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PubMed code 20097068

Compile data set for download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50306906
PNG
(((R)-7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropy...)
Show SMILES CC1=Nc2ccnn2[C@@H](C1C(=O)N1CCC[C@H]1c1ccc(F)cc1)c1ccc(Cl)c(Cl)c1 |r,t:1|
Show InChI InChI=1S/C24H21Cl2FN4O/c1-14-22(24(32)30-12-2-3-20(30)15-4-7-17(27)8-5-15)23(31-21(29-14)10-11-28-31)16-6-9-18(25)19(26)13-16/h4-11,13,20,22-23H,2-3,12H2,1H3/t20-,22?,23+/m0/s1
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n/an/a 50n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 20: 1436-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.085
BindingDB Entry DOI: 10.7270/Q2MG7PM1
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50306891
PNG
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCCC1c1ccc(F)cc1)c1ccc(Cl)c(Cl)c1 |t:1|
Show InChI InChI=1S/C24H21Cl2FN4O/c1-14-22(24(32)30-12-2-3-20(30)15-4-7-17(27)8-5-15)23(31-21(29-14)10-11-28-31)16-6-9-18(25)19(26)13-16/h4-11,13,20,22-23H,2-3,12H2,1H3
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n/an/a 70n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 20: 1436-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.085
BindingDB Entry DOI: 10.7270/Q2MG7PM1
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50306891
PNG
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCCC1c1ccc(F)cc1)c1ccc(Cl)c(Cl)c1 |t:1|
Show InChI InChI=1S/C24H21Cl2FN4O/c1-14-22(24(32)30-12-2-3-20(30)15-4-7-17(27)8-5-15)23(31-21(29-14)10-11-28-31)16-6-9-18(25)19(26)13-16/h4-11,13,20,22-23H,2-3,12H2,1H3
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n/an/a 70n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 20: 1436-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.085
BindingDB Entry DOI: 10.7270/Q2MG7PM1
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50306905
PNG
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Show SMILES Cc1cc(no1)[C@@H]1CCCN1C(=O)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C |r,c:32|
Show InChI InChI=1S/C22H21Cl2N5O2/c1-12-10-17(27-31-12)18-4-3-9-28(18)22(30)20-13(2)26-19-7-8-25-29(19)21(20)14-5-6-15(23)16(24)11-14/h5-8,10-11,18,20-21H,3-4,9H2,1-2H3/t18-,20?,21?/m0/s1
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n/an/a 90n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 20: 1436-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.085
BindingDB Entry DOI: 10.7270/Q2MG7PM1
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50306904
PNG
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Show SMILES Cc1cc(on1)[C@@H]1CCCN1C(=O)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C |r,c:32|
Show InChI InChI=1S/C22H21Cl2N5O2/c1-12-10-18(31-27-12)17-4-3-9-28(17)22(30)20-13(2)26-19-7-8-25-29(19)21(20)14-5-6-15(23)16(24)11-14/h5-8,10-11,17,20-21H,3-4,9H2,1-2H3/t17-,20?,21?/m0/s1
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n/an/a 110n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 20: 1436-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.085
BindingDB Entry DOI: 10.7270/Q2MG7PM1
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50306890
PNG
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCCC1c1ccccc1)c1ccc(Cl)c(Cl)c1 |t:1|
Show InChI InChI=1S/C24H22Cl2N4O/c1-15-22(24(31)29-13-5-8-20(29)16-6-3-2-4-7-16)23(30-21(28-15)11-12-27-30)17-9-10-18(25)19(26)14-17/h2-4,6-7,9-12,14,20,22-23H,5,8,13H2,1H3
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n/an/a 150n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 20: 1436-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.085
BindingDB Entry DOI: 10.7270/Q2MG7PM1
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50306893
PNG
((2S)-methyl 1-(7-(3,4-dichlorophenyl)-5-methyl-4,7...)
Show SMILES COC(=O)[C@@H]1CCCN1C(=O)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C |r,c:29|
Show InChI InChI=1S/C20H20Cl2N4O3/c1-11-17(19(27)25-9-3-4-15(25)20(28)29-2)18(26-16(24-11)7-8-23-26)12-5-6-13(21)14(22)10-12/h5-8,10,15,17-18H,3-4,9H2,1-2H3/t15-,17?,18?/m0/s1
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Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 20: 1436-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.085
BindingDB Entry DOI: 10.7270/Q2MG7PM1
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50306892
PNG
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCC(C1)c1ccc(F)cc1)c1ccc(Cl)c(Cl)c1 |t:1|
Show InChI InChI=1S/C24H21Cl2FN4O/c1-14-22(24(32)30-11-9-17(13-30)15-2-5-18(27)6-3-15)23(31-21(29-14)8-10-28-31)16-4-7-19(25)20(26)12-16/h2-8,10,12,17,22-23H,9,11,13H2,1H3
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n/an/a 160n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 20: 1436-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.085
BindingDB Entry DOI: 10.7270/Q2MG7PM1
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50306897
PNG
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Show SMILES Cc1noc(n1)[C@@H]1CCCN1C(=O)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C |r,c:32|
Show InChI InChI=1S/C21H20Cl2N6O2/c1-11-18(21(30)28-9-3-4-16(28)20-26-12(2)27-31-20)19(29-17(25-11)7-8-24-29)13-5-6-14(22)15(23)10-13/h5-8,10,16,18-19H,3-4,9H2,1-2H3/t16-,18?,19?/m0/s1
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n/an/a 160n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 20: 1436-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.085
BindingDB Entry DOI: 10.7270/Q2MG7PM1
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50254778
PNG
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Show SMILES COC[C@@H]1CCCN1C(=O)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C |r,c:28|
Show InChI InChI=1S/C20H22Cl2N4O2/c1-12-18(20(27)25-9-3-4-14(25)11-28-2)19(26-17(24-12)7-8-23-26)13-5-6-15(21)16(22)10-13/h5-8,10,14,18-19H,3-4,9,11H2,1-2H3/t14-,18?,19?/m0/s1
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Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 20: 1436-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.085
BindingDB Entry DOI: 10.7270/Q2MG7PM1
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50306900
PNG
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Show SMILES Cc1nc(sc1C)[C@@H]1CCCN1C(=O)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C |r,c:33|
Show InChI InChI=1S/C23H23Cl2N5OS/c1-12-14(3)32-22(28-12)18-5-4-10-29(18)23(31)20-13(2)27-19-8-9-26-30(19)21(20)15-6-7-16(24)17(25)11-15/h6-9,11,18,20-21H,4-5,10H2,1-3H3/t18-,20?,21?/m0/s1
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Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 20: 1436-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.085
BindingDB Entry DOI: 10.7270/Q2MG7PM1
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50306894
PNG
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCCC1c1ccncc1)c1ccc(Cl)c(Cl)c1 |t:1|
Show InChI InChI=1S/C23H21Cl2N5O/c1-14-21(23(31)29-12-2-3-19(29)15-6-9-26-10-7-15)22(30-20(28-14)8-11-27-30)16-4-5-17(24)18(25)13-16/h4-11,13,19,21-22H,2-3,12H2,1H3
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Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 20: 1436-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.085
BindingDB Entry DOI: 10.7270/Q2MG7PM1
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50306899
PNG
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCC[C@H]1c1nnn(C)n1)c1ccc(Cl)c(Cl)c1 |r,t:1|
Show InChI InChI=1S/C20H20Cl2N8O/c1-11-17(20(31)29-9-3-4-15(29)19-25-27-28(2)26-19)18(30-16(24-11)7-8-23-30)12-5-6-13(21)14(22)10-12/h5-8,10,15,17-18H,3-4,9H2,1-2H3/t15-,17?,18?/m0/s1
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Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 20: 1436-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.085
BindingDB Entry DOI: 10.7270/Q2MG7PM1
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50254697
PNG
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCCC1)c1ccc(Cl)c(Cl)c1 |t:1|
Show InChI InChI=1S/C18H18Cl2N4O/c1-11-16(18(25)23-8-2-3-9-23)17(24-15(22-11)6-7-21-24)12-4-5-13(19)14(20)10-12/h4-7,10,16-17H,2-3,8-9H2,1H3
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Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 20: 1436-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.085
BindingDB Entry DOI: 10.7270/Q2MG7PM1
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50306896
PNG
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCCC1c1ccccn1)c1ccc(Cl)c(Cl)c1 |t:1|
Show InChI InChI=1S/C23H21Cl2N5O/c1-14-21(23(31)29-12-4-6-19(29)18-5-2-3-10-26-18)22(30-20(28-14)9-11-27-30)15-7-8-16(24)17(25)13-15/h2-3,5,7-11,13,19,21-22H,4,6,12H2,1H3
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Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 20: 1436-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.085
BindingDB Entry DOI: 10.7270/Q2MG7PM1
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50306897
PNG
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Show SMILES Cc1noc(n1)[C@@H]1CCCN1C(=O)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C |r,c:32|
Show InChI InChI=1S/C21H20Cl2N6O2/c1-11-18(21(30)28-9-3-4-16(28)20-26-12(2)27-31-20)19(29-17(25-11)7-8-24-29)13-5-6-14(22)15(23)10-13/h5-8,10,16,18-19H,3-4,9H2,1-2H3/t16-,18?,19?/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 20: 1436-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.085
BindingDB Entry DOI: 10.7270/Q2MG7PM1
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50306895
PNG
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCCC1c1cccnc1)c1ccc(Cl)c(Cl)c1 |t:1|
Show InChI InChI=1S/C23H21Cl2N5O/c1-14-21(23(31)29-11-3-5-19(29)16-4-2-9-26-13-16)22(30-20(28-14)8-10-27-30)15-6-7-17(24)18(25)12-15/h2,4,6-10,12-13,19,21-22H,3,5,11H2,1H3
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Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 20: 1436-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.085
BindingDB Entry DOI: 10.7270/Q2MG7PM1
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50306889
PNG
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Show SMILES COC[C@H]1CCCN1C(=O)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C |r,c:28|
Show InChI InChI=1S/C20H22Cl2N4O2/c1-12-18(20(27)25-9-3-4-14(25)11-28-2)19(26-17(24-12)7-8-23-26)13-5-6-15(21)16(22)10-13/h5-8,10,14,18-19H,3-4,9,11H2,1-2H3/t14-,18?,19?/m1/s1
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Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 20: 1436-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.085
BindingDB Entry DOI: 10.7270/Q2MG7PM1
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50306904
PNG
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Show SMILES Cc1cc(on1)[C@@H]1CCCN1C(=O)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C |r,c:32|
Show InChI InChI=1S/C22H21Cl2N5O2/c1-12-10-18(31-27-12)17-4-3-9-28(17)22(30)20-13(2)26-19-7-8-25-29(19)21(20)14-5-6-15(23)16(24)11-14/h5-8,10-11,17,20-21H,3-4,9H2,1-2H3/t17-,20?,21?/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 20: 1436-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.085
BindingDB Entry DOI: 10.7270/Q2MG7PM1
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50306902
PNG
(3-((2S)-1-(7-(3,4-dichlorophenyl)-5-methyl-4,7-dih...)
Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCC[C@H]1c1n[nH]c(=O)n1C)c1ccc(Cl)c(Cl)c1 |r,t:1|
Show InChI InChI=1S/C21H21Cl2N7O2/c1-11-17(20(31)29-9-3-4-15(29)19-26-27-21(32)28(19)2)18(30-16(25-11)7-8-24-30)12-5-6-13(22)14(23)10-12/h5-8,10,15,17-18H,3-4,9H2,1-2H3,(H,27,32)/t15-,17?,18?/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 20: 1436-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.085
BindingDB Entry DOI: 10.7270/Q2MG7PM1
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50306903
PNG
(((S)-2-(5-amino-1,3,4-thiadiazol-2-yl)pyrrolidin-1...)
Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCC[C@H]1c1nnc(N)s1)c1ccc(Cl)c(Cl)c1 |r,t:1|
Show InChI InChI=1S/C20H19Cl2N7OS/c1-10-16(19(30)28-8-2-3-14(28)18-26-27-20(23)31-18)17(29-15(25-10)6-7-24-29)11-4-5-12(21)13(22)9-11/h4-7,9,14,16-17H,2-3,8H2,1H3,(H2,23,27)/t14-,16?,17?/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 20: 1436-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.085
BindingDB Entry DOI: 10.7270/Q2MG7PM1
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50306901
PNG
(((S)-2-(4H-1,2,4-triazol-3-yl)pyrrolidin-1-yl)(7-(...)
Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCC[C@H]1c1nnc[nH]1)c1ccc(Cl)c(Cl)c1 |r,t:1|
Show InChI InChI=1S/C20H19Cl2N7O/c1-11-17(20(30)28-8-2-3-15(28)19-23-10-24-27-19)18(29-16(26-11)6-7-25-29)12-4-5-13(21)14(22)9-12/h4-7,9-10,15,17-18H,2-3,8H2,1H3,(H,23,24,27)/t15-,17?,18?/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 20: 1436-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.085
BindingDB Entry DOI: 10.7270/Q2MG7PM1
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50306898
PNG
(((S)-2-(1H-tetrazol-5-yl)pyrrolidin-1-yl)(7-(3,4-d...)
Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCC[C@H]1c1nnn[nH]1)c1ccc(Cl)c(Cl)c1 |r,t:1|
Show InChI InChI=1S/C19H18Cl2N8O/c1-10-16(19(30)28-8-2-3-14(28)18-24-26-27-25-18)17(29-15(23-10)6-7-22-29)11-4-5-12(20)13(21)9-11/h4-7,9,14,16-17H,2-3,8H2,1H3,(H,24,25,26,27)/t14-,16?,17?/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 20: 1436-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.085
BindingDB Entry DOI: 10.7270/Q2MG7PM1
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50306905
PNG
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Show SMILES Cc1cc(no1)[C@@H]1CCCN1C(=O)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C |r,c:32|
Show InChI InChI=1S/C22H21Cl2N5O2/c1-12-10-17(27-31-12)18-4-3-9-28(18)22(30)20-13(2)26-19-7-8-25-29(19)21(20)14-5-6-15(23)16(24)11-14/h5-8,10-11,18,20-21H,3-4,9H2,1-2H3/t18-,20?,21?/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 20: 1436-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.085
BindingDB Entry DOI: 10.7270/Q2MG7PM1
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50306891
PNG
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCCC1c1ccc(F)cc1)c1ccc(Cl)c(Cl)c1 |t:1|
Show InChI InChI=1S/C24H21Cl2FN4O/c1-14-22(24(32)30-12-2-3-20(30)15-4-7-17(27)8-5-15)23(31-21(29-14)10-11-28-31)16-6-9-18(25)19(26)13-16/h4-11,13,20,22-23H,2-3,12H2,1H3
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n/an/a 1.80E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 20: 1436-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.085
BindingDB Entry DOI: 10.7270/Q2MG7PM1
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50306891
PNG
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCCC1c1ccc(F)cc1)c1ccc(Cl)c(Cl)c1 |t:1|
Show InChI InChI=1S/C24H21Cl2FN4O/c1-14-22(24(32)30-12-2-3-20(30)15-4-7-17(27)8-5-15)23(31-21(29-14)10-11-28-31)16-6-9-18(25)19(26)13-16/h4-11,13,20,22-23H,2-3,12H2,1H3
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n/an/a 2.10E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 20: 1436-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.085
BindingDB Entry DOI: 10.7270/Q2MG7PM1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%