Affinity Data by PubMed id=19897364

PubMed code 19897364

Found 21 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Voltage-dependent calcium channel alpha-2 delta subunit (Sus scrofa)	BDBM50304703 (2-((3R)-1-(aminomethyl)-3-propylcyclopentyl)acetic...) Show SMILES CCC[C@@H]1CCC(CN)(CC(O)=O)C1 \|r\| Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins				Bioorg Med Chem Lett 20: 362-5 (2010) Article DOI: 10.1016/j.bmcl.2009.10.089 BindingDB Entry DOI: 10.7270/Q2XD11S7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-dependent calcium channel alpha-2 delta subunit (Sus scrofa)	BDBM50304707 (2-((1R,3R)-1-(aminomethyl)-3-methylcyclopentyl)ace...) Show SMILES C[C@@H]1CC[C@](CN)(CC(O)=O)C1 \|r\| Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins				Bioorg Med Chem Lett 20: 362-5 (2010) Article DOI: 10.1016/j.bmcl.2009.10.089 BindingDB Entry DOI: 10.7270/Q2XD11S7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-dependent calcium channel alpha-2 delta subunit (Sus scrofa)	BDBM50304702 (2-((3R)-1-(aminomethyl)-3-ethylcyclopentyl)acetic ...) Show SMILES CC[C@@H]1CCC(CN)(CC(O)=O)C1 \|r\| Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins				Bioorg Med Chem Lett 20: 362-5 (2010) Article DOI: 10.1016/j.bmcl.2009.10.089 BindingDB Entry DOI: 10.7270/Q2XD11S7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-dependent calcium channel alpha-2 delta subunit (Sus scrofa)	BDBM50304693 (2-(1-(aminomethyl)-3-ethylcyclopentyl)acetic acid ...) Show SMILES CCC1CCC(CN)(CC(O)=O)C1 Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins				Bioorg Med Chem Lett 20: 362-5 (2010) Article DOI: 10.1016/j.bmcl.2009.10.089 BindingDB Entry DOI: 10.7270/Q2XD11S7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-dependent calcium channel alpha-2 delta subunit (Sus scrofa)	BDBM50304694 (2-(1-(aminomethyl)-3-propylcyclopentyl)acetic acid...) Show SMILES CCCC1CCC(CN)(CC(O)=O)C1 Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	69	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins				Bioorg Med Chem Lett 20: 362-5 (2010) Article DOI: 10.1016/j.bmcl.2009.10.089 BindingDB Entry DOI: 10.7270/Q2XD11S7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-dependent calcium channel alpha-2 delta subunit (Sus scrofa)	BDBM50304708 (2-((1S,3R)-1-(aminomethyl)-3-methylcyclopentyl)ace...) Show SMILES C[C@@H]1CC[C@@](CN)(CC(O)=O)C1 \|r\| Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	71	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins				Bioorg Med Chem Lett 20: 362-5 (2010) Article DOI: 10.1016/j.bmcl.2009.10.089 BindingDB Entry DOI: 10.7270/Q2XD11S7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-dependent calcium channel alpha-2 delta subunit (Sus scrofa)	BDBM50164279 ((S)-3-(aminomethyl)-5-methylhexanoic acid \| (S)-3-...) Show SMILES CC(C)C[C@H](CN)CC(O)=O \|r\| Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins				Bioorg Med Chem Lett 20: 362-5 (2010) Article DOI: 10.1016/j.bmcl.2009.10.089 BindingDB Entry DOI: 10.7270/Q2XD11S7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-dependent calcium channel alpha-2 delta subunit (Sus scrofa)	BDBM50304692 (2-(1-(aminomethyl)-3-methylcyclopentyl)acetic acid...) Show SMILES CC1CCC(CN)(CC(O)=O)C1 Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	82	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins				Bioorg Med Chem Lett 20: 362-5 (2010) Article DOI: 10.1016/j.bmcl.2009.10.089 BindingDB Entry DOI: 10.7270/Q2XD11S7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-dependent calcium channel alpha-2 delta subunit (Sus scrofa)	BDBM50304701 (2-((3R)-1-(aminomethyl)-3-methylcyclopentyl)acetic...) Show SMILES C[C@@H]1CCC(CN)(CC(O)=O)C1 \|r\| Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	88	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins				Bioorg Med Chem Lett 20: 362-5 (2010) Article DOI: 10.1016/j.bmcl.2009.10.089 BindingDB Entry DOI: 10.7270/Q2XD11S7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-dependent calcium channel alpha-2 delta subunit (Sus scrofa)	BDBM50080153 ((1-Aminomethyl-cyclohexyl)-acetic acid \| 2-(1-(ami...) Show SMILES NCC1(CC(O)=O)CCCCC1 Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins				Bioorg Med Chem Lett 20: 362-5 (2010) Article DOI: 10.1016/j.bmcl.2009.10.089 BindingDB Entry DOI: 10.7270/Q2XD11S7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Voltage-dependent calcium channel alpha-2 delta subunit (Sus scrofa)	BDBM50304691 (CHEMBL610734 \| Gababutin) Show SMILES NCC1(CC(O)=O)CCCC1 Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	420	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins				Bioorg Med Chem Lett 20: 362-5 (2010) Article DOI: 10.1016/j.bmcl.2009.10.089 BindingDB Entry DOI: 10.7270/Q2XD11S7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-dependent calcium channel alpha-2 delta subunit (Sus scrofa)	BDBM50304695 (2-(1-(aminomethyl)-3-butylcyclopentyl)acetic acid ...) Show SMILES CCCCC1CCC(CN)(CC(O)=O)C1 Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	690	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins				Bioorg Med Chem Lett 20: 362-5 (2010) Article DOI: 10.1016/j.bmcl.2009.10.089 BindingDB Entry DOI: 10.7270/Q2XD11S7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-dependent calcium channel alpha-2 delta subunit (Sus scrofa)	BDBM50304705 (2-((3S)-1-(aminomethyl)-3-ethylcyclopentyl)acetic ...) Show SMILES CC[C@H]1CCC(CN)(CC(O)=O)C1 \|r\| Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	706	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins				Bioorg Med Chem Lett 20: 362-5 (2010) Article DOI: 10.1016/j.bmcl.2009.10.089 BindingDB Entry DOI: 10.7270/Q2XD11S7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-dependent calcium channel alpha-2 delta subunit (Sus scrofa)	BDBM50304696 (2-(1-(aminomethyl)-3-isobutylcyclopentyl)acetic ac...) Show SMILES CC(C)CC1CCC(CN)(CC(O)=O)C1 Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	760	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins				Bioorg Med Chem Lett 20: 362-5 (2010) Article DOI: 10.1016/j.bmcl.2009.10.089 BindingDB Entry DOI: 10.7270/Q2XD11S7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-dependent calcium channel alpha-2 delta subunit (Sus scrofa)	BDBM50304706 (2-((3S)-1-(aminomethyl)-3-propylcyclopentyl)acetic...) Show SMILES CCC[C@H]1CCC(CN)(CC(O)=O)C1 \|r\| Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins				Bioorg Med Chem Lett 20: 362-5 (2010) Article DOI: 10.1016/j.bmcl.2009.10.089 BindingDB Entry DOI: 10.7270/Q2XD11S7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-dependent calcium channel alpha-2 delta subunit (Sus scrofa)	BDBM50304704 (2-((3S)-1-(aminomethyl)-3-methylcyclopentyl)acetic...) Show SMILES C[C@H]1CCC(CN)(CC(O)=O)C1 \|r\| Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins				Bioorg Med Chem Lett 20: 362-5 (2010) Article DOI: 10.1016/j.bmcl.2009.10.089 BindingDB Entry DOI: 10.7270/Q2XD11S7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-dependent calcium channel alpha-2 delta subunit (Sus scrofa)	BDBM50304690 (2-(1-(aminomethyl)-3,3-dimethylcyclopentyl)acetic ...) Show SMILES CC1(C)CCC(CN)(CC(O)=O)C1 Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.18E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins				Bioorg Med Chem Lett 20: 362-5 (2010) Article DOI: 10.1016/j.bmcl.2009.10.089 BindingDB Entry DOI: 10.7270/Q2XD11S7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-dependent calcium channel alpha-2 delta subunit (Sus scrofa)	BDBM50304698 (2-(1-(aminomethyl)-3-phenylcyclopentyl)acetic acid...) Show SMILES NCC1(CC(O)=O)CCC(C1)c1ccccc1 Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.06E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins				Bioorg Med Chem Lett 20: 362-5 (2010) Article DOI: 10.1016/j.bmcl.2009.10.089 BindingDB Entry DOI: 10.7270/Q2XD11S7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-dependent calcium channel alpha-2 delta subunit (Sus scrofa)	BDBM50304700 (2-(1-(aminomethyl)-3-phenethylcyclopentyl)acetic a...) Show SMILES NCC1(CC(O)=O)CCC(CCc2ccccc2)C1 Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.23E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins				Bioorg Med Chem Lett 20: 362-5 (2010) Article DOI: 10.1016/j.bmcl.2009.10.089 BindingDB Entry DOI: 10.7270/Q2XD11S7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-dependent calcium channel alpha-2 delta subunit (Sus scrofa)	BDBM50304699 (2-(1-(aminomethyl)-3-benzylcyclopentyl)acetic acid...) Show SMILES NCC1(CC(O)=O)CCC(Cc2ccccc2)C1 Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.28E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins				Bioorg Med Chem Lett 20: 362-5 (2010) Article DOI: 10.1016/j.bmcl.2009.10.089 BindingDB Entry DOI: 10.7270/Q2XD11S7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-dependent calcium channel alpha-2 delta subunit (Sus scrofa)	BDBM50304697 (2-(1-(aminomethyl)-3-tert-butylcyclopentyl)acetic ...) Show SMILES CC(C)(C)C1CCC(CN)(CC(O)=O)C1 Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins				Bioorg Med Chem Lett 20: 362-5 (2010) Article DOI: 10.1016/j.bmcl.2009.10.089 BindingDB Entry DOI: 10.7270/Q2XD11S7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%