BindingDB logo
myBDB logout

PubMed code 22913487

Compile data set for download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Methionine aminopeptidase 1


(Homo sapiens (Human))		BDBM50398199
PNG
(CHEMBL1738934)
Show SMILES CO[C@H]([C@H](O)[C@@H](O)[C@H](O)\C=C\C(C)(C)C)C(=O)NCC(N)=O |r|
Show InChI InChI=1S/C14H26N2O6/c1-14(2,3)6-5-8(17)10(19)11(20)12(22-4)13(21)16-7-9(15)18/h5-6,8,10-12,17,19-20H,7H2,1-4H3,(H2,15,18)(H,16,21)/b6-5+/t8-,10+,11-,12-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
n/an/a 3.59E+3n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mn(II) form of human methionine aminopeptidase1 expressed in Escherichia coli at 100 mM

J Med Chem 55: 8021-7 (2012)


Article DOI: 10.1021/jm3008695
BindingDB Entry DOI: 10.7270/Q2T43V72
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Methionine aminopeptidase 1


(Homo sapiens (Human))		BDBM50398196
PNG
(CHEMBL2181034)
Show SMILES CO[C@H]([C@H](O)[C@@H](O)[C@H](O)\C=C\C(C)(C)C)C(=O)NCCC(c1ccco1)c1ccccc1 |r|
Show InChI InChI=1S/C25H35NO6/c1-25(2,3)14-12-19(27)21(28)22(29)23(31-4)24(30)26-15-13-18(20-11-8-16-32-20)17-9-6-5-7-10-17/h5-12,14,16,18-19,21-23,27-29H,13,15H2,1-4H3,(H,26,30)/b14-12+/t18?,19-,21+,22-,23-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.14E+3n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mn(II) form of human methionine aminopeptidase1 expressed in Escherichia coli at 100 mM

J Med Chem 55: 8021-7 (2012)


Article DOI: 10.1021/jm3008695
BindingDB Entry DOI: 10.7270/Q2T43V72
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Homo sapiens (Human))		BDBM50398197
PNG
(CHEMBL1738933)
Show SMILES CO[C@H]([C@H](O)[C@@H](O)[C@H](O)\C=C\C(C)(C)C)C(=O)NC1Cc2ccccc2C1 |r|
Show InChI InChI=1S/C21H31NO5/c1-21(2,3)10-9-16(23)17(24)18(25)19(27-4)20(26)22-15-11-13-7-5-6-8-14(13)12-15/h5-10,15-19,23-25H,11-12H2,1-4H3,(H,22,26)/b10-9+/t16-,17+,18-,19-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
n/an/a 5.58E+3n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mn(II) form of human methionine aminopeptidase1 expressed in Escherichia coli at 100 mM

J Med Chem 55: 8021-7 (2012)


Article DOI: 10.1021/jm3008695
BindingDB Entry DOI: 10.7270/Q2T43V72
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Methionine aminopeptidase 1


(Homo sapiens (Human))		BDBM50398198
PNG
(CHEMBL2181035)
Show SMILES CO[C@H]([C@H](O)[C@@H](O)[C@H](O)\C=C\C(C)(C)C)C(=O)NCC1CCCN(C1)C(=O)C1CC1 |r|
Show InChI InChI=1S/C22H38N2O6/c1-22(2,3)10-9-16(25)17(26)18(27)19(30-4)20(28)23-12-14-6-5-11-24(13-14)21(29)15-7-8-15/h9-10,14-19,25-27H,5-8,11-13H2,1-4H3,(H,23,28)/b10-9+/t14?,16-,17+,18-,19-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.45E+3n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mn(II) form of human methionine aminopeptidase1 expressed in Escherichia coli at 100 mM

J Med Chem 55: 8021-7 (2012)


Article DOI: 10.1021/jm3008695
BindingDB Entry DOI: 10.7270/Q2T43V72
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%