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PubMed code 20373302

Compile data set for download or QSAR
Found 5 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone acetyltransferase p300


(Homo sapiens (Human))		BDBM84874
PNG
(Guttiferone A, 3)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6@H]1-[#6][C@@]2([#6]\[#6]=[#6](\[#6])-[#6])[#6](=O)-[#6](-[#6](=O)-c3ccc(-[#8])c(-[#8])c3)-[#6](=O)[C@]([#6]\[#6]=[#6](\[#6])-[#6])([#6]2=O)[C@]1([#6])[#6]-[#6]=[#6](-[#6])-[#6] |r,THB:35:34:15.26.13:36.6.5|
Show InChI InChI=1S/C37H48O6/c1-22(2)10-12-27-21-36(18-15-24(5)6)32(41)30(31(40)26-11-13-28(38)29(39)20-26)33(42)37(34(36)43,19-16-25(7)8)35(27,9)17-14-23(3)4/h10-11,13-16,20,27,30,38-39H,12,17-19,21H2,1-9H3/t27-,30?,35+,36-,37+/m0/s1
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Article
PubMed
n/an/an/a 100n/an/an/an/a37



Universitá degli Studi di Salerno



Assay Description
The p300 activity assays were performed by a colorimetric kit (JM-K322-100, MBL) using active recombinant p300/HAT as positive control and acetyl-CoA...

Chembiochem 11: 818-27 (2010)


Article DOI: 10.1002/cbic.200900721
BindingDB Entry DOI: 10.7270/Q2S1810J
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens (Human))		BDBM84873
PNG
(Nemorosone, 2)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6@@H]1-[#6][C@@]2([#6]\[#6]=[#6](\[#6])-[#6])[#6](=O)-[#6](-[#6]\[#6]=[#6](\[#6])-[#6])-[#6](=O)[C@@]([#6](=O)-c3ccccc3)([#6]2=O)C1([#6])[#6] |r,THB:33:32:15.21.13:34.6.5|
Show InChI InChI=1S/C33H42O4/c1-21(2)14-16-25-20-32(19-18-23(5)6)28(35)26(17-15-22(3)4)29(36)33(30(32)37,31(25,7)8)27(34)24-12-10-9-11-13-24/h9-15,18,25-26H,16-17,19-20H2,1-8H3/t25-,26?,32+,33+/m1/s1
PDB
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UniProtKB/SwissProt

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antibodypedia
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UniChem

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PubMed
n/an/an/a 250n/an/an/an/a37



Universitá degli Studi di Salerno



Assay Description
The p300 activity assays were performed by a colorimetric kit (JM-K322-100, MBL) using active recombinant p300/HAT as positive control and acetyl-CoA...

Chembiochem 11: 818-27 (2010)


Article DOI: 10.1002/cbic.200900721
BindingDB Entry DOI: 10.7270/Q2S1810J
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens (Human))		BDBM84877
PNG
(Clusianone, 10)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6@@H]1-[#6][C@@]2([#6]\[#6]=[#6](/[#6])-[#6])[#6](=O)-[#6](-[#6](=O)-c3ccccc3)-[#6](=O)[C@]([#6]\[#6]=[#6](/[#6])-[#6])([#6]2=O)C1([#6])[#6] |r,THB:33:32:15.24.13:34.6.5|
Show InChI InChI=1S/C33H42O4/c1-21(2)14-15-25-20-32(18-16-22(3)4)28(35)26(27(34)24-12-10-9-11-13-24)29(36)33(30(32)37,31(25,7)8)19-17-23(5)6/h9-14,16-17,25-26H,15,18-20H2,1-8H3/t25-,26?,32+,33-/m1/s1
PDB
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UniProtKB/SwissProt

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PubMed
n/an/an/a 810n/an/an/an/a37



Universitá degli Studi di Salerno



Assay Description
The p300 activity assays were performed by a colorimetric kit (JM-K322-100, MBL) using active recombinant p300/HAT as positive control and acetyl-CoA...

Chembiochem 11: 818-27 (2010)


Article DOI: 10.1002/cbic.200900721
BindingDB Entry DOI: 10.7270/Q2S1810J
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens (Human))		BDBM84875
PNG
(Guttiferone E, 4)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6](-[#6]-[#6](-[#6]=[#6](-[#6])-[#6])[C@]12[#6]-[#6@H](-[#6]\[#6]=[#6](\[#6])-[#6])C([#6])([#6])[C@]([#6]\[#6]=[#6](\[#6])-[#6])([#6](=O)-[#6](-[#6](=O)-c3ccc(-[#8])c(-[#8])c3)-[#6]1=O)[#6]2=O)-[#6](-[#6])=[#6] |r,TLB:45:44:31.29.42:20.13.14|
Show InChI InChI=1S/C43H58O6/c1-25(2)13-15-30(29(9)10)22-33(21-28(7)8)42-24-32(17-14-26(3)4)41(11,12)43(40(42)49,20-19-27(5)6)39(48)36(38(42)47)37(46)31-16-18-34(44)35(45)23-31/h13-14,16,18-19,21,23,30,32-33,36,44-45H,9,15,17,20,22,24H2,1-8,10-12H3/t30?,32-,33?,36?,42+,43+/m0/s1
PDB
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UniChem

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PubMed
n/an/an/a 390n/an/an/an/a37



Universitá degli Studi di Salerno



Assay Description
The p300 activity assays were performed by a colorimetric kit (JM-K322-100, MBL) using active recombinant p300/HAT as positive control and acetyl-CoA...

Chembiochem 11: 818-27 (2010)


Article DOI: 10.1002/cbic.200900721
BindingDB Entry DOI: 10.7270/Q2S1810J
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens (Human))		BDBM50241990
PNG
(CHEMBL502489 | Camboginol | Garcinol | Garcinol, 1)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6@@H](-[#6][C@@]12[#6]-[#6@@H](-[#6]\[#6]=[#6](\[#6])-[#6])C([#6])([#6])[C@@]([#6]\[#6]=[#6](\[#6])-[#6])([#6](=O)-[#6](-[#6](=O)-c3ccc(-[#8])c(-[#8])c3)-[#6]1=O)[#6]2=O)-[#6](-[#6])=[#6] |r,TLB:40:39:26.24.37:15.8.9|
Show InChI InChI=1S/C38H50O6/c1-22(2)11-13-27(25(7)8)20-37-21-28(15-12-23(3)4)36(9,10)38(35(37)44,18-17-24(5)6)34(43)31(33(37)42)32(41)26-14-16-29(39)30(40)19-26/h11-12,14,16-17,19,27-28,31,39-40H,7,13,15,18,20-21H2,1-6,8-10H3/t27-,28+,31?,37+,38-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/a 400n/an/an/an/a37



Universitá degli Studi di Salerno



Assay Description
The p300 activity assays were performed by a colorimetric kit (JM-K322-100, MBL) using active recombinant p300/HAT as positive control and acetyl-CoA...

Chembiochem 11: 818-27 (2010)


Article DOI: 10.1002/cbic.200900721
BindingDB Entry DOI: 10.7270/Q2S1810J
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%