Affinity Data by PubMed id=22626654

PubMed code 22626654

Found 7 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tryptophan 2,3-dioxygenase (Homo sapiens (Human))	BDBM50289137 (6-Fluoro-3-((E)-2-pyridin-3-yl-vinyl)-1H-indole \| ...) Show SMILES Fc1ccc2c(\C=C\c3cccnc3)c[nH]c2c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur (FUNDP) Curated by ChEMBL					Assay Description Inhibition of liver TDO				Eur J Med Chem 54: 95-102 (2012) Article DOI: 10.1016/j.ejmech.2012.04.033 BindingDB Entry DOI: 10.7270/Q2XS5WFD
University of Namur (FUNDP) Curated by ChEMBL					More data for this Ligand-Target Pair
Tryptophan 2,3-dioxygenase (Homo sapiens (Human))	BDBM50350281 (CHEMBL1812527) Show SMILES Clc1cccc2c(\C=C\c3cccnc3)c[nH]c12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur (FUNDP) Curated by ChEMBL					Assay Description Competitive inhibition of human purified TDO by Henri-Michaelis-Menten equation analysis				Eur J Med Chem 54: 95-102 (2012) Article DOI: 10.1016/j.ejmech.2012.04.033 BindingDB Entry DOI: 10.7270/Q2XS5WFD
University of Namur (FUNDP) Curated by ChEMBL					More data for this Ligand-Target Pair
Tryptophan 2,3-dioxygenase (Homo sapiens (Human))	BDBM50289137 (6-Fluoro-3-((E)-2-pyridin-3-yl-vinyl)-1H-indole \| ...) Show SMILES Fc1ccc2c(\C=C\c3cccnc3)c[nH]c2c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur (FUNDP) Curated by ChEMBL					Assay Description Inhibition of human purified TDO assessed as formation of kynurenine from N-formylkynurenine preincubated for 10 mins measured after 5 to 20 mins by ...				Eur J Med Chem 54: 95-102 (2012) Article DOI: 10.1016/j.ejmech.2012.04.033 BindingDB Entry DOI: 10.7270/Q2XS5WFD
University of Namur (FUNDP) Curated by ChEMBL					More data for this Ligand-Target Pair
Tryptophan 2,3-dioxygenase (Homo sapiens (Human))	BDBM50350275 (CHEMBL1812520) Show SMILES Clc1ccc2c(\C=C\c3cccnc3)c[nH]c2c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur (FUNDP) Curated by ChEMBL					Assay Description Inhibition of human purified TDO assessed as formation of kynurenine from N-formylkynurenine preincubated for 10 mins measured after 5 to 20 mins by ...				Eur J Med Chem 54: 95-102 (2012) Article DOI: 10.1016/j.ejmech.2012.04.033 BindingDB Entry DOI: 10.7270/Q2XS5WFD
University of Namur (FUNDP) Curated by ChEMBL					More data for this Ligand-Target Pair
Tryptophan 2,3-dioxygenase (Homo sapiens (Human))	BDBM50350267 (CHEMBL1812512) Show SMILES Clc1ccc2[nH]cc(\C=C\c3cccnc3)c2c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur (FUNDP) Curated by ChEMBL					Assay Description Inhibition of human purified TDO assessed as formation of kynurenine from N-formylkynurenine preincubated for 10 mins measured after 5 to 20 mins by ...				Eur J Med Chem 54: 95-102 (2012) Article DOI: 10.1016/j.ejmech.2012.04.033 BindingDB Entry DOI: 10.7270/Q2XS5WFD
University of Namur (FUNDP) Curated by ChEMBL					More data for this Ligand-Target Pair
Tryptophan 2,3-dioxygenase (Homo sapiens (Human))	BDBM50350281 (CHEMBL1812527) Show SMILES Clc1cccc2c(\C=C\c3cccnc3)c[nH]c12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur (FUNDP) Curated by ChEMBL					Assay Description Inhibition of human purified TDO assessed as initial rate of L-Trp oxidation at 100 uM of substrate concentration				Eur J Med Chem 54: 95-102 (2012) Article DOI: 10.1016/j.ejmech.2012.04.033 BindingDB Entry DOI: 10.7270/Q2XS5WFD
University of Namur (FUNDP) Curated by ChEMBL					More data for this Ligand-Target Pair
Tryptophan 2,3-dioxygenase (Homo sapiens (Human))	BDBM50350281 (CHEMBL1812527) Show SMILES Clc1cccc2c(\C=C\c3cccnc3)c[nH]c12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur (FUNDP) Curated by ChEMBL					Assay Description Inhibition of human purified TDO assessed as formation of kynurenine from N-formylkynurenine preincubated for 10 mins measured after 5 to 20 mins by ...				Eur J Med Chem 54: 95-102 (2012) Article DOI: 10.1016/j.ejmech.2012.04.033 BindingDB Entry DOI: 10.7270/Q2XS5WFD
University of Namur (FUNDP) Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%