Affinity Data by PubMed id=21109332

PubMed code 21109332

Found 6 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Dihydroorotate dehydrogenase (quinone), mitochondrial (Rattus norvegicus (rat))	BDBM14712 ((2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)pheny...) Show SMILES CC(=O)C(C#N)C(=O)Nc1ccc(cc1)C(F)(F)F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Torino Curated by ChEMBL					Assay Description Inhibition of DHODH in Wistar rat liver homogenates by DCIP reduction assay				Eur J Med Chem 46: 383-92 (2010) Article DOI: 10.1016/j.ejmech.2010.10.029 BindingDB Entry DOI: 10.7270/Q2SQ90NX
Universit£ di Torino Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Dihydroorotate dehydrogenase (quinone), mitochondrial (Rattus norvegicus (rat))	BDBM50054601 (5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazole...) Show SMILES Cc1oncc1C(=O)Nc1ccc(cc1)C(F)(F)F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Torino Curated by ChEMBL					Assay Description Inhibition of DHODH in Wistar rat liver homogenates by DCIP reduction assay				Eur J Med Chem 46: 383-92 (2010) Article DOI: 10.1016/j.ejmech.2010.10.029 BindingDB Entry DOI: 10.7270/Q2SQ90NX
Universit£ di Torino Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Rattus norvegicus (rat))	BDBM50335631 (2-Nitro-3-oxo-3-[(4-trifluoromethyl)phenyl]aminopr...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Torino Curated by ChEMBL					Assay Description Inhibition of DHODH in Wistar rat liver homogenates by DCIP reduction assay				Eur J Med Chem 46: 383-92 (2010) Article DOI: 10.1016/j.ejmech.2010.10.029 BindingDB Entry DOI: 10.7270/Q2SQ90NX
Universit£ di Torino Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Rattus norvegicus (rat))	BDBM50335629 (2-Nitro-3-oxo-3-(biphenyl-4-yl)aminopropionitrile ...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Torino Curated by ChEMBL					Assay Description Inhibition of DHODH in Wistar rat liver homogenates by DCIP reduction assay				Eur J Med Chem 46: 383-92 (2010) Article DOI: 10.1016/j.ejmech.2010.10.029 BindingDB Entry DOI: 10.7270/Q2SQ90NX
Universit£ di Torino Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Rattus norvegicus (rat))	BDBM50335630 (2-Hydroxyimino-3-oxo-3-[4-(trifluoromethyl)phenyl]...) Show SMILES FC(F)(F)c1ccc(NC(=O)C(N=O)C#N)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Torino Curated by ChEMBL					Assay Description Inhibition of DHODH in Wistar rat liver homogenates by DCIP reduction assay				Eur J Med Chem 46: 383-92 (2010) Article DOI: 10.1016/j.ejmech.2010.10.029 BindingDB Entry DOI: 10.7270/Q2SQ90NX
Universit£ di Torino Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Rattus norvegicus (rat))	BDBM50335632 (2-Nitro-3-(4-nitrophenyl)amino-3-oxopropionitrile ...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Torino Curated by ChEMBL					Assay Description Inhibition of DHODH in Wistar rat liver homogenates by DCIP reduction assay				Eur J Med Chem 46: 383-92 (2010) Article DOI: 10.1016/j.ejmech.2010.10.029 BindingDB Entry DOI: 10.7270/Q2SQ90NX
Universit£ di Torino Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%