Affinity Data by PubMed id=20621728

PubMed code 20621728

Found 19 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50321576 (1-(4-(3-aminoazetidine-1-carbonyl)-5-(2-fluoro-4-i...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Takeda San Diego Curated by ChEMBL					Assay Description Inhibition of MEK1 by cascade assay method				Bioorg Med Chem Lett 20: 4156-8 (2010) Article DOI: 10.1016/j.bmcl.2010.05.058 BindingDB Entry DOI: 10.7270/Q2SF2X4Z
Takeda San Diego Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50321561 (1-acetyl-4-(2-fluoro-4-iodophenylamino)-N-(2-hydro...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Takeda San Diego Curated by ChEMBL					Assay Description Inhibition of MEK1 by cascade assay method				Bioorg Med Chem Lett 20: 4156-8 (2010) Article DOI: 10.1016/j.bmcl.2010.05.058 BindingDB Entry DOI: 10.7270/Q2SF2X4Z
Takeda San Diego Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50321567 ((S)-5-acetyl-N-(2,3-dihydroxypropoxy)-2-(2-fluoro-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Takeda San Diego Curated by ChEMBL					Assay Description Inhibition of MEK1 by cascade assay method				Bioorg Med Chem Lett 20: 4156-8 (2010) Article DOI: 10.1016/j.bmcl.2010.05.058 BindingDB Entry DOI: 10.7270/Q2SF2X4Z
Takeda San Diego Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50321577 ((R)-1-(5-(2-fluoro-4-iodophenylamino)-4-(3-hydroxy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Takeda San Diego Curated by ChEMBL					Assay Description Inhibition of MEK1 by cascade assay method				Bioorg Med Chem Lett 20: 4156-8 (2010) Article DOI: 10.1016/j.bmcl.2010.05.058 BindingDB Entry DOI: 10.7270/Q2SF2X4Z
Takeda San Diego Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50321572 ((S)-5-acetyl-4-chloro-N-(2,3-dihydroxypropoxy)-2-(...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Takeda San Diego Curated by ChEMBL					Assay Description Inhibition of MEK1 by cascade assay method				Bioorg Med Chem Lett 20: 4156-8 (2010) Article DOI: 10.1016/j.bmcl.2010.05.058 BindingDB Entry DOI: 10.7270/Q2SF2X4Z
Takeda San Diego Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50321570 (5-acetyl-4-chloro-2-(2-fluoro-4-iodophenylamino)-N...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Takeda San Diego Curated by ChEMBL					Assay Description Inhibition of MEK1 by cascade assay method				Bioorg Med Chem Lett 20: 4156-8 (2010) Article DOI: 10.1016/j.bmcl.2010.05.058 BindingDB Entry DOI: 10.7270/Q2SF2X4Z
Takeda San Diego Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50321564 (5-acetyl-2-(2-fluoro-4-iodophenylamino)-N-(2-hydro...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Takeda San Diego Curated by ChEMBL					Assay Description Inhibition of MEK1 by cascade assay method				Bioorg Med Chem Lett 20: 4156-8 (2010) Article DOI: 10.1016/j.bmcl.2010.05.058 BindingDB Entry DOI: 10.7270/Q2SF2X4Z
Takeda San Diego Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50321574 ((S)-5-acetyl-N-(2,3-dihydroxypropoxy)-4-fluoro-2-(...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Takeda San Diego Curated by ChEMBL					Assay Description Inhibition of MEK1 by cascade assay method				Bioorg Med Chem Lett 20: 4156-8 (2010) Article DOI: 10.1016/j.bmcl.2010.05.058 BindingDB Entry DOI: 10.7270/Q2SF2X4Z
Takeda San Diego Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50321568 (5-acetyl-N-(1,3-dihydroxypropan-2-yloxy)-2-(2-fluo...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Takeda San Diego Curated by ChEMBL					Assay Description Inhibition of MEK1 by cascade assay method				Bioorg Med Chem Lett 20: 4156-8 (2010) Article DOI: 10.1016/j.bmcl.2010.05.058 BindingDB Entry DOI: 10.7270/Q2SF2X4Z
Takeda San Diego Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50321566 ((R)-5-acetyl-N-(2,3-dihydroxypropoxy)-2-(2-fluoro-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Takeda San Diego Curated by ChEMBL					Assay Description Inhibition of MEK1 by cascade assay method				Bioorg Med Chem Lett 20: 4156-8 (2010) Article DOI: 10.1016/j.bmcl.2010.05.058 BindingDB Entry DOI: 10.7270/Q2SF2X4Z
Takeda San Diego Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50321562 (1-acetyl-4-(2-fluoro-4-iodophenylamino)-N-(2-hydro...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Takeda San Diego Curated by ChEMBL					Assay Description Inhibition of MEK1 by cascade assay method				Bioorg Med Chem Lett 20: 4156-8 (2010) Article DOI: 10.1016/j.bmcl.2010.05.058 BindingDB Entry DOI: 10.7270/Q2SF2X4Z
Takeda San Diego Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50321573 ((R)-5-acetyl-N-(2,3-dihydroxypropoxy)-4-fluoro-2-(...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Takeda San Diego Curated by ChEMBL					Assay Description Inhibition of MEK1 by cascade assay method				Bioorg Med Chem Lett 20: 4156-8 (2010) Article DOI: 10.1016/j.bmcl.2010.05.058 BindingDB Entry DOI: 10.7270/Q2SF2X4Z
Takeda San Diego Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50321575 (1-(5-(2-fluoro-4-iodophenylamino)-4-(3-hydroxyazet...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Takeda San Diego Curated by ChEMBL					Assay Description Inhibition of MEK1 by cascade assay method				Bioorg Med Chem Lett 20: 4156-8 (2010) Article DOI: 10.1016/j.bmcl.2010.05.058 BindingDB Entry DOI: 10.7270/Q2SF2X4Z
Takeda San Diego Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50321571 ((R)-5-acetyl-4-chloro-N-(2,3-dihydroxypropoxy)-2-(...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Takeda San Diego Curated by ChEMBL					Assay Description Inhibition of MEK1 by cascade assay method				Bioorg Med Chem Lett 20: 4156-8 (2010) Article DOI: 10.1016/j.bmcl.2010.05.058 BindingDB Entry DOI: 10.7270/Q2SF2X4Z
Takeda San Diego Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50321563 (5-acetyl-2-(2-fluoro-4-iodophenylamino)-1-methyl-1...) Show SMILES CC(=O)c1cc(C(O)=O)c(Nc2ccc(I)cc2F)n1C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Takeda San Diego Curated by ChEMBL					Assay Description Inhibition of MEK1 by cascade assay method				Bioorg Med Chem Lett 20: 4156-8 (2010) Article DOI: 10.1016/j.bmcl.2010.05.058 BindingDB Entry DOI: 10.7270/Q2SF2X4Z
Takeda San Diego Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50321565 (5-acetyl-2-(2-fluoro-4-iodophenylamino)-N-(3-hydro...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
Takeda San Diego Curated by ChEMBL					Assay Description Inhibition of MEK1 by cascade assay method				Bioorg Med Chem Lett 20: 4156-8 (2010) Article DOI: 10.1016/j.bmcl.2010.05.058 BindingDB Entry DOI: 10.7270/Q2SF2X4Z
Takeda San Diego Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50321560 (1-acetyl-4-(2-fluoro-4-iodophenylamino)-5-methyl-1...) Show SMILES CC(=O)n1cc(C(O)=O)c(Nc2ccc(I)cc2F)c1C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a	n/a
Takeda San Diego Curated by ChEMBL					Assay Description Inhibition of MEK1 by cascade assay method				Bioorg Med Chem Lett 20: 4156-8 (2010) Article DOI: 10.1016/j.bmcl.2010.05.058 BindingDB Entry DOI: 10.7270/Q2SF2X4Z
Takeda San Diego Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50321569 (5-acetyl-2-(2-fluoro-4-iodophenylamino)-N-(3-hydro...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Takeda San Diego Curated by ChEMBL					Assay Description Inhibition of MEK1 by cascade assay method				Bioorg Med Chem Lett 20: 4156-8 (2010) Article DOI: 10.1016/j.bmcl.2010.05.058 BindingDB Entry DOI: 10.7270/Q2SF2X4Z
Takeda San Diego Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50321559 (1-acetyl-4-(2-fluoro-4-iodophenylamino)-1H-pyrrole...) Show SMILES CC(=O)n1cc(Nc2ccc(I)cc2F)c(c1)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
Takeda San Diego Curated by ChEMBL					Assay Description Inhibition of MEK1 by cascade assay method				Bioorg Med Chem Lett 20: 4156-8 (2010) Article DOI: 10.1016/j.bmcl.2010.05.058 BindingDB Entry DOI: 10.7270/Q2SF2X4Z
Takeda San Diego Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%