Found 5 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Myeloperoxidase
(Homo sapiens (Human)) | BDBM92467
(2-Thioxanthine, TX2)Show InChI InChI=1S/C12H9FN4OS/c13-8-3-1-7(2-4-8)5-17-10-9(14-6-15-10)11(18)16-12(17)19/h1-4,6H,5H2,(H,14,15)(H,16,18,19) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| MMDB
PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | 7.4 | 21 |
AstraZeneca R&D
| Assay Description
The chlorination activity of MPO was determined by measuring the production of hypocholorous acid. |
J Biol Chem 286: 37578-89 (2011)
Article DOI: 10.1074/jbc.M111.266981
BindingDB Entry DOI: 10.7270/Q2M32TCV |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Myeloperoxidase
(Homo sapiens (Human)) | BDBM92469
(2-Thioxanthine, TX4)Show SMILES O=c1[nH]c(=S)n(C[C@H]2CCCO2)c2nc[nH]c12 |r| Show InChI InChI=1S/C10H12N4O2S/c15-9-7-8(12-5-11-7)14(10(17)13-9)4-6-2-1-3-16-6/h5-6H,1-4H2,(H,11,12)(H,13,15,17)/t6-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | 7.4 | 21 |
AstraZeneca R&D
| Assay Description
The chlorination activity of MPO was determined by measuring the production of hypocholorous acid. |
J Biol Chem 286: 37578-89 (2011)
Article DOI: 10.1074/jbc.M111.266981
BindingDB Entry DOI: 10.7270/Q2M32TCV |
More data for this
Ligand-Target Pair |
3D Structure (docked) |
Myeloperoxidase
(Homo sapiens (Human)) | BDBM92470
(2-Thioxanthine, TX5)Show InChI InChI=1S/C8H10N4O2S/c1-14-3-2-12-6-5(9-4-10-6)7(13)11-8(12)15/h4H,2-3H2,1H3,(H,9,10)(H,11,13,15) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| MMDB
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | 7.4 | 21 |
AstraZeneca R&D
| Assay Description
The chlorination activity of MPO was determined by measuring the production of hypocholorous acid. |
J Biol Chem 286: 37578-89 (2011)
Article DOI: 10.1074/jbc.M111.266981
BindingDB Entry DOI: 10.7270/Q2M32TCV |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Myeloperoxidase
(Homo sapiens (Human)) | BDBM92468
(2-Thioxanthine, TX3)Show InChI InChI=1S/C10H12N4O2S/c15-9-7-8(12-5-11-7)14(10(17)13-9)4-6-2-1-3-16-6/h5-6H,1-4H2,(H,11,12)(H,13,15,17) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | 7.4 | 21 |
AstraZeneca R&D
| Assay Description
The chlorination activity of MPO was determined by measuring the production of hypocholorous acid. |
J Biol Chem 286: 37578-89 (2011)
Article DOI: 10.1074/jbc.M111.266981
BindingDB Entry DOI: 10.7270/Q2M32TCV |
More data for this
Ligand-Target Pair |
3D Structure (docked) |
Myeloperoxidase
(Homo sapiens (Human)) | BDBM92466
(2-Thioxanthine, TX1)Show InChI InChI=1S/C9H12N4OS/c1-5(2)3-13-7-6(10-4-11-7)8(14)12-9(13)15/h4-5H,3H2,1-2H3,(H,10,11)(H,12,14,15) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | 7.4 | 21 |
AstraZeneca R&D
| Assay Description
The chlorination activity of MPO was determined by measuring the production of hypocholorous acid. |
J Biol Chem 286: 37578-89 (2011)
Article DOI: 10.1074/jbc.M111.266981
BindingDB Entry DOI: 10.7270/Q2M32TCV |
More data for this
Ligand-Target Pair |
3D Structure (docked) |
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