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PubMed code 23041456

Compile data set for download or QSAR
Found 10 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50391732
PNG
(CHEMBL2147257)
Show SMILES CNC(=O)[C@@H](Cc1c[nH]c2cc(Cl)ccc12)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(cc1)C(=O)P(O)(O)O)NC(=O)[C@H]1CCCC[C@@H]1C(O)=O |r|
Show InChI InChI=1S/C44H52ClN6O13P/c1-46-39(55)36(21-27-23-47-33-22-28(45)15-16-29(27)33)51-40(56)32(17-18-37(52)53)48-41(57)35(19-24-7-3-2-4-8-24)50-42(58)34(49-38(54)30-9-5-6-10-31(30)43(59)60)20-25-11-13-26(14-12-25)44(61)65(62,63)64/h2-4,7-8,11-16,22-23,30-32,34-36,47,62-65H,5-6,9-10,17-21H2,1H3,(H,46,55)(H,48,57)(H,49,54)(H,50,58)(H,51,56)(H,52,53)(H,59,60)/t30-,31-,32-,34-,35-,36+/m0/s1
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n/an/a 2.50E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of pre-activated human GST-His6-tagged IGF-1R expressed in Sf9 cells using Ac-EAEDEPEGDYFEWLE-NHMe as substrate after 25 mins by luminesce...

Eur J Med Chem 57: 1-9 (2012)


Article DOI: 10.1016/j.ejmech.2012.08.038
BindingDB Entry DOI: 10.7270/Q24J0G6V
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50391735
PNG
(CHEMBL2147260)
Show SMILES CNC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(cc1)C(=O)P(O)(O)O)NC(=O)[C@H]1CCCC[C@@H]1C(O)=O |r|
Show InChI InChI=1S/C42H51ClN5O13P/c1-44-37(52)32(22-26-13-17-28(43)18-14-26)47-38(53)31(19-20-35(49)50)45-39(54)34(21-24-7-3-2-4-8-24)48-40(55)33(46-36(51)29-9-5-6-10-30(29)41(56)57)23-25-11-15-27(16-12-25)42(58)62(59,60)61/h2-4,7-8,11-18,29-34,59-62H,5-6,9-10,19-23H2,1H3,(H,44,52)(H,45,54)(H,46,51)(H,47,53)(H,48,55)(H,49,50)(H,56,57)/t29-,30-,31-,32-,33-,34-/m0/s1
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n/an/a 1.40E+4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of pre-activated human GST-His6-tagged IGF-1R expressed in Sf9 cells using Ac-EAEDEPEGDYFEWLE-NHMe as substrate after 25 mins by luminesce...

Eur J Med Chem 57: 1-9 (2012)


Article DOI: 10.1016/j.ejmech.2012.08.038
BindingDB Entry DOI: 10.7270/Q24J0G6V
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50391731
PNG
(CHEMBL2147368)
Show SMILES CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(cc1)C(=O)P(O)(O)O)NC(=O)[C@H](CC(O)=O)NC(C)=O |r|
Show InChI InChI=1S/C42H50N7O14P/c1-23(50)45-34(21-36(53)54)41(59)48-32(19-25-12-14-26(15-13-25)42(60)64(61,62)63)40(58)47-31(18-24-8-4-3-5-9-24)39(57)46-30(16-17-35(51)52)38(56)49-33(37(55)43-2)20-27-22-44-29-11-7-6-10-28(27)29/h3-15,22,30-34,44,61-64H,16-21H2,1-2H3,(H,43,55)(H,45,50)(H,46,57)(H,47,58)(H,48,59)(H,49,56)(H,51,52)(H,53,54)/t30-,31-,32-,33-,34-/m0/s1
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n/an/a 1.56E+4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of pre-activated human GST-His6-tagged IGF-1R expressed in Sf9 cells using Ac-EAEDEPEGDYFEWLE-NHMe as substrate after 25 mins by luminesce...

Eur J Med Chem 57: 1-9 (2012)


Article DOI: 10.1016/j.ejmech.2012.08.038
BindingDB Entry DOI: 10.7270/Q24J0G6V
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50391733
PNG
(CHEMBL2147258)
Show SMILES CNC(=O)[C@H](Cc1c[nH]c2cc(Cl)ccc12)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(cc1)C(=O)P(O)(O)O)NC(=O)[C@H](CCC(O)=O)NC(C)=O |r|
Show InChI InChI=1S/C43H51ClN7O14P/c1-23(52)47-30(14-16-36(53)54)39(58)49-34(19-25-8-10-26(11-9-25)43(62)66(63,64)65)42(61)50-33(18-24-6-4-3-5-7-24)41(60)48-31(15-17-37(55)56)40(59)51-35(38(57)45-2)20-27-22-46-32-21-28(44)12-13-29(27)32/h3-13,21-22,30-31,33-35,46,63-66H,14-20H2,1-2H3,(H,45,57)(H,47,52)(H,48,60)(H,49,58)(H,50,61)(H,51,59)(H,53,54)(H,55,56)/t30-,31-,33-,34-,35-/m0/s1
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n/an/a 2.16E+4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of pre-activated human GST-His6-tagged IGF-1R expressed in Sf9 cells using Ac-EAEDEPEGDYFEWLE-NHMe as substrate after 25 mins by luminesce...

Eur J Med Chem 57: 1-9 (2012)


Article DOI: 10.1016/j.ejmech.2012.08.038
BindingDB Entry DOI: 10.7270/Q24J0G6V
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50391738
PNG
(CHEMBL2147365)
Show SMILES CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(cc1)C(=O)P(O)(O)O)NC(=O)[C@H]1CCCC[C@@H]1C(O)=O |r|
Show InChI InChI=1S/C44H53N6O13P/c1-45-39(54)36(23-28-24-46-32-14-8-7-11-29(28)32)50-40(55)33(19-20-37(51)52)47-41(56)35(21-25-9-3-2-4-10-25)49-42(57)34(48-38(53)30-12-5-6-13-31(30)43(58)59)22-26-15-17-27(18-16-26)44(60)64(61,62)63/h2-4,7-11,14-18,24,30-31,33-36,46,61-64H,5-6,12-13,19-23H2,1H3,(H,45,54)(H,47,56)(H,48,53)(H,49,57)(H,50,55)(H,51,52)(H,58,59)/t30-,31-,33-,34-,35-,36+/m0/s1
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n/an/a 2.28E+4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of pre-activated human GST-His6-tagged IGF-1R expressed in Sf9 cells using Ac-EAEDEPEGDYFEWLE-NHMe as substrate after 25 mins by luminesce...

Eur J Med Chem 57: 1-9 (2012)


Article DOI: 10.1016/j.ejmech.2012.08.038
BindingDB Entry DOI: 10.7270/Q24J0G6V
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50391736
PNG
(CHEMBL2147261)
Show SMILES CNC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(cc1)C(=O)P(O)(O)O)NC(=O)[C@H](CCC(O)=O)NC(C)=O |r|
Show InChI InChI=1S/C41H50ClN6O14P/c1-23(49)44-29(16-18-34(50)51)37(55)47-33(22-25-8-12-27(13-9-25)41(59)63(60,61)62)40(58)48-32(20-24-6-4-3-5-7-24)39(57)45-30(17-19-35(52)53)38(56)46-31(36(54)43-2)21-26-10-14-28(42)15-11-26/h3-15,29-33,60-63H,16-22H2,1-2H3,(H,43,54)(H,44,49)(H,45,57)(H,46,56)(H,47,55)(H,48,58)(H,50,51)(H,52,53)/t29-,30-,31-,32-,33-/m0/s1
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n/an/a 4.05E+4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of pre-activated human GST-His6-tagged IGF-1R expressed in Sf9 cells using Ac-EAEDEPEGDYFEWLE-NHMe as substrate after 25 mins by luminesce...

Eur J Med Chem 57: 1-9 (2012)


Article DOI: 10.1016/j.ejmech.2012.08.038
BindingDB Entry DOI: 10.7270/Q24J0G6V
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50391739
PNG
(CHEMBL2147366)
Show SMILES CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(cc1)C(=O)P(O)(O)O)NC(=O)[C@H](CCC(O)=O)NC(C)=O |r|
Show InChI InChI=1S/C43H52N7O14P/c1-24(51)46-31(16-18-36(52)53)39(57)48-34(21-26-12-14-27(15-13-26)43(61)65(62,63)64)42(60)49-33(20-25-8-4-3-5-9-25)41(59)47-32(17-19-37(54)55)40(58)50-35(38(56)44-2)22-28-23-45-30-11-7-6-10-29(28)30/h3-15,23,31-35,45,62-65H,16-22H2,1-2H3,(H,44,56)(H,46,51)(H,47,59)(H,48,57)(H,49,60)(H,50,58)(H,52,53)(H,54,55)/t31-,32-,33-,34-,35+/m0/s1
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n/an/a 5.13E+4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of pre-activated human GST-His6-tagged IGF-1R expressed in Sf9 cells using Ac-EAEDEPEGDYFEWLE-NHMe as substrate after 25 mins by luminesce...

Eur J Med Chem 57: 1-9 (2012)


Article DOI: 10.1016/j.ejmech.2012.08.038
BindingDB Entry DOI: 10.7270/Q24J0G6V
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50391740
PNG
(CHEMBL2147367)
Show SMILES CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(cc1)C(=O)P(O)(O)O)NC(=O)[C@H](Cc1cccnc1)NC(C)=O |r|
Show InChI InChI=1S/C46H53N8O12P/c1-27(55)50-36(23-30-11-8-20-48-25-30)43(60)52-38(22-29-14-16-31(17-15-29)46(63)67(64,65)66)45(62)53-37(21-28-9-4-3-5-10-28)44(61)51-35(18-19-40(56)57)42(59)54-39(41(58)47-2)24-32-26-49-34-13-7-6-12-33(32)34/h3-17,20,25-26,35-39,49,64-67H,18-19,21-24H2,1-2H3,(H,47,58)(H,50,55)(H,51,61)(H,52,60)(H,53,62)(H,54,59)(H,56,57)/t35-,36-,37-,38-,39+/m0/s1
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n/an/a 7.82E+4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of pre-activated human GST-His6-tagged IGF-1R expressed in Sf9 cells using Ac-EAEDEPEGDYFEWLE-NHMe as substrate after 25 mins by luminesce...

Eur J Med Chem 57: 1-9 (2012)


Article DOI: 10.1016/j.ejmech.2012.08.038
BindingDB Entry DOI: 10.7270/Q24J0G6V
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50391734
PNG
(CHEMBL2147259)
Show SMILES CNC(=O)[C@H](Cc1c[nH]c2cc(Cl)ccc12)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(cc1)C(=O)P(O)(O)O)NC(=O)[C@H](Cc1cccnc1)NC(C)=O |r|
Show InChI InChI=1S/C46H52ClN8O12P/c1-26(56)51-36(21-29-9-6-18-49-24-29)43(61)53-38(20-28-10-12-30(13-11-28)46(64)68(65,66)67)45(63)54-37(19-27-7-4-3-5-8-27)44(62)52-34(16-17-40(57)58)42(60)55-39(41(59)48-2)22-31-25-50-35-23-32(47)14-15-33(31)35/h3-15,18,23-25,34,36-39,50,65-68H,16-17,19-22H2,1-2H3,(H,48,59)(H,51,56)(H,52,62)(H,53,61)(H,54,63)(H,55,60)(H,57,58)/t34-,36-,37-,38-,39-/m0/s1
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n/an/a 9.40E+4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of pre-activated human GST-His6-tagged IGF-1R expressed in Sf9 cells using Ac-EAEDEPEGDYFEWLE-NHMe as substrate after 25 mins by luminesce...

Eur J Med Chem 57: 1-9 (2012)


Article DOI: 10.1016/j.ejmech.2012.08.038
BindingDB Entry DOI: 10.7270/Q24J0G6V
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50391737
PNG
(CHEMBL2147262)
Show SMILES CNC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(cc1)C(=O)P(O)(O)O)NC(=O)[C@H](Cc1cccnc1)NC(C)=O |r|
Show InChI InChI=1S/C44H51ClN7O12P/c1-26(53)48-35(24-30-9-6-20-47-25-30)41(58)51-37(23-28-10-14-31(15-11-28)44(61)65(62,63)64)43(60)52-36(21-27-7-4-3-5-8-27)42(59)49-33(18-19-38(54)55)40(57)50-34(39(56)46-2)22-29-12-16-32(45)17-13-29/h3-17,20,25,33-37,62-65H,18-19,21-24H2,1-2H3,(H,46,56)(H,48,53)(H,49,59)(H,50,57)(H,51,58)(H,52,60)(H,54,55)/t33-,34-,35-,36-,37-/m0/s1
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n/an/a 4.89E+5n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of pre-activated human GST-His6-tagged IGF-1R expressed in Sf9 cells using Ac-EAEDEPEGDYFEWLE-NHMe as substrate after 25 mins by luminesce...

Eur J Med Chem 57: 1-9 (2012)


Article DOI: 10.1016/j.ejmech.2012.08.038
BindingDB Entry DOI: 10.7270/Q24J0G6V
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%