Found 23 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50326574
(6-phenylpyridazin-3-yl thiophene-2-carboxylate | C...)Show InChI InChI=1S/C15H10N2O2S/c18-15(13-7-4-10-20-13)19-14-9-8-12(16-17-14)11-5-2-1-3-6-11/h1-10H | PDB MMDB
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| Article PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010 BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50326574
(6-phenylpyridazin-3-yl thiophene-2-carboxylate | C...)Show InChI InChI=1S/C15H10N2O2S/c18-15(13-7-4-10-20-13)19-14-9-8-12(16-17-14)11-5-2-1-3-6-11/h1-10H | PDB MMDB
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CHEMBL PC cid PC sid UniChem
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| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity in presence of Triton X-100 as detergent |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010 BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM33627
((1,3-benzoxazol-2-ylthio)formic acid butyl ester |...)Show InChI InChI=1S/C12H13NO3S/c1-2-3-8-15-12(14)17-11-13-9-6-4-5-7-10(9)16-11/h4-7H,2-3,8H2,1H3 | PDB MMDB
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PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010 BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM33627
((1,3-benzoxazol-2-ylthio)formic acid butyl ester |...)Show InChI InChI=1S/C12H13NO3S/c1-2-3-8-15-12(14)17-11-13-9-6-4-5-7-10(9)16-11/h4-7H,2-3,8H2,1H3 | PDB MMDB
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PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity in presence of Triton X-100 as detergent |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010 BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50326573
(1-Phenyl-3-(2-thiazolyl)-2-thiourea | 1-phenyl-3-(...)Show InChI InChI=1S/C9H8N4S2/c14-8(12-9-13-10-6-15-9)11-7-4-2-1-3-5-7/h1-6H,(H2,11,12,13,14) | PDB MMDB
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| Article PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010 BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50326573
(1-Phenyl-3-(2-thiazolyl)-2-thiourea | 1-phenyl-3-(...)Show InChI InChI=1S/C9H8N4S2/c14-8(12-9-13-10-6-15-9)11-7-4-2-1-3-5-7/h1-6H,(H2,11,12,13,14) | PDB MMDB
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CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity in presence of Triton X-100 as detergent |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010 BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM47541
(1-(2-chlorophenyl)-3-(2-pyridinyl)thiourea | 1-(2-...)Show InChI InChI=1S/C12H10ClN3S/c13-9-5-1-2-6-10(9)15-12(17)16-11-7-3-4-8-14-11/h1-8H,(H2,14,15,16,17) | PDB MMDB
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Similars
| Article PubMed
| n/a | n/a | 1.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity in presence of Triton X-100 as detergent |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010 BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM47541
(1-(2-chlorophenyl)-3-(2-pyridinyl)thiourea | 1-(2-...)Show InChI InChI=1S/C12H10ClN3S/c13-9-5-1-2-6-10(9)15-12(17)16-11-7-3-4-8-14-11/h1-8H,(H2,14,15,16,17) | PDB MMDB
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Similars
| Article PubMed
| n/a | n/a | 1.04E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010 BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50326572
(CHEMBL1253383 | N-(2-bromobenzoyloxy)-4-chlorobenz...)Show InChI InChI=1S/C14H9BrClNO3/c15-12-4-2-1-3-11(12)14(19)20-17-13(18)9-5-7-10(16)8-6-9/h1-8H,(H,17,18) | PDB MMDB
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CHEMBL PC cid PC sid UniChem
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| n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010 BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50326572
(CHEMBL1253383 | N-(2-bromobenzoyloxy)-4-chlorobenz...)Show InChI InChI=1S/C14H9BrClNO3/c15-12-4-2-1-3-11(12)14(19)20-17-13(18)9-5-7-10(16)8-6-9/h1-8H,(H,17,18) | PDB MMDB
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CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity in presence of Triton X-100 as detergent |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010 BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50326570
((1H-benzo[d][1,2,3]triazol-1-yl)(2-methoxyphenyl)m...)Show InChI InChI=1S/C14H11N3O2/c1-19-13-9-5-2-6-10(13)14(18)17-12-8-4-3-7-11(12)15-16-17/h2-9H,1H3 | PDB MMDB
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010 BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50326571
(5-(2-nitro-4-(trifluoromethylsulfonyl)phenylthio)-...)Show SMILES [O-][N+](=O)c1cc(ccc1Sc1nnc(S)s1)S(=O)(=O)C(F)(F)F Show InChI InChI=1S/C9H4F3N3O4S4/c10-9(11,12)23(18,19)4-1-2-6(5(3-4)15(16)17)21-8-14-13-7(20)22-8/h1-3H,(H,13,20) | PDB MMDB
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| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 9.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010 BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50326570
((1H-benzo[d][1,2,3]triazol-1-yl)(2-methoxyphenyl)m...)Show InChI InChI=1S/C14H11N3O2/c1-19-13-9-5-2-6-10(13)14(18)17-12-8-4-3-7-11(12)15-16-17/h2-9H,1H3 | PDB MMDB
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.22E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity in presence of Triton X-100 as detergent |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010 BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50326569
(CHEMBL1253492 | methyl 2-(4-methyl-5-(thiophen-2-y...)Show InChI InChI=1S/C10H11N3O2S2/c1-13-9(7-4-3-5-16-7)11-12-10(13)17-6-8(14)15-2/h3-5H,6H2,1-2H3 | PDB MMDB
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CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.86E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010 BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50326569
(CHEMBL1253492 | methyl 2-(4-methyl-5-(thiophen-2-y...)Show InChI InChI=1S/C10H11N3O2S2/c1-13-9(7-4-3-5-16-7)11-12-10(13)17-6-8(14)15-2/h3-5H,6H2,1-2H3 | PDB MMDB
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CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.84E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity in presence of Triton X-100 as detergent |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010 BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50096008
(3-Acetyl-7-hydroxy-chromen-2-one | 3-acetyl-7-hydr...)Show InChI InChI=1S/C11H8O4/c1-6(12)9-4-7-2-3-8(13)5-10(7)15-11(9)14/h2-5,13H,1H3 | PDB MMDB
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CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.52E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010 BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50326576
(3-(2,4-difluorophenylamino)-1-(5-methylfuran-2-yl)...)Show InChI InChI=1S/C14H11F2NO2/c1-9-2-5-14(19-9)13(18)6-7-17-12-4-3-10(15)8-11(12)16/h2-5,7-8H,6H2,1H3 | PDB MMDB
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| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.75E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010 BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50326568
(CHEMBL1253493 | N-(furan-2-ylmethyl)-7-nitrobenzo[...)Show InChI InChI=1S/C11H8N4O4/c16-15(17)9-4-3-8(10-11(9)14-19-13-10)12-6-7-2-1-5-18-7/h1-5,12H,6H2 | PDB MMDB
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CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 6.04E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010 BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50326567
(CHEMBL1253544 | ethyl 2-cyano-3-(2,4-dihydroxyphen...)Show InChI InChI=1S/C12H11NO4/c1-2-17-12(16)9(7-13)5-8-3-4-10(14)6-11(8)15/h3-6,14-15H,2H2,1H3/b9-5+ | PDB MMDB
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CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 6.21E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010 BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM52230
((Z)-2-(1,3-benzoxazol-2-yl)-3-(2-pyridinylamino)-2...)Show InChI InChI=1S/C15H11N3O2/c19-10-11(9-17-14-7-3-4-8-16-14)15-18-12-5-1-2-6-13(12)20-15/h1-11H | PDB MMDB
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| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.42E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010 BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50096008
(3-Acetyl-7-hydroxy-chromen-2-one | 3-acetyl-7-hydr...)Show InChI InChI=1S/C11H8O4/c1-6(12)9-4-7-2-3-8(13)5-10(7)15-11(9)14/h2-5,13H,1H3 | PDB MMDB
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Patents
Similars
| Article PubMed
| n/a | n/a | 1.03E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity in presence of Triton X-100 as detergent |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010 BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50326567
(CHEMBL1253544 | ethyl 2-cyano-3-(2,4-dihydroxyphen...)Show InChI InChI=1S/C12H11NO4/c1-2-17-12(16)9(7-13)5-8-3-4-10(14)6-11(8)15/h3-6,14-15H,2H2,1H3/b9-5+ | PDB MMDB
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CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.10E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity in presence of Triton X-100 as detergent |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010 BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50326577
(3-nitroso-2-phenylindolizine | CHEMBL1253586)Show InChI InChI=1S/C14H10N2O/c17-15-14-13(11-6-2-1-3-7-11)10-12-8-4-5-9-16(12)14/h1-10H | PDB MMDB
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CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 1.21E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010 BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this Ligand-Target Pair | |