Affinity Data by PubMed id=22932316

PubMed code 22932316

Found 8 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histone deacetylase 1 (Homo sapiens (Human))	BDBM19130 ((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Inhibition of HDAC1 by fluorometric assay				Bioorg Med Chem Lett 22: 6200-4 (2012) Article DOI: 10.1016/j.bmcl.2012.08.006 BindingDB Entry DOI: 10.7270/Q2BG2Q8K
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM19149 (CHEMBL98 \| N-hydroxy-N'-phenyloctanediamide \| SAHA...) Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Inhibition of HDAC1 by fluorometric assay				Bioorg Med Chem Lett 22: 6200-4 (2012) Article DOI: 10.1016/j.bmcl.2012.08.006 BindingDB Entry DOI: 10.7270/Q2BG2Q8K
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50421333 (CHEMBL2088206) Show SMILES CN(C)c1ccc(CC(=O)NCCC(=O)NO)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Inhibition of HDAC1 by fluorometric assay				Bioorg Med Chem Lett 22: 6200-4 (2012) Article DOI: 10.1016/j.bmcl.2012.08.006 BindingDB Entry DOI: 10.7270/Q2BG2Q8K
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50421332 (CHEMBL2088207) Show SMILES ONC(=O)CCNC(=O)Cc1ccc(cc1)[N+]([O-])=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.94E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Inhibition of HDAC1 by fluorometric assay				Bioorg Med Chem Lett 22: 6200-4 (2012) Article DOI: 10.1016/j.bmcl.2012.08.006 BindingDB Entry DOI: 10.7270/Q2BG2Q8K
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50421331 (CHEMBL2088208) Show SMILES ONC(=O)CCNC(=O)\C=C\c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Inhibition of HDAC1 by fluorometric assay				Bioorg Med Chem Lett 22: 6200-4 (2012) Article DOI: 10.1016/j.bmcl.2012.08.006 BindingDB Entry DOI: 10.7270/Q2BG2Q8K
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50421334 (CHEMBL2088205) Show SMILES Cc1ccc(CCC(=O)NCCC(=O)NO)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Inhibition of HDAC1 by fluorometric assay				Bioorg Med Chem Lett 22: 6200-4 (2012) Article DOI: 10.1016/j.bmcl.2012.08.006 BindingDB Entry DOI: 10.7270/Q2BG2Q8K
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50421335 (CHEMBL2088204) Show SMILES Cc1ccc(OCC(=O)NCCC(=O)NO)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Inhibition of HDAC1 by fluorometric assay				Bioorg Med Chem Lett 22: 6200-4 (2012) Article DOI: 10.1016/j.bmcl.2012.08.006 BindingDB Entry DOI: 10.7270/Q2BG2Q8K
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50421336 (CHEMBL2088203) Show SMILES CN(C)c1ccc(\C=C\C(=O)NCCC(=O)NO)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>2.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Inhibition of HDAC1 by fluorometric assay				Bioorg Med Chem Lett 22: 6200-4 (2012) Article DOI: 10.1016/j.bmcl.2012.08.006 BindingDB Entry DOI: 10.7270/Q2BG2Q8K
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%