Affinity Data by PubMed id=22595175

PubMed code 22595175

Found 18 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Myeloblastin (Homo sapiens (Human))	BDBM50384111 (CHEMBL2029556) Show SMILES COc1ccc(cc1)C(=O)N1C(=O)OC(C)(C)C1=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Lisbon Curated by ChEMBL					Assay Description Inhibition of proteinase 3 using N-MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide as substrate after 60 mins				Bioorg Med Chem Lett 22: 3993-7 (2012) Article DOI: 10.1016/j.bmcl.2012.04.093 BindingDB Entry DOI: 10.7270/Q2NZ88PG
University of Lisbon Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin G (Homo sapiens (Human))	BDBM50384108 (CHEMBL2029554) Show SMILES CC1(C)OC(=O)N(Cc2ccccc2)C1=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Lisbon Curated by ChEMBL					Assay Description Inhibition of cathepsin G using Suc-Ala-Ala-Pro-Phe-p-nitroanilide as substrate after 30 mins				Bioorg Med Chem Lett 22: 3993-7 (2012) Article DOI: 10.1016/j.bmcl.2012.04.093 BindingDB Entry DOI: 10.7270/Q2NZ88PG
University of Lisbon Curated by ChEMBL					More data for this Ligand-Target Pair
Neutrophil elastase (Homo sapiens (Human))	BDBM50384112 (CHEMBL2029557) Show SMILES Cc1ccc(cc1)S(=O)(=O)N1C(=O)OC(C)(C)C1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Lisbon Curated by ChEMBL					Assay Description Inhibition of human neutrophil elastase using chromogenic substrate (N-MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide after 120 mins				Bioorg Med Chem Lett 22: 3993-7 (2012) Article DOI: 10.1016/j.bmcl.2012.04.093 BindingDB Entry DOI: 10.7270/Q2NZ88PG
University of Lisbon Curated by ChEMBL					More data for this Ligand-Target Pair
Myeloblastin (Homo sapiens (Human))	BDBM50384104 (CHEMBL2029559) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Lisbon Curated by ChEMBL					Assay Description Inhibition of proteinase 3 using N-MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide as substrate after 60 mins				Bioorg Med Chem Lett 22: 3993-7 (2012) Article DOI: 10.1016/j.bmcl.2012.04.093 BindingDB Entry DOI: 10.7270/Q2NZ88PG
University of Lisbon Curated by ChEMBL					More data for this Ligand-Target Pair
Neutrophil elastase (Homo sapiens (Human))	BDBM50384111 (CHEMBL2029556) Show SMILES COc1ccc(cc1)C(=O)N1C(=O)OC(C)(C)C1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.02E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Lisbon Curated by ChEMBL					Assay Description Inhibition of human neutrophil elastase using chromogenic substrate (N-MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide after 120 mins				Bioorg Med Chem Lett 22: 3993-7 (2012) Article DOI: 10.1016/j.bmcl.2012.04.093 BindingDB Entry DOI: 10.7270/Q2NZ88PG
University of Lisbon Curated by ChEMBL					More data for this Ligand-Target Pair
Myeloblastin (Homo sapiens (Human))	BDBM50384108 (CHEMBL2029554) Show SMILES CC1(C)OC(=O)N(Cc2ccccc2)C1=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.28E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Lisbon Curated by ChEMBL					Assay Description Inhibition of proteinase 3 using N-MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide as substrate after 60 mins				Bioorg Med Chem Lett 22: 3993-7 (2012) Article DOI: 10.1016/j.bmcl.2012.04.093 BindingDB Entry DOI: 10.7270/Q2NZ88PG
University of Lisbon Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin G (Homo sapiens (Human))	BDBM50384111 (CHEMBL2029556) Show SMILES COc1ccc(cc1)C(=O)N1C(=O)OC(C)(C)C1=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.42E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Lisbon Curated by ChEMBL					Assay Description Inhibition of cathepsin G using Suc-Ala-Ala-Pro-Phe-p-nitroanilide as substrate after 30 mins				Bioorg Med Chem Lett 22: 3993-7 (2012) Article DOI: 10.1016/j.bmcl.2012.04.093 BindingDB Entry DOI: 10.7270/Q2NZ88PG
University of Lisbon Curated by ChEMBL					More data for this Ligand-Target Pair
Myeloblastin (Homo sapiens (Human))	BDBM50384112 (CHEMBL2029557) Show SMILES Cc1ccc(cc1)S(=O)(=O)N1C(=O)OC(C)(C)C1=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.45E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Lisbon Curated by ChEMBL					Assay Description Inhibition of proteinase 3 using N-MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide as substrate after 60 mins				Bioorg Med Chem Lett 22: 3993-7 (2012) Article DOI: 10.1016/j.bmcl.2012.04.093 BindingDB Entry DOI: 10.7270/Q2NZ88PG
University of Lisbon Curated by ChEMBL					More data for this Ligand-Target Pair
Neutrophil elastase (Homo sapiens (Human))	BDBM50384104 (CHEMBL2029559) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.56E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Lisbon Curated by ChEMBL					Assay Description Inhibition of human neutrophil elastase using chromogenic substrate (N-MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide after 120 mins				Bioorg Med Chem Lett 22: 3993-7 (2012) Article DOI: 10.1016/j.bmcl.2012.04.093 BindingDB Entry DOI: 10.7270/Q2NZ88PG
University of Lisbon Curated by ChEMBL					More data for this Ligand-Target Pair
Neutrophil elastase (Homo sapiens (Human))	BDBM50384108 (CHEMBL2029554) Show SMILES CC1(C)OC(=O)N(Cc2ccccc2)C1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.56E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Lisbon Curated by ChEMBL					Assay Description Inhibition of human neutrophil elastase using chromogenic substrate (N-MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide after 120 mins				Bioorg Med Chem Lett 22: 3993-7 (2012) Article DOI: 10.1016/j.bmcl.2012.04.093 BindingDB Entry DOI: 10.7270/Q2NZ88PG
University of Lisbon Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin G (Homo sapiens (Human))	BDBM50384104 (CHEMBL2029559) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Lisbon Curated by ChEMBL					Assay Description Inhibition of cathepsin G using Suc-Ala-Ala-Pro-Phe-p-nitroanilide as substrate after 30 mins				Bioorg Med Chem Lett 22: 3993-7 (2012) Article DOI: 10.1016/j.bmcl.2012.04.093 BindingDB Entry DOI: 10.7270/Q2NZ88PG
University of Lisbon Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin G (Homo sapiens (Human))	BDBM50384112 (CHEMBL2029557) Show SMILES Cc1ccc(cc1)S(=O)(=O)N1C(=O)OC(C)(C)C1=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.69E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Lisbon Curated by ChEMBL					Assay Description Inhibition of cathepsin G using Suc-Ala-Ala-Pro-Phe-p-nitroanilide as substrate after 30 mins				Bioorg Med Chem Lett 22: 3993-7 (2012) Article DOI: 10.1016/j.bmcl.2012.04.093 BindingDB Entry DOI: 10.7270/Q2NZ88PG
University of Lisbon Curated by ChEMBL					More data for this Ligand-Target Pair
Neutrophil elastase (Homo sapiens (Human))	BDBM50384110 (CHEMBL2029555) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Lisbon Curated by ChEMBL					Assay Description Inhibition of human neutrophil elastase using chromogenic substrate (N-MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide after 120 mins				Bioorg Med Chem Lett 22: 3993-7 (2012) Article DOI: 10.1016/j.bmcl.2012.04.093 BindingDB Entry DOI: 10.7270/Q2NZ88PG
University of Lisbon Curated by ChEMBL					More data for this Ligand-Target Pair
Neutrophil elastase (Homo sapiens (Human))	BDBM50384113 (CHEMBL2029558) Show SMILES COc1ccc(cc1)C(=O)n1c(O)c(C)oc1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Lisbon Curated by ChEMBL					Assay Description Inhibition of human neutrophil elastase using chromogenic substrate (N-MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide after 120 mins				Bioorg Med Chem Lett 22: 3993-7 (2012) Article DOI: 10.1016/j.bmcl.2012.04.093 BindingDB Entry DOI: 10.7270/Q2NZ88PG
University of Lisbon Curated by ChEMBL					More data for this Ligand-Target Pair
Neutrophil elastase (Homo sapiens (Human))	BDBM50384107 (CHEMBL2029553) Show SMILES CC1OC(=O)N(C1=O)c1ccc(cc1)[N+]([O-])=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Lisbon Curated by ChEMBL					Assay Description Inhibition of human neutrophil elastase using chromogenic substrate (N-MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide after 120 mins				Bioorg Med Chem Lett 22: 3993-7 (2012) Article DOI: 10.1016/j.bmcl.2012.04.093 BindingDB Entry DOI: 10.7270/Q2NZ88PG
University of Lisbon Curated by ChEMBL					More data for this Ligand-Target Pair
Neutrophil elastase (Homo sapiens (Human))	BDBM50384109 (CHEMBL2029350) Show SMILES COc1ccc(cc1)N1C(=O)OC(C)(C)C1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Lisbon Curated by ChEMBL					Assay Description Inhibition of human neutrophil elastase using chromogenic substrate (N-MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide after 120 mins				Bioorg Med Chem Lett 22: 3993-7 (2012) Article DOI: 10.1016/j.bmcl.2012.04.093 BindingDB Entry DOI: 10.7270/Q2NZ88PG
University of Lisbon Curated by ChEMBL					More data for this Ligand-Target Pair
Neutrophil elastase (Homo sapiens (Human))	BDBM50384106 (CHEMBL2029552) Show SMILES COc1ccc(cc1)N1C(=O)OC(C)C1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Lisbon Curated by ChEMBL					Assay Description Inhibition of human neutrophil elastase using chromogenic substrate (N-MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide after 120 mins				Bioorg Med Chem Lett 22: 3993-7 (2012) Article DOI: 10.1016/j.bmcl.2012.04.093 BindingDB Entry DOI: 10.7270/Q2NZ88PG
University of Lisbon Curated by ChEMBL					More data for this Ligand-Target Pair
Neutrophil elastase (Homo sapiens (Human))	BDBM50384105 (CHEMBL2029551) Show SMILES Cc1oc(=O)n(Cc2ccccc2)c1O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Lisbon Curated by ChEMBL					Assay Description Inhibition of human neutrophil elastase using chromogenic substrate (N-MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide after 120 mins				Bioorg Med Chem Lett 22: 3993-7 (2012) Article DOI: 10.1016/j.bmcl.2012.04.093 BindingDB Entry DOI: 10.7270/Q2NZ88PG
University of Lisbon Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%