Found 6 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM69530
((4-Amino-2-phenylamino-thiazol-5-yl)-phenyl-methan...)Show InChI InChI=1S/C16H13N3OS/c17-15-14(13(20)11-7-3-1-4-8-11)21-16(19-15)18-12-9-5-2-6-10-12/h1-10H,17H2,(H,18,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 720 | n/a | n/a | n/a | n/a | n/a | n/a |
Sejong University
Curated by ChEMBL
| Assay Description Inhibition of MAPK p38alpha |
Bioorg Med Chem Lett 22: 2195-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.104 BindingDB Entry DOI: 10.7270/Q2474B9Z |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50365804
(CHEMBL1956879)Show SMILES Cn1cc(\C=C2\C(=O)NC(=O)N(CCc3ccccc3)C2=O)c2ccccc12 Show InChI InChI=1S/C22H19N3O3/c1-24-14-16(17-9-5-6-10-19(17)24)13-18-20(26)23-22(28)25(21(18)27)12-11-15-7-3-2-4-8-15/h2-10,13-14H,11-12H2,1H3,(H,23,26,28)/b18-13- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.71E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sejong University
Curated by ChEMBL
| Assay Description Inhibition of MAPK p38alpha |
Bioorg Med Chem Lett 22: 2195-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.104 BindingDB Entry DOI: 10.7270/Q2474B9Z |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50365805
(CHEMBL1956880)Show SMILES Cc1cccc(c1)-c1nc(Nc2ccc(cc2)C(O)=O)c2ccccc2n1 Show InChI InChI=1S/C22H17N3O2/c1-14-5-4-6-16(13-14)20-24-19-8-3-2-7-18(19)21(25-20)23-17-11-9-15(10-12-17)22(26)27/h2-13H,1H3,(H,26,27)(H,23,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.04E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sejong University
Curated by ChEMBL
| Assay Description Inhibition of MAPK p38alpha |
Bioorg Med Chem Lett 22: 2195-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.104 BindingDB Entry DOI: 10.7270/Q2474B9Z |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50365806
(CHEMBL1956881)Show SMILES CCn1cc(\C=C2\Oc3c(ccc(O)c3CN3CCOCC3)C2=O)c2ccccc12 Show InChI InChI=1S/C24H24N2O4/c1-2-26-14-16(17-5-3-4-6-20(17)26)13-22-23(28)18-7-8-21(27)19(24(18)30-22)15-25-9-11-29-12-10-25/h3-8,13-14,27H,2,9-12,15H2,1H3/b22-13+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sejong University
Curated by ChEMBL
| Assay Description Inhibition of MAPK p38alpha |
Bioorg Med Chem Lett 22: 2195-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.104 BindingDB Entry DOI: 10.7270/Q2474B9Z |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50365807
(CHEMBL1956882)Show SMILES O=C1N(CCc2nc3c4c(-c5ccco5)c(oc4ncn3n2)-c2ccco2)C(=O)c2ccccc12 Show InChI InChI=1S/C25H15N5O5/c31-24-14-5-1-2-6-15(14)25(32)29(24)10-9-18-27-22-20-19(16-7-3-11-33-16)21(17-8-4-12-34-17)35-23(20)26-13-30(22)28-18/h1-8,11-13H,9-10H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sejong University
Curated by ChEMBL
| Assay Description Inhibition of MAPK p38alpha |
Bioorg Med Chem Lett 22: 2195-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.104 BindingDB Entry DOI: 10.7270/Q2474B9Z |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50354686
(CHEMBL1524400)Show SMILES NC(=O)c1ccc(Nc2nnc(-c3ccc(O)cc3)c3ccccc23)cc1 Show InChI InChI=1S/C21H16N4O2/c22-20(27)14-5-9-15(10-6-14)23-21-18-4-2-1-3-17(18)19(24-25-21)13-7-11-16(26)12-8-13/h1-12,26H,(H2,22,27)(H,23,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sejong University
Curated by ChEMBL
| Assay Description Inhibition of MAPK p38alpha |
Bioorg Med Chem Lett 22: 2195-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.104 BindingDB Entry DOI: 10.7270/Q2474B9Z |
More data for this Ligand-Target Pair | |