Affinity Data by PubMed id=20081815

PubMed code 20081815

Found 6 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Transthyretin (Homo sapiens (Human))	BDBM50323722 (4-fluorophenyl 3-(4-hydroxy-3,5-dimethylstyryl)ben...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	1.96E+3	n/a	n/a	n/a	n/a	4.4	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of wild type TTR amyloidogenesis assessed as inhibition of fibril formation after 72 hrs at pH 4.4 by spectrophotometry relative to untrea...				Nat Chem Biol 6: 133-9 (2010) Article DOI: 10.1038/nchembio.281 BindingDB Entry DOI: 10.7270/Q2QF8T2G
The Scripps Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transthyretin (Homo sapiens (Human))	BDBM50323724 (CHEMBL1213660 \| S-phenyl 3-(4-hydroxy-3,5-dimethyl...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	4.4	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of wild type TTR amyloidogenesis assessed as inhibition of fibril formation after 72 hrs at pH 4.4 by spectrophotometry relative to untrea...				Nat Chem Biol 6: 133-9 (2010) Article DOI: 10.1038/nchembio.281 BindingDB Entry DOI: 10.7270/Q2QF8T2G
The Scripps Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM50323725 (CHEMBL1213659 \| S-phenyl 3-(3,5-dibromo-4-hydroxys...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	4.4	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of wild type TTR amyloidogenesis assessed as inhibition of fibril formation after 72 hrs at pH 4.4 by spectrophotometry relative to untrea...				Nat Chem Biol 6: 133-9 (2010) Article DOI: 10.1038/nchembio.281 BindingDB Entry DOI: 10.7270/Q2QF8T2G
The Scripps Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM50323723 (2-nitrophenyl 3-(4-hydroxy-3,5-dimethylstyryl)benz...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.26E+3	n/a	n/a	n/a	n/a	4.4	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of wild type TTR amyloidogenesis assessed as inhibition of fibril formation after 72 hrs at pH 4.4 by spectrophotometry relative to untrea...				Nat Chem Biol 6: 133-9 (2010) Article DOI: 10.1038/nchembio.281 BindingDB Entry DOI: 10.7270/Q2QF8T2G
The Scripps Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM50012781 (3-(4-hydroxy-3,5-dimethylstyryl)benzoic acid \| 3-[...) Show SMILES Cc1cc(\C=C\c2cccc(c2)C(O)=O)cc(C)c1O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.07E+3	n/a	n/a	n/a	n/a	4.4	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of wild type TTR amyloidogenesis assessed as inhibition of fibril formation after 72 hrs at pH 4.4 by spectrophotometry relative to untrea...				Nat Chem Biol 6: 133-9 (2010) Article DOI: 10.1038/nchembio.281 BindingDB Entry DOI: 10.7270/Q2QF8T2G
The Scripps Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM50012798 ((E)-2,6-dimethyl-4-styrylphenol \| 2,6-Dimethyl-4-s...) Show SMILES Cc1cc(\C=C\c2ccccc2)cc(C)c1O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	3.08E+3	n/a	n/a	n/a	n/a	4.4	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of wild type TTR amyloidogenesis assessed as inhibition of fibril formation after 72 hrs at pH 4.4 by spectrophotometry relative to untrea...				Nat Chem Biol 6: 133-9 (2010) Article DOI: 10.1038/nchembio.281 BindingDB Entry DOI: 10.7270/Q2QF8T2G
The Scripps Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

* indicates data uncertainty>20%