Found 18 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50390673
(CHEMBL2070198)Show SMILES Brc1cccc(Nc2ncnc3ccc(NCc4ccc5OCCCOc5c4)cc23)c1 Show InChI InChI=1S/C24H21BrN4O2/c25-17-3-1-4-19(12-17)29-24-20-13-18(6-7-21(20)27-15-28-24)26-14-16-5-8-22-23(11-16)31-10-2-9-30-22/h1,3-8,11-13,15,26H,2,9-10,14H2,(H,27,28,29) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 98 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University
Curated by ChEMBL
| Assay Description
Inhibition of EGFR in human A431 cell lysate using tyrosine/glutamic acid polymer as substrate by ELISA |
Bioorg Med Chem Lett 22: 5870-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.079
BindingDB Entry DOI: 10.7270/Q26T0NRG |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50390674
(CHEMBL2070199)Show SMILES Clc1cccc(Nc2ncnc3ccc(NCc4ccc5OCCCOc5c4)cc23)c1 Show InChI InChI=1S/C24H21ClN4O2/c25-17-3-1-4-19(12-17)29-24-20-13-18(6-7-21(20)27-15-28-24)26-14-16-5-8-22-23(11-16)31-10-2-9-30-22/h1,3-8,11-13,15,26H,2,9-10,14H2,(H,27,28,29) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 216 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University
Curated by ChEMBL
| Assay Description
Inhibition of EGFR in human A431 cell lysate using tyrosine/glutamic acid polymer as substrate by ELISA |
Bioorg Med Chem Lett 22: 5870-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.079
BindingDB Entry DOI: 10.7270/Q26T0NRG |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50390670
(CHEMBL2070191)Show SMILES Clc1cccc(Nc2ncnc3ccc(NCc4ccc5OCOc5c4)cc23)c1 Show InChI InChI=1S/C22H17ClN4O2/c23-15-2-1-3-17(9-15)27-22-18-10-16(5-6-19(18)25-12-26-22)24-11-14-4-7-20-21(8-14)29-13-28-20/h1-10,12,24H,11,13H2,(H,25,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 570 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University
Curated by ChEMBL
| Assay Description
Inhibition of EGFR in human A431 cell lysate using tyrosine/glutamic acid polymer as substrate by ELISA |
Bioorg Med Chem Lett 22: 5870-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.079
BindingDB Entry DOI: 10.7270/Q26T0NRG |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50390669
(CHEMBL2070197)Show SMILES Brc1cccc(Nc2ncnc3ccc(NCc4ccc5OCOc5c4)cc23)c1 Show InChI InChI=1S/C22H17BrN4O2/c23-15-2-1-3-17(9-15)27-22-18-10-16(5-6-19(18)25-12-26-22)24-11-14-4-7-20-21(8-14)29-13-28-20/h1-10,12,24H,11,13H2,(H,25,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University
Curated by ChEMBL
| Assay Description
Inhibition of EGFR in human A431 cell lysate using tyrosine/glutamic acid polymer as substrate by ELISA |
Bioorg Med Chem Lett 22: 5870-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.079
BindingDB Entry DOI: 10.7270/Q26T0NRG |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50390672
(CHEMBL2070193)Show SMILES Clc1cccc(Nc2ncnc3ccc(NCc4ccc5OCCOc5c4)cc23)c1 Show InChI InChI=1S/C23H19ClN4O2/c24-16-2-1-3-18(11-16)28-23-19-12-17(5-6-20(19)26-14-27-23)25-13-15-4-7-21-22(10-15)30-9-8-29-21/h1-7,10-12,14,25H,8-9,13H2,(H,26,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 790 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University
Curated by ChEMBL
| Assay Description
Inhibition of EGFR in human A431 cell lysate using tyrosine/glutamic acid polymer as substrate by ELISA |
Bioorg Med Chem Lett 22: 5870-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.079
BindingDB Entry DOI: 10.7270/Q26T0NRG |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50390676
(CHEMBL2070201)Show SMILES Clc1cccc(Nc2ncnc3ccc(NCc4ccc5OCCCCOc5c4)cc23)c1 Show InChI InChI=1S/C25H23ClN4O2/c26-18-4-3-5-20(13-18)30-25-21-14-19(7-8-22(21)28-16-29-25)27-15-17-6-9-23-24(12-17)32-11-2-1-10-31-23/h3-9,12-14,16,27H,1-2,10-11,15H2,(H,28,29,30) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 920 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University
Curated by ChEMBL
| Assay Description
Inhibition of EGFR in human A431 cell lysate using tyrosine/glutamic acid polymer as substrate by ELISA |
Bioorg Med Chem Lett 22: 5870-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.079
BindingDB Entry DOI: 10.7270/Q26T0NRG |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50390671
(CHEMBL2070192)Show SMILES Brc1cccc(Nc2ncnc3ccc(NCc4ccc5OCCOc5c4)cc23)c1 Show InChI InChI=1S/C23H19BrN4O2/c24-16-2-1-3-18(11-16)28-23-19-12-17(5-6-20(19)26-14-27-23)25-13-15-4-7-21-22(10-15)30-9-8-29-21/h1-7,10-12,14,25H,8-9,13H2,(H,26,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.02E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University
Curated by ChEMBL
| Assay Description
Inhibition of EGFR in human A431 cell lysate using tyrosine/glutamic acid polymer as substrate by ELISA |
Bioorg Med Chem Lett 22: 5870-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.079
BindingDB Entry DOI: 10.7270/Q26T0NRG |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50390675
(CHEMBL2070200)Show SMILES Brc1cccc(Nc2ncnc3ccc(NCc4ccc5OCCCCOc5c4)cc23)c1 Show InChI InChI=1S/C25H23BrN4O2/c26-18-4-3-5-20(13-18)30-25-21-14-19(7-8-22(21)28-16-29-25)27-15-17-6-9-23-24(12-17)32-11-2-1-10-31-23/h3-9,12-14,16,27H,1-2,10-11,15H2,(H,28,29,30) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.14E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University
Curated by ChEMBL
| Assay Description
Inhibition of EGFR in human A431 cell lysate using tyrosine/glutamic acid polymer as substrate by ELISA |
Bioorg Med Chem Lett 22: 5870-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.079
BindingDB Entry DOI: 10.7270/Q26T0NRG |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50390666
(CHEMBL2070194)Show SMILES Clc1cccc(Nc2ncnc3ccc(NC(=O)c4cccc5OCCOc45)cc23)c1 Show InChI InChI=1S/C23H17ClN4O3/c24-14-3-1-4-15(11-14)27-22-18-12-16(7-8-19(18)25-13-26-22)28-23(29)17-5-2-6-20-21(17)31-10-9-30-20/h1-8,11-13H,9-10H2,(H,28,29)(H,25,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.29E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University
Curated by ChEMBL
| Assay Description
Inhibition of EGFR in human A431 cell lysate using tyrosine/glutamic acid polymer as substrate by ELISA |
Bioorg Med Chem Lett 22: 5870-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.079
BindingDB Entry DOI: 10.7270/Q26T0NRG |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50390665
(CHEMBL2070190)Show SMILES Brc1cccc(Nc2ncnc3ccc(NC(=O)c4cccc5OCCOc45)cc23)c1 Show InChI InChI=1S/C23H17BrN4O3/c24-14-3-1-4-15(11-14)27-22-18-12-16(7-8-19(18)25-13-26-22)28-23(29)17-5-2-6-20-21(17)31-10-9-30-20/h1-8,11-13H,9-10H2,(H,28,29)(H,25,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.63E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University
Curated by ChEMBL
| Assay Description
Inhibition of EGFR in human A431 cell lysate using tyrosine/glutamic acid polymer as substrate by ELISA |
Bioorg Med Chem Lett 22: 5870-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.079
BindingDB Entry DOI: 10.7270/Q26T0NRG |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50390668
(CHEMBL2070196)Show SMILES Clc1cccc(Nc2ncnc3ccc(NC(=O)C4COc5ccccc5O4)cc23)c1 Show InChI InChI=1S/C23H17ClN4O3/c24-14-4-3-5-15(10-14)27-22-17-11-16(8-9-18(17)25-13-26-22)28-23(29)21-12-30-19-6-1-2-7-20(19)31-21/h1-11,13,21H,12H2,(H,28,29)(H,25,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University
Curated by ChEMBL
| Assay Description
Inhibition of EGFR in human A431 cell lysate using tyrosine/glutamic acid polymer as substrate by ELISA |
Bioorg Med Chem Lett 22: 5870-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.079
BindingDB Entry DOI: 10.7270/Q26T0NRG |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50390667
(CHEMBL2070195)Show SMILES Brc1cccc(Nc2ncnc3ccc(NC(=O)C4COc5ccccc5O4)cc23)c1 Show InChI InChI=1S/C23H17BrN4O3/c24-14-4-3-5-15(10-14)27-22-17-11-16(8-9-18(17)25-13-26-22)28-23(29)21-12-30-19-6-1-2-7-20(19)31-21/h1-11,13,21H,12H2,(H,28,29)(H,25,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.68E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University
Curated by ChEMBL
| Assay Description
Inhibition of EGFR in human A431 cell lysate using tyrosine/glutamic acid polymer as substrate by ELISA |
Bioorg Med Chem Lett 22: 5870-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.079
BindingDB Entry DOI: 10.7270/Q26T0NRG |
More data for this
Ligand-Target Pair | |
Receptor tyrosine-protein kinase erbB-2
(Homo sapiens (Human)) | BDBM50390673
(CHEMBL2070198)Show SMILES Brc1cccc(Nc2ncnc3ccc(NCc4ccc5OCCCOc5c4)cc23)c1 Show InChI InChI=1S/C24H21BrN4O2/c25-17-3-1-4-19(12-17)29-24-20-13-18(6-7-21(20)27-15-28-24)26-14-16-5-8-22-23(11-16)31-10-2-9-30-22/h1,3-8,11-13,15,26H,2,9-10,14H2,(H,27,28,29) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant HER2 expressed in baculovirus infected Sf9 cells using [32P]ATP incubated for 30 mins prior to ATP addition measured after ... |
Bioorg Med Chem Lett 22: 5870-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.079
BindingDB Entry DOI: 10.7270/Q26T0NRG |
More data for this
Ligand-Target Pair | |
Receptor tyrosine-protein kinase erbB-2
(Homo sapiens (Human)) | BDBM50390670
(CHEMBL2070191)Show SMILES Clc1cccc(Nc2ncnc3ccc(NCc4ccc5OCOc5c4)cc23)c1 Show InChI InChI=1S/C22H17ClN4O2/c23-15-2-1-3-17(9-15)27-22-18-10-16(5-6-19(18)25-12-26-22)24-11-14-4-7-20-21(8-14)29-13-28-20/h1-10,12,24H,11,13H2,(H,25,26,27) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant HER2 expressed in baculovirus infected Sf9 cells using [32P]ATP incubated for 30 mins prior to ATP addition measured after ... |
Bioorg Med Chem Lett 22: 5870-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.079
BindingDB Entry DOI: 10.7270/Q26T0NRG |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50390676
(CHEMBL2070201)Show SMILES Clc1cccc(Nc2ncnc3ccc(NCc4ccc5OCCCCOc5c4)cc23)c1 Show InChI InChI=1S/C25H23ClN4O2/c26-18-4-3-5-20(13-18)30-25-21-14-19(7-8-22(21)28-16-29-25)27-15-17-6-9-23-24(12-17)32-11-2-1-10-31-23/h3-9,12-14,16,27H,1-2,10-11,15H2,(H,28,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 using ATP incubated for 30 mins prior to ATP addition measured after 60 mins by fluorimetry |
Bioorg Med Chem Lett 22: 5870-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.079
BindingDB Entry DOI: 10.7270/Q26T0NRG |
More data for this
Ligand-Target Pair | |
Receptor tyrosine-protein kinase erbB-2
(Homo sapiens (Human)) | BDBM50390676
(CHEMBL2070201)Show SMILES Clc1cccc(Nc2ncnc3ccc(NCc4ccc5OCCCCOc5c4)cc23)c1 Show InChI InChI=1S/C25H23ClN4O2/c26-18-4-3-5-20(13-18)30-25-21-14-19(7-8-22(21)28-16-29-25)27-15-17-6-9-23-24(12-17)32-11-2-1-10-31-23/h3-9,12-14,16,27H,1-2,10-11,15H2,(H,28,29,30) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant HER2 expressed in baculovirus infected Sf9 cells using [32P]ATP incubated for 30 mins prior to ATP addition measured after ... |
Bioorg Med Chem Lett 22: 5870-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.079
BindingDB Entry DOI: 10.7270/Q26T0NRG |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50390673
(CHEMBL2070198)Show SMILES Brc1cccc(Nc2ncnc3ccc(NCc4ccc5OCCCOc5c4)cc23)c1 Show InChI InChI=1S/C24H21BrN4O2/c25-17-3-1-4-19(12-17)29-24-20-13-18(6-7-21(20)27-15-28-24)26-14-16-5-8-22-23(11-16)31-10-2-9-30-22/h1,3-8,11-13,15,26H,2,9-10,14H2,(H,27,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 using ATP incubated for 30 mins prior to ATP addition measured after 60 mins by fluorimetry |
Bioorg Med Chem Lett 22: 5870-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.079
BindingDB Entry DOI: 10.7270/Q26T0NRG |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50390670
(CHEMBL2070191)Show SMILES Clc1cccc(Nc2ncnc3ccc(NCc4ccc5OCOc5c4)cc23)c1 Show InChI InChI=1S/C22H17ClN4O2/c23-15-2-1-3-17(9-15)27-22-18-10-16(5-6-19(18)25-12-26-22)24-11-14-4-7-20-21(8-14)29-13-28-20/h1-10,12,24H,11,13H2,(H,25,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 using ATP incubated for 30 mins prior to ATP addition measured after 60 mins by fluorimetry |
Bioorg Med Chem Lett 22: 5870-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.079
BindingDB Entry DOI: 10.7270/Q26T0NRG |
More data for this
Ligand-Target Pair | |
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