Affinity Data by PubMed id=22444875

PubMed code 22444875

Found 25 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Aromatase (Homo sapiens (Human))	BDBM10015 (2-[3-(1-cyano-1-methylethyl)-5-(1H-1,2,4-triazol-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Northern Kentucky University Curated by ChEMBL					Assay Description Inhibition of aromatase				Bioorg Med Chem 20: 2603-13 (2012) Article DOI: 10.1016/j.bmc.2012.02.042 BindingDB Entry DOI: 10.7270/Q29S1S24
Northern Kentucky University Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM50380169 (CHEMBL2011180) Show SMILES COc1ccc2OCC(C(=O)c2c1)c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Northern Kentucky University Curated by ChEMBL					Assay Description Inhibition of human recombinant aromatase expressed in baculovirus/insect cells using 7-methoxy-trifluoromethylcoumarin as substrate after 30 mins by...				Bioorg Med Chem 20: 2603-13 (2012) Article DOI: 10.1016/j.bmc.2012.02.042 BindingDB Entry DOI: 10.7270/Q29S1S24
Northern Kentucky University Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM31768 (CHEMBL295698 \| Ketoconazole \| Nizoral \| Panfungol) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northern Kentucky University Curated by ChEMBL					Assay Description Inhibition of human recombinant aromatase expressed in baculovirus/insect cells using 7-methoxy-trifluoromethylcoumarin as substrate after 30 mins by...				Bioorg Med Chem 20: 2603-13 (2012) Article DOI: 10.1016/j.bmc.2012.02.042 BindingDB Entry DOI: 10.7270/Q29S1S24
Northern Kentucky University Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM7461 (5,7-dihydroxy-2-phenyl-4H-chromen-4-one \| 5,7-dihy...) Show SMILES Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northern Kentucky University Curated by ChEMBL					Assay Description Inhibition of aromatase				Bioorg Med Chem 20: 2603-13 (2012) Article DOI: 10.1016/j.bmc.2012.02.042 BindingDB Entry DOI: 10.7270/Q29S1S24
Northern Kentucky University Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM50380168 (CHEMBL2011177) Show SMILES O=C1C(COc2ccccc12)c1ccc(Oc2ccccc2)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northern Kentucky University Curated by ChEMBL					Assay Description Inhibition of human recombinant aromatase expressed in baculovirus/insect cells using 7-methoxy-trifluoromethylcoumarin as substrate after 30 mins by...				Bioorg Med Chem 20: 2603-13 (2012) Article DOI: 10.1016/j.bmc.2012.02.042 BindingDB Entry DOI: 10.7270/Q29S1S24
Northern Kentucky University Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM50380176 (CHEMBL2011188) Show SMILES Clc1ccc2OCC(C(=O)c2c1)c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northern Kentucky University Curated by ChEMBL					Assay Description Inhibition of human recombinant aromatase expressed in baculovirus/insect cells using 7-methoxy-trifluoromethylcoumarin as substrate after 30 mins by...				Bioorg Med Chem 20: 2603-13 (2012) Article DOI: 10.1016/j.bmc.2012.02.042 BindingDB Entry DOI: 10.7270/Q29S1S24
Northern Kentucky University Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM50380174 (CHEMBL2011186) Show SMILES O=C1C(COc2ccccc12)c1cccnc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northern Kentucky University Curated by ChEMBL					Assay Description Inhibition of human recombinant aromatase expressed in baculovirus/insect cells using 7-methoxy-trifluoromethylcoumarin as substrate after 30 mins by...				Bioorg Med Chem 20: 2603-13 (2012) Article DOI: 10.1016/j.bmc.2012.02.042 BindingDB Entry DOI: 10.7270/Q29S1S24
Northern Kentucky University Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM50380160 (CHEMBL2011184) Show SMILES COc1cc(OC)cc(c1)C1COc2ccccc2C1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Northern Kentucky University Curated by ChEMBL					Assay Description Inhibition of human recombinant aromatase expressed in baculovirus/insect cells using 7-methoxy-trifluoromethylcoumarin as substrate after 30 mins by...				Bioorg Med Chem 20: 2603-13 (2012) Article DOI: 10.1016/j.bmc.2012.02.042 BindingDB Entry DOI: 10.7270/Q29S1S24
Northern Kentucky University Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM50380164 (CHEMBL2011173) Show SMILES Cc1ccc2C(=O)C(COc2c1)c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Northern Kentucky University Curated by ChEMBL					Assay Description Inhibition of human recombinant aromatase expressed in baculovirus/insect cells using 7-methoxy-trifluoromethylcoumarin as substrate after 30 mins by...				Bioorg Med Chem 20: 2603-13 (2012) Article DOI: 10.1016/j.bmc.2012.02.042 BindingDB Entry DOI: 10.7270/Q29S1S24
Northern Kentucky University Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM50380165 (CHEMBL2011174) Show SMILES Cc1cccc(c1)C1COc2ccccc2C1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Northern Kentucky University Curated by ChEMBL					Assay Description Inhibition of human recombinant aromatase expressed in baculovirus/insect cells using 7-methoxy-trifluoromethylcoumarin as substrate after 30 mins by...				Bioorg Med Chem 20: 2603-13 (2012) Article DOI: 10.1016/j.bmc.2012.02.042 BindingDB Entry DOI: 10.7270/Q29S1S24
Northern Kentucky University Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM50380167 (CHEMBL2011176) Show SMILES O=C1C(COc2ccc3ccccc3c12)c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Northern Kentucky University Curated by ChEMBL					Assay Description Inhibition of human recombinant aromatase expressed in baculovirus/insect cells using 7-methoxy-trifluoromethylcoumarin as substrate after 30 mins by...				Bioorg Med Chem 20: 2603-13 (2012) Article DOI: 10.1016/j.bmc.2012.02.042 BindingDB Entry DOI: 10.7270/Q29S1S24
Northern Kentucky University Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM50380172 (CHEMBL2011183) Show SMILES COc1ccc(cc1)C1COc2ccccc2C1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Northern Kentucky University Curated by ChEMBL					Assay Description Inhibition of human recombinant aromatase expressed in baculovirus/insect cells using 7-methoxy-trifluoromethylcoumarin as substrate after 30 mins by...				Bioorg Med Chem 20: 2603-13 (2012) Article DOI: 10.1016/j.bmc.2012.02.042 BindingDB Entry DOI: 10.7270/Q29S1S24
Northern Kentucky University Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM50380177 (CHEMBL2011189) Show SMILES Brc1ccc2OCC(C(=O)c2c1)c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Northern Kentucky University Curated by ChEMBL					Assay Description Inhibition of human recombinant aromatase expressed in baculovirus/insect cells using 7-methoxy-trifluoromethylcoumarin as substrate after 30 mins by...				Bioorg Med Chem 20: 2603-13 (2012) Article DOI: 10.1016/j.bmc.2012.02.042 BindingDB Entry DOI: 10.7270/Q29S1S24
Northern Kentucky University Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM50380162 (CHEMBL2011171) Show SMILES O=C1C(COc2ccccc12)c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Northern Kentucky University Curated by ChEMBL					Assay Description Inhibition of human recombinant aromatase expressed in baculovirus/insect cells using 7-methoxy-trifluoromethylcoumarin as substrate after 30 mins by...				Bioorg Med Chem 20: 2603-13 (2012) Article DOI: 10.1016/j.bmc.2012.02.042 BindingDB Entry DOI: 10.7270/Q29S1S24
Northern Kentucky University Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM50380173 (CHEMBL2011185) Show SMILES O=C1C(COc2ccccc12)c1ccsc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Northern Kentucky University Curated by ChEMBL					Assay Description Inhibition of human recombinant aromatase expressed in baculovirus/insect cells using 7-methoxy-trifluoromethylcoumarin as substrate after 30 mins by...				Bioorg Med Chem 20: 2603-13 (2012) Article DOI: 10.1016/j.bmc.2012.02.042 BindingDB Entry DOI: 10.7270/Q29S1S24
Northern Kentucky University Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM50380175 (CHEMBL2011187) Show SMILES Fc1ccc2OCC(C(=O)c2c1)c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Northern Kentucky University Curated by ChEMBL					Assay Description Inhibition of human recombinant aromatase expressed in baculovirus/insect cells using 7-methoxy-trifluoromethylcoumarin as substrate after 30 mins by...				Bioorg Med Chem 20: 2603-13 (2012) Article DOI: 10.1016/j.bmc.2012.02.042 BindingDB Entry DOI: 10.7270/Q29S1S24
Northern Kentucky University Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM50380166 (CHEMBL2011175) Show SMILES Cc1ccc(cc1)C1COc2ccccc2C1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Northern Kentucky University Curated by ChEMBL					Assay Description Inhibition of human recombinant aromatase expressed in baculovirus/insect cells using 7-methoxy-trifluoromethylcoumarin as substrate after 30 mins by...				Bioorg Med Chem 20: 2603-13 (2012) Article DOI: 10.1016/j.bmc.2012.02.042 BindingDB Entry DOI: 10.7270/Q29S1S24
Northern Kentucky University Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM50380179 (CHEMBL1165711) Show SMILES COc1ccc2C(=O)C(COc2c1)c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Northern Kentucky University Curated by ChEMBL					Assay Description Inhibition of human recombinant aromatase expressed in baculovirus/insect cells using 7-methoxy-trifluoromethylcoumarin as substrate after 30 mins by...				Bioorg Med Chem 20: 2603-13 (2012) Article DOI: 10.1016/j.bmc.2012.02.042 BindingDB Entry DOI: 10.7270/Q29S1S24
Northern Kentucky University Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM50380163 (CHEMBL2011172) Show SMILES Cc1ccc2OCC(C(=O)c2c1)c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Northern Kentucky University Curated by ChEMBL					Assay Description Inhibition of human recombinant aromatase expressed in baculovirus/insect cells using 7-methoxy-trifluoromethylcoumarin as substrate after 30 mins by...				Bioorg Med Chem 20: 2603-13 (2012) Article DOI: 10.1016/j.bmc.2012.02.042 BindingDB Entry DOI: 10.7270/Q29S1S24
Northern Kentucky University Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM50380178 (CHEMBL2011190) Show SMILES CC(C)(C)c1ccc2OCC(C(=O)c2c1)c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Northern Kentucky University Curated by ChEMBL					Assay Description Inhibition of human recombinant aromatase expressed in baculovirus/insect cells using 7-methoxy-trifluoromethylcoumarin as substrate after 30 mins by...				Bioorg Med Chem 20: 2603-13 (2012) Article DOI: 10.1016/j.bmc.2012.02.042 BindingDB Entry DOI: 10.7270/Q29S1S24
Northern Kentucky University Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM50380170 (CHEMBL2011181) Show SMILES COc1ccccc1C1COc2ccccc2C1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Northern Kentucky University Curated by ChEMBL					Assay Description Inhibition of human recombinant aromatase expressed in baculovirus/insect cells using 7-methoxy-trifluoromethylcoumarin as substrate after 30 mins by...				Bioorg Med Chem 20: 2603-13 (2012) Article DOI: 10.1016/j.bmc.2012.02.042 BindingDB Entry DOI: 10.7270/Q29S1S24
Northern Kentucky University Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM50380171 (CHEMBL2011182) Show SMILES COc1cccc(c1)C1COc2ccccc2C1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Northern Kentucky University Curated by ChEMBL					Assay Description Inhibition of human recombinant aromatase expressed in baculovirus/insect cells using 7-methoxy-trifluoromethylcoumarin as substrate after 30 mins by...				Bioorg Med Chem 20: 2603-13 (2012) Article DOI: 10.1016/j.bmc.2012.02.042 BindingDB Entry DOI: 10.7270/Q29S1S24
Northern Kentucky University Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM9461 (5,7-dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one...) Show SMILES COc1ccc(cc1)-c1coc2cc(O)cc(O)c2c1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.13E+5	n/a	n/a	n/a	n/a	n/a	n/a
Northern Kentucky University Curated by ChEMBL					Assay Description Inhibition of aromatase				Bioorg Med Chem 20: 2603-13 (2012) Article DOI: 10.1016/j.bmc.2012.02.042 BindingDB Entry DOI: 10.7270/Q29S1S24
Northern Kentucky University Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM50380180 (CHEMBL2011192) Show SMILES Oc1ccc(cc1)C1COc2ccccc2C1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+5	n/a	n/a	n/a	n/a	n/a	n/a
Northern Kentucky University Curated by ChEMBL					Assay Description Inhibition of aromatase				Bioorg Med Chem 20: 2603-13 (2012) Article DOI: 10.1016/j.bmc.2012.02.042 BindingDB Entry DOI: 10.7270/Q29S1S24
Northern Kentucky University Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM50380161 (CHEMBL2011191) Show SMILES OC1Oc2ccccc2C(=O)C1c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+5	n/a	n/a	n/a	n/a	n/a	n/a
Northern Kentucky University Curated by ChEMBL					Assay Description Inhibition of aromatase				Bioorg Med Chem 20: 2603-13 (2012) Article DOI: 10.1016/j.bmc.2012.02.042 BindingDB Entry DOI: 10.7270/Q29S1S24
Northern Kentucky University Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%