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PubMed code 21420863

Compile data set for download or QSAR
Found 32 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340362
PNG
(2-(4-chloro-2-fluorophenyl)-1-{3-[4-(3-acetylamino...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCn2c(nc3ccccc23)-c2ccc(Cl)cc2F)CC1
Show InChI InChI=1S/C29H30ClFN4O/c1-20(36)32-24-7-4-6-22(18-24)21-12-16-34(17-13-21)14-5-15-35-28-9-3-2-8-27(28)33-29(35)25-11-10-23(30)19-26(25)31/h2-4,6-11,18-19,21H,5,12-17H2,1H3,(H,32,36)
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n/an/a 1n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340346
PNG
(2-(4-chlorophenyl)-1-{3-[4-(3-acetylaminophenyl)pi...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCn2c(nc3ccccc23)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C29H31ClN4O/c1-21(35)31-26-7-4-6-24(20-26)22-14-18-33(19-15-22)16-5-17-34-28-9-3-2-8-27(28)32-29(34)23-10-12-25(30)13-11-23/h2-4,6-13,20,22H,5,14-19H2,1H3,(H,31,35)
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n/an/a 1n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340341
PNG
(2-phenyl-1-{3-[4-(3-acetylaminophenyl)piperidin-1-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCn2c(nc3ccccc23)-c2ccccc2)CC1
Show InChI InChI=1S/C29H32N4O/c1-22(34)30-26-12-7-11-25(21-26)23-15-19-32(20-16-23)17-8-18-33-28-14-6-5-13-27(28)31-29(33)24-9-3-2-4-10-24/h2-7,9-14,21,23H,8,15-20H2,1H3,(H,30,34)
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n/an/a 2n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340360
PNG
(2-(2,4-dichlorophenyl)-1-{3-[4-(3-acetylaminopheny...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCn2c(nc3ccccc23)-c2ccc(Cl)cc2Cl)CC1
Show InChI InChI=1S/C29H30Cl2N4O/c1-20(36)32-24-7-4-6-22(18-24)21-12-16-34(17-13-21)14-5-15-35-28-9-3-2-8-27(28)33-29(35)25-11-10-23(30)19-26(25)31/h2-4,6-11,18-19,21H,5,12-17H2,1H3,(H,32,36)
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n/an/a 3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50340346
PNG
(2-(4-chlorophenyl)-1-{3-[4-(3-acetylaminophenyl)pi...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCn2c(nc3ccccc23)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C29H31ClN4O/c1-21(35)31-26-7-4-6-24(20-26)22-14-18-33(19-15-22)16-5-17-34-28-9-3-2-8-27(28)32-29(34)23-10-12-25(30)13-11-23/h2-4,6-13,20,22H,5,14-19H2,1H3,(H,31,35)
PDB
MMDB

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n/an/a 3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition hERG by patch clamp method

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340349
PNG
(2-(4-trifluoromethylphenyl)-1-{3-[4-(3-acetylamino...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCn2c(nc3ccccc23)-c2ccc(cc2)C(F)(F)F)CC1
Show InChI InChI=1S/C30H31F3N4O/c1-21(38)34-26-7-4-6-24(20-26)22-14-18-36(19-15-22)16-5-17-37-28-9-3-2-8-27(28)35-29(37)23-10-12-25(13-11-23)30(31,32)33/h2-4,6-13,20,22H,5,14-19H2,1H3,(H,34,38)
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n/an/a 3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340363
PNG
(2-(3,4-difluorophenyl)-1-{3-[4-(3-acetylaminopheny...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCn2c(nc3ccccc23)-c2ccc(F)c(F)c2)CC1
Show InChI InChI=1S/C29H30F2N4O/c1-20(36)32-24-7-4-6-22(18-24)21-12-16-34(17-13-21)14-5-15-35-28-9-3-2-8-27(28)33-29(35)23-10-11-25(30)26(31)19-23/h2-4,6-11,18-19,21H,5,12-17H2,1H3,(H,32,36)
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n/an/a 4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340364
PNG
(2-(2-chloro-4-fluorophenyl)-1-{3-[4-(3-acetylamino...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCn2c(nc3ccccc23)-c2ccc(F)cc2Cl)CC1
Show InChI InChI=1S/C29H30ClFN4O/c1-20(36)32-24-7-4-6-22(18-24)21-12-16-34(17-13-21)14-5-15-35-28-9-3-2-8-27(28)33-29(35)25-11-10-23(31)19-26(25)30/h2-4,6-11,18-19,21H,5,12-17H2,1H3,(H,32,36)
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n/an/a 4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340367
PNG
(2-(4-chlorophenyl)-1-{3-[4-(3-isobutyrylaminopheny...)
Show SMILES CC(C)C(=O)Nc1cccc(c1)C1CCN(CCCn2c(nc3ccccc23)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C31H35ClN4O/c1-22(2)31(37)33-27-8-5-7-25(21-27)23-15-19-35(20-16-23)17-6-18-36-29-10-4-3-9-28(29)34-30(36)24-11-13-26(32)14-12-24/h3-5,7-14,21-23H,6,15-20H2,1-2H3,(H,33,37)
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n/an/a 5n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340345
PNG
(2-(3-chlorophenyl)-1-{3-[4-(3-acetylaminophenyl)pi...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCn2c(nc3ccccc23)-c2cccc(Cl)c2)CC1
Show InChI InChI=1S/C29H31ClN4O/c1-21(35)31-26-10-5-7-23(20-26)22-13-17-33(18-14-22)15-6-16-34-28-12-3-2-11-27(28)32-29(34)24-8-4-9-25(30)19-24/h2-5,7-12,19-20,22H,6,13-18H2,1H3,(H,31,35)
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n/an/a 5n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340354
PNG
(2-(4-bromophenyl)-1-{3-[4-(3-acetylaminophenyl)pip...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCn2c(nc3ccccc23)-c2ccc(Br)cc2)CC1
Show InChI InChI=1S/C29H31BrN4O/c1-21(35)31-26-7-4-6-24(20-26)22-14-18-33(19-15-22)16-5-17-34-28-9-3-2-8-27(28)32-29(34)23-10-12-25(30)13-11-23/h2-4,6-13,20,22H,5,14-19H2,1H3,(H,31,35)
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n/an/a 5n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340351
PNG
(2-(3-methoxyphenyl)-1-{3-[4-(3-acetylaminophenyl)p...)
Show SMILES COc1cccc(c1)-c1nc2ccccc2n1CCCN1CCC(CC1)c1cccc(NC(C)=O)c1
Show InChI InChI=1S/C30H34N4O2/c1-22(35)31-26-10-5-8-24(20-26)23-14-18-33(19-15-23)16-7-17-34-29-13-4-3-12-28(29)32-30(34)25-9-6-11-27(21-25)36-2/h3-6,8-13,20-21,23H,7,14-19H2,1-2H3,(H,31,35)
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n/an/a 7n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340357
PNG
(2-(4-biphenyl)-1-{3-[4-(3-acetylaminophenyl)piperi...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCn2c(nc3ccccc23)-c2ccc(cc2)-c2ccccc2)CC1
Show InChI InChI=1S/C35H36N4O/c1-26(40)36-32-12-7-11-31(25-32)29-19-23-38(24-20-29)21-8-22-39-34-14-6-5-13-33(34)37-35(39)30-17-15-28(16-18-30)27-9-3-2-4-10-27/h2-7,9-18,25,29H,8,19-24H2,1H3,(H,36,40)
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n/an/a 8n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340352
PNG
(2-(4-methoxyphenyl)-1-{3-[4-(3-acetylaminophenyl)p...)
Show SMILES COc1ccc(cc1)-c1nc2ccccc2n1CCCN1CCC(CC1)c1cccc(NC(C)=O)c1
Show InChI InChI=1S/C30H34N4O2/c1-22(35)31-26-8-5-7-25(21-26)23-15-19-33(20-16-23)17-6-18-34-29-10-4-3-9-28(29)32-30(34)24-11-13-27(36-2)14-12-24/h3-5,7-14,21,23H,6,15-20H2,1-2H3,(H,31,35)
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n/an/a 9n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340344
PNG
(2-(2-chlorophenyl)-1-{3-[4-(3-acetylaminophenyl)pi...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCn2c(nc3ccccc23)-c2ccccc2Cl)CC1
Show InChI InChI=1S/C29H31ClN4O/c1-21(35)31-24-9-6-8-23(20-24)22-14-18-33(19-15-22)16-7-17-34-28-13-5-4-12-27(28)32-29(34)25-10-2-3-11-26(25)30/h2-6,8-13,20,22H,7,14-19H2,1H3,(H,31,35)
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n/an/a 10n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340359
PNG
(2-(4-cyanophenyl)-1-{3-[4-(3-acetylaminophenyl)pip...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCn2c(nc3ccccc23)-c2ccc(cc2)C#N)CC1
Show InChI InChI=1S/C30H31N5O/c1-22(36)32-27-7-4-6-26(20-27)24-14-18-34(19-15-24)16-5-17-35-29-9-3-2-8-28(29)33-30(35)25-12-10-23(21-31)11-13-25/h2-4,6-13,20,24H,5,14-19H2,1H3,(H,32,36)
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n/an/a 16n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340368
PNG
(2-(4-chlorophenyl)-1-{3-[4-(3-benzoylaminophenyl)p...)
Show SMILES Clc1ccc(cc1)-c1nc2ccccc2n1CCCN1CCC(CC1)c1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C34H33ClN4O/c35-29-16-14-26(15-17-29)33-37-31-12-4-5-13-32(31)39(33)21-7-20-38-22-18-25(19-23-38)28-10-6-11-30(24-28)36-34(40)27-8-2-1-3-9-27/h1-6,8-17,24-25H,7,18-23H2,(H,36,40)
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n/an/a 19n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340361
PNG
(2-(3,4-dichlorophenyl)-1-{3-[4-(3-acetylaminopheny...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCn2c(nc3ccccc23)-c2ccc(Cl)c(Cl)c2)CC1
Show InChI InChI=1S/C29H30Cl2N4O/c1-20(36)32-24-7-4-6-22(18-24)21-12-16-34(17-13-21)14-5-15-35-28-9-3-2-8-27(28)33-29(35)23-10-11-25(30)26(31)19-23/h2-4,6-11,18-19,21H,5,12-17H2,1H3,(H,32,36)
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n/an/a 24n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340342
PNG
(2-phenyl-1-{4-[4-(3-acetylaminophenyl)piperidin-1-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCCn2c(nc3ccccc23)-c2ccccc2)CC1
Show InChI InChI=1S/C30H34N4O/c1-23(35)31-27-13-9-12-26(22-27)24-16-20-33(21-17-24)18-7-8-19-34-29-15-6-5-14-28(29)32-30(34)25-10-3-2-4-11-25/h2-6,9-15,22,24H,7-8,16-21H2,1H3,(H,31,35)
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n/an/a 29n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340348
PNG
(2-(3-trifluoromethylphenyl)-1-{3-[4-(3-acetylamino...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCn2c(nc3ccccc23)-c2cccc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C30H31F3N4O/c1-21(38)34-26-10-5-7-23(20-26)22-13-17-36(18-14-22)15-6-16-37-28-12-3-2-11-27(28)35-29(37)24-8-4-9-25(19-24)30(31,32)33/h2-5,7-12,19-20,22H,6,13-18H2,1H3,(H,34,38)
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n/an/a 30n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340355
PNG
(2-(4-Ethylphenyl)-1-{3-[4-(3-acetylaminophenyl)pip...)
Show SMILES CCc1ccc(cc1)-c1nc2ccccc2n1CCCN1CCC(CC1)c1cccc(NC(C)=O)c1
Show InChI InChI=1S/C31H36N4O/c1-3-24-12-14-26(15-13-24)31-33-29-10-4-5-11-30(29)35(31)19-7-18-34-20-16-25(17-21-34)27-8-6-9-28(22-27)32-23(2)36/h4-6,8-15,22,25H,3,7,16-21H2,1-2H3,(H,32,36)
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n/an/a 32n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340358
PNG
(2-(4-phenoxyphenyl)-1-{3-[4-(3-acetylaminophenyl)p...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCn2c(nc3ccccc23)-c2ccc(Oc3ccccc3)cc2)CC1
Show InChI InChI=1S/C35H36N4O2/c1-26(40)36-30-10-7-9-29(25-30)27-19-23-38(24-20-27)21-8-22-39-34-14-6-5-13-33(34)37-35(39)28-15-17-32(18-16-28)41-31-11-3-2-4-12-31/h2-7,9-18,25,27H,8,19-24H2,1H3,(H,36,40)
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n/an/a 42n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340347
PNG
(2-(2-trifluoromethylphenyl)-1-{3-[4-(3-acetylamino...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCn2c(nc3ccccc23)-c2ccccc2C(F)(F)F)CC1
Show InChI InChI=1S/C30H31F3N4O/c1-21(38)34-24-9-6-8-23(20-24)22-14-18-36(19-15-22)16-7-17-37-28-13-5-4-12-27(28)35-29(37)25-10-2-3-11-26(25)30(31,32)33/h2-6,8-13,20,22H,7,14-19H2,1H3,(H,34,38)
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n/an/a 50n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340353
PNG
(2-(4-Fluorophenyl)-1-{3-[4-(3-acetylaminophenyl)pi...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCn2c(nc3ccccc23)-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C29H31FN4O/c1-21(35)31-26-7-4-6-24(20-26)22-14-18-33(19-15-22)16-5-17-34-28-9-3-2-8-27(28)32-29(34)23-10-12-25(30)13-11-23/h2-4,6-13,20,22H,5,14-19H2,1H3,(H,31,35)
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n/an/a 56n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340356
PNG
(2-(4-isopropylphenyl)-1-{3-[4-(3-acetylaminophenyl...)
Show SMILES CC(C)c1ccc(cc1)-c1nc2ccccc2n1CCCN1CCC(CC1)c1cccc(NC(C)=O)c1
Show InChI InChI=1S/C32H38N4O/c1-23(2)25-12-14-27(15-13-25)32-34-30-10-4-5-11-31(30)36(32)19-7-18-35-20-16-26(17-21-35)28-8-6-9-29(22-28)33-24(3)37/h4-6,8-15,22-23,26H,7,16-21H2,1-3H3,(H,33,37)
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n/an/a 60n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340343
PNG
(2-phenyl-1-{5-[4-(3-acetylaminophenyl)piperidin-1-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCCCn2c(nc3ccccc23)-c2ccccc2)CC1
Show InChI InChI=1S/C31H36N4O/c1-24(36)32-28-14-10-13-27(23-28)25-17-21-34(22-18-25)19-8-3-9-20-35-30-16-7-6-15-29(30)33-31(35)26-11-4-2-5-12-26/h2,4-7,10-16,23,25H,3,8-9,17-22H2,1H3,(H,32,36)
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n/an/a 74n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340370
PNG
(2-(4-chlorophenyl)-1-{3-[4-(3-(4-methylbenzoylamin...)
Show SMILES Clc1ccc(cc1)-c1nc2ccccc2n1CCCN1CCC(CC1)c1cccc(NC(=O)c2cccc(Cl)c2)c1
Show InChI InChI=1S/C34H32Cl2N4O/c35-28-14-12-25(13-15-28)33-38-31-10-1-2-11-32(31)40(33)19-5-18-39-20-16-24(17-21-39)26-6-4-9-30(23-26)37-34(41)27-7-3-8-29(36)22-27/h1-4,6-15,22-24H,5,16-21H2,(H,37,41)
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n/an/a 213n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340369
PNG
(2-(4-chlorophenyl)-1-{3-[4-(3-(3-chlorobenzoylamin...)
Show SMILES Cc1ccc(cc1)C(=O)Nc1cccc(c1)C1CCN(CCCn2c(nc3ccccc23)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C35H35ClN4O/c1-25-10-12-28(13-11-25)35(41)37-31-7-4-6-29(24-31)26-18-22-39(23-19-26)20-5-21-40-33-9-3-2-8-32(33)38-34(40)27-14-16-30(36)17-15-27/h2-4,6-17,24,26H,5,18-23H2,1H3,(H,37,41)
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n/an/a 300n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340350
PNG
(2-(2-methoxyphenyl)-1-{3-[4-(3-acetylaminophenyl)p...)
Show SMILES COc1ccccc1-c1nc2ccccc2n1CCCN1CCC(CC1)c1cccc(NC(C)=O)c1
Show InChI InChI=1S/C30H34N4O2/c1-22(35)31-25-10-7-9-24(21-25)23-15-19-33(20-16-23)17-8-18-34-28-13-5-4-12-27(28)32-30(34)26-11-3-6-14-29(26)36-2/h3-7,9-14,21,23H,8,15-20H2,1-2H3,(H,31,35)
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n/an/a 747n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340366
PNG
(2-(4-chlorophenyl)-1-{5-[4-(4-acetylaminophenyl)pi...)
Show SMILES CC(=O)Nc1ccc(cc1)C1CCN(CCCn2c(nc3ccccc23)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C29H31ClN4O/c1-21(35)31-26-13-9-22(10-14-26)23-15-19-33(20-16-23)17-4-18-34-28-6-3-2-5-27(28)32-29(34)24-7-11-25(30)12-8-24/h2-3,5-14,23H,4,15-20H2,1H3,(H,31,35)
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n/an/a 5.38E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340365
PNG
(2-(4-chlorophenyl)-1-{5-[4-(2-acetylaminophenyl)pi...)
Show SMILES CC(=O)Nc1ccccc1C1CCN(CCCn2c(nc3ccccc23)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C29H31ClN4O/c1-21(35)31-26-8-3-2-7-25(26)22-15-19-33(20-16-22)17-6-18-34-28-10-5-4-9-27(28)32-29(34)23-11-13-24(30)14-12-23/h2-5,7-14,22H,6,15-20H2,1H3,(H,31,35)
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n/an/a>6.00E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50340340
PNG
(2-phenyl-1-{2-[4-(3-acetylaminophenyl)piperidin-1-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCn2c(nc3ccccc23)-c2ccccc2)CC1
Show InChI InChI=1S/C28H30N4O/c1-21(33)29-25-11-7-10-24(20-25)22-14-16-31(17-15-22)18-19-32-27-13-6-5-12-26(27)30-28(32)23-8-3-2-4-9-23/h2-13,20,22H,14-19H2,1H3,(H,29,33)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay

Bioorg Med Chem Lett 21: 2309-12 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.099
BindingDB Entry DOI: 10.7270/Q20002DT
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%