Affinity Data by PubMed id=19729315

PubMed code 19729315

Found 8 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Hepatocyte nuclear factor 4-alpha (Homo sapiens (Human))	BDBM22594 (7-methoxy-4-nitro-5-oxatricyclo[7.4.0.0^{2,6}]trid...) Show SMILES COc1cc2ccccc2c2cc(oc12)[N+]([O-])=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.47E+3	n/a	n/a	n/a	n/a
Universit£ de Rennes 1 Curated by ChEMBL					Assay Description Agonist activity at human full length HNF4alpha nuclear receptor expressed in human HepG2/C3A cells cotransfected with LexADBD assessed as increase i...				Bioorg Med Chem 17: 7021-30 (2009) Article DOI: 10.1016/j.bmc.2009.07.079 BindingDB Entry DOI: 10.7270/Q28S4Q07
Universit£ de Rennes 1 Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte nuclear factor 4-alpha (Homo sapiens (Human))	BDBM50304336 (2-Nitro-naphtho[2,1-b]furan-7-ol \| 2-nitronaphtho[...) Show SMILES Oc1ccc2c3cc(oc3ccc2c1)[N+]([O-])=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.95E+3	n/a	n/a	n/a	n/a
Universit£ de Rennes 1 Curated by ChEMBL					Assay Description Agonist activity at human full length HNF4alpha nuclear receptor expressed in human HepG2/C3A cells cotransfected with LexADBD assessed as increase i...				Bioorg Med Chem 17: 7021-30 (2009) Article DOI: 10.1016/j.bmc.2009.07.079 BindingDB Entry DOI: 10.7270/Q28S4Q07
Universit£ de Rennes 1 Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte nuclear factor 4-alpha (Homo sapiens (Human))	BDBM50304339 (8-Methoxy-2-nitro-naphtho[2,1-b]furan \| 8-methoxy-...) Show SMILES COc1ccc2ccc3oc(cc3c2c1)[N+]([O-])=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.33E+3	n/a	n/a	n/a	n/a
Universit£ de Rennes 1 Curated by ChEMBL					Assay Description Agonist activity at human full length HNF4alpha nuclear receptor expressed in human HepG2/C3A cells cotransfected with LexADBD assessed as increase i...				Bioorg Med Chem 17: 7021-30 (2009) Article DOI: 10.1016/j.bmc.2009.07.079 BindingDB Entry DOI: 10.7270/Q28S4Q07
Universit£ de Rennes 1 Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte nuclear factor 4-alpha (Homo sapiens (Human))	BDBM50304340 (2-Nitro-naphtho[2,1-b]furan \| 2-nitronaphtho[2,1-b...) Show SMILES [O-][N+](=O)c1cc2c(ccc3ccccc23)o1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.09E+3	n/a	n/a	n/a	n/a
Universit£ de Rennes 1 Curated by ChEMBL					Assay Description Agonist activity at human full length HNF4alpha nuclear receptor expressed in human HepG2/C3A cells cotransfected with LexADBD assessed as increase i...				Bioorg Med Chem 17: 7021-30 (2009) Article DOI: 10.1016/j.bmc.2009.07.079 BindingDB Entry DOI: 10.7270/Q28S4Q07
Universit£ de Rennes 1 Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte nuclear factor 4-alpha (Homo sapiens (Human))	BDBM50304337 (2-(2-Nitro-naphtho[2,1-b]furan-1-yl)-ethanol \| 2-(...) Show SMILES OCCc1c(oc2ccc3ccccc3c12)[N+]([O-])=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.22E+3	n/a	n/a	n/a	n/a
Universit£ de Rennes 1 Curated by ChEMBL					Assay Description Agonist activity at human full length HNF4alpha nuclear receptor expressed in human HepG2/C3A cells cotransfected with LexADBD assessed as increase i...				Bioorg Med Chem 17: 7021-30 (2009) Article DOI: 10.1016/j.bmc.2009.07.079 BindingDB Entry DOI: 10.7270/Q28S4Q07
Universit£ de Rennes 1 Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte nuclear factor 4-alpha (Homo sapiens (Human))	BDBM50304341 (7-Methoxy-2-nitro-naphtho[2,1-b]furan \| 7-methoxy-...) Show SMILES COc1ccc2c3cc(oc3ccc2c1)[N+]([O-])=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.57E+3	n/a	n/a	n/a	n/a
Universit£ de Rennes 1 Curated by ChEMBL					Assay Description Agonist activity at human full length HNF4alpha nuclear receptor expressed in human HepG2/C3A cells cotransfected with LexADBD assessed as increase i...				Bioorg Med Chem 17: 7021-30 (2009) Article DOI: 10.1016/j.bmc.2009.07.079 BindingDB Entry DOI: 10.7270/Q28S4Q07
Universit£ de Rennes 1 Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte nuclear factor 4-alpha (Homo sapiens (Human))	BDBM50304338 (1-Methyl-2-nitro-naphtho[2,1-b]furan \| 1-methyl-2-...) Show SMILES Cc1c(oc2ccc3ccccc3c12)[N+]([O-])=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.28E+3	n/a	n/a	n/a	n/a
Universit£ de Rennes 1 Curated by ChEMBL					Assay Description Agonist activity at human full length HNF4alpha nuclear receptor expressed in human HepG2/C3A cells cotransfected with LexADBD assessed as increase i...				Bioorg Med Chem 17: 7021-30 (2009) Article DOI: 10.1016/j.bmc.2009.07.079 BindingDB Entry DOI: 10.7270/Q28S4Q07
Universit£ de Rennes 1 Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte nuclear factor 4-alpha (Homo sapiens (Human))	BDBM50304342 (CHEMBL611816 \| naphtho[2,1-b]furan-2-carboxamide) Show SMILES NC(=O)c1cc2c(ccc3ccccc23)o1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Universit£ de Rennes 1 Curated by ChEMBL					Assay Description Agonist activity at human full length HNF4alpha nuclear receptor expressed in human HepG2/C3A cells cotransfected with LexADBD assessed as increase i...				Bioorg Med Chem 17: 7021-30 (2009) Article DOI: 10.1016/j.bmc.2009.07.079 BindingDB Entry DOI: 10.7270/Q28S4Q07
Universit£ de Rennes 1 Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%