99,1.97,;-2.67,2.76,;-2.67,4.35,;-1.36,1.97,;-5.3,-.41,;-6.6,.38,;-6.6,1.97,;-7.9,-.41,;-7.9,-2,;-6.6,-2.79,;-5.29,-2.01,;-3.98,-2.8,;-4,-4.39,;-2.68,-5.19,;-5.3,-5.18,;-6.6,-4.38,;-9.23,.39,;-10.53,-.4,;-10.53,-2,;-11.83,.39,;-11.83,1.97,;-10.53,2.77,;-10.53,4.36,;-9.22,5.17,;-9.22,6.74,;-13.14,-.4,;-14.45,.39,;-14.45,1.98,;-15.76,-.4,;-15.76,-2,;-14.45,-2.78,;-17.08,.4,;-18.37,-.39,;-18.37,-1.98,;-19.69,.4,;-19.69,1.98,;-18.37,2.78,;-17.06,1.98,;-15.77,2.78,;-15.75,4.36,;-14.44,5.16,;-17.07,5.18,;-18.37,4.37,;-20.99,-.39,;-22.3,.4,;-22.3,1.99,;-23.62,-.39,;-23.62,-1.98,;-22.3,-2.77,;-21,-1.98,;-22.3,-4.37,;-24.91,.4,;-26.23,-.38,;-26.23,-1.98,;-27.54,.41,;-27.54,1.99,;-26.23,2.79,;-28.85,-.38,;-30.17,.41,;-30.17,2,;-31.45,-.38,;-32.79,.41,;-34.08,-.37,;-34.08,-1.97,;-35.39,.42,;-35.39,2,;-34.08,2.8,;-32.78,2,;-31.46,2.8,;-31.46,4.38,;-32.78,5.19,;-34.08,4.38,;-36.69,-.37,;-38,.42,;-38,2.01,;-39.33,-.37,;-40.63,.42,;-41.93,-.37,;-41.93,-1.96,;-43.24,.43,;-44.55,-.36,;-45.86,.43,;-45.86,2.01,;-47.17,-.36,;-47.17,-1.95,;-45.86,-2.75,;-45.86,-4.34,;-47.18,-5.14,;-44.56,-5.14,;-48.47,.43,;-49.78,-.36,;-49.78,-1.95,;-51.1,.43,;-51.1,2.02,;-49.78,2.82,;-52.4,-.36,;-53.75,.42,;-53.75,1.95,;-55.07,2.72,;-56.33,1.85,;-57.56,2.78,;-57.06,4.24,;-55.51,4.21,;-55.08,-.35,;-56.41,.42,;-55.08,-1.9,;-39.33,-1.96,;-40.63,-2.76,;-38,-2.76,;-31.45,-1.97,;-32.79,-2.77,;-30.17,-2.77,;31.35,-2.06,;32.67,-2.85,;30.05,-2.85,;48.36,.31,;48.36,1.9,;49.69,-.49,;50.98,.31,;50.98,1.89,;52.3,2.69,;53.61,1.89,;52.3,4.28,;52.3,-.49,;52.3,-2.08,;53.6,.3,;54.91,-.49,;54.91,-2.09,;53.6,-2.88,;56.22,-2.87,;56.22,.3,;57.56,-.45,;56.22,1.89,)| Show InChI InChI=1S/C154H228N42O48S/c1-74(2)55-99(135(226)179-98(49-54-245-12)134(225)186-106(63-115(158)206)145(236)195-122(79(9)200)125(159)216)182-139(230)105(61-86-67-167-91-32-20-19-31-90(86)91)180-127(218)78(8)171-149(240)121(76(5)6)194-143(234)103(57-82-27-15-13-16-28-82)185-141(232)108(65-119(212)213)187-131(222)92(33-21-23-50-155)173-126(217)77(7)170-129(220)94(35-25-52-165-153(160)161)174-130(221)95(36-26-53-166-154(162)163)175-133(224)97(46-48-117(208)209)178-140(231)107(64-118(210)211)188-136(227)100(56-75(3)4)181-137(228)101(59-84-37-41-88(203)42-38-84)183-132(223)93(34-22-24-51-156)176-147(238)112(71-198)191-138(229)102(60-85-39-43-89(204)44-40-85)184-142(233)109(66-120(214)215)189-148(239)113(72-199)192-151(242)124(81(11)202)196-144(235)104(58-83-29-17-14-18-30-83)190-150(241)123(80(10)201)193-116(207)69-168-128(219)96(45-47-114(157)205)177-146(237)111(70-197)172-110(152(243)244)62-87-68-164-73-169-87/h13-20,27-32,37-44,67-68,73-81,92-113,121-124,167,172,197-204H,21-26,33-36,45-66,69-72,155-156H2,1-12H3,(H2,157,205)(H2,158,206)(H2,159,216)(H,164,169)(H,168,219)(H,170,220)(H,171,240)(H,173,217)(H,174,221)(H,175,224)(H,176,238)(H,177,237)(H,178,231)(H,179,226)(H,180,218)(H,181,228)(H,182,230)(H,183,223)(H,184,233)(H,185,232)(H,186,225)(H,187,222)(H,188,227)(H,189,239)(H,190,241)(H,191,229)(H,192,242)(H,193,207)(H,194,234)(H,195,236)(H,196,235)(H,208,209)(H,210,211)(H,212,213)(H,214,215)(H,243,244)(H4,160,161,165)(H4,162,163,166)/t77-,78-,79+,80+,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,121-,122-,123-,124-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon receptor (Homo sapiens (Human)) | BDBM50324721 (CHEMBL1222095) Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O |r| Show InChI InChI=1S/C152H219N35O51S/c1-14-75(6)121(148(232)163-78(9)127(211)172-105(61-86-66-158-91-32-22-21-31-90(86)91)139(223)174-99(55-73(2)3)135(219)171-98(51-54-239-13)134(218)178-106(63-114(156)197)144(228)187-124(81(12)193)152(237)238)185-142(226)103(57-82-27-17-15-18-28-82)176-133(217)97(46-50-118(203)204)169-130(214)92(33-23-25-52-153)165-126(210)77(8)161-125(209)76(7)162-129(213)95(43-47-113(155)196)168-132(216)96(45-49-117(201)202)170-140(224)107(64-119(205)206)179-136(220)100(56-74(4)5)173-137(221)101(59-84-35-39-88(194)40-36-84)175-131(215)93(34-24-26-53-154)166-146(230)111(70-189)182-138(222)102(60-85-37-41-89(195)42-38-85)177-141(225)108(65-120(207)208)180-147(231)112(71-190)183-150(234)123(80(11)192)186-143(227)104(58-83-29-19-16-20-30-83)181-149(233)122(79(10)191)184-115(198)68-159-128(212)94(44-48-116(199)200)167-145(229)110(69-188)164-109(151(235)236)62-87-67-157-72-160-87/h15-22,27-32,35-42,66-67,72-81,92-112,121-124,158,164,188-195H,14,23-26,33-34,43-65,68-71,153-154H2,1-13H3,(H2,155,196)(H2,156,197)(H,157,160)(H,159,212)(H,161,209)(H,162,213)(H,163,232)(H,165,210)(H,166,230)(H,167,229)(H,168,216)(H,169,214)(H,170,224)(H,171,219)(H,172,211)(H,173,221)(H,174,223)(H,175,215)(H,176,217)(H,177,225)(H,178,218)(H,179,220)(H,180,231)(H,181,233)(H,182,222)(H,183,234)(H,184,198)(H,185,226)(H,186,227)(H,187,228)(H,199,200)(H,201,202)(H,203,204)(H,205,206)(H,207,208)(H,235,236)(H,237,238)/t75-,76-,77-,78-,79+,80+,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,121-,122-,123-,124-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50324723 (CHEMBL1222097) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:205.213,177.190,167.174,147.160,132.141,112.119,98.103,76.86,62.70,43.53,30.37,8.12,231.237,wD:196.207,188.194,219.227,173.178,222.230,159.168,141.147,120.132,104.111,87.97,71.74,54.61,39.41,16.28,4.4,239.245,240.248,209.214,(49.71,-5.2,;48.4,-4.41,;48.4,-2.82,;47.1,-2.03,;47.1,-.44,;45.79,.36,;44.49,-.43,;44.49,-2.02,;43.17,.37,;43.17,1.95,;44.49,2.75,;44.49,4.34,;45.79,1.95,;41.87,-.43,;40.55,.37,;40.55,1.95,;39.25,-.43,;39.25,-2.02,;40.55,-2.81,;41.93,-2.17,;42.95,-3.35,;42.18,-4.73,;42.65,-6.24,;41.63,-7.42,;40.16,-7.08,;39.69,-5.57,;40.7,-4.39,;37.94,.37,;36.63,-.42,;36.63,-2.02,;35.32,.38,;35.32,1.96,;36.63,2.76,;36.63,4.35,;35.32,5.13,;37.94,5.14,;34.01,-.42,;32.71,.38,;32.71,1.96,;31.39,-.42,;30.08,.38,;28.78,-.42,;28.78,-2.01,;27.46,.38,;27.46,1.97,;28.78,2.77,;30.08,1.97,;31.39,2.76,;31.39,4.35,;30.09,5.14,;28.78,4.35,;26.17,-.41,;24.84,.39,;24.84,1.97,;23.55,-.41,;23.55,-2,;24.84,-2.79,;26.2,-2.05,;24.81,-4.34,;22.23,.39,;20.93,-.41,;20.93,-2,;19.61,.39,;19.61,1.98,;20.95,2.75,;20.95,4.3,;22.29,5.08,;22.29,6.63,;18.3,-.4,;17,.4,;17,1.98,;15.69,-.4,;15.69,-1.99,;14.39,.4,;13.07,-.39,;13.07,-1.99,;11.76,.4,;11.76,1.99,;13.07,2.8,;13.07,4.37,;14.39,5.16,;14.39,6.76,;13.07,7.55,;15.69,7.55,;10.46,-.39,;9.13,.41,;9.13,2,;7.82,-.38,;7.82,-1.98,;9.13,-2.77,;9.13,-4.36,;10.45,-5.16,;10.45,-6.75,;9.12,-7.55,;11.76,-7.55,;6.51,.42,;5.22,-.37,;5.22,-1.98,;3.9,.42,;3.9,2.01,;5.22,2.8,;2.6,-.37,;1.29,.42,;1.29,2.01,;-.03,-.37,;-.03,-1.96,;1.29,-2.75,;2.58,-1.96,;1.29,-4.35,;-1.33,.43,;-2.64,-.36,;-2.64,-1.96,;-3.96,.43,;-3.96,2.01,;-2.64,2.81,;-2.64,4.4,;-1.32,2.01,;-5.25,-.36,;-6.57,.43,;-6.57,2.02,;-7.87,-.36,;-7.87,-1.96,;-6.57,-2.74,;-5.26,-1.96,;-3.96,-2.75,;-3.95,-4.34,;-2.64,-5.14,;-5.26,-5.14,;-6.57,-4.34,;-9.19,.44,;-10.5,-.35,;-10.5,-1.95,;-11.8,.44,;-11.8,2.02,;-10.5,2.82,;-10.5,4.41,;-9.19,5.21,;-9.19,6.79,;-13.11,-.35,;-14.42,.44,;-14.42,2.03,;-15.72,-.35,;-15.72,-1.95,;-14.42,-2.74,;-17.05,.44,;-18.34,-.34,;-18.34,-1.94,;-19.65,.45,;-19.65,2.03,;-18.34,2.83,;-17.04,2.03,;-15.72,2.83,;-15.72,4.41,;-14.41,5.21,;-17.04,5.21,;-18.35,4.42,;-20.97,-.34,;-22.27,.45,;-22.27,2.04,;-23.59,-.34,;-23.59,-1.93,;-22.27,-2.73,;-20.98,-1.93,;-22.27,-4.32,;-24.89,.45,;-26.2,-.33,;-26.2,-1.93,;-27.51,.46,;-27.51,2.04,;-26.2,2.84,;-28.81,-.33,;-30.14,.46,;-30.14,2.04,;-31.43,-.33,;-32.75,.46,;-34.05,-.33,;-34.05,-1.92,;-35.36,.47,;-35.36,2.05,;-34.05,2.85,;-32.75,2.05,;-31.43,2.84,;-31.43,4.43,;-32.74,5.23,;-34.04,4.44,;-36.66,-.32,;-37.98,.47,;-37.98,2.05,;-39.29,-.32,;-40.6,.47,;-41.9,-.32,;-41.9,-1.91,;-43.2,.47,;-44.53,-.31,;-45.83,.48,;-45.83,2.06,;-47.14,-.31,;-47.14,-1.9,;-45.83,-2.7,;-45.83,-4.29,;-47.14,-5.09,;-44.54,-5.09,;-48.45,.48,;-49.75,-.31,;-49.75,-1.9,;-51.08,.48,;-51.08,2.07,;-49.74,2.87,;-52.37,-.3,;-53.72,.48,;-53.72,2.02,;-55.06,2.8,;-56.32,1.92,;-57.57,2.86,;-57.06,4.34,;-55.49,4.31,;-55.06,-.3,;-56.41,.48,;-55.06,-1.86,;-39.29,-1.91,;-40.6,-2.71,;-37.98,-2.71,;-31.43,-1.92,;-32.75,-2.72,;-30.14,-2.72,;31.39,-2.01,;32.71,-2.8,;30.08,-2.8,;48.4,.36,;48.4,1.95,;49.72,-.44,;51.02,.36,;51.02,1.94,;52.34,2.74,;53.64,1.94,;52.34,4.33,;52.34,-.44,;52.34,-2.03,;53.64,.35,;54.95,-.45,;54.95,-2.04,;53.64,-2.83,;56.26,-2.83,;56.26,.35,;57.57,-.45,;56.26,1.94,)| Show InChI InChI=1S/C154H229N43O48S/c1-74(2)54-98(134(226)178-97(48-53-246-11)133(225)186-105(62-116(159)209)144(236)196-122(78(8)202)125(160)217)181-138(230)104(60-85-66-168-90-31-19-18-30-89(85)90)185-132(224)96(45-47-115(158)208)179-149(241)121(76(5)6)195-142(234)102(56-81-26-14-12-15-27-81)184-139(231)106(63-118(211)212)187-130(222)91(32-20-22-49-155)173-126(218)77(7)171-128(220)93(34-24-51-166-153(161)162)174-129(221)94(35-25-52-167-154(163)164)176-147(239)112(71-200)192-141(233)108(65-120(215)216)188-135(227)99(55-75(3)4)180-136(228)100(58-83-36-40-87(205)41-37-83)182-131(223)92(33-21-23-50-156)175-146(238)111(70-199)191-137(229)101(59-84-38-42-88(206)43-39-84)183-140(232)107(64-119(213)214)189-148(240)113(72-201)193-151(243)124(80(10)204)197-143(235)103(57-82-28-16-13-17-29-82)190-150(242)123(79(9)203)194-117(210)68-169-127(219)95(44-46-114(157)207)177-145(237)110(69-198)172-109(152(244)245)61-86-67-165-73-170-86/h12-19,26-31,36-43,66-67,73-80,91-113,121-124,168,172,198-206H,20-25,32-35,44-65,68-72,155-156H2,1-11H3,(H2,157,207)(H2,158,208)(H2,159,209)(H2,160,217)(H,165,170)(H,169,219)(H,171,220)(H,173,218)(H,174,221)(H,175,238)(H,176,239)(H,177,237)(H,178,226)(H,179,241)(H,180,228)(H,181,230)(H,182,223)(H,183,232)(H,184,231)(H,185,224)(H,186,225)(H,187,222)(H,188,227)(H,189,240)(H,190,242)(H,191,229)(H,192,233)(H,193,243)(H,194,210)(H,195,234)(H,196,236)(H,197,235)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,161,162,166)(H4,163,164,167)/t77-,78+,79+,80+,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,121-,122-,123-,124-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.130 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon receptor (Homo sapiens (Human)) | BDBM50098571 (CHEMBL266481 | GLUCAGON | His-Ser-Gln-Gly-Thr-Phe-...) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0710 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon receptor (Homo sapiens (Human)) | BDBM50324731 (CHEMBL1222074 | HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR) Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O |r,wU:60.66,47.53,37.38,19.25,4.4,181.184,203.208,105.111,151.154,123.133,167.172,95.99,77.87,wD:69.74,42.43,28.34,8.16,2.2,176.180,195.200,210.215,223.228,113.117,101.103,142.150,134.137,164.169,119.121,89.93,154.156,(69.72,-44.64,;69.72,-46.17,;71.06,-46.95,;72.39,-46.18,;71.06,-48.5,;69.72,-49.27,;68.4,-48.5,;68.4,-46.96,;67.06,-49.27,;67.06,-50.81,;68.4,-51.58,;69.73,-50.8,;71.06,-51.57,;71.07,-53.11,;69.73,-53.88,;68.4,-53.12,;65.72,-48.5,;64.38,-49.27,;64.38,-50.81,;63.05,-48.5,;63.05,-46.96,;64.38,-46.19,;64.38,-44.64,;63.04,-43.88,;65.72,-43.88,;61.72,-49.28,;60.38,-48.51,;60.38,-46.96,;59.05,-49.28,;59.05,-50.82,;60.38,-51.59,;60.38,-53.12,;61.72,-53.9,;61.72,-55.43,;57.72,-48.51,;56.38,-49.28,;56.38,-50.82,;55.04,-48.51,;55.04,-46.97,;53.71,-49.29,;52.38,-48.52,;52.38,-46.97,;51.04,-49.29,;51.04,-50.83,;49.71,-48.52,;48.37,-49.29,;48.37,-50.83,;47.04,-48.52,;47.04,-46.98,;48.37,-46.21,;48.37,-44.67,;47.04,-43.9,;49.71,-43.9,;45.71,-49.29,;44.37,-48.53,;44.37,-46.98,;43.03,-49.3,;41.7,-48.53,;40.37,-49.3,;40.37,-50.84,;39.04,-48.53,;39.04,-46.99,;40.37,-46.22,;40.37,-44.68,;39.03,-43.91,;41.7,-43.91,;37.7,-49.3,;36.37,-48.54,;36.37,-46.99,;35.03,-49.31,;35.03,-50.84,;36.37,-51.62,;36.37,-53.16,;37.7,-50.84,;33.69,-48.55,;32.36,-49.31,;32.36,-50.85,;31.03,-48.55,;31.03,-47,;32.36,-46.23,;33.69,-47,;35.02,-46.22,;35.02,-44.68,;36.36,-43.91,;33.68,-43.92,;32.36,-44.69,;29.69,-49.31,;28.36,-48.55,;28.36,-47.01,;27.03,-49.32,;27.03,-50.85,;28.36,-51.63,;25.69,-48.55,;24.35,-49.32,;24.35,-50.86,;23.02,-48.56,;23.02,-47.01,;24.35,-46.24,;21.68,-49.32,;20.35,-48.56,;20.35,-47.02,;19.01,-49.32,;17.69,-48.56,;16.35,-49.33,;16.35,-50.86,;15.01,-48.57,;15.01,-47.02,;16.35,-46.25,;17.68,-47.02,;16.35,-44.7,;13.68,-49.33,;12.35,-48.57,;12.35,-47.03,;11.01,-49.33,;11.01,-50.88,;12.35,-51.65,;9.68,-48.57,;9.65,-47.04,;10.98,-46.25,;8.32,-46.28,;8.3,-44.73,;6.96,-43.98,;5.63,-44.76,;6.95,-42.44,;8.27,-41.65,;9.62,-42.42,;9.63,-43.96,;10.97,-44.71,;12.29,-43.93,;12.28,-42.39,;10.94,-41.63,;5.61,-41.67,;5.59,-40.13,;6.92,-39.36,;4.24,-39.38,;4.23,-37.84,;2.89,-37.07,;1.56,-37.86,;2.87,-35.53,;1.54,-34.78,;1.52,-33.24,;2.85,-32.45,;.18,-32.48,;-1.15,-33.27,;-1.13,-34.81,;-2.46,-35.59,;-3.8,-34.83,;-2.44,-37.13,;.17,-30.94,;-1.17,-30.19,;-2.5,-30.97,;-1.19,-28.65,;.14,-27.86,;-2.53,-27.88,;-2.56,-26.32,;-1.25,-25.53,;-1.23,-23.99,;-2.59,-23.29,;-2.36,-21.76,;-.82,-21.52,;-.11,-22.9,;-3.91,-25.57,;-3.94,-24.03,;-5.24,-26.37,;2.92,-40.16,;1.58,-39.4,;2.93,-41.7,;6.99,-47.06,;5.65,-46.3,;7,-48.6,;19.01,-50.86,;20.35,-51.64,;17.69,-51.64,;72.39,-49.26,;72.39,-50.8,;73.73,-48.49,;75.05,-49.25,;75.05,-50.8,;76.4,-48.49,;76.4,-46.95,;77.73,-49.25,;79.07,-48.49,;79.07,-46.94,;80.39,-46.17,;81.8,-46.79,;82.83,-45.65,;82.06,-44.32,;82.54,-42.85,;81.5,-41.7,;79.99,-42.03,;79.53,-43.49,;80.55,-44.63,;80.39,-49.25,;80.39,-50.78,;81.73,-48.48,;83.07,-49.24,;83.07,-50.78,;84.4,-51.56,;84.4,-53.1,;85.75,-50.78,;84.4,-48.48,;84.4,-46.94,;85.74,-49.24,;87.07,-48.48,;87.07,-46.93,;88.41,-46.16,;85.74,-46.15,;88.41,-49.24,;88.41,-50.77,;89.74,-48.47,;91.07,-49.23,;91.07,-50.77,;92.41,-51.55,;92.41,-53.09,;93.74,-53.85,;93.74,-55.4,;92.41,-48.47,;92.41,-46.92,;93.74,-49.23,;95.08,-48.47,;96.41,-49.23,;96.41,-50.77,;97.75,-48.47,;99.08,-49.23,;99.08,-50.76,;100.42,-51.54,;100.42,-53.08,;101.75,-53.84,;101.75,-55.38,;100.42,-56.16,;103.09,-56.16,;100.42,-48.45,;101.75,-49.22,;100.42,-46.91,)| Show InChI InChI=1S/C149H225N39O46/c1-17-76(10)119(145(230)166-80(14)126(211)174-103(60-86-63-158-90-36-25-24-35-89(86)90)135(220)176-99(56-73(4)5)136(221)185-117(74(6)7)143(228)173-92(37-26-28-52-150)127(212)159-65-110(196)167-91(122(153)207)39-30-54-157-149(154)155)187-137(222)101(57-83-31-20-18-21-32-83)177-132(217)97(47-51-115(203)204)172-131(216)93(38-27-29-53-151)169-125(210)79(13)164-123(208)78(12)165-130(215)96(44-48-109(152)195)168-111(197)66-160-129(214)95(46-50-114(201)202)171-133(218)98(55-72(2)3)175-134(219)100(59-85-40-42-88(194)43-41-85)178-140(225)106(68-189)181-142(227)108(70-191)182-144(229)118(75(8)9)186-139(224)104(62-116(205)206)179-141(226)107(69-190)183-147(232)121(82(16)193)188-138(223)102(58-84-33-22-19-23-34-84)180-146(231)120(81(15)192)184-112(198)67-161-128(213)94(45-49-113(199)200)170-124(209)77(11)163-105(148(233)234)61-87-64-156-71-162-87/h18-25,31-36,40-43,63-64,71-82,91-108,117-121,158,163,189-194H,17,26-30,37-39,44-62,65-70,150-151H2,1-16H3,(H2,152,195)(H2,153,207)(H,156,162)(H,159,212)(H,160,214)(H,161,213)(H,164,208)(H,165,215)(H,166,230)(H,167,196)(H,168,197)(H,169,210)(H,170,209)(H,171,218)(H,172,216)(H,173,228)(H,174,211)(H,175,219)(H,176,220)(H,177,217)(H,178,225)(H,179,226)(H,180,231)(H,181,227)(H,182,229)(H,183,232)(H,184,198)(H,185,221)(H,186,224)(H,187,222)(H,188,223)(H,199,200)(H,201,202)(H,203,204)(H,205,206)(H,233,234)(H4,154,155,157)/t76-,77-,78-,79-,80-,81+,82-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,117-,118-,119-,120-,121-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon receptor (Homo sapiens (Human)) | BDBM50324732 (CHEMBL1222075) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:205.213,177.190,167.174,147.160,132.141,112.119,98.103,76.86,62.70,43.53,30.37,8.12,231.237,wD:196.207,188.194,219.227,173.178,222.230,159.168,141.147,120.132,104.111,87.97,71.74,54.61,39.41,16.28,4.4,239.245,240.248,209.214,(21.88,-5.16,;20.57,-4.37,;20.57,-2.78,;19.27,-1.98,;19.27,-.39,;17.96,.41,;16.65,-.39,;16.65,-1.98,;15.33,.41,;15.33,2,;16.65,2.8,;16.65,4.38,;17.96,2,;14.03,-.38,;12.72,.41,;12.72,2,;11.41,-.38,;11.41,-1.97,;12.72,-2.77,;14.09,-2.12,;15.11,-3.31,;14.35,-4.69,;14.81,-6.2,;13.79,-7.38,;12.32,-7.04,;11.85,-5.52,;12.87,-4.35,;10.1,.42,;8.79,-.38,;8.79,-1.97,;7.48,.42,;7.48,2,;8.79,2.81,;8.79,4.39,;7.48,5.18,;10.11,5.18,;6.17,-.37,;4.86,.42,;4.86,2.01,;3.55,-.37,;2.24,.42,;.94,-.37,;.94,-1.96,;-.38,.43,;-.38,2.01,;.94,2.82,;2.24,2.01,;3.55,2.81,;3.55,4.4,;2.25,5.19,;.94,4.4,;-1.68,-.37,;-3.01,.43,;-3.01,2.02,;-4.3,-.36,;-4.3,-1.95,;-3.01,-2.75,;-1.69,-1.95,;-3.01,-4.34,;-5.61,.43,;-6.92,-.36,;-6.92,-1.95,;-8.24,.44,;-8.24,2.02,;-6.92,2.83,;-6.92,4.41,;-8.23,5.2,;-5.61,5.2,;-9.55,-.36,;-10.85,.44,;-10.85,2.03,;-12.17,-.35,;-12.17,-1.95,;-13.46,.44,;-14.79,-.34,;-14.79,-1.94,;-16.1,.45,;-16.1,2.03,;-14.79,2.84,;-14.79,4.42,;-13.47,5.21,;-13.47,6.81,;-14.78,7.61,;-12.17,7.61,;-17.41,-.34,;-18.72,.45,;-18.72,2.04,;-20.03,-.34,;-20.03,-1.94,;-18.72,-2.73,;-18.72,-4.32,;-17.4,-5.11,;-17.4,-6.71,;-18.73,-7.51,;-16.11,-7.51,;-21.35,.46,;-22.63,-.33,;-22.63,-1.93,;-23.96,.46,;-23.96,2.05,;-22.63,2.85,;-25.26,-.32,;-26.57,.47,;-26.57,2.05,;-27.89,-.32,;-27.89,-1.92,;-26.57,-2.71,;-25.28,-1.92,;-26.57,-4.3,;-29.2,.47,;-30.5,-.32,;-30.5,-1.92,;-31.82,.47,;-31.82,2.06,;-30.5,2.86,;-30.5,4.45,;-29.18,2.06,;-33.12,-.31,;-34.44,.47,;-34.44,2.06,;-35.73,-.31,;-35.73,-1.91,;-34.44,-2.7,;-33.13,-1.91,;-31.82,-2.71,;-31.81,-4.3,;-30.5,-5.09,;-33.12,-5.09,;-34.43,-4.3,;-37.06,.48,;-38.37,-.31,;-38.37,-1.91,;-39.67,.48,;-39.67,2.07,;-38.37,2.87,;-38.37,4.46,;-37.06,5.26,;-37.06,6.85,;-40.98,-.3,;-42.29,.48,;-42.29,2.07,;-43.59,-.3,;-43.59,-1.9,;-42.29,-2.69,;-44.92,.49,;-46.22,-.3,;-46.22,-1.89,;-47.53,.49,;-47.53,2.08,;-46.22,2.88,;-44.91,2.07,;-43.59,2.87,;-43.6,4.46,;-42.28,5.26,;-44.91,5.27,;-46.22,4.47,;-48.84,-.29,;-50.15,.49,;-50.15,2.08,;-51.46,-.29,;-51.46,-1.88,;-50.15,-2.69,;-48.85,-1.88,;-50.15,-4.28,;-52.76,.5,;-54.08,-.29,;-54.08,-1.88,;-55.39,.5,;-55.39,2.09,;-54.08,2.89,;-56.69,-.29,;-58.02,.5,;-58.02,2.09,;-59.31,-.28,;-60.63,.51,;-61.93,-.28,;-61.93,-1.87,;-63.25,.51,;-63.25,2.09,;-61.93,2.9,;-60.63,2.09,;-59.31,2.89,;-59.31,4.48,;-60.62,5.29,;-61.92,4.48,;-64.55,-.28,;-65.86,.51,;-65.86,2.1,;-67.17,-.27,;-68.49,.51,;-69.79,-.27,;-69.79,-1.86,;-71.09,.52,;-72.42,-.27,;-73.73,.52,;-73.73,2.11,;-75.03,-.27,;-75.03,-1.86,;-73.73,-2.66,;-73.73,-4.25,;-75.02,-5.05,;-72.43,-5.04,;-76.34,.52,;-77.65,-.27,;-77.65,-1.85,;-78.97,.52,;-78.97,2.11,;-77.63,2.92,;-80.26,-.26,;-81.63,.51,;-81.63,2.05,;-82.95,2.82,;-84.22,1.95,;-85.46,2.88,;-84.95,4.35,;-83.41,4.32,;-82.97,-.26,;-84.31,.52,;-82.97,-1.82,;-67.17,-1.87,;-68.49,-2.67,;-65.86,-2.67,;-59.31,-1.88,;-60.63,-2.68,;-58.02,-2.68,;3.55,-1.96,;4.86,-2.76,;2.24,-2.76,;20.57,.4,;20.57,1.99,;21.89,-.39,;23.19,.4,;23.19,1.99,;24.51,2.79,;25.82,1.99,;24.51,4.38,;24.51,-.4,;24.51,-1.99,;25.81,.4,;27.12,-.4,;27.12,-1.99,;25.81,-2.79,;28.44,-2.78,;28.44,.39,;29.75,-.4,;28.44,1.98,)| Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-96(133(226)177-95(47-51-246-11)132(225)185-103(60-115(158)209)143(236)195-121(76(8)201)124(159)217)180-137(230)102(58-83-64-167-88-29-19-18-28-87(83)88)184-131(224)94(43-46-114(157)208)178-148(241)120(74(5)6)194-141(234)100(54-79-24-14-12-15-25-79)183-138(231)104(61-117(211)212)186-130(223)93(42-45-113(156)207)172-125(218)75(7)170-127(220)90(31-22-49-165-152(160)161)173-128(221)91(32-23-50-166-153(162)163)175-146(239)110(69-199)191-140(233)106(63-119(215)216)187-134(227)97(53-73(3)4)179-135(228)98(56-81-33-37-85(204)38-34-81)181-129(222)89(30-20-21-48-154)174-145(238)109(68-198)190-136(229)99(57-82-35-39-86(205)40-36-82)182-139(232)105(62-118(213)214)188-147(240)111(70-200)192-150(243)123(78(10)203)196-142(235)101(55-80-26-16-13-17-27-80)189-149(242)122(77(9)202)193-116(210)66-168-126(219)92(41-44-112(155)206)176-144(237)108(67-197)171-107(151(244)245)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,89-111,120-123,167,171,197-205H,20-23,30-32,41-63,66-70,154H2,1-11H3,(H2,155,206)(H2,156,207)(H2,157,208)(H2,158,209)(H2,159,217)(H,164,169)(H,168,219)(H,170,220)(H,172,218)(H,173,221)(H,174,238)(H,175,239)(H,176,237)(H,177,226)(H,178,241)(H,179,228)(H,180,230)(H,181,222)(H,182,232)(H,183,231)(H,184,224)(H,185,225)(H,186,223)(H,187,227)(H,188,240)(H,189,242)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,236)(H,196,235)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.150 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon receptor (Homo sapiens (Human)) | BDBM50324702 (CHEMBL1222076) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:208.216,180.193,170.177,150.163,135.144,115.122,98.106,76.86,62.70,43.53,30.37,8.12,234.240,wD:199.210,191.197,222.230,176.181,225.233,162.171,144.150,123.135,107.114,87.97,71.74,54.61,39.41,16.28,4.4,242.248,243.251,212.217,(49.71,-5.25,;48.4,-4.46,;48.4,-2.87,;47.1,-2.08,;47.1,-.49,;45.79,.31,;44.48,-.48,;44.48,-2.07,;43.17,.31,;43.17,1.9,;44.48,2.7,;44.48,4.29,;45.79,1.9,;41.86,-.48,;40.54,.32,;40.54,1.9,;39.25,-.48,;39.25,-2.07,;40.54,-2.86,;41.92,-2.22,;42.95,-3.4,;42.17,-4.78,;42.64,-6.29,;41.63,-7.47,;40.16,-7.14,;39.69,-5.63,;40.7,-4.44,;37.94,.32,;36.63,-.47,;36.63,-2.07,;35.32,.32,;35.32,1.91,;36.63,2.71,;36.63,4.29,;35.32,5.08,;37.94,5.08,;33.99,-.47,;32.7,.32,;32.7,1.91,;31.37,-.47,;30.07,.33,;28.77,-.47,;28.77,-2.06,;27.45,.33,;27.45,1.92,;28.77,2.72,;30.08,1.91,;31.38,2.71,;31.38,4.3,;30.08,5.09,;28.77,4.3,;26.16,-.46,;24.84,.33,;24.84,1.92,;23.53,-.46,;23.53,-2.05,;24.84,-2.84,;26.15,-2.05,;24.84,-4.43,;22.23,.34,;20.91,-.46,;20.91,-2.05,;19.6,.34,;19.6,1.92,;20.91,2.73,;20.91,4.31,;19.61,5.1,;22.24,5.1,;18.3,-.45,;16.98,.34,;16.98,1.93,;15.68,-.45,;15.68,-2.04,;14.38,.35,;13.06,-.44,;13.06,-2.04,;11.76,.35,;11.76,1.93,;13.06,2.74,;13.06,4.32,;14.38,5.11,;14.38,6.7,;13.07,7.5,;15.67,7.5,;10.44,-.44,;9.13,.35,;9.13,1.94,;7.82,-.43,;7.82,-2.03,;9.13,-2.82,;9.13,-4.42,;10.46,-5.19,;10.46,-6.73,;11.8,-7.5,;9.13,-7.5,;6.5,.36,;5.22,-.42,;5.22,-2.03,;3.9,.37,;3.9,1.95,;5.24,2.72,;5.24,4.26,;3.9,5.03,;6.57,5.03,;2.6,-.42,;1.29,.37,;1.29,1.95,;-.03,-.42,;-.03,-2.02,;1.29,-2.81,;2.58,-2.02,;1.29,-4.4,;-1.34,.37,;-2.65,-.41,;-2.65,-2.01,;-3.96,.38,;-3.96,1.96,;-2.65,2.76,;-2.65,4.35,;-1.32,1.96,;-5.25,-.41,;-6.57,.38,;-6.57,1.96,;-7.87,-.41,;-7.87,-2.01,;-6.57,-2.8,;-5.27,-2.01,;-3.96,-2.8,;-3.95,-4.39,;-2.64,-5.19,;-5.26,-5.19,;-6.57,-4.39,;-9.19,.38,;-10.5,-.4,;-10.5,-2,;-11.81,.38,;-11.81,1.97,;-10.5,2.77,;-10.5,4.36,;-9.2,5.15,;-9.2,6.74,;-13.11,-.4,;-14.42,.39,;-14.42,1.97,;-15.72,-.4,;-15.72,-2,;-14.42,-2.79,;-17.05,.39,;-18.35,-.39,;-18.35,-1.99,;-19.65,.39,;-19.65,1.98,;-18.35,2.78,;-17.04,1.98,;-15.73,2.78,;-15.73,4.36,;-14.41,5.16,;-17.04,5.16,;-18.35,4.37,;-20.97,-.39,;-22.27,.4,;-22.27,1.98,;-23.59,-.39,;-23.59,-1.98,;-22.27,-2.78,;-20.98,-1.98,;-22.27,-4.37,;-24.89,.4,;-26.21,-.39,;-26.21,-1.98,;-27.52,.4,;-27.52,1.99,;-26.21,2.79,;-28.82,-.38,;-30.14,.41,;-30.14,1.99,;-31.43,-.38,;-32.75,.41,;-34.05,-.38,;-34.05,-1.97,;-35.37,.41,;-35.37,2,;-34.05,2.8,;-32.75,1.99,;-31.43,2.79,;-31.43,4.38,;-32.74,5.18,;-34.04,4.39,;-36.67,-.37,;-37.99,.41,;-37.99,2,;-39.29,-.37,;-40.6,.42,;-41.91,-.37,;-41.91,-1.96,;-43.2,.42,;-44.53,-.36,;-45.84,.42,;-45.84,2.01,;-47.14,-.36,;-47.14,-1.95,;-45.84,-2.75,;-45.84,-4.34,;-47.14,-5.14,;-44.54,-5.14,;-48.45,.42,;-49.76,-.36,;-49.76,-1.95,;-51.08,.42,;-51.08,2.02,;-49.74,2.82,;-52.37,-.37,;-53.74,.42,;-53.74,1.96,;-55.06,2.72,;-56.33,1.85,;-57.56,2.78,;-57.06,4.25,;-55.51,4.22,;-55.07,-.36,;-56.41,.42,;-55.07,-1.91,;-39.29,-1.96,;-40.6,-2.76,;-37.99,-2.76,;-31.43,-1.97,;-32.75,-2.77,;-30.14,-2.77,;31.37,-2.06,;32.7,-2.85,;30.07,-2.85,;48.4,.31,;48.4,1.89,;49.72,-.49,;51.02,.3,;51.02,1.89,;52.33,2.69,;53.64,1.89,;52.33,4.28,;52.33,-.49,;52.33,-2.08,;53.64,.3,;54.95,-.5,;54.95,-2.09,;53.64,-2.88,;56.26,-2.88,;56.26,.3,;57.56,-.5,;56.26,1.88,)| Show InChI InChI=1S/C155H227N43O50S/c1-73(2)54-98(136(230)180-97(49-53-249-11)135(229)188-105(62-116(160)210)146(240)197-123(77(8)202)126(161)220)183-140(234)104(60-84-66-169-89-29-19-18-28-88(84)89)187-134(228)95(43-47-115(159)209)181-150(244)122(75(5)6)196-144(238)102(56-80-24-14-12-15-25-80)186-142(236)107(64-120(216)217)189-133(227)94(42-46-114(158)208)174-127(221)76(7)172-129(223)91(31-22-51-167-154(162)163)175-130(224)92(32-23-52-168-155(164)165)176-132(226)96(44-48-118(212)213)179-141(235)106(63-119(214)215)190-137(231)99(55-74(3)4)182-138(232)100(58-82-33-37-86(205)38-34-82)184-131(225)90(30-20-21-50-156)177-148(242)111(70-200)193-139(233)101(59-83-35-39-87(206)40-36-83)185-143(237)108(65-121(218)219)191-149(243)112(71-201)194-152(246)125(79(10)204)198-145(239)103(57-81-26-16-13-17-27-81)192-151(245)124(78(9)203)195-117(211)68-170-128(222)93(41-45-113(157)207)178-147(241)110(69-199)173-109(153(247)248)61-85-67-166-72-171-85/h12-19,24-29,33-40,66-67,72-79,90-112,122-125,169,173,199-206H,20-23,30-32,41-65,68-71,156H2,1-11H3,(H2,157,207)(H2,158,208)(H2,159,209)(H2,160,210)(H2,161,220)(H,166,171)(H,170,222)(H,172,223)(H,174,221)(H,175,224)(H,176,226)(H,177,242)(H,178,241)(H,179,235)(H,180,230)(H,181,244)(H,182,232)(H,183,234)(H,184,225)(H,185,237)(H,186,236)(H,187,228)(H,188,229)(H,189,227)(H,190,231)(H,191,243)(H,192,245)(H,193,233)(H,194,246)(H,195,211)(H,196,238)(H,197,240)(H,198,239)(H,212,213)(H,214,215)(H,216,217)(H,218,219)(H,247,248)(H4,162,163,167)(H4,164,165,168)/t76-,77+,78+,79+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0490 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon receptor (Homo sapiens (Human)) | BDBM50324711 (CHEMBL1222085) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:208.216,180.193,170.177,150.163,135.144,115.122,98.106,76.86,62.70,43.53,30.37,8.12,234.240,wD:199.210,191.197,222.230,176.181,225.233,162.171,144.150,123.135,107.114,87.97,71.74,54.61,39.41,16.28,4.4,242.248,243.251,212.217,(49.79,-5.31,;48.47,-4.51,;48.47,-2.92,;47.17,-2.13,;47.17,-.53,;45.86,.27,;44.55,-.53,;44.55,-2.12,;43.23,.27,;43.23,1.86,;44.55,2.66,;44.55,4.25,;45.86,1.86,;41.93,-.53,;40.61,.27,;40.61,1.86,;39.3,-.52,;39.3,-2.12,;40.61,-2.91,;41.99,-2.27,;43.01,-3.45,;42.24,-4.84,;42.68,-6.28,;41.66,-7.38,;40.18,-7.04,;39.74,-5.59,;40.77,-4.49,;37.99,.28,;36.68,-.52,;36.68,-2.12,;35.37,.28,;35.37,1.87,;36.68,2.67,;36.68,4.26,;35.37,5.05,;38,5.05,;34.05,-.52,;32.75,.28,;32.75,1.87,;31.43,-.52,;30.12,.29,;28.81,-.51,;28.81,-2.11,;27.48,.29,;27.48,1.88,;28.81,2.68,;30.12,1.87,;31.43,2.67,;31.43,4.26,;30.13,5.06,;28.82,4.27,;26.19,-.51,;24.87,.29,;24.87,1.88,;23.57,-.51,;23.57,-2.1,;24.87,-2.89,;26.22,-2.15,;24.83,-4.44,;22.25,.3,;20.94,-.5,;20.94,-2.1,;19.62,.3,;19.62,1.89,;20.94,2.69,;20.94,4.28,;22.29,5.05,;22.29,6.6,;18.32,-.5,;17,.3,;17,1.89,;15.7,-.5,;15.7,-2.09,;14.4,.3,;13.07,-.49,;13.07,-2.09,;11.76,.31,;11.76,1.9,;13.07,2.7,;13.07,4.28,;14.39,5.08,;14.39,6.67,;13.08,7.46,;15.69,7.47,;10.45,-.48,;9.13,.31,;9.13,1.91,;7.82,-.48,;7.82,-2.03,;9.18,-2.81,;9.18,-4.36,;10.52,-5.14,;10.52,-6.69,;11.85,-7.47,;9.16,-7.46,;6.51,.32,;5.22,-.47,;5.22,-2.08,;3.89,.32,;3.89,1.91,;5.24,2.69,;5.24,4.24,;3.89,5.02,;6.58,5.02,;2.59,-.47,;1.28,.33,;1.28,1.92,;-.05,-.46,;-.05,-2.06,;1.28,-2.85,;2.57,-2.06,;1.28,-4.45,;-1.35,.33,;-2.67,-.46,;-2.67,-2.06,;-3.98,.33,;-3.98,1.92,;-2.67,2.72,;-2.67,4.31,;-1.33,1.92,;-5.28,-.46,;-6.6,.34,;-6.6,1.93,;-7.9,-.45,;-7.9,-2.06,;-6.6,-2.85,;-5.29,-2.06,;-3.98,-2.85,;-3.98,-4.44,;-2.66,-5.24,;-5.29,-5.24,;-6.6,-4.44,;-9.22,.34,;-10.53,-.45,;-10.53,-2.05,;-11.84,.34,;-11.84,1.93,;-10.53,2.73,;-10.53,4.32,;-9.23,5.12,;-9.23,6.71,;-13.15,-.45,;-14.46,.35,;-14.46,1.93,;-15.76,-.44,;-15.76,-2.05,;-14.46,-2.84,;-17.1,.35,;-18.39,-.44,;-18.39,-2.04,;-19.7,.35,;-19.7,1.94,;-18.39,2.74,;-17.08,1.94,;-15.77,2.74,;-15.77,4.33,;-14.45,5.13,;-17.09,5.13,;-18.4,4.33,;-21.02,-.44,;-22.33,.36,;-22.33,1.94,;-23.65,-.43,;-23.65,-2.03,;-22.33,-2.83,;-21.03,-2.03,;-22.33,-4.42,;-24.95,.36,;-26.27,-.43,;-26.27,-2.03,;-27.58,.36,;-27.58,1.95,;-26.27,2.75,;-28.88,-.43,;-30.21,.36,;-30.21,1.95,;-31.5,-.43,;-32.82,.37,;-34.13,-.42,;-34.13,-2.02,;-35.44,.37,;-35.44,1.96,;-34.13,2.76,;-32.83,1.96,;-31.5,2.75,;-31.5,4.35,;-32.81,5.15,;-34.12,4.35,;-36.75,-.42,;-38.06,.37,;-38.06,1.96,;-39.38,-.42,;-40.69,.38,;-42,-.41,;-42,-2.01,;-43.29,.38,;-44.62,-.41,;-45.93,.38,;-45.93,1.97,;-47.24,-.41,;-47.24,-2,;-45.93,-2.8,;-45.93,-4.39,;-47.24,-5.19,;-44.63,-5.19,;-48.55,.38,;-49.86,-.41,;-49.86,-2,;-51.19,.38,;-51.19,1.98,;-49.85,2.78,;-52.47,-.41,;-53.83,.38,;-53.83,1.91,;-55.16,2.67,;-56.42,1.81,;-57.66,2.73,;-57.16,4.2,;-55.61,4.17,;-55.18,-.4,;-56.51,.38,;-55.18,-1.95,;-39.38,-2.01,;-40.69,-2.81,;-38.06,-2.81,;-31.5,-2.02,;-32.82,-2.82,;-30.21,-2.82,;31.43,-2.11,;32.75,-2.9,;30.12,-2.9,;48.47,.26,;48.47,1.85,;49.8,-.54,;51.1,.26,;51.1,1.85,;52.42,2.65,;53.73,1.85,;52.42,4.24,;52.42,-.54,;52.42,-2.13,;53.72,.26,;55.03,-.54,;55.03,-2.14,;53.72,-2.93,;56.35,-2.93,;56.35,.26,;57.66,-.55,;56.35,1.84,)| Show InChI InChI=1S/C156H231N43O49S/c1-75(2)56-100(137(230)181-99(50-55-249-11)136(229)189-107(64-117(161)210)147(240)198-124(79(8)203)127(162)220)184-141(234)106(62-86-68-170-91-31-19-18-30-90(86)91)188-135(228)97(45-48-116(160)209)182-151(244)123(77(5)6)197-145(238)104(58-82-26-14-12-15-27-82)187-143(236)109(66-121(216)217)190-132(225)92(32-20-22-51-157)175-128(221)78(7)173-130(223)94(34-24-53-168-155(163)164)176-131(224)95(35-25-54-169-156(165)166)177-134(227)98(46-49-119(212)213)180-142(235)108(65-120(214)215)191-138(231)101(57-76(3)4)183-139(232)102(60-84-36-40-88(206)41-37-84)185-133(226)93(33-21-23-52-158)178-149(242)113(72-201)194-140(233)103(61-85-38-42-89(207)43-39-85)186-144(237)110(67-122(218)219)192-150(243)114(73-202)195-153(246)126(81(10)205)199-146(239)105(59-83-28-16-13-17-29-83)193-152(245)125(80(9)204)196-118(211)70-171-129(222)96(44-47-115(159)208)179-148(241)112(71-200)174-111(154(247)248)63-87-69-167-74-172-87/h12-19,26-31,36-43,68-69,74-81,92-114,123-126,170,174,200-207H,20-25,32-35,44-67,70-73,157-158H2,1-11H3,(H2,159,208)(H2,160,209)(H2,161,210)(H2,162,220)(H,167,172)(H,171,222)(H,173,223)(H,175,221)(H,176,224)(H,177,227)(H,178,242)(H,179,241)(H,180,235)(H,181,230)(H,182,244)(H,183,232)(H,184,234)(H,185,226)(H,186,237)(H,187,236)(H,188,228)(H,189,229)(H,190,225)(H,191,231)(H,192,243)(H,193,245)(H,194,233)(H,195,246)(H,196,211)(H,197,238)(H,198,240)(H,199,239)(H,212,213)(H,214,215)(H,216,217)(H,218,219)(H,247,248)(H4,163,164,168)(H4,165,166,169)/t78-,79+,80+,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,123-,124-,125-,126-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0770 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon receptor (Homo sapiens (Human)) | BDBM50324716 (CHEMBL1222090) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:181.194,171.178,151.164,136.145,116.123,99.107,77.87,63.71,43.53,30.37,8.12,235.241,209.217,wD:192.198,223.231,177.182,226.234,163.172,145.151,124.136,108.115,88.98,72.75,54.62,39.41,16.28,4.4,243.249,244.252,213.218,200.211,(49.67,-5.25,;48.36,-4.46,;48.36,-2.87,;47.06,-2.08,;47.06,-.49,;45.75,.31,;44.45,-.48,;44.45,-2.07,;43.13,.31,;43.13,1.9,;44.45,2.7,;44.45,4.28,;45.75,1.9,;41.82,-.48,;40.51,.31,;40.51,1.9,;39.21,-.48,;39.21,-2.07,;40.51,-2.86,;41.89,-2.22,;42.91,-3.4,;42.14,-4.78,;42.61,-6.29,;41.59,-7.47,;40.12,-7.13,;39.65,-5.62,;40.67,-4.44,;37.9,.32,;36.59,-.47,;36.59,-2.07,;35.28,.32,;35.28,1.91,;36.59,2.71,;36.59,4.29,;35.29,5.08,;37.91,5.08,;33.97,-.47,;32.67,.32,;32.67,1.91,;31.36,-.47,;30.05,.33,;28.74,-.47,;28.74,-2.06,;27.42,.33,;27.42,1.92,;28.74,2.72,;30.09,1.98,;31.41,2.78,;31.37,4.32,;30.01,5.06,;28.7,4.25,;26.13,-.46,;24.8,.33,;24.8,1.92,;23.51,-.46,;23.51,-2.05,;24.8,-2.84,;24.77,-4.38,;23.41,-5.12,;26.08,-5.19,;22.2,.34,;20.89,-.46,;20.89,-2.05,;19.58,.34,;19.58,1.92,;20.89,2.73,;20.89,4.31,;22.23,5.08,;22.23,6.62,;18.27,-.45,;16.96,.34,;16.96,1.93,;15.65,-.45,;15.65,-2.04,;14.36,.35,;13.04,-.44,;13.04,-2.04,;11.73,.35,;11.73,1.93,;13.04,2.74,;13.04,4.32,;14.36,5.11,;14.36,6.71,;13.04,7.49,;15.66,7.5,;10.43,-.44,;9.11,.35,;9.11,1.94,;7.8,-.43,;7.8,-2.03,;9.11,-2.82,;9.11,-4.41,;10.44,-5.19,;10.44,-6.73,;11.78,-7.5,;9.11,-7.5,;6.49,.36,;5.2,-.42,;5.2,-2.03,;3.88,.37,;3.88,1.95,;5.22,2.72,;5.22,4.26,;3.88,5.03,;6.55,5.03,;2.58,-.42,;1.26,.37,;1.26,1.95,;-.05,-.42,;-.05,-2.01,;1.26,-2.81,;2.56,-2.01,;1.26,-4.4,;-1.36,.37,;-2.66,-.41,;-2.66,-2.01,;-3.97,.37,;-3.97,1.96,;-2.66,2.76,;-2.66,4.35,;-1.35,1.96,;-5.28,-.41,;-6.59,.38,;-6.59,1.96,;-7.89,-.41,;-7.89,-2.01,;-6.59,-2.8,;-5.28,-2.01,;-3.98,-2.8,;-3.98,-4.39,;-2.66,-5.19,;-5.28,-5.18,;-6.59,-4.39,;-9.22,.38,;-10.52,-.4,;-10.52,-2,;-11.82,.38,;-11.82,1.97,;-10.52,2.77,;-10.52,4.36,;-9.21,5.16,;-9.21,6.74,;-13.13,-.4,;-14.43,.39,;-14.43,1.97,;-15.76,-.4,;-15.76,-2,;-14.43,-2.79,;-17.07,.39,;-18.37,-.39,;-18.37,-1.99,;-19.69,.39,;-19.69,1.98,;-18.37,2.78,;-17.06,1.97,;-15.76,2.77,;-15.75,4.36,;-14.43,5.16,;-17.06,5.17,;-18.37,4.37,;-20.98,-.39,;-22.29,.4,;-22.29,1.98,;-23.61,-.39,;-23.61,-1.98,;-22.29,-2.78,;-20.99,-1.98,;-22.29,-4.37,;-24.91,.4,;-26.23,-.39,;-26.23,-1.98,;-27.53,.4,;-27.53,1.99,;-26.23,2.79,;-28.84,-.38,;-30.16,.41,;-30.16,1.99,;-31.44,-.38,;-32.78,.41,;-34.07,-.38,;-34.07,-1.97,;-35.38,.41,;-35.38,2,;-34.07,2.8,;-32.77,1.99,;-31.45,2.79,;-31.45,4.38,;-32.77,5.18,;-34.07,4.38,;-36.69,-.37,;-37.99,.41,;-37.99,2,;-39.32,-.37,;-40.62,.42,;-41.92,-.37,;-41.92,-1.96,;-43.23,.42,;-44.54,-.36,;-45.85,.42,;-45.85,2.01,;-47.15,-.36,;-47.15,-1.95,;-45.85,-2.75,;-45.85,-4.34,;-47.16,-5.14,;-44.55,-5.14,;-48.46,.42,;-49.77,-.36,;-49.77,-1.95,;-51.09,.42,;-51.09,2.01,;-49.77,2.82,;-52.4,-.36,;-53.73,.42,;-53.73,1.94,;-55.05,2.7,;-56.3,1.84,;-57.53,2.76,;-57.03,4.21,;-55.49,4.18,;-55.06,-.35,;-56.38,.42,;-55.06,-1.89,;-39.32,-1.96,;-40.62,-2.76,;-37.99,-2.76,;-31.44,-1.97,;-32.78,-2.77,;-30.16,-2.77,;31.36,-2.06,;32.67,-2.85,;30.05,-2.85,;48.36,.31,;48.36,1.89,;49.68,-.49,;50.98,.3,;50.98,1.89,;52.29,2.69,;53.6,1.89,;52.29,4.28,;52.29,-.49,;52.29,-2.08,;53.6,.3,;54.91,-.5,;54.91,-2.09,;53.6,-2.88,;56.22,-2.88,;56.22,.3,;57.53,-.5,;56.22,1.88,)| Show InChI InChI=1S/C157H233N43O49S/c1-76(2)58-102(139(232)183-101(52-57-250-11)138(231)191-109(66-118(162)211)148(241)199-125(80(8)204)128(163)221)186-143(236)108(64-87-69-171-92-31-19-18-30-91(87)92)190-136(229)98(45-49-117(161)210)184-152(245)124(78(5)6)198-146(239)106(60-83-26-14-12-15-27-83)188-137(230)100(47-51-121(215)216)181-132(225)93(32-20-22-53-158)176-129(222)79(7)174-131(224)95(34-24-55-169-156(164)165)177-133(226)96(35-25-56-170-157(166)167)178-135(228)99(46-50-120(213)214)182-144(237)110(67-122(217)218)192-140(233)103(59-77(3)4)185-141(234)104(62-85-36-40-89(207)41-37-85)187-134(227)94(33-21-23-54-159)179-150(243)114(73-202)195-142(235)105(63-86-38-42-90(208)43-39-86)189-145(238)111(68-123(219)220)193-151(244)115(74-203)196-154(247)127(82(10)206)200-147(240)107(61-84-28-16-13-17-29-84)194-153(246)126(81(9)205)197-119(212)71-172-130(223)97(44-48-116(160)209)180-149(242)113(72-201)175-112(155(248)249)65-88-70-168-75-173-88/h12-19,26-31,36-43,69-70,75-82,93-115,124-127,171,175,201-208H,20-25,32-35,44-68,71-74,158-159H2,1-11H3,(H2,160,209)(H2,161,210)(H2,162,211)(H2,163,221)(H,168,173)(H,172,223)(H,174,224)(H,176,222)(H,177,226)(H,178,228)(H,179,243)(H,180,242)(H,181,225)(H,182,237)(H,183,232)(H,184,245)(H,185,234)(H,186,236)(H,187,227)(H,188,230)(H,189,238)(H,190,229)(H,191,231)(H,192,233)(H,193,244)(H,194,246)(H,195,235)(H,196,247)(H,197,212)(H,198,239)(H,199,241)(H,200,240)(H,213,214)(H,215,216)(H,217,218)(H,219,220)(H,248,249)(H4,164,165,169)(H4,166,167,170)/t79-,80+,81+,82+,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,124-,125-,126-,127-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0680 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon receptor (Homo sapiens (Human)) | BDBM50324717 (CHEMBL1222091) Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:173.179,145.156,135.140,115.126,100.107,80.85,63.69,41.49,27.33,8.16,196.200,219.225,235.241,250.256,251.259,wD:164.173,156.160,187.193,141.144,190.196,127.134,109.113,88.98,72.77,52.60,36.37,19.24,4.4,2.2,205.209,227.233,243.249,244.252,177.180,(30.83,-4.4,;30.87,-2.85,;29.55,-2.06,;28.24,-2.86,;29.55,-.47,;28.24,.33,;26.94,-.47,;26.94,-2.06,;25.62,.33,;25.62,1.92,;26.94,2.72,;28.25,1.91,;29.55,2.71,;29.56,4.3,;28.25,5.09,;26.94,4.31,;24.32,-.46,;23,.33,;23,1.92,;21.7,-.46,;21.7,-2.05,;23,-2.84,;24.35,-2.11,;22.96,-4.39,;20.39,.34,;19.07,-.46,;19.07,-2.05,;17.76,.34,;17.76,1.93,;19.07,2.73,;19.07,4.32,;20.42,5.09,;20.42,6.63,;16.45,-.45,;15.14,.34,;15.14,1.93,;13.83,-.45,;13.83,-2.04,;12.54,.35,;11.21,-.44,;11.21,-2.04,;9.91,.35,;9.91,1.93,;11.21,2.75,;11.21,4.32,;12.54,5.11,;12.54,6.71,;11.22,7.5,;13.83,7.5,;8.59,-.44,;7.28,.35,;7.28,1.95,;5.97,-.43,;5.97,-2.03,;7.28,-2.83,;7.28,-4.42,;8.61,-5.19,;8.61,-6.73,;9.95,-7.5,;7.28,-7.5,;4.65,.36,;3.37,-.42,;3.37,-2.03,;2.04,.37,;2.04,1.95,;3.39,2.72,;3.39,4.27,;2.04,5.04,;4.71,5.04,;.75,-.42,;-.57,.37,;-.57,1.95,;-1.89,-.42,;-1.89,-2.02,;-.57,-2.81,;.73,-2.02,;-.57,-4.4,;-3.2,.37,;-4.5,-.41,;-4.5,-2.01,;-5.81,.37,;-5.81,1.96,;-4.5,2.76,;-4.5,4.35,;-3.18,1.96,;-7.11,-.41,;-8.43,.38,;-8.43,1.96,;-9.73,-.41,;-9.73,-2.01,;-8.43,-2.8,;-7.12,-2.01,;-5.81,-2.81,;-5.81,-4.4,;-4.49,-5.19,;-7.12,-5.19,;-8.43,-4.39,;-11.05,.38,;-12.37,-.4,;-12.37,-2,;-13.66,.38,;-13.66,1.97,;-12.37,2.77,;-12.37,4.36,;-11.06,5.16,;-11.06,6.75,;-14.98,-.4,;-16.28,.39,;-16.28,1.97,;-17.59,-.4,;-17.59,-2,;-16.28,-2.79,;-18.92,.39,;-20.21,-.39,;-20.21,-1.99,;-21.52,.39,;-21.52,1.98,;-20.21,2.78,;-18.91,1.98,;-17.59,2.78,;-17.59,4.37,;-16.27,5.17,;-18.91,5.17,;-20.22,4.37,;-22.83,-.39,;-24.14,.4,;-24.14,1.98,;-25.46,-.39,;-25.46,-1.98,;-24.14,-2.78,;-22.84,-1.98,;-24.14,-4.37,;-26.76,.4,;-28.08,-.39,;-28.08,-1.98,;-29.39,.4,;-29.39,1.99,;-28.08,2.79,;-30.68,-.38,;-32.01,.41,;-32.01,1.99,;-33.3,-.38,;-34.62,.41,;-35.93,-.38,;-35.93,-1.97,;-37.24,.41,;-37.24,2,;-35.93,2.8,;-34.63,1.99,;-33.3,2.8,;-33.31,4.38,;-34.62,5.19,;-35.92,4.39,;-38.55,-.37,;-39.85,.41,;-39.85,2,;-41.17,-.37,;-42.48,.42,;-43.79,-.37,;-43.79,-1.96,;-45.08,.42,;-46.41,-.36,;-47.72,.42,;-47.72,2.01,;-49.02,-.36,;-49.02,-1.95,;-47.72,-2.75,;-47.72,-4.35,;-49.02,-5.14,;-46.42,-5.14,;-50.33,.42,;-51.64,-.36,;-51.64,-1.95,;-52.97,.43,;-52.97,2.02,;-51.63,2.82,;-54.27,-.36,;-55.6,.42,;-55.6,1.94,;-56.92,2.7,;-58.17,1.84,;-59.4,2.76,;-58.91,4.22,;-57.36,4.19,;-56.94,-.35,;-58.26,.42,;-56.94,-1.89,;-41.17,-1.96,;-42.48,-2.77,;-39.85,-2.76,;-33.3,-1.97,;-34.62,-2.78,;-32.01,-2.77,;30.87,.32,;30.87,1.91,;32.17,-.47,;33.48,.32,;33.48,1.91,;34.82,2.68,;34.82,4.22,;33.48,4.99,;36.15,4.99,;34.79,-.47,;34.79,-2.07,;36.1,.32,;37.41,-.48,;37.41,-2.07,;38.72,-2.86,;40.09,-2.22,;41.12,-3.4,;40.35,-4.79,;40.81,-6.29,;39.8,-7.47,;38.32,-7.13,;37.85,-5.62,;38.87,-4.45,;38.72,.32,;38.72,1.9,;40.03,-.48,;41.33,.31,;41.33,1.9,;42.65,2.7,;42.65,4.29,;43.96,1.9,;42.65,-.48,;42.65,-2.08,;43.96,.31,;45.27,-.49,;45.27,-2.08,;46.57,-2.87,;46.57,-4.46,;47.88,-5.26,;46.57,.31,;46.57,1.89,;47.89,-.49,;49.19,.3,;49.19,1.89,;50.51,2.69,;51.82,1.89,;50.51,4.28,;50.51,-.49,;50.51,-2.09,;51.81,.3,;53.12,-.5,;53.12,-2.09,;51.81,-2.88,;54.44,-2.88,;54.44,.3,;54.44,1.88,;55.75,-.5,;56.96,.2,;56.96,1.61,;55.75,2.32,;58.18,2.32,;58.18,-.5,;59.4,.2,;58.18,-1.91,)| Show InChI InChI=1S/C161H240N44O51S/c1-13-79(6)126(155(251)187-100(47-50-119(165)216)139(235)193-109(64-89-70-175-94-33-21-20-32-93(89)94)145(241)189-103(58-77(2)3)141(237)186-102(52-57-257-12)140(236)194-110(66-120(166)217)151(247)205-130(84(11)212)158(254)203-127(81(8)209)131(167)227)202-149(245)107(60-85-28-16-14-17-29-85)192-147(243)112(68-124(223)224)195-136(232)95(34-22-24-53-162)180-132(228)80(7)178-134(230)97(36-26-55-173-160(168)169)181-135(231)98(37-27-56-174-161(170)171)182-138(234)101(48-51-122(219)220)185-146(242)111(67-123(221)222)196-142(238)104(59-78(4)5)188-143(239)105(62-87-38-42-91(213)43-39-87)190-137(233)96(35-23-25-54-163)183-153(249)116(74-207)199-144(240)106(63-88-40-44-92(214)45-41-88)191-148(244)113(69-125(225)226)197-154(250)117(75-208)200-157(253)129(83(10)211)204-150(246)108(61-86-30-18-15-19-31-86)198-156(252)128(82(9)210)201-121(218)72-176-133(229)99(46-49-118(164)215)184-152(248)115(73-206)179-114(159(255)256)65-90-71-172-76-177-90/h14-21,28-33,38-45,70-71,76-84,95-117,126-130,175,179,206-214H,13,22-27,34-37,46-69,72-75,162-163H2,1-12H3,(H2,164,215)(H2,165,216)(H2,166,217)(H2,167,227)(H,172,177)(H,176,229)(H,178,230)(H,180,228)(H,181,231)(H,182,234)(H,183,249)(H,184,248)(H,185,242)(H,186,237)(H,187,251)(H,188,239)(H,189,241)(H,190,233)(H,191,244)(H,192,243)(H,193,235)(H,194,236)(H,195,232)(H,196,238)(H,197,250)(H,198,252)(H,199,240)(H,200,253)(H,201,218)(H,202,245)(H,203,254)(H,204,246)(H,205,247)(H,219,220)(H,221,222)(H,223,224)(H,225,226)(H,255,256)(H4,168,169,173)(H4,170,171,174)/t79-,80-,81+,82+,83+,84+,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,126-,127-,128-,129-,130-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0730 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon receptor (Homo sapiens (Human)) | BDBM50324725 (CHEMBL1222099) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc2cnc[nH]2)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O |r,wU:177.185,149.162,139.146,119.132,104.113,84.91,72.75,211.218,62.64,43.53,30.37,8.12,233.240,wD:181.186,168.179,160.166,191.199,145.150,194.202,131.140,113.119,92.104,76.83,200.207,222.229,54.61,39.41,16.28,4.4,241.248,242.251,(14.09,-1.66,;12.78,-.87,;12.78,.73,;11.47,1.51,;11.47,3.11,;10.17,3.91,;8.86,3.11,;8.86,1.52,;7.55,3.91,;7.55,5.49,;8.86,6.29,;8.86,7.88,;10.17,5.49,;6.24,3.11,;4.93,3.91,;4.93,5.5,;3.62,3.11,;3.62,1.52,;4.93,.73,;6.31,1.37,;7.33,.19,;6.56,-1.19,;7.02,-2.69,;6.01,-3.87,;4.54,-3.54,;4.06,-2.03,;5.08,-.85,;2.32,3.91,;1,3.12,;1,1.53,;-.3,3.92,;-.3,5.5,;1,6.3,;1,7.9,;-.3,8.68,;2.32,8.69,;-1.61,3.12,;-2.92,3.92,;-2.92,5.51,;-4.23,3.12,;-5.54,3.92,;-6.85,3.13,;-6.85,1.54,;-8.16,3.93,;-8.16,5.51,;-6.85,6.31,;-5.54,5.51,;-4.23,6.31,;-4.23,7.9,;-5.54,8.7,;-6.84,7.91,;-9.46,3.13,;-10.78,3.93,;-10.78,5.52,;-12.08,3.13,;-12.08,1.54,;-10.78,.75,;-9.46,1.54,;-10.78,-.84,;-13.4,3.93,;-14.71,3.14,;-14.71,1.54,;-16.02,3.94,;-16.02,5.52,;-14.71,6.32,;-14.71,7.91,;-16.04,8.69,;-23.81,11.77,;-30.38,7.89,;-31.73,8.66,;-30.38,6.32,;-31.73,5.55,;-31.73,3.96,;-33.02,3.17,;-34.33,3.97,;-34.33,5.55,;-35.65,3.18,;-35.65,1.58,;-34.33,.79,;-33.04,1.58,;-34.33,-.8,;-36.96,3.97,;-38.27,3.18,;-38.27,1.58,;-39.58,3.97,;-39.58,5.56,;-38.27,6.36,;-38.27,7.94,;-36.94,5.56,;-40.87,3.18,;-42.2,3.97,;-42.2,5.56,;-43.49,3.19,;-43.49,1.59,;-42.2,.8,;-40.89,1.58,;-39.58,.79,;-39.58,-.8,;-38.26,-1.6,;-40.88,-1.59,;-42.19,-.79,;-44.81,3.98,;-46.12,3.19,;-46.12,1.59,;-47.43,3.98,;-47.43,5.57,;-46.12,6.37,;-46.12,7.96,;-44.82,8.76,;-43.45,8.01,;-48.74,3.19,;-50.04,3.98,;-50.04,5.57,;-51.34,3.19,;-51.34,1.6,;-50.04,.81,;-52.67,3.99,;-53.97,3.2,;-53.97,1.61,;-55.27,3.99,;-55.27,5.57,;-53.97,6.37,;-52.66,5.57,;-51.34,6.37,;-51.35,7.96,;-50.03,8.76,;-52.66,8.77,;-53.97,7.97,;-56.59,3.2,;-57.89,3.99,;-57.89,5.58,;-59.21,3.2,;-59.21,1.61,;-57.89,.82,;-56.6,1.61,;-57.89,-.78,;-60.51,4,;-61.83,3.21,;-61.83,1.62,;-63.13,4,;-63.13,5.58,;-61.83,6.38,;-64.43,3.21,;-65.76,4,;-65.76,5.59,;-67.05,3.21,;-68.37,4.01,;-69.67,3.22,;-69.67,1.63,;-70.98,4.01,;-70.98,5.59,;-69.67,6.39,;-68.37,5.59,;-67.05,6.39,;-67.05,7.99,;-68.36,8.78,;-69.66,7.98,;-72.29,3.22,;-73.6,4.01,;-73.6,5.6,;-74.91,3.22,;-76.22,4.01,;-77.53,3.23,;-77.53,1.63,;-78.82,4.02,;-80.15,3.23,;-81.45,4.02,;-81.45,5.61,;-82.76,3.23,;-82.76,1.64,;-81.45,.84,;-81.45,-.75,;-82.76,-1.55,;-80.16,-1.54,;-84.07,4.02,;-85.38,3.23,;-85.38,1.64,;-86.7,4.02,;-86.7,5.61,;-85.36,6.41,;-88,3.23,;-89.35,4.01,;-89.35,5.56,;-90.69,6.33,;-91.96,5.47,;-93.2,6.42,;-92.68,7.9,;-91.11,7.85,;-90.69,3.24,;-92.04,4.01,;-90.69,1.68,;-74.91,1.63,;-76.22,.83,;-73.6,.83,;-67.05,1.62,;-68.37,.82,;-65.76,.83,;-30.4,3.17,;-30.4,1.56,;-29.11,3.96,;-27.8,3.16,;-27.8,1.56,;-26.49,.77,;-26.49,-.82,;-25.17,-1.62,;-25.17,-3.21,;-26.5,-4.01,;-23.88,-4,;-26.49,3.95,;-26.49,5.54,;-25.18,3.16,;-23.87,3.95,;-23.87,5.53,;-22.56,6.34,;-22.56,7.93,;-23.91,8.69,;-25.29,7.91,;-25.32,6.36,;-26.62,8.64,;-22.56,3.15,;-22.56,1.55,;-21.24,3.94,;-19.94,3.14,;-19.94,1.55,;-18.64,3.94,;-18.64,5.52,;-17.32,3.14,;-4.23,1.53,;-2.92,.74,;-5.54,.74,;12.78,3.9,;12.78,5.49,;14.1,3.1,;15.4,3.9,;15.4,5.48,;16.71,6.28,;18.02,5.48,;16.71,7.87,;16.71,3.1,;16.71,1.51,;18.02,3.9,;19.32,3.1,;19.32,1.51,;18.02,.71,;20.63,.72,;20.63,3.89,;21.94,3.09,;20.63,5.48,)| Show InChI InChI=1S/C156H228N42O49S/c1-75(2)56-100(136(227)180-99(50-55-248-11)135(226)188-107(64-117(160)209)146(237)198-126(81(10)204)154(246)247)183-140(231)106(62-86-68-169-91-31-19-18-30-90(86)91)187-134(225)97(45-48-116(159)208)181-150(241)123(77(5)6)196-144(235)104(58-82-26-14-12-15-27-82)186-142(233)109(66-121(214)215)189-131(222)92-33-21-23-52-166-118(210)49-46-98(133(224)176-95(35-25-54-168-156(163)164)130(221)175-94(34-24-53-167-155(161)162)129(220)172-78(7)127(218)174-92)179-141(232)108(65-120(212)213)190-137(228)101(57-76(3)4)182-138(229)102(60-84-36-40-88(205)41-37-84)184-132(223)93(32-20-22-51-157)177-148(239)113(72-200)193-139(230)103(61-85-38-42-89(206)43-39-85)185-143(234)110(67-122(216)217)191-149(240)114(73-201)194-152(243)125(80(9)203)197-145(236)105(59-83-28-16-13-17-29-83)192-151(242)124(79(8)202)195-119(211)70-170-128(219)96(44-47-115(158)207)178-147(238)112(71-199)173-111(153(244)245)63-87-69-165-74-171-87/h12-19,26-31,36-43,68-69,74-81,92-114,123-126,169,173,199-206H,20-25,32-35,44-67,70-73,157H2,1-11H3,(H2,158,207)(H2,159,208)(H2,160,209)(H,165,171)(H,166,210)(H,170,219)(H,172,220)(H,174,218)(H,175,221)(H,176,224)(H,177,239)(H,178,238)(H,179,232)(H,180,227)(H,181,241)(H,182,229)(H,183,231)(H,184,223)(H,185,234)(H,186,233)(H,187,225)(H,188,226)(H,189,222)(H,190,228)(H,191,240)(H,192,242)(H,193,230)(H,194,243)(H,195,211)(H,196,235)(H,197,236)(H,198,237)(H,212,213)(H,214,215)(H,216,217)(H,244,245)(H,246,247)(H4,161,162,167)(H4,163,164,168)/t78-,79+,80+,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,123-,124-,125-,126-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0580 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50324706 (CHEMBL1222080) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)C[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r| Show InChI InChI=1S/C156H229N43O50S/c1-74(2)54-99(138(232)181-98(49-53-250-11)136(230)189-106(63-117(161)211)147(241)198-125(78(8)203)128(162)222)184-142(236)105(60-85-67-170-91-29-19-18-28-90(85)91)188-135(229)97(44-47-116(160)210)182-151(245)124(76(5)6)197-145(239)103(56-81-24-14-12-15-25-81)187-143(237)108(65-122(218)219)190-134(228)96(43-46-115(159)209)177-129(223)77(7)173-131(225)94(32-23-52-169-156(165)166)178-132(226)92(31-22-51-168-155(163)164)176-118(212)62-86(37-48-120(214)215)174-137(231)107(64-121(216)217)191-139(233)100(55-75(3)4)183-140(234)101(58-83-33-38-88(206)39-34-83)185-133(227)93(30-20-21-50-157)179-149(243)112(71-201)194-141(235)102(59-84-35-40-89(207)41-36-84)186-144(238)109(66-123(220)221)192-150(244)113(72-202)195-153(247)127(80(10)205)199-146(240)104(57-82-26-16-13-17-27-82)193-152(246)126(79(9)204)196-119(213)69-171-130(224)95(42-45-114(158)208)180-148(242)111(70-200)175-110(154(248)249)61-87-68-167-73-172-87/h12-19,24-29,33-36,38-41,67-68,73-80,86,92-113,124-127,170,175,200-207H,20-23,30-32,37,42-66,69-72,157H2,1-11H3,(H2,158,208)(H2,159,209)(H2,160,210)(H2,161,211)(H2,162,222)(H,167,172)(H,171,224)(H,173,225)(H,174,231)(H,176,212)(H,177,223)(H,178,226)(H,179,243)(H,180,242)(H,181,232)(H,182,245)(H,183,234)(H,184,236)(H,185,227)(H,186,238)(H,187,237)(H,188,229)(H,189,230)(H,190,228)(H,191,233)(H,192,244)(H,193,246)(H,194,235)(H,195,247)(H,196,213)(H,197,239)(H,198,241)(H,199,240)(H,214,215)(H,216,217)(H,218,219)(H,220,221)(H,248,249)(H4,163,164,168)(H4,165,166,169)/t77-,78+,79+,80+,86-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,124-,125-,126-,127-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.130 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50324708 (CHEMBL1222082) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:207.215,179.192,169.176,149.162,134.143,114.121,98.105,76.86,62.70,43.53,30.37,8.12,233.239,wD:198.209,190.196,221.229,175.180,224.232,161.170,143.149,122.134,106.113,87.97,71.74,54.61,39.41,16.28,4.4,241.247,242.250,211.216,(49.77,-5.35,;48.45,-4.56,;48.45,-2.96,;47.15,-2.17,;47.15,-.58,;45.84,.22,;44.53,-.57,;44.53,-2.17,;43.21,.23,;43.21,1.82,;44.53,2.62,;44.53,4.21,;45.84,1.82,;41.91,-.57,;40.59,.23,;40.59,1.82,;39.28,-.57,;39.28,-2.16,;40.59,-2.95,;41.97,-2.31,;42.99,-3.49,;42.22,-4.88,;42.66,-6.32,;41.64,-7.42,;40.16,-7.08,;39.72,-5.64,;40.75,-4.54,;37.97,.23,;36.66,-.56,;36.66,-2.16,;35.35,.24,;35.35,1.83,;36.66,2.63,;36.66,4.21,;35.36,5,;37.98,5.01,;34.04,-.56,;32.73,.24,;32.73,1.83,;31.4,-.56,;30.09,.24,;28.79,-.55,;28.79,-2.15,;27.46,.25,;27.46,1.83,;28.79,2.64,;30.1,1.83,;31.41,2.63,;31.41,4.22,;30.1,5.01,;28.79,4.22,;26.17,-.55,;24.85,.25,;24.85,1.84,;23.55,-.55,;23.55,-2.14,;24.85,-2.93,;26.16,-2.14,;24.85,-4.53,;22.23,.25,;20.92,-.55,;20.92,-2.14,;19.6,.26,;19.6,1.84,;20.92,2.64,;20.92,4.23,;19.61,5.02,;22.24,5.03,;18.3,-.54,;16.98,.26,;16.98,1.85,;15.68,-.54,;15.68,-2.13,;14.38,.26,;13.05,-.53,;13.05,-2.13,;11.74,.26,;11.74,1.85,;13.05,2.66,;13.05,4.24,;14.37,5.04,;14.37,6.63,;13.06,7.42,;15.67,7.42,;10.43,-.53,;9.12,.27,;9.12,1.86,;7.8,-.52,;7.8,-2.12,;9.16,-2.9,;9.16,-4.45,;10.49,-5.23,;11.85,-4.45,;13.18,-5.23,;11.85,-2.9,;6.49,.28,;5.2,-.51,;5.2,-2.12,;3.87,.28,;3.87,1.87,;5.22,2.65,;6.56,1.87,;5.22,4.2,;2.57,-.51,;1.26,.28,;1.26,1.87,;-.06,-.51,;-.06,-2.11,;1.26,-2.9,;2.55,-2.11,;1.26,-4.49,;-1.37,.29,;-2.68,-.5,;-2.68,-2.1,;-4,.29,;-4,1.88,;-2.68,2.68,;-2.68,4.27,;-1.35,1.88,;-5.3,-.5,;-6.62,.29,;-6.62,1.88,;-7.92,-.5,;-7.92,-2.1,;-6.62,-2.89,;-5.31,-2.1,;-4,-2.89,;-3.99,-4.49,;-2.68,-5.29,;-5.3,-5.28,;-6.62,-4.48,;-9.24,.3,;-10.55,-.49,;-10.55,-2.1,;-11.86,.3,;-11.86,1.89,;-10.55,2.69,;-10.55,4.28,;-9.24,5.08,;-9.24,6.67,;-13.17,-.49,;-14.48,.3,;-14.48,1.89,;-15.78,-.49,;-15.78,-2.09,;-14.48,-2.88,;-17.11,.31,;-18.41,-.48,;-18.41,-2.08,;-19.72,.31,;-19.72,1.9,;-18.41,2.7,;-17.1,1.89,;-15.78,2.69,;-15.79,4.28,;-14.47,5.08,;-17.11,5.08,;-18.41,4.29,;-21.04,-.48,;-22.35,.31,;-22.35,1.9,;-23.67,-.48,;-23.67,-2.07,;-22.35,-2.87,;-21.05,-2.07,;-22.35,-4.46,;-24.97,.32,;-26.29,-.47,;-26.29,-2.07,;-27.59,.32,;-27.59,1.91,;-26.29,2.71,;-28.9,-.47,;-30.23,.32,;-30.23,1.91,;-31.52,-.47,;-32.84,.32,;-34.15,-.47,;-34.15,-2.06,;-35.46,.33,;-35.46,1.92,;-34.15,2.72,;-32.84,1.91,;-31.52,2.71,;-31.52,4.3,;-32.83,5.1,;-34.13,4.31,;-36.77,-.46,;-38.08,.33,;-38.08,1.92,;-39.39,-.46,;-40.71,.33,;-42.01,-.46,;-42.01,-2.05,;-43.31,.34,;-44.64,-.45,;-45.95,.34,;-45.95,1.93,;-47.26,-.45,;-47.26,-2.04,;-45.95,-2.84,;-45.95,-4.44,;-47.26,-5.24,;-44.65,-5.23,;-48.57,.34,;-49.88,-.45,;-49.88,-2.04,;-51.2,.34,;-51.2,1.93,;-49.87,2.74,;-52.49,-.45,;-53.84,.33,;-53.84,1.86,;-55.17,2.62,;-56.43,1.76,;-57.67,2.68,;-57.17,4.15,;-55.62,4.12,;-55.19,-.45,;-56.51,.33,;-55.19,-2,;-39.39,-2.05,;-40.71,-2.85,;-38.08,-2.85,;-31.52,-2.06,;-32.84,-2.86,;-30.23,-2.86,;31.4,-2.15,;32.73,-2.94,;30.09,-2.95,;48.45,.22,;48.45,1.81,;49.78,-.58,;51.08,.22,;51.08,1.81,;52.4,2.61,;53.71,1.81,;52.4,4.2,;52.4,-.58,;52.4,-2.18,;53.7,.22,;55.01,-.59,;55.01,-2.18,;53.7,-2.97,;56.33,-2.97,;56.33,.21,;57.67,-.54,;56.33,1.8,)| Show InChI InChI=1S/C154H225N43O50S/c1-72(2)52-96(134(228)178-95(47-51-248-11)133(227)186-103(60-115(159)209)145(239)196-122(76(8)201)125(160)219)181-138(232)102(58-83-65-168-88-29-19-18-28-87(83)88)185-132(226)94(43-46-114(158)208)179-149(243)121(74(5)6)195-143(237)100(54-79-24-14-12-15-25-79)184-140(234)105(62-118(213)214)187-131(225)93(42-45-113(157)207)173-126(220)75(7)171-128(222)90(31-22-49-166-153(161)162)174-129(223)91(32-23-50-167-154(163)164)175-139(233)104(61-117(211)212)189-142(236)106(63-119(215)216)188-135(229)97(53-73(3)4)180-136(230)98(56-81-33-37-85(204)38-34-81)182-130(224)89(30-20-21-48-155)176-147(241)110(69-199)192-137(231)99(57-82-35-39-86(205)40-36-82)183-141(235)107(64-120(217)218)190-148(242)111(70-200)193-151(245)124(78(10)203)197-144(238)101(55-80-26-16-13-17-27-80)191-150(244)123(77(9)202)194-116(210)67-169-127(221)92(41-44-112(156)206)177-146(240)109(68-198)172-108(152(246)247)59-84-66-165-71-170-84/h12-19,24-29,33-40,65-66,71-78,89-111,121-124,168,172,198-205H,20-23,30-32,41-64,67-70,155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H2,160,219)(H,165,170)(H,169,221)(H,171,222)(H,173,220)(H,174,223)(H,175,233)(H,176,241)(H,177,240)(H,178,228)(H,179,243)(H,180,230)(H,181,232)(H,182,224)(H,183,235)(H,184,234)(H,185,226)(H,186,227)(H,187,225)(H,188,229)(H,189,236)(H,190,242)(H,191,244)(H,192,231)(H,193,245)(H,194,210)(H,195,237)(H,196,239)(H,197,238)(H,211,212)(H,213,214)(H,215,216)(H,217,218)(H,246,247)(H4,161,162,166)(H4,163,164,167)/t75-,76+,77+,78+,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,121-,122-,123-,124-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.570 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50324726 (CHEMBL1222100) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc2cnc[nH]2)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)N1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O |r| Show InChI InChI=1S/C154H225N41O49S/c1-74(2)54-98(133(223)176-97(48-53-245-11)132(222)184-105(62-115(157)206)143(233)195-124(80(10)202)152(243)244)179-137(227)104(60-85-66-166-90-31-19-18-30-89(85)90)183-131(221)96-45-47-116(207)163-50-23-21-33-91(129(219)185-106(63-118(209)210)138(228)182-102(56-81-26-14-12-15-27-81)141(231)193-121(76(5)6)148(238)177-96)171-125(215)77(7)169-127(217)93(34-24-51-164-153(158)159)172-128(218)94(35-25-52-165-154(160)161)174-146(236)112(71-198)190-140(230)108(65-120(213)214)186-134(224)99(55-75(3)4)178-135(225)100(58-83-36-40-87(203)41-37-83)180-130(220)92(32-20-22-49-155)173-145(235)111(70-197)189-136(226)101(59-84-38-42-88(204)43-39-84)181-139(229)107(64-119(211)212)187-147(237)113(72-199)191-150(240)123(79(9)201)194-142(232)103(57-82-28-16-13-17-29-82)188-149(239)122(78(8)200)192-117(208)68-167-126(216)95(44-46-114(156)205)175-144(234)110(69-196)170-109(151(241)242)61-86-67-162-73-168-86/h12-19,26-31,36-43,66-67,73-80,91-113,121-124,166,170,196-204H,20-25,32-35,44-65,68-72,155H2,1-11H3,(H2,156,205)(H2,157,206)(H,162,168)(H,163,207)(H,167,216)(H,169,217)(H,171,215)(H,172,218)(H,173,235)(H,174,236)(H,175,234)(H,176,223)(H,177,238)(H,178,225)(H,179,227)(H,180,220)(H,181,229)(H,182,228)(H,183,221)(H,184,222)(H,185,219)(H,186,224)(H,187,237)(H,188,239)(H,189,226)(H,190,230)(H,191,240)(H,192,208)(H,193,231)(H,194,232)(H,195,233)(H,209,210)(H,211,212)(H,213,214)(H,241,242)(H,243,244)(H4,158,159,164)(H4,160,161,165)/t77-,78+,79+,80+,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,121-,122-,123-,124-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.240 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon receptor (Homo sapiens (Human)) | BDBM50324703 (CHEMBL1222077) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O |r,wU:208.216,180.193,170.177,150.163,135.144,115.122,98.106,76.86,62.70,43.53,30.37,8.12,234.240,wD:199.210,191.197,222.230,176.181,225.233,162.171,144.150,123.135,107.114,87.97,71.74,54.61,39.41,16.28,4.4,242.248,243.251,212.217,(49.71,-5.26,;48.4,-4.46,;48.4,-2.87,;47.1,-2.08,;47.1,-.49,;45.79,.31,;44.48,-.48,;44.48,-2.08,;43.16,.31,;43.16,1.9,;44.48,2.7,;44.48,4.29,;45.79,1.9,;41.86,-.48,;40.55,.32,;40.55,1.9,;39.24,-.48,;39.24,-2.07,;40.55,-2.86,;41.92,-2.22,;42.95,-3.4,;42.18,-4.79,;42.64,-6.29,;41.63,-7.47,;40.15,-7.14,;39.68,-5.63,;40.7,-4.45,;37.93,.32,;36.62,-.47,;36.62,-2.07,;35.31,.32,;35.31,1.91,;36.62,2.71,;36.62,4.3,;35.32,5.08,;37.94,5.09,;34,-.47,;32.69,.32,;32.69,1.91,;31.38,-.47,;30.07,.33,;28.77,-.47,;28.77,-2.06,;27.45,.33,;27.45,1.92,;28.77,2.72,;30.07,1.91,;31.38,2.71,;31.39,4.3,;30.08,5.09,;28.77,4.31,;26.15,-.46,;24.82,.33,;24.82,1.92,;23.53,-.46,;23.53,-2.05,;24.82,-2.84,;26.15,-2.05,;24.82,-4.44,;22.22,.34,;20.91,-.46,;20.91,-2.05,;19.58,.34,;19.58,1.93,;20.91,2.73,;20.91,4.32,;19.59,5.1,;22.22,5.1,;18.28,-.45,;16.98,.34,;16.98,1.93,;15.66,-.45,;15.66,-2.04,;14.37,.35,;13.04,-.44,;13.04,-2.04,;11.73,.35,;11.73,1.93,;13.04,2.75,;13.04,4.32,;14.38,5.11,;14.38,6.71,;13.05,7.5,;15.67,7.5,;10.43,-.44,;9.1,.35,;9.1,1.95,;7.81,-.43,;7.81,-2.03,;9.1,-2.83,;9.1,-4.42,;10.45,-5.19,;10.45,-6.73,;11.78,-7.5,;9.1,-7.5,;6.49,.36,;5.2,-.42,;5.2,-2.03,;3.88,.37,;3.88,1.95,;5.21,2.72,;5.21,4.27,;3.88,5.04,;6.55,5.04,;2.57,-.42,;1.25,.37,;1.25,1.96,;-.07,-.42,;-.07,-2.02,;1.25,-2.81,;2.57,-2.02,;1.25,-4.4,;-1.37,.37,;-2.66,-.41,;-2.66,-2.01,;-3.99,.38,;-3.99,1.96,;-2.66,2.77,;-2.66,4.35,;-1.35,1.96,;-5.29,-.41,;-6.6,.38,;-6.6,1.96,;-7.91,-.41,;-7.91,-2.01,;-6.6,-2.8,;-5.3,-2.01,;-3.99,-2.81,;-3.99,-4.4,;-2.67,-5.19,;-5.3,-5.19,;-6.61,-4.39,;-9.23,.38,;-10.54,-.4,;-10.54,-2,;-11.84,.38,;-11.84,1.97,;-10.54,2.77,;-10.54,4.36,;-9.22,5.16,;-9.22,6.74,;-13.14,-.4,;-14.46,.39,;-14.46,1.97,;-15.77,-.4,;-15.77,-2,;-14.46,-2.79,;-17.08,.39,;-18.39,-.4,;-18.39,-1.99,;-19.7,.39,;-19.7,1.98,;-18.39,2.78,;-17.08,1.98,;-15.77,2.78,;-15.77,4.37,;-14.45,5.16,;-17.07,5.16,;-18.38,4.37,;-21.01,-.39,;-22.32,.4,;-22.32,1.98,;-23.62,-.39,;-23.62,-1.98,;-22.32,-2.78,;-21.01,-1.98,;-22.32,-4.37,;-24.94,.4,;-26.24,-.39,;-26.24,-1.98,;-27.55,.4,;-27.55,1.99,;-26.24,2.79,;-28.86,-.38,;-30.18,.41,;-30.18,1.99,;-31.48,-.38,;-32.8,.41,;-34.11,-.38,;-34.11,-1.97,;-35.42,.41,;-35.42,2,;-34.11,2.8,;-32.81,1.99,;-31.48,2.8,;-31.47,4.38,;-32.79,5.18,;-34.09,4.39,;-36.71,-.37,;-38.03,.41,;-38.03,2,;-39.35,-.37,;-40.64,.42,;-41.96,-.37,;-41.96,-1.96,;-43.26,.42,;-44.59,-.36,;-45.9,.42,;-45.9,2.01,;-47.19,-.36,;-47.19,-1.95,;-45.9,-2.75,;-45.9,-4.35,;-47.2,-5.14,;-44.59,-5.14,;-48.5,.42,;-49.81,-.36,;-49.81,-1.95,;-51.13,.43,;-51.13,2.02,;-49.81,2.82,;-52.43,-.36,;-53.78,.41,;-53.78,1.95,;-55.1,2.71,;-56.37,1.85,;-57.61,2.77,;-57.1,4.25,;-55.55,4.21,;-55.11,-.37,;-56.45,.41,;-55.11,-1.92,;-39.35,-1.96,;-40.64,-2.77,;-38.03,-2.76,;-31.48,-1.97,;-32.8,-2.78,;-30.18,-2.77,;31.38,-2.06,;32.69,-2.85,;30.07,-2.86,;48.4,.31,;48.4,1.89,;49.72,-.49,;51.02,.3,;51.02,1.89,;52.34,2.69,;53.65,1.89,;52.34,4.28,;52.34,-.49,;52.34,-2.09,;53.64,.3,;54.95,-.5,;54.95,-2.09,;53.64,-2.88,;56.27,-2.88,;56.27,.3,;57.61,-.46,;56.27,1.88,)| Show InChI InChI=1S/C155H226N42O51S/c1-73(2)54-98(135(228)179-97(49-53-249-11)134(227)187-105(62-116(160)209)145(238)197-125(79(10)203)153(247)248)182-139(232)104(60-84-66-168-89-29-19-18-28-88(84)89)186-133(226)95(43-47-115(159)208)180-149(242)122(75(5)6)195-143(236)102(56-80-24-14-12-15-25-80)185-141(234)107(64-120(215)216)188-132(225)94(42-46-114(158)207)173-126(219)76(7)171-128(221)91(31-22-51-166-154(161)162)174-129(222)92(32-23-52-167-155(163)164)175-131(224)96(44-48-118(211)212)178-140(233)106(63-119(213)214)189-136(229)99(55-74(3)4)181-137(230)100(58-82-33-37-86(204)38-34-82)183-130(223)90(30-20-21-50-156)176-147(240)111(70-199)192-138(231)101(59-83-35-39-87(205)40-36-83)184-142(235)108(65-121(217)218)190-148(241)112(71-200)193-151(244)124(78(9)202)196-144(237)103(57-81-26-16-13-17-27-81)191-150(243)123(77(8)201)194-117(210)68-169-127(220)93(41-45-113(157)206)177-146(239)110(69-198)172-109(152(245)246)61-85-67-165-72-170-85/h12-19,24-29,33-40,66-67,72-79,90-112,122-125,168,172,198-205H,20-23,30-32,41-65,68-71,156H2,1-11H3,(H2,157,206)(H2,158,207)(H2,159,208)(H2,160,209)(H,165,170)(H,169,220)(H,171,221)(H,173,219)(H,174,222)(H,175,224)(H,176,240)(H,177,239)(H,178,233)(H,179,228)(H,180,242)(H,181,230)(H,182,232)(H,183,223)(H,184,235)(H,185,234)(H,186,226)(H,187,227)(H,188,225)(H,189,229)(H,190,241)(H,191,243)(H,192,231)(H,193,244)(H,194,210)(H,195,236)(H,196,237)(H,197,238)(H,211,212)(H,213,214)(H,215,216)(H,217,218)(H,245,246)(H,247,248)(H4,161,162,166)(H4,163,164,167)/t76-,77+,78+,79+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0530 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon receptor (Homo sapiens (Human)) | BDBM50324706 (CHEMBL1222080) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)C[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r| Show InChI InChI=1S/C156H229N43O50S/c1-74(2)54-99(138(232)181-98(49-53-250-11)136(230)189-106(63-117(161)211)147(241)198-125(78(8)203)128(162)222)184-142(236)105(60-85-67-170-91-29-19-18-28-90(85)91)188-135(229)97(44-47-116(160)210)182-151(245)124(76(5)6)197-145(239)103(56-81-24-14-12-15-25-81)187-143(237)108(65-122(218)219)190-134(228)96(43-46-115(159)209)177-129(223)77(7)173-131(225)94(32-23-52-169-156(165)166)178-132(226)92(31-22-51-168-155(163)164)176-118(212)62-86(37-48-120(214)215)174-137(231)107(64-121(216)217)191-139(233)100(55-75(3)4)183-140(234)101(58-83-33-38-88(206)39-34-83)185-133(227)93(30-20-21-50-157)179-149(243)112(71-201)194-141(235)102(59-84-35-40-89(207)41-36-84)186-144(238)109(66-123(220)221)192-150(244)113(72-202)195-153(247)127(80(10)205)199-146(240)104(57-82-26-16-13-17-27-82)193-152(246)126(79(9)204)196-119(213)69-171-130(224)95(42-45-114(158)208)180-148(242)111(70-200)175-110(154(248)249)61-87-68-167-73-172-87/h12-19,24-29,33-36,38-41,67-68,73-80,86,92-113,124-127,170,175,200-207H,20-23,30-32,37,42-66,69-72,157H2,1-11H3,(H2,158,208)(H2,159,209)(H2,160,210)(H2,161,211)(H2,162,222)(H,167,172)(H,171,224)(H,173,225)(H,174,231)(H,176,212)(H,177,223)(H,178,226)(H,179,243)(H,180,242)(H,181,232)(H,182,245)(H,183,234)(H,184,236)(H,185,227)(H,186,238)(H,187,237)(H,188,229)(H,189,230)(H,190,228)(H,191,233)(H,192,244)(H,193,246)(H,194,235)(H,195,247)(H,196,213)(H,197,239)(H,198,241)(H,199,240)(H,214,215)(H,216,217)(H,218,219)(H,220,221)(H,248,249)(H4,163,164,168)(H4,165,166,169)/t77-,78+,79+,80+,86-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,124-,125-,126-,127-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0540 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon receptor (Homo sapiens (Human)) | BDBM50324719 (CHEMBL1222093 | HAEGTFTSDVSSYLEERRAQDFVQWLMNT) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O |r| Show InChI InChI=1S/C149H220N40O51S/c1-68(2)51-93(173-132(223)95(55-79-33-35-82(196)36-34-79)176-139(230)103(64-190)182-141(232)105(66-192)183-143(234)116(71(7)8)187-138(229)101(60-114(209)210)180-140(231)104(65-191)184-145(236)118(75(12)194)188-136(227)97(54-78-27-19-16-20-28-78)181-144(235)117(74(11)193)185-109(200)63-161-122(213)87(39-44-110(201)202)165-120(211)72(9)163-102(146(237)238)57-81-62-157-67-162-81)130(221)170-91(41-46-112(205)206)126(217)169-90(40-45-111(203)204)125(216)168-86(32-24-49-159-149(155)156)124(215)167-85(31-23-48-158-148(153)154)123(214)164-73(10)121(212)166-88(37-42-106(150)197)127(218)179-100(59-113(207)208)134(225)175-96(53-77-25-17-15-18-26-77)135(226)186-115(70(5)6)142(233)172-89(38-43-107(151)198)128(219)177-98(56-80-61-160-84-30-22-21-29-83(80)84)133(224)174-94(52-69(3)4)131(222)171-92(47-50-241-14)129(220)178-99(58-108(152)199)137(228)189-119(76(13)195)147(239)240/h15-22,25-30,33-36,61-62,67-76,85-105,115-119,160,163,190-196H,23-24,31-32,37-60,63-66H2,1-14H3,(H2,150,197)(H2,151,198)(H2,152,199)(H,157,162)(H,161,213)(H,164,214)(H,165,211)(H,166,212)(H,167,215)(H,168,216)(H,169,217)(H,170,221)(H,171,222)(H,172,233)(H,173,223)(H,174,224)(H,175,225)(H,176,230)(H,177,219)(H,178,220)(H,179,218)(H,180,231)(H,181,235)(H,182,232)(H,183,234)(H,184,236)(H,185,200)(H,186,226)(H,187,229)(H,188,227)(H,189,228)(H,201,202)(H,203,204)(H,205,206)(H,207,208)(H,209,210)(H,237,238)(H,239,240)(H4,153,154,158)(H4,155,156,159)/t72-,73-,74+,75+,76+,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,115-,116-,117-,118-,119-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 50 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon receptor (Homo sapiens (Human)) | BDBM50324726 (CHEMBL1222100) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc2cnc[nH]2)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)N1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O |r| Show InChI InChI=1S/C154H225N41O49S/c1-74(2)54-98(133(223)176-97(48-53-245-11)132(222)184-105(62-115(157)206)143(233)195-124(80(10)202)152(243)244)179-137(227)104(60-85-66-166-90-31-19-18-30-89(85)90)183-131(221)96-45-47-116(207)163-50-23-21-33-91(129(219)185-106(63-118(209)210)138(228)182-102(56-81-26-14-12-15-27-81)141(231)193-121(76(5)6)148(238)177-96)171-125(215)77(7)169-127(217)93(34-24-51-164-153(158)159)172-128(218)94(35-25-52-165-154(160)161)174-146(236)112(71-198)190-140(230)108(65-120(213)214)186-134(224)99(55-75(3)4)178-135(225)100(58-83-36-40-87(203)41-37-83)180-130(220)92(32-20-22-49-155)173-145(235)111(70-197)189-136(226)101(59-84-38-42-88(204)43-39-84)181-139(229)107(64-119(211)212)187-147(237)113(72-199)191-150(240)123(79(9)201)194-142(232)103(57-82-28-16-13-17-29-82)188-149(239)122(78(8)200)192-117(208)68-167-126(216)95(44-46-114(156)205)175-144(234)110(69-196)170-109(151(241)242)61-86-67-162-73-168-86/h12-19,26-31,36-43,66-67,73-80,91-113,121-124,166,170,196-204H,20-25,32-35,44-65,68-72,155H2,1-11H3,(H2,156,205)(H2,157,206)(H,162,168)(H,163,207)(H,167,216)(H,169,217)(H,171,215)(H,172,218)(H,173,235)(H,174,236)(H,175,234)(H,176,223)(H,177,238)(H,178,225)(H,179,227)(H,180,220)(H,181,229)(H,182,228)(H,183,221)(H,184,222)(H,185,219)(H,186,224)(H,187,237)(H,188,239)(H,189,226)(H,190,230)(H,191,240)(H,192,208)(H,193,231)(H,194,232)(H,195,233)(H,209,210)(H,211,212)(H,213,214)(H,241,242)(H,243,244)(H4,158,159,164)(H4,160,161,165)/t77-,78+,79+,80+,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,121-,122-,123-,124-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0780 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50324705 (CHEMBL1222079) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:208.216,180.193,170.177,150.163,135.144,115.122,98.106,76.86,62.70,43.53,30.37,8.12,234.240,wD:199.210,191.197,222.230,176.181,225.233,162.171,144.150,123.135,107.114,87.97,71.74,54.61,39.41,16.28,4.4,242.248,243.251,212.217,(49.72,-5.28,;48.42,-4.48,;48.42,-2.89,;47.11,-2.1,;47.11,-.51,;45.8,.29,;44.5,-.5,;44.5,-2.1,;43.18,.29,;43.18,1.88,;44.5,2.68,;44.5,4.27,;45.81,1.88,;41.87,-.5,;40.55,.3,;40.55,1.88,;39.26,-.5,;39.26,-2.09,;40.55,-2.88,;41.94,-2.24,;42.96,-3.42,;42.19,-4.81,;42.63,-6.25,;41.6,-7.35,;40.12,-7.01,;39.69,-5.56,;40.72,-4.46,;37.95,.3,;36.63,-.49,;36.63,-2.09,;35.32,.3,;35.32,1.89,;36.63,2.69,;36.63,4.28,;35.33,5.06,;37.95,5.07,;34.01,-.49,;32.71,.31,;32.71,1.89,;31.39,-.49,;30.08,.31,;28.78,-.48,;28.78,-2.08,;27.46,.31,;27.46,1.9,;28.78,2.7,;30.09,1.89,;31.39,2.7,;31.39,4.28,;30.09,5.07,;28.78,4.29,;26.16,-.48,;24.84,.31,;24.84,1.9,;23.54,-.48,;23.54,-2.07,;24.84,-2.86,;26.16,-2.07,;24.84,-4.46,;22.23,.32,;20.91,-.48,;20.91,-2.07,;19.6,.32,;19.6,1.91,;20.91,2.71,;20.91,4.3,;19.61,5.08,;22.23,5.08,;18.29,-.47,;16.98,.32,;16.98,1.91,;15.67,-.47,;15.67,-2.06,;14.37,.33,;13.05,-.46,;13.05,-2.06,;11.75,.33,;11.75,1.92,;13.05,2.73,;13.05,4.31,;14.37,5.09,;14.37,6.69,;13.06,7.48,;15.67,7.48,;10.44,-.46,;9.12,.33,;9.12,1.93,;7.81,-.45,;7.81,-2.05,;9.16,-2.83,;9.16,-4.38,;10.5,-5.15,;10.5,-6.7,;11.85,-7.48,;9.16,-7.48,;6.49,.34,;5.21,-.44,;5.21,-2.05,;3.88,.35,;3.88,1.93,;5.23,2.71,;5.23,4.26,;3.88,5.03,;6.56,5.03,;2.59,-.44,;1.27,.35,;1.27,1.94,;-.05,-.44,;-.05,-2.04,;1.27,-2.83,;2.57,-2.04,;1.27,-4.42,;-1.36,.35,;-2.67,-.43,;-2.67,-2.03,;-3.98,.36,;-3.98,1.94,;-2.67,2.75,;-2.67,4.33,;-1.34,1.94,;-5.27,-.43,;-6.6,.36,;-6.6,1.94,;-7.89,-.43,;-7.89,-2.03,;-6.6,-2.82,;-5.28,-2.03,;-3.97,-2.83,;-3.97,-4.42,;-2.66,-5.21,;-5.28,-5.21,;-6.59,-4.41,;-9.21,.36,;-10.53,-.42,;-10.53,-2.02,;-11.83,.36,;-11.83,1.95,;-10.53,2.75,;-10.53,4.34,;-9.22,5.14,;-9.22,6.73,;-13.14,-.42,;-14.45,.37,;-14.45,1.95,;-15.75,-.42,;-15.75,-2.02,;-14.45,-2.81,;-17.08,.37,;-18.38,-.41,;-18.38,-2.01,;-19.68,.37,;-19.68,1.96,;-18.38,2.76,;-17.07,1.96,;-15.75,2.76,;-15.75,4.35,;-14.44,5.14,;-17.07,5.14,;-18.38,4.35,;-21,-.41,;-22.3,.38,;-22.3,1.96,;-23.62,-.41,;-23.62,-2,;-22.3,-2.8,;-21.01,-2,;-22.3,-4.39,;-24.92,.38,;-26.24,-.41,;-26.24,-2,;-27.55,.38,;-27.55,1.97,;-26.24,2.77,;-28.85,-.4,;-30.18,.39,;-30.18,1.97,;-31.46,-.4,;-32.79,.39,;-34.09,-.4,;-34.09,-1.99,;-35.41,.39,;-35.41,1.98,;-34.09,2.78,;-32.79,1.98,;-31.47,2.78,;-31.47,4.37,;-32.78,5.16,;-34.08,4.37,;-36.71,-.39,;-38.03,.4,;-38.03,1.98,;-39.33,-.39,;-40.65,.4,;-41.95,-.39,;-41.95,-1.98,;-43.25,.4,;-44.58,-.38,;-45.88,.4,;-45.88,1.99,;-47.19,-.38,;-47.19,-1.97,;-45.88,-2.77,;-45.88,-4.37,;-47.18,-5.16,;-44.59,-5.16,;-48.5,.41,;-49.81,-.38,;-49.81,-1.97,;-51.13,.41,;-51.13,2,;-49.79,2.8,;-52.42,-.38,;-53.77,.39,;-53.77,1.92,;-55.09,2.69,;-56.35,1.82,;-57.58,2.75,;-57.09,4.22,;-55.54,4.18,;-55.1,-.38,;-56.43,.39,;-55.1,-1.93,;-39.33,-1.98,;-40.65,-2.79,;-38.03,-2.78,;-31.46,-1.99,;-32.79,-2.8,;-30.18,-2.79,;31.39,-2.08,;32.71,-2.87,;30.08,-2.88,;48.42,.29,;48.42,1.87,;49.74,-.51,;51.03,.28,;51.03,1.87,;52.35,2.67,;53.66,1.87,;52.35,4.26,;52.35,-.51,;52.35,-2.1,;53.66,.28,;54.97,-.52,;54.97,-2.11,;53.66,-2.9,;56.28,-2.9,;56.28,.28,;57.58,-.52,;56.28,1.86,)| Show InChI InChI=1S/C155H228N44O49S/c1-73(2)54-98(136(230)181-97(49-53-249-11)135(229)189-105(62-117(161)212)146(240)198-123(77(8)203)126(162)220)184-140(234)104(60-84-66-170-89-29-19-18-28-88(84)89)188-134(228)96(44-48-116(160)211)182-150(244)122(75(5)6)197-144(238)102(56-80-24-14-12-15-25-80)187-142(236)107(64-120(216)217)190-133(227)94(42-46-114(158)209)175-127(221)76(7)173-129(223)91(31-22-51-168-154(163)164)176-130(224)92(32-23-52-169-155(165)166)177-132(226)95(43-47-115(159)210)180-141(235)106(63-119(214)215)191-137(231)99(55-74(3)4)183-138(232)100(58-82-33-37-86(206)38-34-82)185-131(225)90(30-20-21-50-156)178-148(242)111(70-201)194-139(233)101(59-83-35-39-87(207)40-36-83)186-143(237)108(65-121(218)219)192-149(243)112(71-202)195-152(246)125(79(10)205)199-145(239)103(57-81-26-16-13-17-27-81)193-151(245)124(78(9)204)196-118(213)68-171-128(222)93(41-45-113(157)208)179-147(241)110(69-200)174-109(153(247)248)61-85-67-167-72-172-85/h12-19,24-29,33-40,66-67,72-79,90-112,122-125,170,174,200-207H,20-23,30-32,41-65,68-71,156H2,1-11H3,(H2,157,208)(H2,158,209)(H2,159,210)(H2,160,211)(H2,161,212)(H2,162,220)(H,167,172)(H,171,222)(H,173,223)(H,175,221)(H,176,224)(H,177,226)(H,178,242)(H,179,241)(H,180,235)(H,181,230)(H,182,244)(H,183,232)(H,184,234)(H,185,225)(H,186,237)(H,187,236)(H,188,228)(H,189,229)(H,190,227)(H,191,231)(H,192,243)(H,193,245)(H,194,233)(H,195,246)(H,196,213)(H,197,238)(H,198,240)(H,199,239)(H,214,215)(H,216,217)(H,218,219)(H,247,248)(H4,163,164,168)(H4,165,166,169)/t76-,77+,78+,79+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.260 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50324711 (CHEMBL1222085) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:208.216,180.193,170.177,150.163,135.144,115.122,98.106,76.86,62.70,43.53,30.37,8.12,234.240,wD:199.210,191.197,222.230,176.181,225.233,162.171,144.150,123.135,107.114,87.97,71.74,54.61,39.41,16.28,4.4,242.248,243.251,212.217,(49.79,-5.31,;48.47,-4.51,;48.47,-2.92,;47.17,-2.13,;47.17,-.53,;45.86,.27,;44.55,-.53,;44.55,-2.12,;43.23,.27,;43.23,1.86,;44.55,2.66,;44.55,4.25,;45.86,1.86,;41.93,-.53,;40.61,.27,;40.61,1.86,;39.3,-.52,;39.3,-2.12,;40.61,-2.91,;41.99,-2.27,;43.01,-3.45,;42.24,-4.84,;42.68,-6.28,;41.66,-7.38,;40.18,-7.04,;39.74,-5.59,;40.77,-4.49,;37.99,.28,;36.68,-.52,;36.68,-2.12,;35.37,.28,;35.37,1.87,;36.68,2.67,;36.68,4.26,;35.37,5.05,;38,5.05,;34.05,-.52,;32.75,.28,;32.75,1.87,;31.43,-.52,;30.12,.29,;28.81,-.51,;28.81,-2.11,;27.48,.29,;27.48,1.88,;28.81,2.68,;30.12,1.87,;31.43,2.67,;31.43,4.26,;30.13,5.06,;28.82,4.27,;26.19,-.51,;24.87,.29,;24.87,1.88,;23.57,-.51,;23.57,-2.1,;24.87,-2.89,;26.22,-2.15,;24.83,-4.44,;22.25,.3,;20.94,-.5,;20.94,-2.1,;19.62,.3,;19.62,1.89,;20.94,2.69,;20.94,4.28,;22.29,5.05,;22.29,6.6,;18.32,-.5,;17,.3,;17,1.89,;15.7,-.5,;15.7,-2.09,;14.4,.3,;13.07,-.49,;13.07,-2.09,;11.76,.31,;11.76,1.9,;13.07,2.7,;13.07,4.28,;14.39,5.08,;14.39,6.67,;13.08,7.46,;15.69,7.47,;10.45,-.48,;9.13,.31,;9.13,1.91,;7.82,-.48,;7.82,-2.03,;9.18,-2.81,;9.18,-4.36,;10.52,-5.14,;10.52,-6.69,;11.85,-7.47,;9.16,-7.46,;6.51,.32,;5.22,-.47,;5.22,-2.08,;3.89,.32,;3.89,1.91,;5.24,2.69,;5.24,4.24,;3.89,5.02,;6.58,5.02,;2.59,-.47,;1.28,.33,;1.28,1.92,;-.05,-.46,;-.05,-2.06,;1.28,-2.85,;2.57,-2.06,;1.28,-4.45,;-1.35,.33,;-2.67,-.46,;-2.67,-2.06,;-3.98,.33,;-3.98,1.92,;-2.67,2.72,;-2.67,4.31,;-1.33,1.92,;-5.28,-.46,;-6.6,.34,;-6.6,1.93,;-7.9,-.45,;-7.9,-2.06,;-6.6,-2.85,;-5.29,-2.06,;-3.98,-2.85,;-3.98,-4.44,;-2.66,-5.24,;-5.29,-5.24,;-6.6,-4.44,;-9.22,.34,;-10.53,-.45,;-10.53,-2.05,;-11.84,.34,;-11.84,1.93,;-10.53,2.73,;-10.53,4.32,;-9.23,5.12,;-9.23,6.71,;-13.15,-.45,;-14.46,.35,;-14.46,1.93,;-15.76,-.44,;-15.76,-2.05,;-14.46,-2.84,;-17.1,.35,;-18.39,-.44,;-18.39,-2.04,;-19.7,.35,;-19.7,1.94,;-18.39,2.74,;-17.08,1.94,;-15.77,2.74,;-15.77,4.33,;-14.45,5.13,;-17.09,5.13,;-18.4,4.33,;-21.02,-.44,;-22.33,.36,;-22.33,1.94,;-23.65,-.43,;-23.65,-2.03,;-22.33,-2.83,;-21.03,-2.03,;-22.33,-4.42,;-24.95,.36,;-26.27,-.43,;-26.27,-2.03,;-27.58,.36,;-27.58,1.95,;-26.27,2.75,;-28.88,-.43,;-30.21,.36,;-30.21,1.95,;-31.5,-.43,;-32.82,.37,;-34.13,-.42,;-34.13,-2.02,;-35.44,.37,;-35.44,1.96,;-34.13,2.76,;-32.83,1.96,;-31.5,2.75,;-31.5,4.35,;-32.81,5.15,;-34.12,4.35,;-36.75,-.42,;-38.06,.37,;-38.06,1.96,;-39.38,-.42,;-40.69,.38,;-42,-.41,;-42,-2.01,;-43.29,.38,;-44.62,-.41,;-45.93,.38,;-45.93,1.97,;-47.24,-.41,;-47.24,-2,;-45.93,-2.8,;-45.93,-4.39,;-47.24,-5.19,;-44.63,-5.19,;-48.55,.38,;-49.86,-.41,;-49.86,-2,;-51.19,.38,;-51.19,1.98,;-49.85,2.78,;-52.47,-.41,;-53.83,.38,;-53.83,1.91,;-55.16,2.67,;-56.42,1.81,;-57.66,2.73,;-57.16,4.2,;-55.61,4.17,;-55.18,-.4,;-56.51,.38,;-55.18,-1.95,;-39.38,-2.01,;-40.69,-2.81,;-38.06,-2.81,;-31.5,-2.02,;-32.82,-2.82,;-30.21,-2.82,;31.43,-2.11,;32.75,-2.9,;30.12,-2.9,;48.47,.26,;48.47,1.85,;49.8,-.54,;51.1,.26,;51.1,1.85,;52.42,2.65,;53.73,1.85,;52.42,4.24,;52.42,-.54,;52.42,-2.13,;53.72,.26,;55.03,-.54,;55.03,-2.14,;53.72,-2.93,;56.35,-2.93,;56.35,.26,;57.66,-.55,;56.35,1.84,)| Show InChI InChI=1S/C156H231N43O49S/c1-75(2)56-100(137(230)181-99(50-55-249-11)136(229)189-107(64-117(161)210)147(240)198-124(79(8)203)127(162)220)184-141(234)106(62-86-68-170-91-31-19-18-30-90(86)91)188-135(228)97(45-48-116(160)209)182-151(244)123(77(5)6)197-145(238)104(58-82-26-14-12-15-27-82)187-143(236)109(66-121(216)217)190-132(225)92(32-20-22-51-157)175-128(221)78(7)173-130(223)94(34-24-53-168-155(163)164)176-131(224)95(35-25-54-169-156(165)166)177-134(227)98(46-49-119(212)213)180-142(235)108(65-120(214)215)191-138(231)101(57-76(3)4)183-139(232)102(60-84-36-40-88(206)41-37-84)185-133(226)93(33-21-23-52-158)178-149(242)113(72-201)194-140(233)103(61-85-38-42-89(207)43-39-85)186-144(237)110(67-122(218)219)192-150(243)114(73-202)195-153(246)126(81(10)205)199-146(239)105(59-83-28-16-13-17-29-83)193-152(245)125(80(9)204)196-118(211)70-171-129(222)96(44-47-115(159)208)179-148(241)112(71-200)174-111(154(247)248)63-87-69-167-74-172-87/h12-19,26-31,36-43,68-69,74-81,92-114,123-126,170,174,200-207H,20-25,32-35,44-67,70-73,157-158H2,1-11H3,(H2,159,208)(H2,160,209)(H2,161,210)(H2,162,220)(H,167,172)(H,171,222)(H,173,223)(H,175,221)(H,176,224)(H,177,227)(H,178,242)(H,179,241)(H,180,235)(H,181,230)(H,182,244)(H,183,232)(H,184,234)(H,185,226)(H,186,237)(H,187,236)(H,188,228)(H,189,229)(H,190,225)(H,191,231)(H,192,243)(H,193,245)(H,194,233)(H,195,246)(H,196,211)(H,197,238)(H,198,240)(H,199,239)(H,212,213)(H,214,215)(H,216,217)(H,218,219)(H,247,248)(H4,163,164,168)(H4,165,166,169)/t78-,79+,80+,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,123-,124-,125-,126-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0710 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50324714 (CHEMBL1222088) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:178.191,168.175,148.161,133.142,113.120,96.104,76.86,62.70,43.53,30.37,8.12,232.238,206.214,wD:197.208,189.195,220.228,174.179,223.231,160.169,142.148,121.133,105.112,87.95,71.74,54.61,39.41,16.28,4.4,240.246,241.249,210.215,(49.7,-5.19,;48.4,-4.39,;48.4,-2.8,;47.09,-2.01,;47.09,-.42,;45.78,.38,;44.48,-.41,;44.48,-2.01,;43.16,.38,;43.16,1.97,;44.48,2.77,;44.48,4.36,;45.79,1.97,;41.85,-.41,;40.54,.39,;40.54,1.97,;39.24,-.41,;39.24,-2,;40.54,-2.79,;41.92,-2.15,;42.94,-3.33,;42.18,-4.72,;42.64,-6.22,;41.62,-7.4,;40.15,-7.06,;39.68,-5.55,;40.7,-4.38,;37.93,.39,;36.62,-.4,;36.62,-2,;35.31,.39,;35.31,1.98,;36.62,2.78,;36.62,4.37,;35.31,5.17,;37.93,5.16,;33.99,-.4,;32.69,.39,;32.69,1.98,;31.38,-.4,;30.07,.4,;28.76,-.39,;28.76,-1.99,;27.45,.4,;27.45,1.99,;28.76,2.79,;30.07,1.98,;31.38,2.78,;31.38,4.37,;30.07,5.17,;28.77,4.38,;26.15,-.39,;24.82,.4,;24.82,1.99,;23.52,-.39,;23.52,-1.98,;24.86,-2.75,;26.2,-1.98,;24.86,-4.29,;22.21,.41,;20.9,-.39,;20.9,-1.98,;19.59,.41,;19.59,2,;20.9,2.8,;20.9,4.39,;19.57,5.16,;19.57,6.7,;18.27,-.38,;16.97,.41,;16.97,2,;15.65,-.38,;15.65,-1.97,;14.36,.42,;13.04,-.37,;13.04,-1.97,;11.74,.42,;11.74,2,;13.07,2.78,;13.07,4.32,;14.39,5.09,;14.39,6.63,;15.74,7.4,;13.07,7.4,;10.43,-.37,;9.11,.42,;9.11,2.02,;7.8,-.36,;7.8,-1.96,;9.11,-2.76,;9.11,-4.35,;10.42,-5.14,;7.76,-5.11,;6.48,.43,;5.19,-.35,;5.19,-1.96,;3.87,.44,;3.87,2.02,;5.22,2.79,;5.22,4.34,;3.87,5.12,;6.55,5.12,;2.58,-.35,;1.25,.44,;1.25,2.03,;-.06,-.35,;-.06,-1.95,;1.25,-2.74,;2.56,-1.95,;1.25,-4.33,;-1.36,.44,;-2.67,-.34,;-2.67,-1.94,;-3.98,.45,;-3.98,2.03,;-2.67,2.83,;-2.67,4.42,;-1.36,2.03,;-5.29,-.34,;-6.6,.45,;-6.6,2.03,;-7.9,-.34,;-7.9,-1.94,;-6.6,-2.73,;-5.29,-1.94,;-3.98,-2.74,;-3.99,-4.33,;-2.68,-5.12,;-5.3,-5.12,;-6.6,-4.32,;-9.24,.45,;-10.53,-.33,;-10.53,-1.93,;-11.83,.45,;-11.83,2.04,;-10.53,2.84,;-10.53,4.43,;-9.23,5.24,;-9.23,6.83,;-13.14,-.33,;-14.45,.46,;-14.45,2.04,;-15.77,-.33,;-15.77,-1.93,;-14.45,-2.72,;-17.08,.46,;-18.38,-.32,;-18.38,-1.92,;-19.7,.46,;-19.7,2.05,;-18.38,2.85,;-17.07,2.05,;-15.77,2.85,;-15.76,4.44,;-14.44,5.24,;-17.08,5.25,;-18.38,4.44,;-21,-.32,;-22.31,.47,;-22.31,2.05,;-23.63,-.32,;-23.63,-1.91,;-22.31,-2.71,;-21.01,-1.91,;-22.31,-4.3,;-24.93,.47,;-26.25,-.32,;-26.25,-1.91,;-27.55,.47,;-27.55,2.06,;-26.25,2.86,;-28.86,-.31,;-30.18,.48,;-30.18,2.06,;-31.47,-.31,;-32.81,.48,;-34.09,-.31,;-34.09,-1.9,;-35.41,.48,;-35.41,2.07,;-34.09,2.87,;-32.79,2.06,;-31.47,2.87,;-31.47,4.45,;-32.8,5.26,;-34.1,4.46,;-36.71,-.3,;-38.02,.48,;-38.02,2.07,;-39.35,-.3,;-40.65,.49,;-41.95,-.3,;-41.95,-1.89,;-43.26,.49,;-44.58,-.29,;-45.88,.49,;-45.88,2.08,;-47.19,-.29,;-47.19,-1.88,;-45.88,-2.68,;-45.88,-4.28,;-47.2,-5.07,;-44.59,-5.07,;-48.5,.5,;-49.81,-.29,;-49.81,-1.88,;-51.13,.5,;-51.13,2.09,;-49.81,2.89,;-52.43,-.29,;-53.77,.49,;-53.77,2.01,;-55.09,2.77,;-56.34,1.91,;-57.57,2.83,;-57.07,4.29,;-55.53,4.26,;-55.1,-.28,;-56.42,.49,;-55.1,-1.82,;-39.35,-1.89,;-40.65,-2.7,;-38.02,-2.69,;-31.47,-1.9,;-32.81,-2.7,;-30.18,-2.7,;31.38,-1.99,;32.69,-2.78,;30.07,-2.79,;48.4,.38,;48.4,1.96,;49.72,-.42,;51.01,.37,;51.01,1.96,;52.33,2.76,;53.64,1.96,;52.33,4.35,;52.33,-.42,;52.33,-2.01,;53.64,.37,;54.95,-.43,;54.95,-2.02,;53.64,-2.81,;56.26,-2.81,;56.26,.37,;57.57,-.43,;56.26,1.95,)| Show InChI InChI=1S/C155H227N41O50S/c1-74(2)55-99(137(228)178-98(50-54-247-11)136(227)186-106(63-117(161)208)147(238)195-124(78(8)200)127(162)218)181-141(232)105(61-85-67-167-90-30-19-18-29-89(85)90)185-135(226)96(44-48-116(160)207)179-151(242)123(76(5)6)194-145(236)103(57-81-25-14-12-15-26-81)184-143(234)108(65-121(214)215)187-131(222)91(31-20-22-51-156)172-128(219)77(7)170-130(221)93(33-24-53-166-155(163)164)173-133(224)95(43-47-115(159)206)176-134(225)97(45-49-119(210)211)177-142(233)107(64-120(212)213)188-138(229)100(56-75(3)4)180-139(230)101(59-83-34-38-87(203)39-35-83)182-132(223)92(32-21-23-52-157)174-149(240)112(71-198)191-140(231)102(60-84-36-40-88(204)41-37-84)183-144(235)109(66-122(216)217)189-150(241)113(72-199)192-153(244)126(80(10)202)196-146(237)104(58-82-27-16-13-17-28-82)190-152(243)125(79(9)201)193-118(209)69-168-129(220)94(42-46-114(158)205)175-148(239)111(70-197)171-110(154(245)246)62-86-68-165-73-169-86/h12-19,25-30,34-41,67-68,73-80,91-113,123-126,167,171,197-204H,20-24,31-33,42-66,69-72,156-157H2,1-11H3,(H2,158,205)(H2,159,206)(H2,160,207)(H2,161,208)(H2,162,218)(H,165,169)(H,168,220)(H,170,221)(H,172,219)(H,173,224)(H,174,240)(H,175,239)(H,176,225)(H,177,233)(H,178,228)(H,179,242)(H,180,230)(H,181,232)(H,182,223)(H,183,235)(H,184,234)(H,185,226)(H,186,227)(H,187,222)(H,188,229)(H,189,241)(H,190,243)(H,191,231)(H,192,244)(H,193,209)(H,194,236)(H,195,238)(H,196,237)(H,210,211)(H,212,213)(H,214,215)(H,216,217)(H,245,246)(H4,163,164,166)/t77-,78+,79+,80+,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,123-,124-,125-,126-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0750 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50324715 (CHEMBL1222089) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:202.210,174.187,164.171,144.157,129.138,109.116,92.100,76.79,62.70,43.53,30.37,8.12,228.234,wD:193.204,185.191,216.224,170.175,219.227,156.165,138.144,117.129,101.108,81.91,71.74,54.61,39.41,16.28,4.4,236.242,237.245,206.211,(49.71,-4.86,;48.4,-4.06,;48.4,-2.47,;47.1,-1.68,;47.1,-.09,;45.79,.71,;44.48,-.08,;44.48,-1.68,;43.17,.71,;43.17,2.3,;44.48,3.1,;44.48,4.69,;45.79,2.3,;41.86,-.08,;40.55,.72,;40.55,2.3,;39.25,-.08,;39.25,-1.67,;40.55,-2.46,;41.92,-1.82,;42.95,-3,;42.18,-4.39,;42.64,-5.89,;41.63,-7.07,;40.15,-6.73,;39.68,-5.22,;40.7,-4.05,;37.93,.72,;36.62,-.07,;36.62,-1.67,;35.31,.72,;35.31,2.31,;36.62,3.11,;36.62,4.7,;35.32,5.48,;37.94,5.49,;34,-.07,;32.7,.73,;32.7,2.31,;31.38,-.07,;30.07,.73,;28.77,-.07,;28.77,-1.66,;27.45,.73,;27.45,2.32,;28.77,3.12,;30.08,2.31,;31.39,3.11,;31.39,4.7,;30.08,5.49,;28.77,4.71,;26.15,-.06,;24.83,.73,;24.83,2.32,;23.53,-.06,;23.53,-1.65,;24.86,-2.42,;26.2,-1.65,;24.86,-3.96,;22.22,.74,;20.91,-.06,;20.91,-1.65,;19.6,.74,;19.6,2.33,;20.91,3.13,;20.91,4.72,;22.22,5.5,;23.57,4.76,;18.28,-.05,;16.98,.74,;16.98,2.33,;15.67,-.05,;15.67,-1.64,;14.37,.75,;13.05,-.04,;13.05,-1.64,;11.74,.75,;11.74,2.34,;10.43,-.04,;9.11,.75,;9.11,2.35,;7.8,-.03,;7.8,-1.63,;9.11,-2.43,;9.11,-4.02,;10.43,-4.81,;10.4,-6.35,;11.72,-7.15,;9.04,-7.1,;6.48,.76,;5.2,-.02,;5.2,-1.63,;3.87,.77,;3.87,2.35,;5.22,3.12,;5.22,4.67,;3.87,5.44,;6.54,5.44,;2.58,-.02,;1.26,.77,;1.26,2.36,;-.06,-.02,;-.06,-1.62,;1.26,-2.41,;2.56,-1.62,;1.26,-4,;-1.37,.77,;-2.67,-.01,;-2.67,-1.61,;-3.99,.78,;-3.99,2.36,;-2.67,3.17,;-2.67,4.75,;-1.35,2.36,;-5.28,-.01,;-6.6,.78,;-6.6,2.36,;-7.9,-.01,;-7.9,-1.61,;-6.6,-2.4,;-5.29,-1.61,;-3.98,-2.41,;-3.98,-4,;-2.66,-4.79,;-5.29,-4.79,;-6.6,-3.99,;-9.22,.78,;-10.54,-0,;-10.54,-1.6,;-11.83,.78,;-11.83,2.37,;-10.54,3.17,;-10.54,4.76,;-9.23,5.56,;-9.23,7.15,;-13.15,-0,;-14.45,.79,;-14.45,2.37,;-15.76,0,;-15.76,-1.6,;-14.45,-2.39,;-17.09,.79,;-18.38,.01,;-18.38,-1.59,;-19.69,.79,;-19.69,2.38,;-18.38,3.18,;-17.08,2.38,;-15.76,3.18,;-15.76,4.77,;-14.44,5.57,;-17.08,5.57,;-18.39,4.77,;-21,.01,;-22.31,.8,;-22.31,2.38,;-23.63,.01,;-23.63,-1.58,;-22.31,-2.38,;-21.01,-1.58,;-22.31,-3.97,;-24.93,.8,;-26.25,.01,;-26.25,-1.58,;-27.56,.8,;-27.56,2.39,;-26.25,3.19,;-28.85,.02,;-30.18,.81,;-30.18,2.39,;-31.47,.02,;-32.8,.81,;-34.1,.02,;-34.1,-1.57,;-35.41,.81,;-35.41,2.4,;-34.1,3.2,;-32.8,2.4,;-31.47,3.2,;-31.48,4.78,;-32.79,5.59,;-34.09,4.79,;-36.72,.03,;-38.03,.82,;-38.03,2.4,;-39.34,.03,;-40.65,.82,;-41.96,.03,;-41.96,-1.56,;-43.26,.82,;-44.58,.04,;-45.89,.82,;-45.89,2.41,;-47.19,.04,;-47.19,-1.55,;-45.89,-2.35,;-45.89,-3.95,;-47.19,-4.74,;-44.59,-4.74,;-48.5,.83,;-49.81,.04,;-49.81,-1.55,;-51.14,.83,;-51.14,2.42,;-49.8,3.22,;-52.42,.04,;-53.78,.82,;-53.78,2.34,;-55.09,3.1,;-56.35,2.24,;-57.58,3.16,;-57.08,4.62,;-55.54,4.59,;-55.11,.05,;-56.43,.82,;-55.11,-1.49,;-39.34,-1.56,;-40.65,-2.37,;-38.03,-2.36,;-31.47,-1.57,;-32.8,-2.38,;-30.18,-2.37,;31.38,-1.66,;32.7,-2.45,;30.07,-2.46,;48.4,.71,;48.4,2.29,;49.72,-.09,;51.02,.7,;51.02,2.29,;52.34,3.09,;53.65,2.29,;52.34,4.68,;52.34,-.09,;52.34,-1.68,;53.64,.7,;54.95,-.1,;54.95,-1.69,;53.64,-2.48,;56.27,-2.48,;56.27,.7,;57.58,-.1,;56.27,2.28,)| Show InChI InChI=1S/C153H224N40O49S/c1-73(2)54-98(135(224)175-97(49-53-243-12)134(223)183-105(62-115(158)204)145(234)192-122(78(9)197)125(159)214)178-139(228)104(60-85-66-164-90-31-20-19-30-89(85)90)182-133(222)95(44-47-114(157)203)176-149(238)121(75(5)6)191-143(232)102(56-81-26-15-13-16-27-81)181-141(230)107(64-119(210)211)184-130(219)91(32-21-23-50-154)170-127(216)77(8)167-126(215)76(7)168-129(218)93(34-25-52-163-153(160)161)171-132(221)96(45-48-117(206)207)174-140(229)106(63-118(208)209)185-136(225)99(55-74(3)4)177-137(226)100(58-83-35-39-87(200)40-36-83)179-131(220)92(33-22-24-51-155)172-147(236)111(70-195)188-138(227)101(59-84-37-41-88(201)42-38-84)180-142(231)108(65-120(212)213)186-148(237)112(71-196)189-151(240)124(80(11)199)193-144(233)103(57-82-28-17-14-18-29-82)187-150(239)123(79(10)198)190-116(205)68-165-128(217)94(43-46-113(156)202)173-146(235)110(69-194)169-109(152(241)242)61-86-67-162-72-166-86/h13-20,26-31,35-42,66-67,72-80,91-112,121-124,164,169,194-201H,21-25,32-34,43-65,68-71,154-155H2,1-12H3,(H2,156,202)(H2,157,203)(H2,158,204)(H2,159,214)(H,162,166)(H,165,217)(H,167,215)(H,168,218)(H,170,216)(H,171,221)(H,172,236)(H,173,235)(H,174,229)(H,175,224)(H,176,238)(H,177,226)(H,178,228)(H,179,220)(H,180,231)(H,181,230)(H,182,222)(H,183,223)(H,184,219)(H,185,225)(H,186,237)(H,187,239)(H,188,227)(H,189,240)(H,190,205)(H,191,232)(H,192,234)(H,193,233)(H,206,207)(H,208,209)(H,210,211)(H,212,213)(H,241,242)(H4,160,161,163)/t76-,77-,78+,79+,80+,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,121-,122-,123-,124-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0280 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50324721 (CHEMBL1222095) Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O |r| Show InChI InChI=1S/C152H219N35O51S/c1-14-75(6)121(148(232)163-78(9)127(211)172-105(61-86-66-158-91-32-22-21-31-90(86)91)139(223)174-99(55-73(2)3)135(219)171-98(51-54-239-13)134(218)178-106(63-114(156)197)144(228)187-124(81(12)193)152(237)238)185-142(226)103(57-82-27-17-15-18-28-82)176-133(217)97(46-50-118(203)204)169-130(214)92(33-23-25-52-153)165-126(210)77(8)161-125(209)76(7)162-129(213)95(43-47-113(155)196)168-132(216)96(45-49-117(201)202)170-140(224)107(64-119(205)206)179-136(220)100(56-74(4)5)173-137(221)101(59-84-35-39-88(194)40-36-84)175-131(215)93(34-24-26-53-154)166-146(230)111(70-189)182-138(222)102(60-85-37-41-89(195)42-38-85)177-141(225)108(65-120(207)208)180-147(231)112(71-190)183-150(234)123(80(11)192)186-143(227)104(58-83-29-19-16-20-30-83)181-149(233)122(79(10)191)184-115(198)68-159-128(212)94(44-48-116(199)200)167-145(229)110(69-188)164-109(151(235)236)62-87-67-157-72-160-87/h15-22,27-32,35-42,66-67,72-81,92-112,121-124,158,164,188-195H,14,23-26,33-34,43-65,68-71,153-154H2,1-13H3,(H2,155,196)(H2,156,197)(H,157,160)(H,159,212)(H,161,209)(H,162,213)(H,163,232)(H,165,210)(H,166,230)(H,167,229)(H,168,216)(H,169,214)(H,170,224)(H,171,219)(H,172,211)(H,173,221)(H,174,223)(H,175,215)(H,176,217)(H,177,225)(H,178,218)(H,179,220)(H,180,231)(H,181,233)(H,182,222)(H,183,234)(H,184,198)(H,185,226)(H,186,227)(H,187,228)(H,199,200)(H,201,202)(H,203,204)(H,205,206)(H,207,208)(H,235,236)(H,237,238)/t75-,76-,77-,78-,79+,80+,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,121-,122-,123-,124-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0280 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50324722 (CHEMBL1222096) Show SMILES [H][C@](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)([C@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@H](CCNC(N)=N)C(N)=O |r| Show InChI InChI=1S/C151H226N38O49/c1-17-76(10)120(147(234)166-80(14)127(214)175-104(61-86-64-159-90-35-25-24-34-89(86)90)137(224)177-100(57-73(4)5)138(225)186-118(74(6)7)145(232)174-92(36-26-28-53-152)128(215)160-66-110(196)167-91(123(154)210)52-55-158-151(155)156)188-139(226)102(58-83-30-20-18-21-31-83)178-134(221)98(46-51-116(206)207)171-131(218)93(37-27-29-54-153)168-126(213)79(13)164-124(211)78(12)165-130(217)95(43-48-113(200)201)170-132(219)96(44-49-114(202)203)172-133(220)97(45-50-115(204)205)173-135(222)99(56-72(2)3)176-136(223)101(60-85-38-40-88(195)41-39-85)179-142(229)107(68-190)182-144(231)109(70-192)183-146(233)119(75(8)9)187-141(228)105(63-117(208)209)180-143(230)108(69-191)184-149(236)122(82(16)194)189-140(227)103(59-84-32-22-19-23-33-84)181-148(235)121(81(15)193)185-111(197)67-161-129(216)94(42-47-112(198)199)169-125(212)77(11)163-106(150(237)238)62-87-65-157-71-162-87/h18-25,30-35,38-41,64-65,71-82,91-109,118-122,159,163,190-195H,17,26-29,36-37,42-63,66-70,152-153H2,1-16H3,(H2,154,210)(H,157,162)(H,160,215)(H,161,216)(H,164,211)(H,165,217)(H,166,234)(H,167,196)(H,168,213)(H,169,212)(H,170,219)(H,171,218)(H,172,220)(H,173,222)(H,174,232)(H,175,214)(H,176,223)(H,177,224)(H,178,221)(H,179,229)(H,180,230)(H,181,235)(H,182,231)(H,183,233)(H,184,236)(H,185,197)(H,186,225)(H,187,228)(H,188,226)(H,189,227)(H,198,199)(H,200,201)(H,202,203)(H,204,205)(H,206,207)(H,208,209)(H,237,238)(H4,155,156,158)/t76-,77-,78-,79-,80-,81+,82-,91+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,118-,119-,120-,121-,122-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0110 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon receptor (Homo sapiens (Human)) | BDBM50324708 (CHEMBL1222082) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:207.215,179.192,169.176,149.162,134.143,114.121,98.105,76.86,62.70,43.53,30.37,8.12,233.239,wD:198.209,190.196,221.229,175.180,224.232,161.170,143.149,122.134,106.113,87.97,71.74,54.61,39.41,16.28,4.4,241.247,242.250,211.216,(49.77,-5.35,;48.45,-4.56,;48.45,-2.96,;47.15,-2.17,;47.15,-.58,;45.84,.22,;44.53,-.57,;44.53,-2.17,;43.21,.23,;43.21,1.82,;44.53,2.62,;44.53,4.21,;45.84,1.82,;41.91,-.57,;40.59,.23,;40.59,1.82,;39.28,-.57,;39.28,-2.16,;40.59,-2.95,;41.97,-2.31,;42.99,-3.49,;42.22,-4.88,;42.66,-6.32,;41.64,-7.42,;40.16,-7.08,;39.72,-5.64,;40.75,-4.54,;37.97,.23,;36.66,-.56,;36.66,-2.16,;35.35,.24,;35.35,1.83,;36.66,2.63,;36.66,4.21,;35.36,5,;37.98,5.01,;34.04,-.56,;32.73,.24,;32.73,1.83,;31.4,-.56,;30.09,.24,;28.79,-.55,;28.79,-2.15,;27.46,.25,;27.46,1.83,;28.79,2.64,;30.1,1.83,;31.41,2.63,;31.41,4.22,;30.1,5.01,;28.79,4.22,;26.17,-.55,;24.85,.25,;24.85,1.84,;23.55,-.55,;23.55,-2.14,;24.85,-2.93,;26.16,-2.14,;24.85,-4.53,;22.23,.25,;20.92,-.55,;20.92,-2.14,;19.6,.26,;19.6,1.84,;20.92,2.64,;20.92,4.23,;19.61,5.02,;22.24,5.03,;18.3,-.54,;16.98,.26,;16.98,1.85,;15.68,-.54,;15.68,-2.13,;14.38,.26,;13.05,-.53,;13.05,-2.13,;11.74,.26,;11.74,1.85,;13.05,2.66,;13.05,4.24,;14.37,5.04,;14.37,6.63,;13.06,7.42,;15.67,7.42,;10.43,-.53,;9.12,.27,;9.12,1.86,;7.8,-.52,;7.8,-2.12,;9.16,-2.9,;9.16,-4.45,;10.49,-5.23,;11.85,-4.45,;13.18,-5.23,;11.85,-2.9,;6.49,.28,;5.2,-.51,;5.2,-2.12,;3.87,.28,;3.87,1.87,;5.22,2.65,;6.56,1.87,;5.22,4.2,;2.57,-.51,;1.26,.28,;1.26,1.87,;-.06,-.51,;-.06,-2.11,;1.26,-2.9,;2.55,-2.11,;1.26,-4.49,;-1.37,.29,;-2.68,-.5,;-2.68,-2.1,;-4,.29,;-4,1.88,;-2.68,2.68,;-2.68,4.27,;-1.35,1.88,;-5.3,-.5,;-6.62,.29,;-6.62,1.88,;-7.92,-.5,;-7.92,-2.1,;-6.62,-2.89,;-5.31,-2.1,;-4,-2.89,;-3.99,-4.49,;-2.68,-5.29,;-5.3,-5.28,;-6.62,-4.48,;-9.24,.3,;-10.55,-.49,;-10.55,-2.1,;-11.86,.3,;-11.86,1.89,;-10.55,2.69,;-10.55,4.28,;-9.24,5.08,;-9.24,6.67,;-13.17,-.49,;-14.48,.3,;-14.48,1.89,;-15.78,-.49,;-15.78,-2.09,;-14.48,-2.88,;-17.11,.31,;-18.41,-.48,;-18.41,-2.08,;-19.72,.31,;-19.72,1.9,;-18.41,2.7,;-17.1,1.89,;-15.78,2.69,;-15.79,4.28,;-14.47,5.08,;-17.11,5.08,;-18.41,4.29,;-21.04,-.48,;-22.35,.31,;-22.35,1.9,;-23.67,-.48,;-23.67,-2.07,;-22.35,-2.87,;-21.05,-2.07,;-22.35,-4.46,;-24.97,.32,;-26.29,-.47,;-26.29,-2.07,;-27.59,.32,;-27.59,1.91,;-26.29,2.71,;-28.9,-.47,;-30.23,.32,;-30.23,1.91,;-31.52,-.47,;-32.84,.32,;-34.15,-.47,;-34.15,-2.06,;-35.46,.33,;-35.46,1.92,;-34.15,2.72,;-32.84,1.91,;-31.52,2.71,;-31.52,4.3,;-32.83,5.1,;-34.13,4.31,;-36.77,-.46,;-38.08,.33,;-38.08,1.92,;-39.39,-.46,;-40.71,.33,;-42.01,-.46,;-42.01,-2.05,;-43.31,.34,;-44.64,-.45,;-45.95,.34,;-45.95,1.93,;-47.26,-.45,;-47.26,-2.04,;-45.95,-2.84,;-45.95,-4.44,;-47.26,-5.24,;-44.65,-5.23,;-48.57,.34,;-49.88,-.45,;-49.88,-2.04,;-51.2,.34,;-51.2,1.93,;-49.87,2.74,;-52.49,-.45,;-53.84,.33,;-53.84,1.86,;-55.17,2.62,;-56.43,1.76,;-57.67,2.68,;-57.17,4.15,;-55.62,4.12,;-55.19,-.45,;-56.51,.33,;-55.19,-2,;-39.39,-2.05,;-40.71,-2.85,;-38.08,-2.85,;-31.52,-2.06,;-32.84,-2.86,;-30.23,-2.86,;31.4,-2.15,;32.73,-2.94,;30.09,-2.95,;48.45,.22,;48.45,1.81,;49.78,-.58,;51.08,.22,;51.08,1.81,;52.4,2.61,;53.71,1.81,;52.4,4.2,;52.4,-.58,;52.4,-2.18,;53.7,.22,;55.01,-.59,;55.01,-2.18,;53.7,-2.97,;56.33,-2.97,;56.33,.21,;57.67,-.54,;56.33,1.8,)| Show InChI InChI=1S/C154H225N43O50S/c1-72(2)52-96(134(228)178-95(47-51-248-11)133(227)186-103(60-115(159)209)145(239)196-122(76(8)201)125(160)219)181-138(232)102(58-83-65-168-88-29-19-18-28-87(83)88)185-132(226)94(43-46-114(158)208)179-149(243)121(74(5)6)195-143(237)100(54-79-24-14-12-15-25-79)184-140(234)105(62-118(213)214)187-131(225)93(42-45-113(157)207)173-126(220)75(7)171-128(222)90(31-22-49-166-153(161)162)174-129(223)91(32-23-50-167-154(163)164)175-139(233)104(61-117(211)212)189-142(236)106(63-119(215)216)188-135(229)97(53-73(3)4)180-136(230)98(56-81-33-37-85(204)38-34-81)182-130(224)89(30-20-21-48-155)176-147(241)110(69-199)192-137(231)99(57-82-35-39-86(205)40-36-82)183-141(235)107(64-120(217)218)190-148(242)111(70-200)193-151(245)124(78(10)203)197-144(238)101(55-80-26-16-13-17-27-80)191-150(244)123(77(9)202)194-116(210)67-169-127(221)92(41-44-112(156)206)177-146(240)109(68-198)172-108(152(246)247)59-84-66-165-71-170-84/h12-19,24-29,33-40,65-66,71-78,89-111,121-124,168,172,198-205H,20-23,30-32,41-64,67-70,155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H2,160,219)(H,165,170)(H,169,221)(H,171,222)(H,173,220)(H,174,223)(H,175,233)(H,176,241)(H,177,240)(H,178,228)(H,179,243)(H,180,230)(H,181,232)(H,182,224)(H,183,235)(H,184,234)(H,185,226)(H,186,227)(H,187,225)(H,188,229)(H,189,236)(H,190,242)(H,191,244)(H,192,231)(H,193,245)(H,194,210)(H,195,237)(H,196,239)(H,197,238)(H,211,212)(H,213,214)(H,215,216)(H,217,218)(H,246,247)(H4,161,162,166)(H4,163,164,167)/t75-,76+,77+,78+,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,121-,122-,123-,124-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0680 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon receptor (Homo sapiens (Human)) | BDBM50324713 (CHEMBL1222087 | HSQGTFTSDYSKYLDEQAAKEFIAWLMNT) Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O |r| Show InChI InChI=1S/C152H220N36O50S/c1-14-75(6)121(148(232)164-78(9)127(211)173-105(61-86-66-159-91-32-22-21-31-90(86)91)139(223)175-99(55-73(2)3)135(219)172-98(51-54-239-13)134(218)179-106(63-115(157)199)144(228)188-124(81(12)194)152(237)238)186-142(226)103(57-82-27-17-15-18-28-82)177-133(217)97(46-50-118(203)204)170-130(214)92(33-23-25-52-153)166-126(210)77(8)162-125(209)76(7)163-129(213)95(44-48-114(156)198)169-132(216)96(45-49-117(201)202)171-140(224)107(64-119(205)206)180-136(220)100(56-74(4)5)174-137(221)101(59-84-35-39-88(195)40-36-84)176-131(215)93(34-24-26-53-154)167-146(230)111(70-190)183-138(222)102(60-85-37-41-89(196)42-38-85)178-141(225)108(65-120(207)208)181-147(231)112(71-191)184-150(234)123(80(11)193)187-143(227)104(58-83-29-19-16-20-30-83)182-149(233)122(79(10)192)185-116(200)68-160-128(212)94(43-47-113(155)197)168-145(229)110(69-189)165-109(151(235)236)62-87-67-158-72-161-87/h15-22,27-32,35-42,66-67,72-81,92-112,121-124,159,165,189-196H,14,23-26,33-34,43-65,68-71,153-154H2,1-13H3,(H2,155,197)(H2,156,198)(H2,157,199)(H,158,161)(H,160,212)(H,162,209)(H,163,213)(H,164,232)(H,166,210)(H,167,230)(H,168,229)(H,169,216)(H,170,214)(H,171,224)(H,172,219)(H,173,211)(H,174,221)(H,175,223)(H,176,215)(H,177,217)(H,178,225)(H,179,218)(H,180,220)(H,181,231)(H,182,233)(H,183,222)(H,184,234)(H,185,200)(H,186,226)(H,187,227)(H,188,228)(H,201,202)(H,203,204)(H,205,206)(H,207,208)(H,235,236)(H,237,238)/t75-,76-,77-,78-,79+,80+,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,121-,122-,123-,124-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0680 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50098571 (CHEMBL266481 | GLUCAGON | His-Ser-Gln-Gly-Thr-Phe-...) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.30 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50324731 (CHEMBL1222074 | HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR) Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O |r,wU:60.66,47.53,37.38,19.25,4.4,181.184,203.208,105.111,151.154,123.133,167.172,95.99,77.87,wD:69.74,42.43,28.34,8.16,2.2,176.180,195.200,210.215,223.228,113.117,101.103,142.150,134.137,164.169,119.121,89.93,154.156,(69.72,-44.64,;69.72,-46.17,;71.06,-46.95,;72.39,-46.18,;71.06,-48.5,;69.72,-49.27,;68.4,-48.5,;68.4,-46.96,;67.06,-49.27,;67.06,-50.81,;68.4,-51.58,;69.73,-50.8,;71.06,-51.57,;71.07,-53.11,;69.73,-53.88,;68.4,-53.12,;65.72,-48.5,;64.38,-49.27,;64.38,-50.81,;63.05,-48.5,;63.05,-46.96,;64.38,-46.19,;64.38,-44.64,;63.04,-43.88,;65.72,-43.88,;61.72,-49.28,;60.38,-48.51,;60.38,-46.96,;59.05,-49.28,;59.05,-50.82,;60.38,-51.59,;60.38,-53.12,;61.72,-53.9,;61.72,-55.43,;57.72,-48.51,;56.38,-49.28,;56.38,-50.82,;55.04,-48.51,;55.04,-46.97,;53.71,-49.29,;52.38,-48.52,;52.38,-46.97,;51.04,-49.29,;51.04,-50.83,;49.71,-48.52,;48.37,-49.29,;48.37,-50.83,;47.04,-48.52,;47.04,-46.98,;48.37,-46.21,;48.37,-44.67,;47.04,-43.9,;49.71,-43.9,;45.71,-49.29,;44.37,-48.53,;44.37,-46.98,;43.03,-49.3,;41.7,-48.53,;40.37,-49.3,;40.37,-50.84,;39.04,-48.53,;39.04,-46.99,;40.37,-46.22,;40.37,-44.68,;39.03,-43.91,;41.7,-43.91,;37.7,-49.3,;36.37,-48.54,;36.37,-46.99,;35.03,-49.31,;35.03,-50.84,;36.37,-51.62,;36.37,-53.16,;37.7,-50.84,;33.69,-48.55,;32.36,-49.31,;32.36,-50.85,;31.03,-48.55,;31.03,-47,;32.36,-46.23,;33.69,-47,;35.02,-46.22,;35.02,-44.68,;36.36,-43.91,;33.68,-43.92,;32.36,-44.69,;29.69,-49.31,;28.36,-48.55,;28.36,-47.01,;27.03,-49.32,;27.03,-50.85,;28.36,-51.63,;25.69,-48.55,;24.35,-49.32,;24.35,-50.86,;23.02,-48.56,;23.02,-47.01,;24.35,-46.24,;21.68,-49.32,;20.35,-48.56,;20.35,-47.02,;19.01,-49.32,;17.69,-48.56,;16.35,-49.33,;16.35,-50.86,;15.01,-48.57,;15.01,-47.02,;16.35,-46.25,;17.68,-47.02,;16.35,-44.7,;13.68,-49.33,;12.35,-48.57,;12.35,-47.03,;11.01,-49.33,;11.01,-50.88,;12.35,-51.65,;9.68,-48.57,;9.65,-47.04,;10.98,-46.25,;8.32,-46.28,;8.3,-44.73,;6.96,-43.98,;5.63,-44.76,;6.95,-42.44,;8.27,-41.65,;9.62,-42.42,;9.63,-43.96,;10.97,-44.71,;12.29,-43.93,;12.28,-42.39,;10.94,-41.63,;5.61,-41.67,;5.59,-40.13,;6.92,-39.36,;4.24,-39.38,;4.23,-37.84,;2.89,-37.07,;1.56,-37.86,;2.87,-35.53,;1.54,-34.78,;1.52,-33.24,;2.85,-32.45,;.18,-32.48,;-1.15,-33.27,;-1.13,-34.81,;-2.46,-35.59,;-3.8,-34.83,;-2.44,-37.13,;.17,-30.94,;-1.17,-30.19,;-2.5,-30.97,;-1.19,-28.65,;.14,-27.86,;-2.53,-27.88,;-2.56,-26.32,;-1.25,-25.53,;-1.23,-23.99,;-2.59,-23.29,;-2.36,-21.76,;-.82,-21.52,;-.11,-22.9,;-3.91,-25.57,;-3.94,-24.03,;-5.24,-26.37,;2.92,-40.16,;1.58,-39.4,;2.93,-41.7,;6.99,-47.06,;5.65,-46.3,;7,-48.6,;19.01,-50.86,;20.35,-51.64,;17.69,-51.64,;72.39,-49.26,;72.39,-50.8,;73.73,-48.49,;75.05,-49.25,;75.05,-50.8,;76.4,-48.49,;76.4,-46.95,;77.73,-49.25,;79.07,-48.49,;79.07,-46.94,;80.39,-46.17,;81.8,-46.79,;82.83,-45.65,;82.06,-44.32,;82.54,-42.85,;81.5,-41.7,;79.99,-42.03,;79.53,-43.49,;80.55,-44.63,;80.39,-49.25,;80.39,-50.78,;81.73,-48.48,;83.07,-49.24,;83.07,-50.78,;84.4,-51.56,;84.4,-53.1,;85.75,-50.78,;84.4,-48.48,;84.4,-46.94,;85.74,-49.24,;87.07,-48.48,;87.07,-46.93,;88.41,-46.16,;85.74,-46.15,;88.41,-49.24,;88.41,-50.77,;89.74,-48.47,;91.07,-49.23,;91.07,-50.77,;92.41,-51.55,;92.41,-53.09,;93.74,-53.85,;93.74,-55.4,;92.41,-48.47,;92.41,-46.92,;93.74,-49.23,;95.08,-48.47,;96.41,-49.23,;96.41,-50.77,;97.75,-48.47,;99.08,-49.23,;99.08,-50.76,;100.42,-51.54,;100.42,-53.08,;101.75,-53.84,;101.75,-55.38,;100.42,-56.16,;103.09,-56.16,;100.42,-48.45,;101.75,-49.22,;100.42,-46.91,)| Show InChI InChI=1S/C149H225N39O46/c1-17-76(10)119(145(230)166-80(14)126(211)174-103(60-86-63-158-90-36-25-24-35-89(86)90)135(220)176-99(56-73(4)5)136(221)185-117(74(6)7)143(228)173-92(37-26-28-52-150)127(212)159-65-110(196)167-91(122(153)207)39-30-54-157-149(154)155)187-137(222)101(57-83-31-20-18-21-32-83)177-132(217)97(47-51-115(203)204)172-131(216)93(38-27-29-53-151)169-125(210)79(13)164-123(208)78(12)165-130(215)96(44-48-109(152)195)168-111(197)66-160-129(214)95(46-50-114(201)202)171-133(218)98(55-72(2)3)175-134(219)100(59-85-40-42-88(194)43-41-85)178-140(225)106(68-189)181-142(227)108(70-191)182-144(229)118(75(8)9)186-139(224)104(62-116(205)206)179-141(226)107(69-190)183-147(232)121(82(16)193)188-138(223)102(58-84-33-22-19-23-34-84)180-146(231)120(81(15)192)184-112(198)67-161-128(213)94(45-49-113(199)200)170-124(209)77(11)163-105(148(233)234)61-87-64-156-71-162-87/h18-25,31-36,40-43,63-64,71-82,91-108,117-121,158,163,189-194H,17,26-30,37-39,44-62,65-70,150-151H2,1-16H3,(H2,152,195)(H2,153,207)(H,156,162)(H,159,212)(H,160,214)(H,161,213)(H,164,208)(H,165,215)(H,166,230)(H,167,196)(H,168,197)(H,169,210)(H,170,209)(H,171,218)(H,172,216)(H,173,228)(H,174,211)(H,175,219)(H,176,220)(H,177,217)(H,178,225)(H,179,226)(H,180,231)(H,181,227)(H,182,229)(H,183,232)(H,184,198)(H,185,221)(H,186,224)(H,187,222)(H,188,223)(H,199,200)(H,201,202)(H,203,204)(H,205,206)(H,233,234)(H4,154,155,157)/t76-,77-,78-,79-,80-,81+,82-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,117-,118-,119-,120-,121-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0330 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50324732 (CHEMBL1222075) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:205.213,177.190,167.174,147.160,132.141,112.119,98.103,76.86,62.70,43.53,30.37,8.12,231.237,wD:196.207,188.194,219.227,173.178,222.230,159.168,141.147,120.132,104.111,87.97,71.74,54.61,39.41,16.28,4.4,239.245,240.248,209.214,(21.88,-5.16,;20.57,-4.37,;20.57,-2.78,;19.27,-1.98,;19.27,-.39,;17.96,.41,;16.65,-.39,;16.65,-1.98,;15.33,.41,;15.33,2,;16.65,2.8,;16.65,4.38,;17.96,2,;14.03,-.38,;12.72,.41,;12.72,2,;11.41,-.38,;11.41,-1.97,;12.72,-2.77,;14.09,-2.12,;15.11,-3.31,;14.35,-4.69,;14.81,-6.2,;13.79,-7.38,;12.32,-7.04,;11.85,-5.52,;12.87,-4.35,;10.1,.42,;8.79,-.38,;8.79,-1.97,;7.48,.42,;7.48,2,;8.79,2.81,;8.79,4.39,;7.48,5.18,;10.11,5.18,;6.17,-.37,;4.86,.42,;4.86,2.01,;3.55,-.37,;2.24,.42,;.94,-.37,;.94,-1.96,;-.38,.43,;-.38,2.01,;.94,2.82,;2.24,2.01,;3.55,2.81,;3.55,4.4,;2.25,5.19,;.94,4.4,;-1.68,-.37,;-3.01,.43,;-3.01,2.02,;-4.3,-.36,;-4.3,-1.95,;-3.01,-2.75,;-1.69,-1.95,;-3.01,-4.34,;-5.61,.43,;-6.92,-.36,;-6.92,-1.95,;-8.24,.44,;-8.24,2.02,;-6.92,2.83,;-6.92,4.41,;-8.23,5.2,;-5.61,5.2,;-9.55,-.36,;-10.85,.44,;-10.85,2.03,;-12.17,-.35,;-12.17,-1.95,;-13.46,.44,;-14.79,-.34,;-14.79,-1.94,;-16.1,.45,;-16.1,2.03,;-14.79,2.84,;-14.79,4.42,;-13.47,5.21,;-13.47,6.81,;-14.78,7.61,;-12.17,7.61,;-17.41,-.34,;-18.72,.45,;-18.72,2.04,;-20.03,-.34,;-20.03,-1.94,;-18.72,-2.73,;-18.72,-4.32,;-17.4,-5.11,;-17.4,-6.71,;-18.73,-7.51,;-16.11,-7.51,;-21.35,.46,;-22.63,-.33,;-22.63,-1.93,;-23.96,.46,;-23.96,2.05,;-22.63,2.85,;-25.26,-.32,;-26.57,.47,;-26.57,2.05,;-27.89,-.32,;-27.89,-1.92,;-26.57,-2.71,;-25.28,-1.92,;-26.57,-4.3,;-29.2,.47,;-30.5,-.32,;-30.5,-1.92,;-31.82,.47,;-31.82,2.06,;-30.5,2.86,;-30.5,4.45,;-29.18,2.06,;-33.12,-.31,;-34.44,.47,;-34.44,2.06,;-35.73,-.31,;-35.73,-1.91,;-34.44,-2.7,;-33.13,-1.91,;-31.82,-2.71,;-31.81,-4.3,;-30.5,-5.09,;-33.12,-5.09,;-34.43,-4.3,;-37.06,.48,;-38.37,-.31,;-38.37,-1.91,;-39.67,.48,;-39.67,2.07,;-38.37,2.87,;-38.37,4.46,;-37.06,5.26,;-37.06,6.85,;-40.98,-.3,;-42.29,.48,;-42.29,2.07,;-43.59,-.3,;-43.59,-1.9,;-42.29,-2.69,;-44.92,.49,;-46.22,-.3,;-46.22,-1.89,;-47.53,.49,;-47.53,2.08,;-46.22,2.88,;-44.91,2.07,;-43.59,2.87,;-43.6,4.46,;-42.28,5.26,;-44.91,5.27,;-46.22,4.47,;-48.84,-.29,;-50.15,.49,;-50.15,2.08,;-51.46,-.29,;-51.46,-1.88,;-50.15,-2.69,;-48.85,-1.88,;-50.15,-4.28,;-52.76,.5,;-54.08,-.29,;-54.08,-1.88,;-55.39,.5,;-55.39,2.09,;-54.08,2.89,;-56.69,-.29,;-58.02,.5,;-58.02,2.09,;-59.31,-.28,;-60.63,.51,;-61.93,-.28,;-61.93,-1.87,;-63.25,.51,;-63.25,2.09,;-61.93,2.9,;-60.63,2.09,;-59.31,2.89,;-59.31,4.48,;-60.62,5.29,;-61.92,4.48,;-64.55,-.28,;-65.86,.51,;-65.86,2.1,;-67.17,-.27,;-68.49,.51,;-69.79,-.27,;-69.79,-1.86,;-71.09,.52,;-72.42,-.27,;-73.73,.52,;-73.73,2.11,;-75.03,-.27,;-75.03,-1.86,;-73.73,-2.66,;-73.73,-4.25,;-75.02,-5.05,;-72.43,-5.04,;-76.34,.52,;-77.65,-.27,;-77.65,-1.85,;-78.97,.52,;-78.97,2.11,;-77.63,2.92,;-80.26,-.26,;-81.63,.51,;-81.63,2.05,;-82.95,2.82,;-84.22,1.95,;-85.46,2.88,;-84.95,4.35,;-83.41,4.32,;-82.97,-.26,;-84.31,.52,;-82.97,-1.82,;-67.17,-1.87,;-68.49,-2.67,;-65.86,-2.67,;-59.31,-1.88,;-60.63,-2.68,;-58.02,-2.68,;3.55,-1.96,;4.86,-2.76,;2.24,-2.76,;20.57,.4,;20.57,1.99,;21.89,-.39,;23.19,.4,;23.19,1.99,;24.51,2.79,;25.82,1.99,;24.51,4.38,;24.51,-.4,;24.51,-1.99,;25.81,.4,;27.12,-.4,;27.12,-1.99,;25.81,-2.79,;28.44,-2.78,;28.44,.39,;29.75,-.4,;28.44,1.98,)| Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-96(133(226)177-95(47-51-246-11)132(225)185-103(60-115(158)209)143(236)195-121(76(8)201)124(159)217)180-137(230)102(58-83-64-167-88-29-19-18-28-87(83)88)184-131(224)94(43-46-114(157)208)178-148(241)120(74(5)6)194-141(234)100(54-79-24-14-12-15-25-79)183-138(231)104(61-117(211)212)186-130(223)93(42-45-113(156)207)172-125(218)75(7)170-127(220)90(31-22-49-165-152(160)161)173-128(221)91(32-23-50-166-153(162)163)175-146(239)110(69-199)191-140(233)106(63-119(215)216)187-134(227)97(53-73(3)4)179-135(228)98(56-81-33-37-85(204)38-34-81)181-129(222)89(30-20-21-48-154)174-145(238)109(68-198)190-136(229)99(57-82-35-39-86(205)40-36-82)182-139(232)105(62-118(213)214)188-147(240)111(70-200)192-150(243)123(78(10)203)196-142(235)101(55-80-26-16-13-17-27-80)189-149(242)122(77(9)202)193-116(210)66-168-126(219)92(41-44-112(155)206)176-144(237)108(67-197)171-107(151(244)245)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,89-111,120-123,167,171,197-205H,20-23,30-32,41-63,66-70,154H2,1-11H3,(H2,155,206)(H2,156,207)(H2,157,208)(H2,158,209)(H2,159,217)(H,164,169)(H,168,219)(H,170,220)(H,172,218)(H,173,221)(H,174,238)(H,175,239)(H,176,237)(H,177,226)(H,178,241)(H,179,228)(H,180,230)(H,181,222)(H,182,232)(H,183,231)(H,184,224)(H,185,225)(H,186,223)(H,187,227)(H,188,240)(H,189,242)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,236)(H,196,235)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50324707 (CHEMBL1222081) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCS(O)(=O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:209.217,181.194,171.178,151.164,136.145,116.123,98.107,76.86,62.70,43.53,30.37,8.12,235.241,wD:200.211,192.198,223.231,177.182,226.234,163.172,145.151,124.136,108.115,87.97,71.74,54.61,39.41,16.28,4.4,243.249,244.252,213.218,(49.74,-5.28,;48.43,-4.49,;48.43,-2.89,;47.12,-2.1,;47.12,-.51,;45.81,.29,;44.51,-.51,;44.51,-2.1,;43.19,.29,;43.19,1.88,;44.51,2.68,;44.51,4.27,;45.82,1.88,;41.89,-.5,;40.57,.3,;40.57,1.88,;39.26,-.5,;39.26,-2.09,;40.57,-2.88,;41.95,-2.24,;42.97,-3.43,;42.2,-4.81,;42.64,-6.25,;41.62,-7.35,;40.14,-7.01,;39.7,-5.57,;40.73,-4.47,;37.95,.3,;36.64,-.5,;36.64,-2.09,;35.33,.3,;35.33,1.89,;36.64,2.69,;36.64,4.28,;35.34,5.07,;37.96,5.07,;34.02,-.49,;32.72,.31,;32.72,1.89,;31.4,-.49,;30.09,.31,;28.78,-.49,;28.78,-2.08,;27.46,.31,;27.46,1.9,;28.78,2.7,;30.09,1.9,;31.4,2.69,;31.4,4.28,;30.09,5.08,;28.79,4.29,;26.17,-.48,;24.84,.32,;24.84,1.9,;23.55,-.48,;23.55,-2.08,;24.84,-2.86,;26.16,-2.08,;24.84,-4.46,;22.23,.32,;20.92,-.48,;20.92,-2.07,;19.6,.32,;19.6,1.91,;20.92,2.71,;20.92,4.3,;19.61,5.09,;22.23,5.09,;18.29,-.48,;16.99,.33,;16.99,1.91,;15.68,-.47,;15.68,-2.07,;14.38,.33,;13.06,-.46,;13.06,-2.06,;11.75,.33,;11.75,1.92,;13.06,2.73,;13.06,4.31,;14.38,5.1,;14.38,6.69,;13.06,7.48,;15.68,7.49,;10.43,-.46,;9.11,.33,;9.11,1.93,;7.8,-.46,;7.8,-2.06,;9.16,-2.83,;9.16,-4.38,;10.49,-5.16,;10.49,-6.71,;11.85,-7.49,;9.16,-7.49,;6.49,.35,;5.2,-.44,;5.2,-2.05,;3.87,.35,;3.87,1.94,;5.22,2.71,;5.22,4.26,;4.44,5.62,;6.56,5.04,;3.67,4.28,;2.57,-.44,;1.26,.35,;1.26,1.94,;-.06,-.44,;-.06,-2.04,;1.26,-2.83,;2.56,-2.04,;1.26,-4.42,;-1.37,.35,;-2.68,-.44,;-2.68,-2.04,;-3.99,.36,;-3.99,1.94,;-2.68,2.75,;-2.68,4.33,;-1.35,1.94,;-5.29,-.43,;-6.61,.36,;-6.61,1.95,;-7.91,-.43,;-7.91,-2.03,;-6.61,-2.82,;-5.3,-2.03,;-3.99,-2.83,;-3.99,-4.42,;-2.67,-5.22,;-5.3,-5.21,;-6.61,-4.41,;-9.23,.36,;-10.54,-.43,;-10.54,-2.03,;-11.85,.37,;-11.85,1.95,;-10.54,2.75,;-10.54,4.34,;-9.23,5.14,;-9.23,6.73,;-13.16,-.42,;-14.47,.37,;-14.47,1.96,;-15.77,-.42,;-15.77,-2.02,;-14.47,-2.81,;-17.1,.37,;-18.4,-.42,;-18.4,-2.01,;-19.7,.38,;-19.7,1.96,;-18.4,2.76,;-17.09,1.96,;-15.77,2.76,;-15.77,4.35,;-14.46,5.15,;-17.09,5.15,;-18.4,4.35,;-21.02,-.41,;-22.33,.38,;-22.33,1.97,;-23.65,-.41,;-23.65,-2,;-22.33,-2.8,;-21.03,-2,;-22.33,-4.39,;-24.95,.38,;-26.27,-.41,;-26.27,-2,;-27.57,.39,;-27.57,1.97,;-26.27,2.77,;-28.88,-.4,;-30.21,.39,;-30.21,1.98,;-31.5,-.4,;-32.82,.39,;-34.12,-.4,;-34.12,-1.99,;-35.44,.39,;-35.44,1.98,;-34.12,2.78,;-32.82,1.98,;-31.5,2.78,;-31.5,4.37,;-32.81,5.17,;-34.11,4.37,;-36.74,-.4,;-38.05,.4,;-38.05,1.98,;-39.37,-.39,;-40.68,.4,;-41.98,-.39,;-41.98,-1.98,;-43.28,.4,;-44.61,-.39,;-45.92,.41,;-45.92,1.99,;-47.23,-.38,;-47.23,-1.98,;-45.92,-2.77,;-45.92,-4.37,;-47.22,-5.17,;-44.62,-5.16,;-48.54,.41,;-49.85,-.38,;-49.85,-1.97,;-51.17,.41,;-51.17,2,;-49.83,2.8,;-52.47,-.38,;-53.81,.4,;-53.81,1.93,;-55.14,2.7,;-56.4,1.83,;-57.64,2.76,;-57.14,4.22,;-55.59,4.19,;-55.16,-.37,;-56.48,.4,;-55.16,-1.92,;-39.37,-1.99,;-40.68,-2.79,;-38.05,-2.78,;-31.5,-1.99,;-32.82,-2.8,;-30.21,-2.79,;31.4,-2.08,;32.72,-2.87,;30.09,-2.88,;48.43,.29,;48.43,1.88,;49.76,-.51,;51.05,.29,;51.05,1.87,;52.37,2.67,;53.68,1.87,;52.37,4.26,;52.37,-.52,;52.37,-2.11,;53.67,.28,;54.98,-.52,;54.98,-2.11,;53.67,-2.9,;56.3,-2.9,;56.3,.28,;57.64,-.47,;56.3,1.87,)| Show InChI InChI=1S/C154H227N43O51S2/c1-73(2)54-98(135(227)178-96(47-52-249-11)133(225)187-105(62-116(159)209)145(237)196-122(77(8)201)125(160)217)182-139(231)104(60-84-66-168-89-29-19-18-28-88(84)89)186-132(224)95(43-46-115(158)208)180-149(241)121(75(5)6)195-143(235)102(56-80-24-14-12-15-25-80)185-141(233)107(64-119(213)214)188-131(223)94(42-45-114(157)207)173-126(218)76(7)171-128(220)91(31-22-50-166-153(161)162)174-129(221)92(32-23-51-167-154(163)164)175-134(226)97(48-53-250(246,247)248)179-140(232)106(63-118(211)212)189-136(228)99(55-74(3)4)181-137(229)100(58-82-33-37-86(204)38-34-82)183-130(222)90(30-20-21-49-155)176-147(239)111(70-199)192-138(230)101(59-83-35-39-87(205)40-36-83)184-142(234)108(65-120(215)216)190-148(240)112(71-200)193-151(243)124(79(10)203)197-144(236)103(57-81-26-16-13-17-27-81)191-150(242)123(78(9)202)194-117(210)68-169-127(219)93(41-44-113(156)206)177-146(238)110(69-198)172-109(152(244)245)61-85-67-165-72-170-85/h12-19,24-29,33-40,66-67,72-79,90-112,121-124,168,172,198-205H,20-23,30-32,41-65,68-71,155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H2,160,217)(H,165,170)(H,169,219)(H,171,220)(H,173,218)(H,174,221)(H,175,226)(H,176,239)(H,177,238)(H,178,227)(H,179,232)(H,180,241)(H,181,229)(H,182,231)(H,183,222)(H,184,234)(H,185,233)(H,186,224)(H,187,225)(H,188,223)(H,189,228)(H,190,240)(H,191,242)(H,192,230)(H,193,243)(H,194,210)(H,195,235)(H,196,237)(H,197,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,161,162,166)(H4,163,164,167)(H,246,247,248)/t76-,77+,78+,79+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,121-,122-,123-,124-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.120 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50324710 (CHEMBL1222084) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:203.211,175.188,165.172,145.158,130.139,110.117,98.101,223.231,76.86,62.70,43.53,30.37,8.12,232.238,wD:194.205,186.192,217.225,171.176,220.228,157.166,139.145,118.130,102.109,87.97,71.74,54.61,39.41,16.28,4.4,240.246,241.249,207.212,(49.77,-5.31,;48.46,-4.51,;48.46,-2.92,;47.15,-2.13,;47.15,-.53,;45.84,.27,;44.54,-.53,;44.54,-2.12,;43.22,.27,;43.22,1.86,;44.54,2.66,;44.54,4.25,;45.85,1.86,;41.91,-.53,;40.59,.27,;40.59,1.86,;39.29,-.52,;39.29,-2.12,;40.59,-2.91,;41.98,-2.27,;43,-3.45,;42.23,-4.84,;42.67,-6.28,;41.64,-7.38,;40.16,-7.04,;39.72,-5.59,;40.75,-4.49,;37.98,.28,;36.66,-.52,;36.66,-2.12,;35.35,.28,;35.35,1.87,;36.66,2.67,;36.66,4.26,;35.36,5.05,;37.98,5.05,;34.04,-.52,;32.74,.28,;32.74,1.87,;31.42,-.52,;30.11,.29,;28.8,-.51,;28.8,-2.11,;27.47,.29,;27.47,1.88,;28.8,2.68,;30.11,1.87,;31.42,2.67,;31.42,4.26,;30.11,5.06,;28.8,4.27,;26.18,-.51,;24.86,.29,;24.86,1.88,;23.55,-.51,;23.55,-2.1,;24.86,-2.89,;26.17,-2.1,;24.86,-4.48,;22.24,.3,;20.92,-.5,;20.92,-2.1,;19.61,.3,;19.61,1.89,;20.92,2.69,;20.92,4.28,;19.62,5.07,;22.25,5.07,;18.3,-.5,;16.99,.3,;16.99,1.89,;15.68,-.5,;15.68,-2.09,;14.38,.3,;13.06,-.49,;13.06,-2.09,;11.75,.31,;11.75,1.9,;13.06,2.7,;13.06,4.28,;14.38,5.08,;14.38,6.67,;13.07,7.46,;15.68,7.47,;10.44,-.48,;9.12,.31,;9.12,1.91,;7.81,-.48,;7.81,-2.03,;9.16,-2.81,;9.16,-4.36,;10.5,-5.14,;10.5,-6.69,;11.84,-7.47,;9.15,-7.47,;6.49,.32,;5.2,-.47,;5.2,-2.08,;3.87,.32,;2.58,-.47,;1.26,.33,;1.26,1.92,;-.06,-.46,;-.06,-2.06,;1.26,-2.85,;2.56,-2.06,;1.26,-4.45,;-1.37,.33,;-2.68,-.46,;-2.68,-2.06,;-3.99,.33,;-3.99,1.92,;-2.68,2.72,;-2.68,4.31,;-1.35,1.92,;-5.29,-.46,;-6.61,.34,;-6.61,1.93,;-7.91,-.45,;-7.91,-2.06,;-6.61,-2.85,;-5.3,-2.06,;-3.99,-2.85,;-3.99,-4.44,;-2.67,-5.24,;-5.3,-5.24,;-6.61,-4.44,;-9.23,.34,;-10.55,-.45,;-10.55,-2.05,;-11.85,.34,;-11.85,1.93,;-10.55,2.73,;-10.55,4.32,;-9.24,5.12,;-9.24,6.71,;-13.17,-.45,;-14.47,.35,;-14.47,1.93,;-15.78,-.44,;-15.78,-2.05,;-14.47,-2.84,;-17.11,.35,;-18.41,-.44,;-18.41,-2.04,;-19.71,.35,;-19.71,1.94,;-18.41,2.74,;-17.1,1.94,;-15.78,2.74,;-15.78,4.33,;-14.47,5.13,;-17.1,5.13,;-18.41,4.33,;-21.03,-.44,;-22.34,.36,;-22.34,1.94,;-23.66,-.43,;-23.66,-2.03,;-22.34,-2.83,;-21.05,-2.03,;-22.34,-4.42,;-24.96,.36,;-26.28,-.43,;-26.28,-2.03,;-27.59,.36,;-27.59,1.95,;-26.28,2.75,;-28.89,-.43,;-30.23,.36,;-30.23,1.95,;-31.51,-.43,;-32.84,.37,;-34.14,-.42,;-34.14,-2.02,;-35.46,.37,;-35.46,1.96,;-34.14,2.76,;-32.84,1.96,;-31.52,2.75,;-31.52,4.34,;-32.83,5.15,;-34.13,4.35,;-36.76,-.42,;-38.08,.37,;-38.08,1.96,;-39.39,-.42,;-40.7,.38,;-42.01,-.41,;-42.01,-2.01,;-43.31,.38,;-44.64,-.41,;-45.95,.38,;-45.95,1.97,;-47.26,-.41,;-47.26,-2,;-45.94,-2.8,;-45.94,-4.39,;-47.25,-5.19,;-44.65,-5.19,;-48.57,.38,;-49.88,-.41,;-49.88,-2,;-51.2,.38,;-51.2,1.98,;-49.86,2.78,;-52.49,-.41,;-53.85,.37,;-53.85,1.9,;-55.17,2.67,;-56.43,1.8,;-57.67,2.73,;-57.17,4.19,;-55.62,4.16,;-55.19,-.41,;-56.52,.37,;-55.19,-1.96,;-39.39,-2.01,;-40.7,-2.81,;-38.08,-2.81,;-31.51,-2.02,;-32.84,-2.82,;-30.23,-2.82,;3.87,1.91,;2.53,2.67,;5.2,2.71,;31.42,-2.11,;32.74,-2.9,;30.11,-2.9,;48.46,.26,;48.46,1.85,;49.79,-.54,;51.08,.26,;51.08,1.85,;52.4,2.65,;53.71,1.85,;52.4,4.24,;52.4,-.54,;52.4,-2.13,;53.71,.26,;55.02,-.54,;55.02,-2.14,;53.71,-2.93,;56.33,-2.93,;56.33,.26,;57.67,-.5,;56.33,1.84,)| Show InChI InChI=1S/C154H227N43O49S/c1-72(2)53-97(134(227)177-96(48-52-247-12)133(226)186-104(61-115(159)210)143(236)195-121(76(8)201)125(160)218)181-138(231)103(59-84-65-168-89-30-20-19-29-88(84)89)185-132(225)95(44-47-114(158)209)179-148(241)120(74(5)6)194-141(234)101(55-80-25-15-13-16-26-80)184-139(232)105(62-117(212)213)187-131(224)94(43-46-113(157)208)173-126(219)75(7)171-128(221)91(32-23-50-166-153(161)162)174-129(222)92(33-24-51-167-154(163)164)178-150(243)123(78(10)203)197-144(237)107(64-119(216)217)188-135(228)98(54-73(3)4)180-136(229)99(57-82-34-38-86(205)39-35-82)182-130(223)90(31-21-22-49-155)175-146(239)110(69-199)191-137(230)100(58-83-36-40-87(206)41-37-83)183-140(233)106(63-118(214)215)189-147(240)111(70-200)192-151(244)124(79(11)204)196-142(235)102(56-81-27-17-14-18-28-81)190-149(242)122(77(9)202)193-116(211)67-169-127(220)93(42-45-112(156)207)176-145(238)109(68-198)172-108(152(245)246)60-85-66-165-71-170-85/h13-20,25-30,34-41,65-66,71-79,90-111,120-124,168,172,198-206H,21-24,31-33,42-64,67-70,155H2,1-12H3,(H2,156,207)(H2,157,208)(H2,158,209)(H2,159,210)(H2,160,218)(H,165,170)(H,169,220)(H,171,221)(H,173,219)(H,174,222)(H,175,239)(H,176,238)(H,177,227)(H,178,243)(H,179,241)(H,180,229)(H,181,231)(H,182,223)(H,183,233)(H,184,232)(H,185,225)(H,186,226)(H,187,224)(H,188,228)(H,189,240)(H,190,242)(H,191,230)(H,192,244)(H,193,211)(H,194,234)(H,195,236)(H,196,235)(H,197,237)(H,212,213)(H,214,215)(H,216,217)(H,245,246)(H4,161,162,166)(H4,163,164,167)/t75-,76+,77+,78+,79+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-,124-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.580 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50324716 (CHEMBL1222090) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:181.194,171.178,151.164,136.145,116.123,99.107,77.87,63.71,43.53,30.37,8.12,235.241,209.217,wD:192.198,223.231,177.182,226.234,163.172,145.151,124.136,108.115,88.98,72.75,54.62,39.41,16.28,4.4,243.249,244.252,213.218,200.211,(49.67,-5.25,;48.36,-4.46,;48.36,-2.87,;47.06,-2.08,;47.06,-.49,;45.75,.31,;44.45,-.48,;44.45,-2.07,;43.13,.31,;43.13,1.9,;44.45,2.7,;44.45,4.28,;45.75,1.9,;41.82,-.48,;40.51,.31,;40.51,1.9,;39.21,-.48,;39.21,-2.07,;40.51,-2.86,;41.89,-2.22,;42.91,-3.4,;42.14,-4.78,;42.61,-6.29,;41.59,-7.47,;40.12,-7.13,;39.65,-5.62,;40.67,-4.44,;37.9,.32,;36.59,-.47,;36.59,-2.07,;35.28,.32,;35.28,1.91,;36.59,2.71,;36.59,4.29,;35.29,5.08,;37.91,5.08,;33.97,-.47,;32.67,.32,;32.67,1.91,;31.36,-.47,;30.05,.33,;28.74,-.47,;28.74,-2.06,;27.42,.33,;27.42,1.92,;28.74,2.72,;30.09,1.98,;31.41,2.78,;31.37,4.32,;30.01,5.06,;28.7,4.25,;26.13,-.46,;24.8,.33,;24.8,1.92,;23.51,-.46,;23.51,-2.05,;24.8,-2.84,;24.77,-4.38,;23.41,-5.12,;26.08,-5.19,;22.2,.34,;20.89,-.46,;20.89,-2.05,;19.58,.34,;19.58,1.92,;20.89,2.73,;20.89,4.31,;22.23,5.08,;22.23,6.62,;18.27,-.45,;16.96,.34,;16.96,1.93,;15.65,-.45,;15.65,-2.04,;14.36,.35,;13.04,-.44,;13.04,-2.04,;11.73,.35,;11.73,1.93,;13.04,2.74,;13.04,4.32,;14.36,5.11,;14.36,6.71,;13.04,7.49,;15.66,7.5,;10.43,-.44,;9.11,.35,;9.11,1.94,;7.8,-.43,;7.8,-2.03,;9.11,-2.82,;9.11,-4.41,;10.44,-5.19,;10.44,-6.73,;11.78,-7.5,;9.11,-7.5,;6.49,.36,;5.2,-.42,;5.2,-2.03,;3.88,.37,;3.88,1.95,;5.22,2.72,;5.22,4.26,;3.88,5.03,;6.55,5.03,;2.58,-.42,;1.26,.37,;1.26,1.95,;-.05,-.42,;-.05,-2.01,;1.26,-2.81,;2.56,-2.01,;1.26,-4.4,;-1.36,.37,;-2.66,-.41,;-2.66,-2.01,;-3.97,.37,;-3.97,1.96,;-2.66,2.76,;-2.66,4.35,;-1.35,1.96,;-5.28,-.41,;-6.59,.38,;-6.59,1.96,;-7.89,-.41,;-7.89,-2.01,;-6.59,-2.8,;-5.28,-2.01,;-3.98,-2.8,;-3.98,-4.39,;-2.66,-5.19,;-5.28,-5.18,;-6.59,-4.39,;-9.22,.38,;-10.52,-.4,;-10.52,-2,;-11.82,.38,;-11.82,1.97,;-10.52,2.77,;-10.52,4.36,;-9.21,5.16,;-9.21,6.74,;-13.13,-.4,;-14.43,.39,;-14.43,1.97,;-15.76,-.4,;-15.76,-2,;-14.43,-2.79,;-17.07,.39,;-18.37,-.39,;-18.37,-1.99,;-19.69,.39,;-19.69,1.98,;-18.37,2.78,;-17.06,1.97,;-15.76,2.77,;-15.75,4.36,;-14.43,5.16,;-17.06,5.17,;-18.37,4.37,;-20.98,-.39,;-22.29,.4,;-22.29,1.98,;-23.61,-.39,;-23.61,-1.98,;-22.29,-2.78,;-20.99,-1.98,;-22.29,-4.37,;-24.91,.4,;-26.23,-.39,;-26.23,-1.98,;-27.53,.4,;-27.53,1.99,;-26.23,2.79,;-28.84,-.38,;-30.16,.41,;-30.16,1.99,;-31.44,-.38,;-32.78,.41,;-34.07,-.38,;-34.07,-1.97,;-35.38,.41,;-35.38,2,;-34.07,2.8,;-32.77,1.99,;-31.45,2.79,;-31.45,4.38,;-32.77,5.18,;-34.07,4.38,;-36.69,-.37,;-37.99,.41,;-37.99,2,;-39.32,-.37,;-40.62,.42,;-41.92,-.37,;-41.92,-1.96,;-43.23,.42,;-44.54,-.36,;-45.85,.42,;-45.85,2.01,;-47.15,-.36,;-47.15,-1.95,;-45.85,-2.75,;-45.85,-4.34,;-47.16,-5.14,;-44.55,-5.14,;-48.46,.42,;-49.77,-.36,;-49.77,-1.95,;-51.09,.42,;-51.09,2.01,;-49.77,2.82,;-52.4,-.36,;-53.73,.42,;-53.73,1.94,;-55.05,2.7,;-56.3,1.84,;-57.53,2.76,;-57.03,4.21,;-55.49,4.18,;-55.06,-.35,;-56.38,.42,;-55.06,-1.89,;-39.32,-1.96,;-40.62,-2.76,;-37.99,-2.76,;-31.44,-1.97,;-32.78,-2.77,;-30.16,-2.77,;31.36,-2.06,;32.67,-2.85,;30.05,-2.85,;48.36,.31,;48.36,1.89,;49.68,-.49,;50.98,.3,;50.98,1.89,;52.29,2.69,;53.6,1.89,;52.29,4.28,;52.29,-.49,;52.29,-2.08,;53.6,.3,;54.91,-.5,;54.91,-2.09,;53.6,-2.88,;56.22,-2.88,;56.22,.3,;57.53,-.5,;56.22,1.88,)| Show InChI InChI=1S/C157H233N43O49S/c1-76(2)58-102(139(232)183-101(52-57-250-11)138(231)191-109(66-118(162)211)148(241)199-125(80(8)204)128(163)221)186-143(236)108(64-87-69-171-92-31-19-18-30-91(87)92)190-136(229)98(45-49-117(161)210)184-152(245)124(78(5)6)198-146(239)106(60-83-26-14-12-15-27-83)188-137(230)100(47-51-121(215)216)181-132(225)93(32-20-22-53-158)176-129(222)79(7)174-131(224)95(34-24-55-169-156(164)165)177-133(226)96(35-25-56-170-157(166)167)178-135(228)99(46-50-120(213)214)182-144(237)110(67-122(217)218)192-140(233)103(59-77(3)4)185-141(234)104(62-85-36-40-89(207)41-37-85)187-134(227)94(33-21-23-54-159)179-150(243)114(73-202)195-142(235)105(63-86-38-42-90(208)43-39-86)189-145(238)111(68-123(219)220)193-151(244)115(74-203)196-154(247)127(82(10)206)200-147(240)107(61-84-28-16-13-17-29-84)194-153(246)126(81(9)205)197-119(212)71-172-130(223)97(44-48-116(160)209)180-149(242)113(72-201)175-112(155(248)249)65-88-70-168-75-173-88/h12-19,26-31,36-43,69-70,75-82,93-115,124-127,171,175,201-208H,20-25,32-35,44-68,71-74,158-159H2,1-11H3,(H2,160,209)(H2,161,210)(H2,162,211)(H2,163,221)(H,168,173)(H,172,223)(H,174,224)(H,176,222)(H,177,226)(H,178,228)(H,179,243)(H,180,242)(H,181,225)(H,182,237)(H,183,232)(H,184,245)(H,185,234)(H,186,236)(H,187,227)(H,188,230)(H,189,238)(H,190,229)(H,191,231)(H,192,233)(H,193,244)(H,194,246)(H,195,235)(H,196,247)(H,197,212)(H,198,239)(H,199,241)(H,200,240)(H,213,214)(H,215,216)(H,217,218)(H,219,220)(H,248,249)(H4,164,165,169)(H4,166,167,170)/t79-,80+,81+,82+,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,124-,125-,126-,127-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0750 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50324717 (CHEMBL1222091) Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:173.179,145.156,135.140,115.126,100.107,80.85,63.69,41.49,27.33,8.16,196.200,219.225,235.241,250.256,251.259,wD:164.173,156.160,187.193,141.144,190.196,127.134,109.113,88.98,72.77,52.60,36.37,19.24,4.4,2.2,205.209,227.233,243.249,244.252,177.180,(30.83,-4.4,;30.87,-2.85,;29.55,-2.06,;28.24,-2.86,;29.55,-.47,;28.24,.33,;26.94,-.47,;26.94,-2.06,;25.62,.33,;25.62,1.92,;26.94,2.72,;28.25,1.91,;29.55,2.71,;29.56,4.3,;28.25,5.09,;26.94,4.31,;24.32,-.46,;23,.33,;23,1.92,;21.7,-.46,;21.7,-2.05,;23,-2.84,;24.35,-2.11,;22.96,-4.39,;20.39,.34,;19.07,-.46,;19.07,-2.05,;17.76,.34,;17.76,1.93,;19.07,2.73,;19.07,4.32,;20.42,5.09,;20.42,6.63,;16.45,-.45,;15.14,.34,;15.14,1.93,;13.83,-.45,;13.83,-2.04,;12.54,.35,;11.21,-.44,;11.21,-2.04,;9.91,.35,;9.91,1.93,;11.21,2.75,;11.21,4.32,;12.54,5.11,;12.54,6.71,;11.22,7.5,;13.83,7.5,;8.59,-.44,;7.28,.35,;7.28,1.95,;5.97,-.43,;5.97,-2.03,;7.28,-2.83,;7.28,-4.42,;8.61,-5.19,;8.61,-6.73,;9.95,-7.5,;7.28,-7.5,;4.65,.36,;3.37,-.42,;3.37,-2.03,;2.04,.37,;2.04,1.95,;3.39,2.72,;3.39,4.27,;2.04,5.04,;4.71,5.04,;.75,-.42,;-.57,.37,;-.57,1.95,;-1.89,-.42,;-1.89,-2.02,;-.57,-2.81,;.73,-2.02,;-.57,-4.4,;-3.2,.37,;-4.5,-.41,;-4.5,-2.01,;-5.81,.37,;-5.81,1.96,;-4.5,2.76,;-4.5,4.35,;-3.18,1.96,;-7.11,-.41,;-8.43,.38,;-8.43,1.96,;-9.73,-.41,;-9.73,-2.01,;-8.43,-2.8,;-7.12,-2.01,;-5.81,-2.81,;-5.81,-4.4,;-4.49,-5.19,;-7.12,-5.19,;-8.43,-4.39,;-11.05,.38,;-12.37,-.4,;-12.37,-2,;-13.66,.38,;-13.66,1.97,;-12.37,2.77,;-12.37,4.36,;-11.06,5.16,;-11.06,6.75,;-14.98,-.4,;-16.28,.39,;-16.28,1.97,;-17.59,-.4,;-17.59,-2,;-16.28,-2.79,;-18.92,.39,;-20.21,-.39,;-20.21,-1.99,;-21.52,.39,;-21.52,1.98,;-20.21,2.78,;-18.91,1.98,;-17.59,2.78,;-17.59,4.37,;-16.27,5.17,;-18.91,5.17,;-20.22,4.37,;-22.83,-.39,;-24.14,.4,;-24.14,1.98,;-25.46,-.39,;-25.46,-1.98,;-24.14,-2.78,;-22.84,-1.98,;-24.14,-4.37,;-26.76,.4,;-28.08,-.39,;-28.08,-1.98,;-29.39,.4,;-29.39,1.99,;-28.08,2.79,;-30.68,-.38,;-32.01,.41,;-32.01,1.99,;-33.3,-.38,;-34.62,.41,;-35.93,-.38,;-35.93,-1.97,;-37.24,.41,;-37.24,2,;-35.93,2.8,;-34.63,1.99,;-33.3,2.8,;-33.31,4.38,;-34.62,5.19,;-35.92,4.39,;-38.55,-.37,;-39.85,.41,;-39.85,2,;-41.17,-.37,;-42.48,.42,;-43.79,-.37,;-43.79,-1.96,;-45.08,.42,;-46.41,-.36,;-47.72,.42,;-47.72,2.01,;-49.02,-.36,;-49.02,-1.95,;-47.72,-2.75,;-47.72,-4.35,;-49.02,-5.14,;-46.42,-5.14,;-50.33,.42,;-51.64,-.36,;-51.64,-1.95,;-52.97,.43,;-52.97,2.02,;-51.63,2.82,;-54.27,-.36,;-55.6,.42,;-55.6,1.94,;-56.92,2.7,;-58.17,1.84,;-59.4,2.76,;-58.91,4.22,;-57.36,4.19,;-56.94,-.35,;-58.26,.42,;-56.94,-1.89,;-41.17,-1.96,;-42.48,-2.77,;-39.85,-2.76,;-33.3,-1.97,;-34.62,-2.78,;-32.01,-2.77,;30.87,.32,;30.87,1.91,;32.17,-.47,;33.48,.32,;33.48,1.91,;34.82,2.68,;34.82,4.22,;33.48,4.99,;36.15,4.99,;34.79,-.47,;34.79,-2.07,;36.1,.32,;37.41,-.48,;37.41,-2.07,;38.72,-2.86,;40.09,-2.22,;41.12,-3.4,;40.35,-4.79,;40.81,-6.29,;39.8,-7.47,;38.32,-7.13,;37.85,-5.62,;38.87,-4.45,;38.72,.32,;38.72,1.9,;40.03,-.48,;41.33,.31,;41.33,1.9,;42.65,2.7,;42.65,4.29,;43.96,1.9,;42.65,-.48,;42.65,-2.08,;43.96,.31,;45.27,-.49,;45.27,-2.08,;46.57,-2.87,;46.57,-4.46,;47.88,-5.26,;46.57,.31,;46.57,1.89,;47.89,-.49,;49.19,.3,;49.19,1.89,;50.51,2.69,;51.82,1.89,;50.51,4.28,;50.51,-.49,;50.51,-2.09,;51.81,.3,;53.12,-.5,;53.12,-2.09,;51.81,-2.88,;54.44,-2.88,;54.44,.3,;54.44,1.88,;55.75,-.5,;56.96,.2,;56.96,1.61,;55.75,2.32,;58.18,2.32,;58.18,-.5,;59.4,.2,;58.18,-1.91,)| Show InChI InChI=1S/C161H240N44O51S/c1-13-79(6)126(155(251)187-100(47-50-119(165)216)139(235)193-109(64-89-70-175-94-33-21-20-32-93(89)94)145(241)189-103(58-77(2)3)141(237)186-102(52-57-257-12)140(236)194-110(66-120(166)217)151(247)205-130(84(11)212)158(254)203-127(81(8)209)131(167)227)202-149(245)107(60-85-28-16-14-17-29-85)192-147(243)112(68-124(223)224)195-136(232)95(34-22-24-53-162)180-132(228)80(7)178-134(230)97(36-26-55-173-160(168)169)181-135(231)98(37-27-56-174-161(170)171)182-138(234)101(48-51-122(219)220)185-146(242)111(67-123(221)222)196-142(238)104(59-78(4)5)188-143(239)105(62-87-38-42-91(213)43-39-87)190-137(233)96(35-23-25-54-163)183-153(249)116(74-207)199-144(240)106(63-88-40-44-92(214)45-41-88)191-148(244)113(69-125(225)226)197-154(250)117(75-208)200-157(253)129(83(10)211)204-150(246)108(61-86-30-18-15-19-31-86)198-156(252)128(82(9)210)201-121(218)72-176-133(229)99(46-49-118(164)215)184-152(248)115(73-206)179-114(159(255)256)65-90-71-172-76-177-90/h14-21,28-33,38-45,70-71,76-84,95-117,126-130,175,179,206-214H,13,22-27,34-37,46-69,72-75,162-163H2,1-12H3,(H2,164,215)(H2,165,216)(H2,166,217)(H2,167,227)(H,172,177)(H,176,229)(H,178,230)(H,180,228)(H,181,231)(H,182,234)(H,183,249)(H,184,248)(H,185,242)(H,186,237)(H,187,251)(H,188,239)(H,189,241)(H,190,233)(H,191,244)(H,192,243)(H,193,235)(H,194,236)(H,195,232)(H,196,238)(H,197,250)(H,198,252)(H,199,240)(H,200,253)(H,201,218)(H,202,245)(H,203,254)(H,204,246)(H,205,247)(H,219,220)(H,221,222)(H,223,224)(H,225,226)(H,255,256)(H4,168,169,173)(H4,170,171,174)/t79-,80-,81+,82+,83+,84+,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,126-,127-,128-,129-,130-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0680 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50324728 (CHEMBL1222102) Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)C(C)CN[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O |r| Show InChI InChI=1S/C153H222N36O49S/c1-15-76(6)122(149(232)166-80(10)129(212)174-107(62-88-68-161-93-33-23-22-32-92(88)93)141(224)176-101(56-74(2)3)137(220)173-100(52-55-239-14)136(219)180-108(64-116(158)199)146(229)189-125(83(13)194)153(237)238)187-144(227)105(58-84-28-18-16-19-29-84)178-135(218)99(47-51-119(203)204)171-132(215)94(34-24-26-53-154)168-128(211)79(9)164-127(210)78(8)165-131(214)97(45-49-115(157)198)170-134(217)98(46-50-118(201)202)172-142(225)109(65-120(205)206)181-138(221)102(57-75(4)5)175-139(222)103(60-86-36-40-90(195)41-37-86)177-133(216)95(35-25-27-54-155)169-147(230)112(71-190)184-140(223)104(61-87-38-42-91(196)43-39-87)179-143(226)110(66-121(207)208)182-148(231)113(72-191)185-151(234)124(82(12)193)188-145(228)106(59-85-30-20-17-21-31-85)183-150(233)123(81(11)192)186-117(200)70-162-130(213)96(44-48-114(156)197)167-126(209)77(7)67-160-111(152(235)236)63-89-69-159-73-163-89/h16-23,28-33,36-43,68-69,73-83,94-113,122-125,160-161,190-196H,15,24-27,34-35,44-67,70-72,154-155H2,1-14H3,(H2,156,197)(H2,157,198)(H2,158,199)(H,159,163)(H,162,213)(H,164,210)(H,165,214)(H,166,232)(H,167,209)(H,168,211)(H,169,230)(H,170,217)(H,171,215)(H,172,225)(H,173,220)(H,174,212)(H,175,222)(H,176,224)(H,177,216)(H,178,218)(H,179,226)(H,180,219)(H,181,221)(H,182,231)(H,183,233)(H,184,223)(H,185,234)(H,186,200)(H,187,227)(H,188,228)(H,189,229)(H,201,202)(H,203,204)(H,205,206)(H,207,208)(H,235,236)(H,237,238)/t76-,77?,78-,79-,80-,81+,82+,83+,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,122-,123-,124-,125-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0140 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon receptor (Homo sapiens (Human)) | BDBM50324712 (CHEMBL1222086 | HSQGTFTSDYSKYLDEQAAKEFIAWLVKG) Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C152H222N36O48/c1-14-78(8)123(149(232)165-81(11)128(211)174-107(63-88-67-159-93-34-22-21-33-92(88)93)139(222)176-102(58-76(4)5)142(225)186-122(77(6)7)148(231)173-94(35-23-26-54-153)129(212)161-70-121(207)208)187-143(226)105(59-84-29-17-15-18-30-84)178-135(218)100(49-53-118(201)202)171-132(215)95(36-24-27-55-154)167-127(210)80(10)163-126(209)79(9)164-131(214)98(47-51-115(157)197)170-134(217)99(48-52-117(199)200)172-140(223)108(65-119(203)204)180-136(219)101(57-75(2)3)175-137(220)103(61-86-38-42-90(194)43-39-86)177-133(216)96(37-25-28-56-155)168-146(229)112(72-190)183-138(221)104(62-87-40-44-91(195)45-41-87)179-141(224)109(66-120(205)206)181-147(230)113(73-191)184-151(234)125(83(13)193)188-144(227)106(60-85-31-19-16-20-32-85)182-150(233)124(82(12)192)185-116(198)69-160-130(213)97(46-50-114(156)196)169-145(228)111(71-189)166-110(152(235)236)64-89-68-158-74-162-89/h15-22,29-34,38-45,67-68,74-83,94-113,122-125,159,166,189-195H,14,23-28,35-37,46-66,69-73,153-155H2,1-13H3,(H2,156,196)(H2,157,197)(H,158,162)(H,160,213)(H,161,212)(H,163,209)(H,164,214)(H,165,232)(H,167,210)(H,168,229)(H,169,228)(H,170,217)(H,171,215)(H,172,223)(H,173,231)(H,174,211)(H,175,220)(H,176,222)(H,177,216)(H,178,218)(H,179,224)(H,180,219)(H,181,230)(H,182,233)(H,183,221)(H,184,234)(H,185,198)(H,186,225)(H,187,226)(H,188,227)(H,199,200)(H,201,202)(H,203,204)(H,205,206)(H,207,208)(H,235,236)/t78-,79-,80-,81-,82+,83+,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,122-,123-,124-,125-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.470 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon receptor (Homo sapiens (Human)) | BDBM50324724 (CHEMBL1222098) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc2cnc[nH]2)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O |r| Show InChI InChI=1S/C155H224N42O50S/c1-73(2)54-98(135(227)179-97(49-53-248-11)134(226)187-105(62-116(159)209)145(237)197-125(79(10)203)153(246)247)182-139(231)104(60-84-66-168-89-29-19-18-28-88(84)89)186-133(225)95(43-47-115(158)208)180-149(241)122(75(5)6)195-143(235)102(56-80-24-14-12-15-25-80)185-141(233)107(64-120(214)215)188-132(224)94(42-46-114(157)207)173-126(218)76(7)171-128(220)91(31-22-51-166-154(160)161)174-129(221)92(32-23-52-167-155(162)163)175-131(223)96-44-48-117(210)165-50-21-20-30-90(130(222)183-100(58-82-33-37-86(204)38-34-82)137(229)181-99(55-74(3)4)136(228)189-106(63-119(212)213)140(232)178-96)176-147(239)111(70-199)192-138(230)101(59-83-35-39-87(205)40-36-83)184-142(234)108(65-121(216)217)190-148(240)112(71-200)193-151(243)124(78(9)202)196-144(236)103(57-81-26-16-13-17-27-81)191-150(242)123(77(8)201)194-118(211)68-169-127(219)93(41-45-113(156)206)177-146(238)110(69-198)172-109(152(244)245)61-85-67-164-72-170-85/h12-19,24-29,33-40,66-67,72-79,90-112,122-125,168,172,198-205H,20-23,30-32,41-65,68-71H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,170)(H,165,210)(H,169,219)(H,171,220)(H,173,218)(H,174,221)(H,175,223)(H,176,239)(H,177,238)(H,178,232)(H,179,227)(H,180,241)(H,181,229)(H,182,231)(H,183,222)(H,184,234)(H,185,233)(H,186,225)(H,187,226)(H,188,224)(H,189,228)(H,190,240)(H,191,242)(H,192,230)(H,193,243)(H,194,211)(H,195,235)(H,196,236)(H,197,237)(H,212,213)(H,214,215)(H,216,217)(H,244,245)(H,246,247)(H4,160,161,166)(H4,162,163,167)/t76-,77+,78+,79+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0460 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon receptor (Homo sapiens (Human)) | BDBM50324727 (CHEMBL1222101) Show SMILES CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(=O)NCCCC[C@H](NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C |r| Show InChI InChI=1S/C155H227N41O49S/c1-75(2)56-100-135(225)178-99(50-55-246-11)133(223)173-93(134(224)196-125(81(10)203)153(244)245)33-21-23-52-164-117(208)49-46-98(132(222)185-106(139(229)181-100)62-86-67-167-91-31-19-18-30-90(86)91)179-149(239)122(77(5)6)194-143(233)104(58-82-26-14-12-15-27-82)184-140(230)107(64-119(210)211)186-131(221)97(45-48-116(158)207)172-126(216)78(7)170-128(218)94(34-24-53-165-154(159)160)174-129(219)95(35-25-54-166-155(161)162)176-147(237)113(72-199)191-142(232)109(66-121(214)215)187-136(226)101(57-76(3)4)180-137(227)102(60-84-36-40-88(204)41-37-84)182-130(220)92(32-20-22-51-156)175-146(236)112(71-198)190-138(228)103(61-85-38-42-89(205)43-39-85)183-141(231)108(65-120(212)213)188-148(238)114(73-200)192-151(241)124(80(9)202)195-144(234)105(59-83-28-16-13-17-29-83)189-150(240)123(79(8)201)193-118(209)69-168-127(217)96(44-47-115(157)206)177-145(235)111(70-197)171-110(152(242)243)63-87-68-163-74-169-87/h12-19,26-31,36-43,67-68,74-81,92-114,122-125,167,171,197-205H,20-25,32-35,44-66,69-73,156H2,1-11H3,(H2,157,206)(H2,158,207)(H,163,169)(H,164,208)(H,168,217)(H,170,218)(H,172,216)(H,173,223)(H,174,219)(H,175,236)(H,176,237)(H,177,235)(H,178,225)(H,179,239)(H,180,227)(H,181,229)(H,182,220)(H,183,231)(H,184,230)(H,185,222)(H,186,221)(H,187,226)(H,188,238)(H,189,240)(H,190,228)(H,191,232)(H,192,241)(H,193,209)(H,194,233)(H,195,234)(H,196,224)(H,210,211)(H,212,213)(H,214,215)(H,242,243)(H,244,245)(H4,159,160,165)(H4,161,162,166)/t78-,79+,80+,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,122-,123-,124-,125-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0760 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50324702 (CHEMBL1222076) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:208.216,180.193,170.177,150.163,135.144,115.122,98.106,76.86,62.70,43.53,30.37,8.12,234.240,wD:199.210,191.197,222.230,176.181,225.233,162.171,144.150,123.135,107.114,87.97,71.74,54.61,39.41,16.28,4.4,242.248,243.251,212.217,(49.71,-5.25,;48.4,-4.46,;48.4,-2.87,;47.1,-2.08,;47.1,-.49,;45.79,.31,;44.48,-.48,;44.48,-2.07,;43.17,.31,;43.17,1.9,;44.48,2.7,;44.48,4.29,;45.79,1.9,;41.86,-.48,;40.54,.32,;40.54,1.9,;39.25,-.48,;39.25,-2.07,;40.54,-2.86,;41.92,-2.22,;42.95,-3.4,;42.17,-4.78,;42.64,-6.29,;41.63,-7.47,;40.16,-7.14,;39.69,-5.63,;40.7,-4.44,;37.94,.32,;36.63,-.47,;36.63,-2.07,;35.32,.32,;35.32,1.91,;36.63,2.71,;36.63,4.29,;35.32,5.08,;37.94,5.08,;33.99,-.47,;32.7,.32,;32.7,1.91,;31.37,-.47,;30.07,.33,;28.77,-.47,;28.77,-2.06,;27.45,.33,;27.45,1.92,;28.77,2.72,;30.08,1.91,;31.38,2.71,;31.38,4.3,;30.08,5.09,;28.77,4.3,;26.16,-.46,;24.84,.33,;24.84,1.92,;23.53,-.46,;23.53,-2.05,;24.84,-2.84,;26.15,-2.05,;24.84,-4.43,;22.23,.34,;20.91,-.46,;20.91,-2.05,;19.6,.34,;19.6,1.92,;20.91,2.73,;20.91,4.31,;19.61,5.1,;22.24,5.1,;18.3,-.45,;16.98,.34,;16.98,1.93,;15.68,-.45,;15.68,-2.04,;14.38,.35,;13.06,-.44,;13.06,-2.04,;11.76,.35,;11.76,1.93,;13.06,2.74,;13.06,4.32,;14.38,5.11,;14.38,6.7,;13.07,7.5,;15.67,7.5,;10.44,-.44,;9.13,.35,;9.13,1.94,;7.82,-.43,;7.82,-2.03,;9.13,-2.82,;9.13,-4.42,;10.46,-5.19,;10.46,-6.73,;11.8,-7.5,;9.13,-7.5,;6.5,.36,;5.22,-.42,;5.22,-2.03,;3.9,.37,;3.9,1.95,;5.24,2.72,;5.24,4.26,;3.9,5.03,;6.57,5.03,;2.6,-.42,;1.29,.37,;1.29,1.95,;-.03,-.42,;-.03,-2.02,;1.29,-2.81,;2.58,-2.02,;1.29,-4.4,;-1.34,.37,;-2.65,-.41,;-2.65,-2.01,;-3.96,.38,;-3.96,1.96,;-2.65,2.76,;-2.65,4.35,;-1.32,1.96,;-5.25,-.41,;-6.57,.38,;-6.57,1.96,;-7.87,-.41,;-7.87,-2.01,;-6.57,-2.8,;-5.27,-2.01,;-3.96,-2.8,;-3.95,-4.39,;-2.64,-5.19,;-5.26,-5.19,;-6.57,-4.39,;-9.19,.38,;-10.5,-.4,;-10.5,-2,;-11.81,.38,;-11.81,1.97,;-10.5,2.77,;-10.5,4.36,;-9.2,5.15,;-9.2,6.74,;-13.11,-.4,;-14.42,.39,;-14.42,1.97,;-15.72,-.4,;-15.72,-2,;-14.42,-2.79,;-17.05,.39,;-18.35,-.39,;-18.35,-1.99,;-19.65,.39,;-19.65,1.98,;-18.35,2.78,;-17.04,1.98,;-15.73,2.78,;-15.73,4.36,;-14.41,5.16,;-17.04,5.16,;-18.35,4.37,;-20.97,-.39,;-22.27,.4,;-22.27,1.98,;-23.59,-.39,;-23.59,-1.98,;-22.27,-2.78,;-20.98,-1.98,;-22.27,-4.37,;-24.89,.4,;-26.21,-.39,;-26.21,-1.98,;-27.52,.4,;-27.52,1.99,;-26.21,2.79,;-28.82,-.38,;-30.14,.41,;-30.14,1.99,;-31.43,-.38,;-32.75,.41,;-34.05,-.38,;-34.05,-1.97,;-35.37,.41,;-35.37,2,;-34.05,2.8,;-32.75,1.99,;-31.43,2.79,;-31.43,4.38,;-32.74,5.18,;-34.04,4.39,;-36.67,-.37,;-37.99,.41,;-37.99,2,;-39.29,-.37,;-40.6,.42,;-41.91,-.37,;-41.91,-1.96,;-43.2,.42,;-44.53,-.36,;-45.84,.42,;-45.84,2.01,;-47.14,-.36,;-47.14,-1.95,;-45.84,-2.75,;-45.84,-4.34,;-47.14,-5.14,;-44.54,-5.14,;-48.45,.42,;-49.76,-.36,;-49.76,-1.95,;-51.08,.42,;-51.08,2.02,;-49.74,2.82,;-52.37,-.37,;-53.74,.42,;-53.74,1.96,;-55.06,2.72,;-56.33,1.85,;-57.56,2.78,;-57.06,4.25,;-55.51,4.22,;-55.07,-.36,;-56.41,.42,;-55.07,-1.91,;-39.29,-1.96,;-40.6,-2.76,;-37.99,-2.76,;-31.43,-1.97,;-32.75,-2.77,;-30.14,-2.77,;31.37,-2.06,;32.7,-2.85,;30.07,-2.85,;48.4,.31,;48.4,1.89,;49.72,-.49,;51.02,.3,;51.02,1.89,;52.33,2.69,;53.64,1.89,;52.33,4.28,;52.33,-.49,;52.33,-2.08,;53.64,.3,;54.95,-.5,;54.95,-2.09,;53.64,-2.88,;56.26,-2.88,;56.26,.3,;57.56,-.5,;56.26,1.88,)| Show InChI InChI=1S/C155H227N43O50S/c1-73(2)54-98(136(230)180-97(49-53-249-11)135(229)188-105(62-116(160)210)146(240)197-123(77(8)202)126(161)220)183-140(234)104(60-84-66-169-89-29-19-18-28-88(84)89)187-134(228)95(43-47-115(159)209)181-150(244)122(75(5)6)196-144(238)102(56-80-24-14-12-15-25-80)186-142(236)107(64-120(216)217)189-133(227)94(42-46-114(158)208)174-127(221)76(7)172-129(223)91(31-22-51-167-154(162)163)175-130(224)92(32-23-52-168-155(164)165)176-132(226)96(44-48-118(212)213)179-141(235)106(63-119(214)215)190-137(231)99(55-74(3)4)182-138(232)100(58-82-33-37-86(205)38-34-82)184-131(225)90(30-20-21-50-156)177-148(242)111(70-200)193-139(233)101(59-83-35-39-87(206)40-36-83)185-143(237)108(65-121(218)219)191-149(243)112(71-201)194-152(246)125(79(10)204)198-145(239)103(57-81-26-16-13-17-27-81)192-151(245)124(78(9)203)195-117(211)68-170-128(222)93(41-45-113(157)207)178-147(241)110(69-199)173-109(153(247)248)61-85-67-166-72-171-85/h12-19,24-29,33-40,66-67,72-79,90-112,122-125,169,173,199-206H,20-23,30-32,41-65,68-71,156H2,1-11H3,(H2,157,207)(H2,158,208)(H2,159,209)(H2,160,210)(H2,161,220)(H,166,171)(H,170,222)(H,172,223)(H,174,221)(H,175,224)(H,176,226)(H,177,242)(H,178,241)(H,179,235)(H,180,230)(H,181,244)(H,182,232)(H,183,234)(H,184,225)(H,185,237)(H,186,236)(H,187,228)(H,188,229)(H,189,227)(H,190,231)(H,191,243)(H,192,245)(H,193,233)(H,194,246)(H,195,211)(H,196,238)(H,197,240)(H,198,239)(H,212,213)(H,214,215)(H,216,217)(H,218,219)(H,247,248)(H4,162,163,167)(H4,164,165,168)/t76-,77+,78+,79+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.170 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50324709 (CHEMBL1222083) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:203.211,175.188,165.172,145.158,130.139,110.117,76.86,62.70,43.53,30.37,8.12,229.235,wD:207.212,194.205,186.192,217.225,171.176,220.228,157.166,139.145,118.130,102.109,87.97,71.74,54.61,39.41,16.28,4.4,237.243,238.246,(49.79,-5.31,;48.48,-4.51,;48.48,-2.92,;47.17,-2.13,;47.17,-.53,;45.86,.27,;44.55,-.53,;44.55,-2.13,;43.24,.27,;43.24,1.86,;44.55,2.66,;44.55,4.25,;45.87,1.86,;41.93,-.53,;40.61,.27,;40.61,1.86,;39.31,-.52,;39.31,-2.12,;40.61,-2.91,;41.99,-2.27,;43.02,-3.45,;42.25,-4.84,;42.69,-6.28,;41.66,-7.38,;40.18,-7.04,;39.74,-5.59,;40.77,-4.49,;38,.28,;36.68,-.52,;36.68,-2.12,;35.37,.28,;35.37,1.87,;36.68,2.67,;36.68,4.26,;35.38,5.05,;38,5.05,;34.06,-.52,;32.75,.28,;32.75,1.87,;31.43,-.52,;30.12,.29,;28.82,-.51,;28.82,-2.11,;27.5,.29,;27.5,1.88,;28.82,2.68,;30.13,1.87,;31.43,2.67,;31.44,4.26,;30.13,5.06,;28.82,4.27,;26.2,-.51,;24.87,.29,;24.87,1.88,;23.58,-.51,;23.58,-2.1,;24.87,-2.89,;26.19,-2.1,;24.87,-4.49,;22.26,.3,;20.95,-.5,;20.95,-2.1,;19.63,.3,;19.63,1.89,;20.95,2.69,;20.95,4.28,;19.64,5.07,;22.26,5.07,;18.32,-.5,;17,.3,;17,1.89,;15.7,-.5,;15.7,-2.09,;14.4,.3,;13.07,-.49,;13.07,-2.09,;11.76,.31,;11.76,1.9,;13.07,2.7,;13.07,4.28,;14.39,5.08,;14.39,6.67,;13.08,7.46,;15.69,7.47,;10.45,-.48,;9.14,.31,;9.14,1.91,;7.82,-.48,;7.82,-2.03,;9.18,-2.81,;9.18,-4.36,;10.52,-5.14,;10.52,-6.69,;11.85,-7.47,;9.17,-7.47,;6.51,.32,;5.22,-.47,;5.22,-2.08,;3.89,.32,;2.59,-.47,;1.28,.33,;1.28,1.92,;-.05,-.46,;-.05,-2.07,;1.28,-2.86,;2.57,-2.07,;1.28,-4.45,;-1.35,.33,;-2.67,-.46,;-2.67,-2.06,;-3.98,.33,;-3.98,1.92,;-2.67,2.72,;-2.67,4.31,;-1.33,1.92,;-5.28,-.46,;-6.6,.34,;-6.6,1.93,;-7.9,-.45,;-7.9,-2.06,;-6.6,-2.85,;-5.29,-2.06,;-3.98,-2.85,;-3.98,-4.44,;-2.66,-5.24,;-5.29,-5.24,;-6.6,-4.44,;-9.22,.34,;-10.53,-.45,;-10.53,-2.05,;-11.84,.34,;-11.84,1.93,;-10.53,2.73,;-10.53,4.32,;-9.23,5.12,;-9.23,6.71,;-13.15,-.45,;-14.46,.35,;-14.46,1.93,;-15.77,-.44,;-15.77,-2.05,;-14.46,-2.84,;-17.1,.35,;-18.39,-.44,;-18.39,-2.04,;-19.7,.35,;-19.7,1.94,;-18.39,2.74,;-17.08,1.94,;-15.77,2.74,;-15.77,4.33,;-14.45,5.13,;-17.09,5.13,;-18.4,4.33,;-21.02,-.44,;-22.33,.36,;-22.33,1.94,;-23.65,-.44,;-23.65,-2.03,;-22.33,-2.83,;-21.03,-2.03,;-22.33,-4.42,;-24.95,.36,;-26.27,-.43,;-26.27,-2.03,;-27.58,.36,;-27.58,1.95,;-26.27,2.75,;-28.88,-.43,;-30.21,.36,;-30.21,1.95,;-31.5,-.43,;-32.83,.37,;-34.13,-.42,;-34.13,-2.02,;-35.45,.37,;-35.45,1.96,;-34.13,2.76,;-32.83,1.96,;-31.5,2.75,;-31.51,4.35,;-32.82,5.15,;-34.12,4.35,;-36.75,-.42,;-38.07,.37,;-38.07,1.96,;-39.38,-.42,;-40.69,.38,;-42,-.41,;-42,-2.01,;-43.3,.38,;-44.63,-.41,;-45.93,.38,;-45.93,1.97,;-47.25,-.41,;-47.25,-2,;-45.93,-2.8,;-45.93,-4.39,;-47.24,-5.2,;-44.64,-5.19,;-48.56,.38,;-49.87,-.41,;-49.87,-2,;-51.19,.38,;-51.19,1.98,;-49.85,2.78,;-52.48,-.41,;-53.84,.38,;-53.84,1.91,;-55.17,2.67,;-56.42,1.81,;-57.66,2.73,;-57.16,4.2,;-55.61,4.17,;-55.18,-.4,;-56.51,.38,;-55.18,-1.95,;-39.38,-2.01,;-40.69,-2.81,;-38.07,-2.81,;-31.5,-2.02,;-32.83,-2.82,;-30.21,-2.82,;31.43,-2.11,;32.75,-2.9,;30.12,-2.9,;48.48,.26,;48.48,1.85,;49.8,-.54,;51.1,.26,;51.1,1.85,;52.42,2.65,;53.73,1.85,;52.42,4.24,;52.42,-.54,;52.42,-2.13,;53.73,.26,;55.04,-.54,;55.04,-2.14,;53.73,-2.93,;56.35,-2.93,;56.35,.25,;57.66,-.55,;56.35,1.84,)| Show InChI InChI=1S/C152H223N43O48S/c1-72(2)52-96(134(226)177-95(47-51-244-11)133(225)185-103(60-114(157)207)143(235)194-121(76(8)199)124(158)216)180-138(230)102(58-83-64-166-88-29-19-18-28-87(83)88)184-132(224)94(43-46-113(156)206)178-147(239)120(74(5)6)193-141(233)100(54-79-24-14-12-15-25-79)183-139(231)105(62-118(212)213)187-131(223)93(42-45-112(155)205)173-125(217)75(7)170-128(220)91(32-23-50-165-152(161)162)174-129(221)89(31-22-49-164-151(159)160)172-115(208)66-168-127(219)104(61-117(210)211)186-135(227)97(53-73(3)4)179-136(228)98(56-81-33-37-85(202)38-34-81)181-130(222)90(30-20-21-48-153)175-145(237)109(69-197)190-137(229)99(57-82-35-39-86(203)40-36-82)182-140(232)106(63-119(214)215)188-146(238)110(70-198)191-149(241)123(78(10)201)195-142(234)101(55-80-26-16-13-17-27-80)189-148(240)122(77(9)200)192-116(209)67-167-126(218)92(41-44-111(154)204)176-144(236)108(68-196)171-107(150(242)243)59-84-65-163-71-169-84/h12-19,24-29,33-40,64-65,71-78,89-110,120-123,166,171,196-203H,20-23,30-32,41-63,66-70,153H2,1-11H3,(H2,154,204)(H2,155,205)(H2,156,206)(H2,157,207)(H2,158,216)(H,163,169)(H,167,218)(H,168,219)(H,170,220)(H,172,208)(H,173,217)(H,174,221)(H,175,237)(H,176,236)(H,177,226)(H,178,239)(H,179,228)(H,180,230)(H,181,222)(H,182,232)(H,183,231)(H,184,224)(H,185,225)(H,186,227)(H,187,223)(H,188,238)(H,189,240)(H,190,229)(H,191,241)(H,192,209)(H,193,233)(H,194,235)(H,195,234)(H,210,211)(H,212,213)(H,214,215)(H,242,243)(H4,159,160,164)(H4,161,162,165)/t75-,76+,77+,78+,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,120-,121-,122-,123-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.580 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50324712 (CHEMBL1222086 | HSQGTFTSDYSKYLDEQAAKEFIAWLVKG) Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C152H222N36O48/c1-14-78(8)123(149(232)165-81(11)128(211)174-107(63-88-67-159-93-34-22-21-33-92(88)93)139(222)176-102(58-76(4)5)142(225)186-122(77(6)7)148(231)173-94(35-23-26-54-153)129(212)161-70-121(207)208)187-143(226)105(59-84-29-17-15-18-30-84)178-135(218)100(49-53-118(201)202)171-132(215)95(36-24-27-55-154)167-127(210)80(10)163-126(209)79(9)164-131(214)98(47-51-115(157)197)170-134(217)99(48-52-117(199)200)172-140(223)108(65-119(203)204)180-136(219)101(57-75(2)3)175-137(220)103(61-86-38-42-90(194)43-39-86)177-133(216)96(37-25-28-56-155)168-146(229)112(72-190)183-138(221)104(62-87-40-44-91(195)45-41-87)179-141(224)109(66-120(205)206)181-147(230)113(73-191)184-151(234)125(83(13)193)188-144(227)106(60-85-31-19-16-20-32-85)182-150(233)124(82(12)192)185-116(198)69-160-130(213)97(46-50-114(156)196)169-145(228)111(71-189)166-110(152(235)236)64-89-68-158-74-162-89/h15-22,29-34,38-45,67-68,74-83,94-113,122-125,159,166,189-195H,14,23-28,35-37,46-66,69-73,153-155H2,1-13H3,(H2,156,196)(H2,157,197)(H,158,162)(H,160,213)(H,161,212)(H,163,209)(H,164,214)(H,165,232)(H,167,210)(H,168,229)(H,169,228)(H,170,217)(H,171,215)(H,172,223)(H,173,231)(H,174,211)(H,175,220)(H,176,222)(H,177,216)(H,178,218)(H,179,224)(H,180,219)(H,181,230)(H,182,233)(H,183,221)(H,184,234)(H,185,198)(H,186,225)(H,187,226)(H,188,227)(H,199,200)(H,201,202)(H,203,204)(H,205,206)(H,207,208)(H,235,236)/t78-,79-,80-,81-,82+,83+,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,122-,123-,124-,125-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0150 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon-like peptide 1 receptor (Homo sapiens (Human)) | BDBM50324724 (CHEMBL1222098) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc2cnc[nH]2)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O |r| Show InChI InChI=1S/C155H224N42O50S/c1-73(2)54-98(135(227)179-97(49-53-248-11)134(226)187-105(62-116(159)209)145(237)197-125(79(10)203)153(246)247)182-139(231)104(60-84-66-168-89-29-19-18-28-88(84)89)186-133(225)95(43-47-115(158)208)180-149(241)122(75(5)6)195-143(235)102(56-80-24-14-12-15-25-80)185-141(233)107(64-120(214)215)188-132(224)94(42-46-114(157)207)173-126(218)76(7)171-128(220)91(31-22-51-166-154(160)161)174-129(221)92(32-23-52-167-155(162)163)175-131(223)96-44-48-117(210)165-50-21-20-30-90(130(222)183-100(58-82-33-37-86(204)38-34-82)137(229)181-99(55-74(3)4)136(228)189-106(63-119(212)213)140(232)178-96)176-147(239)111(70-199)192-138(230)101(59-83-35-39-87(205)40-36-83)184-142(234)108(65-121(216)217)190-148(240)112(71-200)193-151(243)124(78(9)202)196-144(236)103(57-81-26-16-13-17-27-81)191-150(242)123(77(8)201)194-118(211)68-169-127(219)93(41-45-113(156)206)177-146(238)110(69-198)172-109(152(244)245)61-85-67-164-72-170-85/h12-19,24-29,33-40,66-67,72-79,90-112,122-125,168,172,198-205H,20-23,30-32,41-65,68-71H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,170)(H,165,210)(H,169,219)(H,171,220)(H,173,218)(H,174,221)(H,175,223)(H,176,239)(H,177,238)(H,178,232)(H,179,227)(H,180,241)(H,181,229)(H,182,231)(H,183,222)(H,184,234)(H,185,233)(H,186,225)(H,187,226)(H,188,224)(H,189,228)(H,190,240)(H,191,242)(H,192,230)(H,193,243)(H,194,211)(H,195,235)(H,196,236)(H,197,237)(H,212,213)(H,214,215)(H,216,217)(H,244,245)(H,246,247)(H4,160,161,166)(H4,162,163,167)/t76-,77+,78+,79+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-/m0/s1 | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0510 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucagon receptor (Homo sapiens (Human)) | BDBM50324715 (CHEMBL1222089) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:202.210,174.187,164.171,144.157,129.138,109.116,92.100,76.79,62.70,43.53,30.37,8.12,228.234,wD:193.204,185.191,216.224,170.175,219.227,156.165,138.144,117.129,101.108,81.91,71.74,54.61,39.41,16.28,4.4,236.242,237.245,206.211,(49.71,-4.86,;48.4,-4.06,;48.4,-2.47,;47.1,-1.68,;47.1,-.09,;45.79,.71,;44.48,-.08,;44.48,-1.68,;43.17,.71,;43.17,2.3,;44.48,3.1,;44.48,4.69,;45.79,2.3,;41.86,-.08,;40.55,.72,;40.55,2.3,;39.25,-.08,;39.25,-1.67,;40.55,-2.46,;41.92,-1.82,;42.95,-3,;42.18,-4.39,;42.64,-5.89,;41.63,-7.07,;40.15,-6.73,;39.68,-5.22,;40.7,-4.05,;37.93,.72,;36.62,-.07,;36.62,-1.67,;35.31,.72,;35.31,2.31,;36.62,3.11,;36.62,4.7,;35.32,5.48,;37.94,5.49,;34,-.07,;32.7,.73,;32.7,2.31,;31.38,-.07,;30.07,.73,;28.77,-.07,;28.77,-1.66,;27.45,.73,;27.45,2.32,;28.77,3.12,;30.08,2.31,;31.39,3.11,;31.39,4.7,;30.08,5.49,;28.77,4.71,;26.15,-.06,;24.83,.73,;24.83,2.32,;23.53,-.06,;23.53,-1.65,;24.86,-2.42,;26.2,-1.65,;24.86,-3.96,;22.22,.74,;20.91,-.06,;20.91,-1.65,;19.6,.74,;19.6,2.33,;20.91,3.13,;20.91,4.72,;22.22,5.5,;23.57,4.76,;18.28,-.05,;16.98,.74,;16.98,2.33,;15.67,-.05,;15.67,-1.64,;14.37,.75,;13.05,-.04,;13.05,-1.64,;11.74,.75,;11.74,2.34,;10.43,-.04,;9.11,.75,;9.11,2.35,;7.8,-.03,;7.8,-1.63,;9.11,-2.43,;9.11,-4.02,;10.43,-4.81,;10.4,-6.35,;11.72,-7.15,;9.04,-7.1,;6.48,.76,;5.2,-.02,;5.2,-1.63,;3.87,.77,;3.87,2.35,;5.22,3.12,;5.22,4.67,;3.87,5.44,;6.54,5.44,;2.58,-.02,;1.26,.77,;1.26,2.36,;-.06,-.02,;-.06,-1.62,;1.26,-2.41,;2.56,-1.62,;1.26,-4,;-1.37,.77,;-2.67,-.01,;-2.67,-1.61,;-3.99,.78,;-3.99,2.36,;-2.67,3.17,;-2.67,4.75,;-1.35,2.36,;-5.28,-.01,;-6.6,.78,;-6.6,2.36,;-7.9,-.01,;-7.9,-1.61,;-6.6,-2.4,;-5.29,-1.61,;-3.98,-2.41,;-3.98,-4,;-2.66,-4.79,;-5.29,-4.79,;-6.6,-3.99,;-9.22,.78,;-10.54,-0,;-10.54,-1.6,;-11.83,.78,;-11.83,2.37,;-10.54,3.17,;-10.54,4.76,;-9.23,5.56,;-9.23,7.15,;-13.15,-0,;-14.45,.79,;-14.45,2.37,;-15.76,0,;-15.76,-1.6,;-14.45,-2.39,;-17.09,.79,;-18.38,.01,;-18.38,-1.59,;-19.69,.79,;-19.69,2.38,;-18.38,3.18,;-17.08,2.38,;-15.76,3.18,;-15.76,4.77,;-14.44,5.57,;-17.08,5.57,;-18.39,4.77,;-21,.01,;-22.31,.8,;-22.31,2.38,;-23.63,.01,;-23.63,-1.58,;-22.31,-2.38,;-21.01,-1.58,;-22.31,-3.97,;-24.93,.8,;-26.25,.01,;-26.25,-1.58,;-27.56,.8,;-27.56,2.39,;-26.25,3.19,;-28.85,.02,;-30.18,.81,;-30.18,2.39,;-31.47,.02,;-32.8,.81,;-34.1,.02,;-34.1,-1.57,;-35.41,.81,;-35.41,2.4,;-34.1,3.2,;-32.8,2.4,;-31.47,3.2,;-31.48,4.78,;-32.79,5.59,;-34.09,4.79,;-36.72,.03,;-38.03,.82,;-38.03,2.4,;-39.34,.03,;-40.65,.82,;-41.96,.03,;-41.96,-1.56,;-43.26,.82,;-44.58,.04,;-45.89,.82,;-45.89,2.41,;-47.19,.04,;-47.19,-1.55,;-45.89,-2.35,;-45.89,-3.95,;-47.19,-4.74,;-44.59,-4.74,;-48.5,.83,;-49.81,.04,;-49.81,-1.55,;-51.14,.83,;-51.14,2.42,;-49.8,3.22,;-52.42,.04,;-53.78,.82,;-53.78,2.34,;-55.09,3.1,;-56.35,2.24,;-57.58,3.16,;-57.08,4.62,;-55.54,4.59,;-55.11,.05,;-56.43,.82,;-55.11,-1.49,;-39.34,-1.56,;-40.65,-2.37,;-38.03,-2.36,;-31.47,-1.57,;-32.8,-2.38,;-30.18,-2.37,;31.38,-1.66,;32.7,-2.45,;30.07,-2.46,;48.4,.71,;48.4,2.29,;49.72,-.09,;51.02,.7,;51.02,2.29,;52.34,3.09,;53.65,2.29,;52.34,4.68,;52.34,-.09,;52.34,-1.68,;53.64,.7,;54.95,-.1,;54.95,-1.69,;53.64,-2.48,;56.27,-2.48,;56.27,.7,;57.58,-.1,;56.27,2.28,)| Show InChI InChI=1S/C153H224N40O49S/c1-73(2)54-98(135(224)175-97(49-53-243-12)134(223)183-105(62-115(158)204)145(234)192-122(78(9)197)125(159)214)178-139(228)104(60-85-66-164-90-31-20-19-30-89(85)90)182-133(222)95(44-47-114(157)203)176-149(238)121(75(5)6)191-143(232)102(56-81-26-15-13-16-27-81)181-141(230)107(64-119(210)211)184-130(219)91(32-21-23-50-154)170-127(216)77(8)167-126(215)76(7)168-129(218)93(34-25-52-163-153(160)161)171-132(221)96(45-48-117(206)207)174-140(229)106(63-118(208)209)185-136(225)99(55-74(3)4)177-137(226)100(58-83-35-39-87(200)40-36-83)179-131(220)92(33-22-24-51-155)172-147(236)111(70-195)188-138(227)101(59-84-37-41-88(201)42-38-84)180-142(231)108(65-120(212)213)186-148(237)112(71-196)189-151(240)124(80(11)199)193-144(233)103(57-82-28-17-14-18-29-82)187-150(239)123(79(10)198)190-116(205)68-165-128(217)94(43-46-113(156)202)173-146(235)110(69-194)169-109(152(241)242)61-86-67-162-72-166-86/h13-20,26-31,35-42,66-67,72-80,91-112,121-124,164,169,194-201H,21-25,32-34,43-65,68-71,154-155H2,1-12H3,(H2,156,202)(H2,157,203)(H2,158,204)(H2,159,214)(H,162,166)(H,165,217)(H,167,215)(H,168,218)(H,170,216)(H,171,221)(H,172,236)(H,173,235)(H,174,229)(H,175,224)(H,176,238)(H,177,226)(H,178,228)(H,179,220)(H,180,231)(H,181,230)(H,182,222)(H,183,223)(H,184,219)(H,185,225)(H,186,237)(H,187,239)(H,188,227)(H,189,240)(H,190,205)(H,191,232)(H,192,234)(H,193,233)(H,206,207)(H,208,209)(H,210,211)(H,212,213)(H,241,242)(H4,160,161,163)/t76-,77-,78+,79+,80+,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,121-,122-,123-,124-/m0/s1 | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0870 | n/a | n/a | n/a | n/a |
Indiana University Curated by ChEMBL | Assay Description Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay | Nat Chem Biol 5: 749-57 (2009) Article DOI: 10.1038/nchembio.209 BindingDB Entry DOI: 10.7270/Q2WW7JNF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
