Affinity Data by PubMed id=19954984

PubMed code 19954984

Found 8 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Transthyretin (Homo sapiens (Human))	BDBM60927 (1-anilinonaphthalene-8-sulfonic acid \| 8-Anilino-1...) Show SMILES OS(=O)(=O)c1cccc2cccc(Nc3ccccc3)c12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Binding affinity to wild type human TTR denominated hormone binding site expressed in Escherichia coli assessed as dissociation constant for second l...				Bioorg Med Chem 18: 100-10 (2010) Article DOI: 10.1016/j.bmc.2009.11.025 BindingDB Entry DOI: 10.7270/Q29P31RQ
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transthyretin (Homo sapiens (Human))	BDBM50308731 (1-amino-5-naphthalene sulfonate \| 5-aminonaphthale...) Show SMILES Nc1cccc2c(cccc12)S(O)(=O)=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	6.40E+4	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Binding affinity to wild type human TTR denominated hormone binding site expressed in Escherichia coli by FRET analysis				Bioorg Med Chem 18: 100-10 (2010) Article DOI: 10.1016/j.bmc.2009.11.025 BindingDB Entry DOI: 10.7270/Q29P31RQ
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transthyretin (Homo sapiens (Human))	BDBM60927 (1-anilinonaphthalene-8-sulfonic acid \| 8-Anilino-1...) Show SMILES OS(=O)(=O)c1cccc2cccc(Nc3ccccc3)c12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Binding affinity to wild type human TTR denominated hormone binding site expressed in Escherichia coli by isothermal direct titrimetric assay				Bioorg Med Chem 18: 100-10 (2010) Article DOI: 10.1016/j.bmc.2009.11.025 BindingDB Entry DOI: 10.7270/Q29P31RQ
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transthyretin (Homo sapiens (Human))	BDBM60927 (1-anilinonaphthalene-8-sulfonic acid \| 8-Anilino-1...) Show SMILES OS(=O)(=O)c1cccc2cccc(Nc3ccccc3)c12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Binding affinity to wild type human TTR denominated hormone binding site expressed in Escherichia coli by direct fluorescence titration method				Bioorg Med Chem 18: 100-10 (2010) Article DOI: 10.1016/j.bmc.2009.11.025 BindingDB Entry DOI: 10.7270/Q29P31RQ
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transthyretin (Homo sapiens (Human))	BDBM60927 (1-anilinonaphthalene-8-sulfonic acid \| 8-Anilino-1...) Show SMILES OS(=O)(=O)c1cccc2cccc(Nc3ccccc3)c12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Binding affinity to wild type human TTR denominated hormone binding site expressed in Escherichia coli assessed as dissociation constant for first li...				Bioorg Med Chem 18: 100-10 (2010) Article DOI: 10.1016/j.bmc.2009.11.025 BindingDB Entry DOI: 10.7270/Q29P31RQ
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transthyretin (Homo sapiens (Human))	BDBM60927 (1-anilinonaphthalene-8-sulfonic acid \| 8-Anilino-1...) Show SMILES OS(=O)(=O)c1cccc2cccc(Nc3ccccc3)c12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Binding affinity to wild type human TTR denominated hormone binding site expressed in Escherichia coli assessed as dissociation constant for second l...				Bioorg Med Chem 18: 100-10 (2010) Article DOI: 10.1016/j.bmc.2009.11.025 BindingDB Entry DOI: 10.7270/Q29P31RQ
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transthyretin (Homo sapiens (Human))	BDBM60927 (1-anilinonaphthalene-8-sulfonic acid \| 8-Anilino-1...) Show SMILES OS(=O)(=O)c1cccc2cccc(Nc3ccccc3)c12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Binding affinity to wild type human TTR denominated hormone binding site expressed in Escherichia coli assessed as dissociation constant for first li...				Bioorg Med Chem 18: 100-10 (2010) Article DOI: 10.1016/j.bmc.2009.11.025 BindingDB Entry DOI: 10.7270/Q29P31RQ
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transthyretin (Homo sapiens (Human))	BDBM60927 (1-anilinonaphthalene-8-sulfonic acid \| 8-Anilino-1...) Show SMILES OS(=O)(=O)c1cccc2cccc(Nc3ccccc3)c12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Binding affinity to wild type human TTR denominated hormone binding site expressed in Escherichia coli by equilibrium dialysis				Bioorg Med Chem 18: 100-10 (2010) Article DOI: 10.1016/j.bmc.2009.11.025 BindingDB Entry DOI: 10.7270/Q29P31RQ
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

* indicates data uncertainty>20%