Affinity Data by PubMed id=20954731

PubMed code 20954731

Found 18 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Prostaglandin G/H synthase 1 (Homo sapiens (Human))	BDBM50330857 (2-(2-fluoro-4-(((1,2-trans)-2-hydroxycyclopentyl)m...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Kumamoto University Curated by ChEMBL					Assay Description Inhibition of COX1 in human whole blood assessed as TXB2 biosynthesis after 24 hrs by EIA				J Med Chem 53: 7879-82 (2010) Article DOI: 10.1021/jm101116s BindingDB Entry DOI: 10.7270/Q2WS8TGV
Kumamoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Homo sapiens (Human))	BDBM50140321 ((S)-2-[4-((1R,2S)-2-Hydroxy-cyclopentylmethyl)-phe...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kumamoto University Curated by ChEMBL					Assay Description Inhibition of COX1 in human whole blood assessed as TXB2 biosynthesis after 24 hrs by EIA				J Med Chem 53: 7879-82 (2010) Article DOI: 10.1021/jm101116s BindingDB Entry DOI: 10.7270/Q2WS8TGV
Kumamoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Homo sapiens (Human))	BDBM50330856 (2-(2-bromo-4-(((1,2-trans)-2-hydroxycyclopentyl)me...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kumamoto University Curated by ChEMBL					Assay Description Inhibition of COX1 in human whole blood assessed as TXB2 biosynthesis after 24 hrs by EIA				J Med Chem 53: 7879-82 (2010) Article DOI: 10.1021/jm101116s BindingDB Entry DOI: 10.7270/Q2WS8TGV
Kumamoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50140321 ((S)-2-[4-((1R,2S)-2-Hydroxy-cyclopentylmethyl)-phe...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kumamoto University Curated by ChEMBL					Assay Description Inhibition of COX2 in human whole blood assessed as PGE2 biosynthesis after 24 hrs by EIA				J Med Chem 53: 7879-82 (2010) Article DOI: 10.1021/jm101116s BindingDB Entry DOI: 10.7270/Q2WS8TGV
Kumamoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50330857 (2-(2-fluoro-4-(((1,2-trans)-2-hydroxycyclopentyl)m...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kumamoto University Curated by ChEMBL					Assay Description Inhibition of COX2 in human whole blood assessed as PGE2 biosynthesis after 24 hrs by EIA				J Med Chem 53: 7879-82 (2010) Article DOI: 10.1021/jm101116s BindingDB Entry DOI: 10.7270/Q2WS8TGV
Kumamoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Homo sapiens (Human))	BDBM50330854 (2-(4-(((1,2-cis)-2-hydroxycyclopentyl)methyl)pheny...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kumamoto University Curated by ChEMBL					Assay Description Inhibition of COX1 in human whole blood assessed as TXB2 biosynthesis after 24 hrs by EIA				J Med Chem 53: 7879-82 (2010) Article DOI: 10.1021/jm101116s BindingDB Entry DOI: 10.7270/Q2WS8TGV
Kumamoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Homo sapiens (Human))	BDBM50330852 (2-(2-bromo-4-(((1,2-cis)-2-hydroxycyclopentyl)meth...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kumamoto University Curated by ChEMBL					Assay Description Inhibition of COX1 in human whole blood assessed as TXB2 biosynthesis after 24 hrs by EIA				J Med Chem 53: 7879-82 (2010) Article DOI: 10.1021/jm101116s BindingDB Entry DOI: 10.7270/Q2WS8TGV
Kumamoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Homo sapiens (Human))	BDBM50330855 (2-(2-fluoro-4-(((1,2-cis)-2-hydroxycyclopentyl)met...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kumamoto University Curated by ChEMBL					Assay Description Inhibition of COX1 in human whole blood assessed as TXB2 biosynthesis after 24 hrs by EIA				J Med Chem 53: 7879-82 (2010) Article DOI: 10.1021/jm101116s BindingDB Entry DOI: 10.7270/Q2WS8TGV
Kumamoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50330856 (2-(2-bromo-4-(((1,2-trans)-2-hydroxycyclopentyl)me...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kumamoto University Curated by ChEMBL					Assay Description Inhibition of COX2 in human whole blood assessed as PGE2 biosynthesis after 24 hrs by EIA				J Med Chem 53: 7879-82 (2010) Article DOI: 10.1021/jm101116s BindingDB Entry DOI: 10.7270/Q2WS8TGV
Kumamoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50330853 (CHEMBL66552 \| Sodium; 2-[4-(2-oxo-cyclopentylmethy...) Show SMILES CC(C([O-])=O)c1ccc(CC2CCCC2=O)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.01E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kumamoto University Curated by ChEMBL					Assay Description Inhibition of COX2 in human whole blood assessed as PGE2 biosynthesis after 24 hrs by EIA				J Med Chem 53: 7879-82 (2010) Article DOI: 10.1021/jm101116s BindingDB Entry DOI: 10.7270/Q2WS8TGV
Kumamoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50330854 (2-(4-(((1,2-cis)-2-hydroxycyclopentyl)methyl)pheny...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.22E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kumamoto University Curated by ChEMBL					Assay Description Inhibition of COX2 in human whole blood assessed as PGE2 biosynthesis after 24 hrs by EIA				J Med Chem 53: 7879-82 (2010) Article DOI: 10.1021/jm101116s BindingDB Entry DOI: 10.7270/Q2WS8TGV
Kumamoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50330851 (CHEMBL1275921 \| fluoro loxoprofen) Show SMILES CC(C([O-])=O)c1ccc(CC2CCCC2=O)cc1F Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.43E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kumamoto University Curated by ChEMBL					Assay Description Inhibition of COX2 in human whole blood assessed as PGE2 biosynthesis after 24 hrs by EIA				J Med Chem 53: 7879-82 (2010) Article DOI: 10.1021/jm101116s BindingDB Entry DOI: 10.7270/Q2WS8TGV
Kumamoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Homo sapiens (Human))	BDBM50330853 (CHEMBL66552 \| Sodium; 2-[4-(2-oxo-cyclopentylmethy...) Show SMILES CC(C([O-])=O)c1ccc(CC2CCCC2=O)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.35E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kumamoto University Curated by ChEMBL					Assay Description Inhibition of COX1 in human whole blood assessed as TXB2 biosynthesis after 24 hrs by EIA				J Med Chem 53: 7879-82 (2010) Article DOI: 10.1021/jm101116s BindingDB Entry DOI: 10.7270/Q2WS8TGV
Kumamoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Homo sapiens (Human))	BDBM50330851 (CHEMBL1275921 \| fluoro loxoprofen) Show SMILES CC(C([O-])=O)c1ccc(CC2CCCC2=O)cc1F Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.42E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kumamoto University Curated by ChEMBL					Assay Description Inhibition of COX1 in human whole blood assessed as TXB2 biosynthesis after 24 hrs by EIA				J Med Chem 53: 7879-82 (2010) Article DOI: 10.1021/jm101116s BindingDB Entry DOI: 10.7270/Q2WS8TGV
Kumamoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Homo sapiens (Human))	BDBM50330850 (CHEMBL1275940 \| bromoloxoprofen) Show SMILES CC(C([O-])=O)c1ccc(CC2CCCC2=O)cc1Br Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.03E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kumamoto University Curated by ChEMBL					Assay Description Inhibition of COX1 in human whole blood assessed as TXB2 biosynthesis after 24 hrs by EIA				J Med Chem 53: 7879-82 (2010) Article DOI: 10.1021/jm101116s BindingDB Entry DOI: 10.7270/Q2WS8TGV
Kumamoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50330852 (2-(2-bromo-4-(((1,2-cis)-2-hydroxycyclopentyl)meth...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kumamoto University Curated by ChEMBL					Assay Description Inhibition of COX2 in human whole blood assessed as PGE2 biosynthesis after 24 hrs by EIA				J Med Chem 53: 7879-82 (2010) Article DOI: 10.1021/jm101116s BindingDB Entry DOI: 10.7270/Q2WS8TGV
Kumamoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50330855 (2-(2-fluoro-4-(((1,2-cis)-2-hydroxycyclopentyl)met...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kumamoto University Curated by ChEMBL					Assay Description Inhibition of COX2 in human whole blood assessed as PGE2 biosynthesis after 24 hrs by EIA				J Med Chem 53: 7879-82 (2010) Article DOI: 10.1021/jm101116s BindingDB Entry DOI: 10.7270/Q2WS8TGV
Kumamoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50330850 (CHEMBL1275940 \| bromoloxoprofen) Show SMILES CC(C([O-])=O)c1ccc(CC2CCCC2=O)cc1Br Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.53E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kumamoto University Curated by ChEMBL					Assay Description Inhibition of COX2 in human whole blood assessed as PGE2 biosynthesis after 24 hrs by EIA				J Med Chem 53: 7879-82 (2010) Article DOI: 10.1021/jm101116s BindingDB Entry DOI: 10.7270/Q2WS8TGV
Kumamoto University Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%