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PubMed code 19877691

Compile data set for download or QSAR
Found 36 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50299922
PNG
(1-(Pent-4-enoyl)-(3S)-3-[1(R)-(4-phenylbutanoyloxy...)
Show SMILES C[C@@H](OC(=O)CCCc1ccccc1)C1CN(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C20H25NO4/c1-3-4-12-18(22)21-14-17(20(21)24)15(2)25-19(23)13-8-11-16-9-6-5-7-10-16/h3,5-7,9-10,15,17H,1,4,8,11-14H2,2H3/t15-,17?/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50299926
PNG
(1-(Hexa-5-enoyl)-(3S)-3-[1(R)-(4-phenylbutanoyloxy...)
Show SMILES C[C@@H](OC(=O)CCCc1ccccc1)[C@@H]1CN(C(=O)CCCC=C)C1=O |r|
Show InChI InChI=1S/C21H27NO4/c1-3-4-6-13-19(23)22-15-18(21(22)25)16(2)26-20(24)14-9-12-17-10-7-5-8-11-17/h3,5,7-8,10-11,16,18H,1,4,6,9,12-15H2,2H3/t16-,18+/m1/s1
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Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50299923
PNG
(1-(Pent-4-enoyl)-(3S)-3-[1(R)-(biphenylacetyloxy)-...)
Show SMILES C[C@@H](OC(=O)Cc1ccc(cc1)-c1ccccc1)[C@@H]1CN(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C24H25NO4/c1-3-4-10-22(26)25-16-21(24(25)28)17(2)29-23(27)15-18-11-13-20(14-12-18)19-8-6-5-7-9-19/h3,5-9,11-14,17,21H,1,4,10,15-16H2,2H3/t17-,21+/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50299927
PNG
(1-(Hexa-5-enoyl)-(3S)-3-[1(R)-(biphenylacetyloxy)-...)
Show SMILES C[C@@H](OC(=O)Cc1ccc(cc1)-c1ccccc1)[C@@H]1CN(C(=O)CCCC=C)C1=O |r|
Show InChI InChI=1S/C25H27NO4/c1-3-4-6-11-23(27)26-17-22(25(26)29)18(2)30-24(28)16-19-12-14-21(15-13-19)20-9-7-5-8-10-20/h3,5,7-10,12-15,18,22H,1,4,6,11,16-17H2,2H3/t18-,22+/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50299917
PNG
(1-(4-Phenylbutanoyl)-(3S)-3-[1(R)-(4-phenylbutanoy...)
Show SMILES C[C@@H](OC(=O)CCCc1ccccc1)[C@@H]1CN(C(=O)CCCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C25H29NO4/c1-19(30-24(28)17-9-15-21-12-6-3-7-13-21)22-18-26(25(22)29)23(27)16-8-14-20-10-4-2-5-11-20/h2-7,10-13,19,22H,8-9,14-18H2,1H3/t19-,22+/m1/s1
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n/an/a 30n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50299925
PNG
(1-(Pent-4-enoyl)-(3S)-3-[1(R)-(hexa-5-enoyloxy)-et...)
Show SMILES C[C@@H](OC(=O)CCCC=C)[C@@H]1CN(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C16H23NO4/c1-4-6-8-10-15(19)21-12(3)13-11-17(16(13)20)14(18)9-7-5-2/h4-5,12-13H,1-2,6-11H2,3H3/t12-,13+/m1/s1
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n/an/a 32n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50299919
PNG
(1-(4-Phenylbutanoyl)-(3S)-3-[1(R)-(biphenylacetylo...)
Show SMILES C[C@@H](OC(=O)Cc1ccc(cc1)-c1ccccc1)[C@@H]1CN(C(=O)CCCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C29H29NO4/c1-21(26-20-30(29(26)33)27(31)14-8-11-22-9-4-2-5-10-22)34-28(32)19-23-15-17-25(18-16-23)24-12-6-3-7-13-24/h2-7,9-10,12-13,15-18,21,26H,8,11,14,19-20H2,1H3/t21-,26+/m1/s1
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n/an/a 32n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50299918
PNG
(1-(4-Phenylbutanoyl)-(3S)-3-[1(R)-(5-phenylpentano...)
Show SMILES C[C@@H](OC(=O)CCCCc1ccccc1)[C@@H]1CN(C(=O)CCCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C26H31NO4/c1-20(31-25(29)18-9-8-15-21-11-4-2-5-12-21)23-19-27(26(23)30)24(28)17-10-16-22-13-6-3-7-14-22/h2-7,11-14,20,23H,8-10,15-19H2,1H3/t20-,23+/m1/s1
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n/an/a 45n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50299913
PNG
(1-(3-Phenylpropanoyl)-(3S)-3-[1(R)-(4-phenylbutano...)
Show SMILES C[C@@H](OC(=O)CCCc1ccccc1)[C@@H]1CN(C(=O)CCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C24H27NO4/c1-18(29-23(27)14-8-13-19-9-4-2-5-10-19)21-17-25(24(21)28)22(26)16-15-20-11-6-3-7-12-20/h2-7,9-12,18,21H,8,13-17H2,1H3/t18-,21+/m1/s1
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n/an/a 49n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50299915
PNG
(1-(3-Phenylpropanoyl)-(3S)-3-[1(R)-(biphenylacetyl...)
Show SMILES C[C@@H](OC(=O)Cc1ccc(cc1)-c1ccccc1)[C@@H]1CN(C(=O)CCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C28H27NO4/c1-20(25-19-29(28(25)32)26(30)17-14-21-8-4-2-5-9-21)33-27(31)18-22-12-15-24(16-13-22)23-10-6-3-7-11-23/h2-13,15-16,20,25H,14,17-19H2,1H3/t20-,25+/m1/s1
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n/an/a 50n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50299916
PNG
(1-(4-Phenylbutanoyl)-(3S)-3-[1(R)-(3-phenylpropano...)
Show SMILES C[C@@H](OC(=O)CCc1ccccc1)[C@@H]1CN(C(=O)CCCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C24H27NO4/c1-18(29-23(27)16-15-20-11-6-3-7-12-20)21-17-25(24(21)28)22(26)14-8-13-19-9-4-2-5-10-19/h2-7,9-12,18,21H,8,13-17H2,1H3/t18-,21+/m1/s1
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n/an/a 57n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50299914
PNG
(1-(3-Phenylpropanoyl)-(3S)-3-[1(R)-(5-phenylpentan...)
Show SMILES C[C@@H](OC(=O)CCCCc1ccccc1)[C@@H]1CN(C(=O)CCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C25H29NO4/c1-19(30-24(28)15-9-8-14-20-10-4-2-5-11-20)22-18-26(25(22)29)23(27)17-16-21-12-6-3-7-13-21/h2-7,10-13,19,22H,8-9,14-18H2,1H3/t19-,22+/m1/s1
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n/an/a 91n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50299924
PNG
(1-(Pent-4-enoyl)-(3S)-3-[1(R)-(pent-4-enoyloxy)-et...)
Show SMILES C[C@@H](OC(=O)CCC=C)[C@@H]1CN(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C15H21NO4/c1-4-6-8-13(17)16-10-12(15(16)19)11(3)20-14(18)9-7-5-2/h4-5,11-12H,1-2,6-10H2,3H3/t11-,12+/m1/s1
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n/an/a 98n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50299912
PNG
(1-(3-Phenylpropanoyl)-(3S)-3-[1(R)-(3-phenylpropan...)
Show SMILES C[C@@H](OC(=O)CCc1ccccc1)[C@@H]1CN(C(=O)CCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C23H25NO4/c1-17(28-22(26)15-13-19-10-6-3-7-11-19)20-16-24(23(20)27)21(25)14-12-18-8-4-2-5-9-18/h2-11,17,20H,12-16H2,1H3/t17-,20+/m1/s1
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n/an/a 157n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50299921
PNG
(1-(5-Phenylpentanoyl)-(3S)-3-[1(R)-(biphenylacetyl...)
Show SMILES C[C@@H](OC(=O)Cc1ccc(cc1)-c1ccccc1)[C@@H]1CN(C(=O)CCCCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C30H31NO4/c1-22(35-29(33)20-24-16-18-26(19-17-24)25-13-6-3-7-14-25)27-21-31(30(27)34)28(32)15-9-8-12-23-10-4-2-5-11-23/h2-7,10-11,13-14,16-19,22,27H,8-9,12,15,20-21H2,1H3/t22-,27+/m1/s1
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Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50299920
PNG
(1-(5-Phenylpentanoyl)-(3S)-3-[1(R)-(4-phenylbutano...)
Show SMILES C[C@@H](OC(=O)CCCc1ccccc1)[C@@H]1CN(C(=O)CCCCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C26H31NO4/c1-20(31-25(29)18-10-16-22-13-6-3-7-14-22)23-19-27(26(23)30)24(28)17-9-8-15-21-11-4-2-5-12-21/h2-7,11-14,20,23H,8-10,15-19H2,1H3/t20-,23+/m1/s1
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n/an/a 449n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50299938
PNG
(1-(4-Phenylbutanoyl)-(3R,4R)-3-[1(R)-(biphenylacet...)
Show SMILES C[C@@H](OC(=O)Cc1ccc(cc1)-c1ccccc1)[C@@H]1[C@@H](OC(C)=O)N(C(=O)CCCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C31H31NO6/c1-21(37-28(35)20-24-16-18-26(19-17-24)25-13-7-4-8-14-25)29-30(36)32(31(29)38-22(2)33)27(34)15-9-12-23-10-5-3-6-11-23/h3-8,10-11,13-14,16-19,21,29,31H,9,12,15,20H2,1-2H3/t21-,29+,31-/m1/s1
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n/an/a 708n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50299935
PNG
(1-(3-Phenylpropanoyl)-(3R,4R)-3-[1(R)-(biphenylace...)
Show SMILES C[C@@H](OC(=O)Cc1ccc(cc1)-c1ccccc1)[C@@H]1[C@@H](OC(C)=O)N(C(=O)CCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C30H29NO6/c1-20(36-27(34)19-23-13-16-25(17-14-23)24-11-7-4-8-12-24)28-29(35)31(30(28)37-21(2)32)26(33)18-15-22-9-5-3-6-10-22/h3-14,16-17,20,28,30H,15,18-19H2,1-2H3/t20-,28+,30-/m1/s1
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n/an/a 826n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50299934
PNG
(1-(3-Phenylpropanoyl)-(3R,4R)-3-[1(R)-(4-phenylbut...)
Show SMILES C[C@@H](OC(=O)CCCc1ccccc1)[C@@H]1[C@@H](OC(C)=O)N(C(=O)CCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C26H29NO6/c1-18(32-23(30)15-9-14-20-10-5-3-6-11-20)24-25(31)27(26(24)33-19(2)28)22(29)17-16-21-12-7-4-8-13-21/h3-8,10-13,18,24,26H,9,14-17H2,1-2H3/t18-,24+,26-/m1/s1
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n/an/a 960n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))		BDBM50299923
PNG
(1-(Pent-4-enoyl)-(3S)-3-[1(R)-(biphenylacetyloxy)-...)
Show SMILES C[C@@H](OC(=O)Cc1ccc(cc1)-c1ccccc1)[C@@H]1CN(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C24H25NO4/c1-3-4-10-22(26)25-16-21(24(25)28)17(2)29-23(27)15-18-11-13-20(14-12-18)19-8-6-5-7-9-19/h3,5-9,11-14,17,21H,1,4,10,15-16H2,2H3/t17-,21+/m1/s1
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n/an/a 1.84E+3n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MGL using 2-oleoylglycerol by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50299929
PNG
(1-(Pent-4-enoyl)-(3R,4R)-3-[1(R)-(pent-4-enoyloxy)...)
Show SMILES C[C@@H](OC(=O)CCC=C)[C@@H]1[C@@H](OC(C)=O)N(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C17H23NO6/c1-5-7-9-13(20)18-16(22)15(17(18)24-12(4)19)11(3)23-14(21)10-8-6-2/h5-6,11,15,17H,1-2,7-10H2,3-4H3/t11-,15+,17-/m1/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50299933
PNG
(1-(3-Phenylpropanoyl)-(3R,4R)-3-[1(R)-(3-phenylpro...)
Show SMILES C[C@@H](OC(=O)CCc1ccccc1)[C@@H]1[C@@H](OC(C)=O)N(C(=O)CCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C25H27NO6/c1-17(31-22(29)16-14-20-11-7-4-8-12-20)23-24(30)26(25(23)32-18(2)27)21(28)15-13-19-9-5-3-6-10-19/h3-12,17,23,25H,13-16H2,1-2H3/t17-,23+,25-/m1/s1
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n/an/a 2.19E+3n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50299937
PNG
(1-(4-Phenylbutanoyl)-(3R,4R)-3-[1(R)-(4-phenylbuta...)
Show SMILES C[C@@H](OC(=O)CCCc1ccccc1)[C@@H]1[C@@H](OC(C)=O)N(C(=O)CCCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C27H31NO6/c1-19(33-24(31)18-10-16-22-13-7-4-8-14-22)25-26(32)28(27(25)34-20(2)29)23(30)17-9-15-21-11-5-3-6-12-21/h3-8,11-14,19,25,27H,9-10,15-18H2,1-2H3/t19-,25+,27-/m1/s1
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n/an/a 3.12E+3n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))		BDBM50299922
PNG
(1-(Pent-4-enoyl)-(3S)-3-[1(R)-(4-phenylbutanoyloxy...)
Show SMILES C[C@@H](OC(=O)CCCc1ccccc1)C1CN(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C20H25NO4/c1-3-4-12-18(22)21-14-17(20(21)24)15(2)25-19(23)13-8-11-16-9-6-5-7-10-16/h3,5-7,9-10,15,17H,1,4,8,11-14H2,2H3/t15-,17?/m1/s1
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n/an/a 4.06E+3n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MGL using 2-oleoylglycerol by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))		BDBM50299925
PNG
(1-(Pent-4-enoyl)-(3S)-3-[1(R)-(hexa-5-enoyloxy)-et...)
Show SMILES C[C@@H](OC(=O)CCCC=C)[C@@H]1CN(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C16H23NO4/c1-4-6-8-10-15(19)21-12(3)13-11-17(16(13)20)14(18)9-7-5-2/h4-5,12-13H,1-2,6-11H2,3H3/t12-,13+/m1/s1
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n/an/a 4.72E+3n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MGL using 2-oleoylglycerol by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50299936
PNG
(1-(4-Phenylbutanoyl)-(3R,4R)-3-[1(R)-(3-phenylprop...)
Show SMILES C[C@@H](OC(=O)CCc1ccccc1)[C@@H]1[C@@H](OC(C)=O)N(C(=O)CCCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C26H29NO6/c1-18(32-23(30)17-16-21-12-7-4-8-13-21)24-25(31)27(26(24)33-19(2)28)22(29)15-9-14-20-10-5-3-6-11-20/h3-8,10-13,18,24,26H,9,14-17H2,1-2H3/t18-,24+,26-/m1/s1
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n/an/a 4.90E+3n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50299928
PNG
((3S)-3-[1(R)-(Biphenylacetyloxy)-ethyl]-azetidin-2...)
Show SMILES C[C@@H](OC(=O)Cc1ccc(cc1)-c1ccccc1)[C@@H]1CNC1=O |r|
Show InChI InChI=1S/C19H19NO3/c1-13(17-12-20-19(17)22)23-18(21)11-14-7-9-16(10-8-14)15-5-3-2-4-6-15/h2-10,13,17H,11-12H2,1H3,(H,20,22)/t13-,17+/m1/s1
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n/an/a 6.50E+3n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50299911
PNG
(1-(Pent-4-enoyl)-(3S)-3-[1(R)-hydroxyethyl]-azetid...)
Show SMILES C[C@@H](O)[C@@H]1CN(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C10H15NO3/c1-3-4-5-9(13)11-6-8(7(2)12)10(11)14/h3,7-8,12H,1,4-6H2,2H3/t7-,8+/m1/s1
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n/an/a 7.90E+3n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))		BDBM50299926
PNG
(1-(Hexa-5-enoyl)-(3S)-3-[1(R)-(4-phenylbutanoyloxy...)
Show SMILES C[C@@H](OC(=O)CCCc1ccccc1)[C@@H]1CN(C(=O)CCCC=C)C1=O |r|
Show InChI InChI=1S/C21H27NO4/c1-3-4-6-13-19(23)22-15-18(21(22)25)16(2)26-20(24)14-9-12-17-10-7-5-8-11-17/h3,5,7-8,10-11,16,18H,1,4,6,9,12-15H2,2H3/t16-,18+/m1/s1
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n/an/a 8.51E+3n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MGL using 2-oleoylglycerol by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))		BDBM50299927
PNG
(1-(Hexa-5-enoyl)-(3S)-3-[1(R)-(biphenylacetyloxy)-...)
Show SMILES C[C@@H](OC(=O)Cc1ccc(cc1)-c1ccccc1)[C@@H]1CN(C(=O)CCCC=C)C1=O |r|
Show InChI InChI=1S/C25H27NO4/c1-3-4-6-11-23(27)26-17-22(25(26)29)18(2)30-24(28)16-19-12-14-21(15-13-19)20-9-7-5-8-10-20/h3,5,7-10,12-15,18,22H,1,4,6,11,16-17H2,2H3/t18-,22+/m1/s1
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n/an/a 1.46E+4n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MGL using 2-oleoylglycerol by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))		BDBM50299924
PNG
(1-(Pent-4-enoyl)-(3S)-3-[1(R)-(pent-4-enoyloxy)-et...)
Show SMILES C[C@@H](OC(=O)CCC=C)[C@@H]1CN(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C15H21NO4/c1-4-6-8-13(17)16-10-12(15(16)19)11(3)20-14(18)9-7-5-2/h4-5,11-12H,1-2,6-10H2,3H3/t11-,12+/m1/s1
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n/an/a 2.33E+4n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MGL using 2-oleoylglycerol by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))		BDBM50299929
PNG
(1-(Pent-4-enoyl)-(3R,4R)-3-[1(R)-(pent-4-enoyloxy)...)
Show SMILES C[C@@H](OC(=O)CCC=C)[C@@H]1[C@@H](OC(C)=O)N(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C17H23NO6/c1-5-7-9-13(20)18-16(22)15(17(18)24-12(4)19)11(3)23-14(21)10-8-6-2/h5-6,11,15,17H,1-2,7-10H2,3-4H3/t11-,15+,17-/m1/s1
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n/an/a 1.33E+5n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MGL using 2-oleoylglycerol by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50299931
PNG
(1-(4-Phenylbutanoyl)-(3R,4R)-3-[1(R)-hydroxyethyl]...)
Show SMILES C[C@@H](O)[C@@H]1[C@@H](OC(C)=O)N(C(=O)CCCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C17H21NO5/c1-11(19)15-16(22)18(17(15)23-12(2)20)14(21)10-6-9-13-7-4-3-5-8-13/h3-5,7-8,11,15,17,19H,6,9-10H2,1-2H3/t11-,15+,17-/m1/s1
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n/an/a 1.83E+5n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50299930
PNG
(1-(3-Phenylpropanoyl)-(3R,4R)-3-[1(R)-hydroxyethyl...)
Show SMILES C[C@@H](O)[C@@H]1[C@@H](OC(C)=O)N(C(=O)CCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C16H19NO5/c1-10(18)14-15(21)17(16(14)22-11(2)19)13(20)9-8-12-6-4-3-5-7-12/h3-7,10,14,16,18H,8-9H2,1-2H3/t10-,14+,16-/m1/s1
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n/an/a 2.24E+5n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50299939
PNG
(1-(3-Phenylpropanoyl)-(3S)-3-[1(R)-hydroxyethyl]-a...)
Show SMILES C[C@@H](O)[C@@H]1CN(C(=O)CCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C14H17NO3/c1-10(16)12-9-15(14(12)18)13(17)8-7-11-5-3-2-4-6-11/h2-6,10,12,16H,7-9H2,1H3/t10-,12+/m1/s1
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n/an/a 4.09E+5n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50299932
PNG
(1-(Pent-4-enoyl)-(3R,4R)-3-[1(R)-(hydroxyethyl]-4-...)
Show SMILES C[C@@H](O)[C@@H]1[C@@H](OC(C)=O)N(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C12H17NO5/c1-4-5-6-9(16)13-11(17)10(7(2)14)12(13)18-8(3)15/h4,7,10,12,14H,1,5-6H2,2-3H3/t7-,10+,12-/m1/s1
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n/an/a 5.37E+5n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay

J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%