Affinity Data by PubMed id=21617763

PubMed code 21617763

Found 18 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM50336960 (3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-th...) Show SMILES Oc1ccc2sc3c(SCCNC3=O)c2c1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28.3	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of human recombinant PKD1 after 10 mins by radiometric assay				ACS Med Chem Lett 2: 154-159 (2012) Article DOI: 10.1021/ml100230n BindingDB Entry DOI: 10.7270/Q29G5NTR
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Polycystin-2 (Homo sapiens (Human))	BDBM50336958 (2-Methoxy-7H,8H,9H-1,4-thiazepino[7',6'-5,4]thioph...) Show SMILES COc1ncc2sc3c(SCCNC3=O)c2n1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of human recombinant PKD2 after 10 mins by radiometric assay				ACS Med Chem Lett 2: 154-159 (2012) Article DOI: 10.1021/ml100230n BindingDB Entry DOI: 10.7270/Q29G5NTR
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM50336961 (3,4-Dihydro-9-azido-[1]benzothieno[2,3-f]-1,4-thia...) Show SMILES [N-]=[N+]=Nc1ccc2sc3c(SCCNC3=O)c2c1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	74.9	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of human recombinant PKD1 after 10 mins by radiometric assay				ACS Med Chem Lett 2: 154-159 (2012) Article DOI: 10.1021/ml100230n BindingDB Entry DOI: 10.7270/Q29G5NTR
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM50119286 (3-Methoxy-7,8-dihydro-6H-5,10-dithia-8-aza-benzo[a...) Show SMILES COc1ccc2sc3c(SCCNC3=O)c2c1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	82.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of human recombinant PKD1 after 10 mins by radiometric assay				ACS Med Chem Lett 2: 154-159 (2012) Article DOI: 10.1021/ml100230n BindingDB Entry DOI: 10.7270/Q29G5NTR
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM50336962 (2,3,4,5-Tetrahydro-10-hydroxybenzo[b]thieno[2,3-f]...) Show SMILES Oc1ccc2sc3c(SCCCNC3=O)c2c1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	111	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of human recombinant PKD1 after 10 mins by radiometric assay				ACS Med Chem Lett 2: 154-159 (2012) Article DOI: 10.1021/ml100230n BindingDB Entry DOI: 10.7270/Q29G5NTR
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM50336958 (2-Methoxy-7H,8H,9H-1,4-thiazepino[7',6'-5,4]thioph...) Show SMILES COc1ncc2sc3c(SCCNC3=O)c2n1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	124	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of human recombinant PKD1 after 10 mins by radiometric assay				ACS Med Chem Lett 2: 154-159 (2012) Article DOI: 10.1021/ml100230n BindingDB Entry DOI: 10.7270/Q29G5NTR
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM50336959 (3,4,5,10-Tetrahydro-7-hydroxy-azepino[3,4-b]indol-...) Show SMILES Oc1ccc2[nH]c3c(CCCNC3=O)c2c1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of human recombinant PKD1 after 10 mins by radiometric assay				ACS Med Chem Lett 2: 154-159 (2012) Article DOI: 10.1021/ml100230n BindingDB Entry DOI: 10.7270/Q29G5NTR
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM32334 (7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c...) Show SMILES Oc1ccc2oc3c(CCCNC3=O)c2c1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	182	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of human recombinant PKD1 after 10 mins by radiometric assay				ACS Med Chem Lett 2: 154-159 (2012) Article DOI: 10.1021/ml100230n BindingDB Entry DOI: 10.7270/Q29G5NTR
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM50336963 (2,3,4,5-Tetrahydro-10-methoxybenzo[b]thieno[2,3-f]...) Show SMILES COc1ccc2sc3c(SCCCNC3=O)c2c1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	193	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of human recombinant PKD1 after 10 mins by radiometric assay				ACS Med Chem Lett 2: 154-159 (2012) Article DOI: 10.1021/ml100230n BindingDB Entry DOI: 10.7270/Q29G5NTR
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Polycystin-2 (Homo sapiens (Human))	BDBM32334 (7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c...) Show SMILES Oc1ccc2oc3c(CCCNC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of human recombinant PKD2 after 10 mins by radiometric assay				ACS Med Chem Lett 2: 154-159 (2012) Article DOI: 10.1021/ml100230n BindingDB Entry DOI: 10.7270/Q29G5NTR
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM50336961 (3,4-Dihydro-9-azido-[1]benzothieno[2,3-f]-1,4-thia...) Show SMILES [N-]=[N+]=Nc1ccc2sc3c(SCCNC3=O)c2c1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of PKD1 autophosphorylation at Ser916 in human PMA-induced LNCAP cells by Western blotting				ACS Med Chem Lett 2: 154-159 (2012) Article DOI: 10.1021/ml100230n BindingDB Entry DOI: 10.7270/Q29G5NTR
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM50336960 (3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-th...) Show SMILES Oc1ccc2sc3c(SCCNC3=O)c2c1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of PKD1 autophosphorylation at Ser916 in human PMA-induced LNCAP cells by Western blotting				ACS Med Chem Lett 2: 154-159 (2012) Article DOI: 10.1021/ml100230n BindingDB Entry DOI: 10.7270/Q29G5NTR
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM50336962 (2,3,4,5-Tetrahydro-10-hydroxybenzo[b]thieno[2,3-f]...) Show SMILES Oc1ccc2sc3c(SCCCNC3=O)c2c1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of PKD1 autophosphorylation at Ser916 in human PMA-induced LNCAP cells by Western blotting				ACS Med Chem Lett 2: 154-159 (2012) Article DOI: 10.1021/ml100230n BindingDB Entry DOI: 10.7270/Q29G5NTR
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM50119286 (3-Methoxy-7,8-dihydro-6H-5,10-dithia-8-aza-benzo[a...) Show SMILES COc1ccc2sc3c(SCCNC3=O)c2c1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of PKD1 autophosphorylation at Ser916 in human PMA-induced LNCAP cells by Western blotting				ACS Med Chem Lett 2: 154-159 (2012) Article DOI: 10.1021/ml100230n BindingDB Entry DOI: 10.7270/Q29G5NTR
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM50336958 (2-Methoxy-7H,8H,9H-1,4-thiazepino[7',6'-5,4]thioph...) Show SMILES COc1ncc2sc3c(SCCNC3=O)c2n1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of PKD1 autophosphorylation at Ser916 in human PMA-induced LNCAP cells by Western blotting				ACS Med Chem Lett 2: 154-159 (2012) Article DOI: 10.1021/ml100230n BindingDB Entry DOI: 10.7270/Q29G5NTR
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM32334 (7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c...) Show SMILES Oc1ccc2oc3c(CCCNC3=O)c2c1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.18E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of PKD1 autophosphorylation at Ser916 in human PMA-induced LNCAP cells by Western blotting				ACS Med Chem Lett 2: 154-159 (2012) Article DOI: 10.1021/ml100230n BindingDB Entry DOI: 10.7270/Q29G5NTR
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM50336963 (2,3,4,5-Tetrahydro-10-methoxybenzo[b]thieno[2,3-f]...) Show SMILES COc1ccc2sc3c(SCCCNC3=O)c2c1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.86E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of PKD1 autophosphorylation at Ser916 in human PMA-induced LNCAP cells by Western blotting				ACS Med Chem Lett 2: 154-159 (2012) Article DOI: 10.1021/ml100230n BindingDB Entry DOI: 10.7270/Q29G5NTR
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM50336959 (3,4,5,10-Tetrahydro-7-hydroxy-azepino[3,4-b]indol-...) Show SMILES Oc1ccc2[nH]c3c(CCCNC3=O)c2c1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of PKD1 autophosphorylation at Ser916 in human PMA-induced LNCAP cells by Western blotting				ACS Med Chem Lett 2: 154-159 (2012) Article DOI: 10.1021/ml100230n BindingDB Entry DOI: 10.7270/Q29G5NTR
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%