Affinity Data by PubMed id=20580552

PubMed code 20580552

Found 8 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 14 (Homo sapiens (Human))	BDBM50059889 ((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-fused NIK expressed in Sf9 cells after 60 mins by radiometric protein kinase assay				Bioorg Med Chem Lett 20: 4515-20 (2010) Article DOI: 10.1016/j.bmcl.2010.06.027 BindingDB Entry DOI: 10.7270/Q2D79BKX
University of Namur Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 14 (Homo sapiens (Human))	BDBM50322999 (4-(ethoxymethylene)isoquinoline-1,3(2H,4H)-dione \|...) Show SMILES CCO\C=C1\C(=O)NC(=O)c2ccccc12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-fused NIK expressed in Sf9 cells after 60 mins by radiometric protein kinase assay				Bioorg Med Chem Lett 20: 4515-20 (2010) Article DOI: 10.1016/j.bmcl.2010.06.027 BindingDB Entry DOI: 10.7270/Q2D79BKX
University of Namur Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 14 (Homo sapiens (Human))	BDBM50322995 (CHEMBL1210769 \| cid_349435 \| isoquinoline-1,3(2H,4...) Show SMILES O=C1Cc2ccccc2C(=O)N1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-fused NIK expressed in Sf9 cells after 60 mins by radiometric protein kinase assay				Bioorg Med Chem Lett 20: 4515-20 (2010) Article DOI: 10.1016/j.bmcl.2010.06.027 BindingDB Entry DOI: 10.7270/Q2D79BKX
University of Namur Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 14 (Homo sapiens (Human))	BDBM50322996 (2,7-naphthyridine-1,3,6,8-tetrone \| CHEMBL1210770) Show SMILES O=C1CC2CC(=O)NC(=O)C2C(=O)N1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-fused NIK expressed in Sf9 cells after 60 mins by radiometric protein kinase assay				Bioorg Med Chem Lett 20: 4515-20 (2010) Article DOI: 10.1016/j.bmcl.2010.06.027 BindingDB Entry DOI: 10.7270/Q2D79BKX
University of Namur Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 14 (Homo sapiens (Human))	BDBM50322998 (4-(thiophen-2-ylmethylene)isoquinoline-1,3(2H,4H)-...) Show SMILES O=C1NC(=O)c2ccccc2\C1=C/c1cccs1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-fused NIK expressed in Sf9 cells after 60 mins by radiometric protein kinase assay				Bioorg Med Chem Lett 20: 4515-20 (2010) Article DOI: 10.1016/j.bmcl.2010.06.027 BindingDB Entry DOI: 10.7270/Q2D79BKX
University of Namur Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 14 (Homo sapiens (Human))	BDBM50323000 (5,7-dichloroquinazoline-2,4(1H,3H)-dione \| CHEMBL1...) Show SMILES Clc1cc(Cl)c2c(c1)[nH]c(=O)[nH]c2=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-fused NIK expressed in Sf9 cells after 60 mins by radiometric protein kinase assay				Bioorg Med Chem Lett 20: 4515-20 (2010) Article DOI: 10.1016/j.bmcl.2010.06.027 BindingDB Entry DOI: 10.7270/Q2D79BKX
University of Namur Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 14 (Homo sapiens (Human))	BDBM50012070 (5-Hydroxy-2-methyl-[1,4]naphthoquinone \| 5-hydroxy...) Show SMILES CC1=CC(=O)c2c(O)cccc2C1=O \|t:1\| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-fused NIK expressed in Sf9 cells after 60 mins by radiometric protein kinase assay				Bioorg Med Chem Lett 20: 4515-20 (2010) Article DOI: 10.1016/j.bmcl.2010.06.027 BindingDB Entry DOI: 10.7270/Q2D79BKX
University of Namur Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 14 (Homo sapiens (Human))	BDBM50322997 (1,2-dihydroisoquinolin-3(4H)-one \| CHEMBL1210771) Show SMILES O=C1Cc2ccccc2CN1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-fused NIK expressed in Sf9 cells after 60 mins by radiometric protein kinase assay				Bioorg Med Chem Lett 20: 4515-20 (2010) Article DOI: 10.1016/j.bmcl.2010.06.027 BindingDB Entry DOI: 10.7270/Q2D79BKX
University of Namur Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%