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PubMed code 2308147

Compile data set for download or QSAR
Found 54 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015081
PNG
(2-(2-Amino-3-hydroxy-propionylamino)-N1-{1-[1-benz...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccccc1)\C=C\C(CCCc1ccccc1)CCCc1ccccc1
Show InChI InChI=1S/C41H55N5O5/c1-29(2)38(46-40(50)36(27-37(43)48)45-39(49)35(42)28-47)41(51)44-34(26-33-18-10-5-11-19-33)25-24-32(22-12-20-30-14-6-3-7-15-30)23-13-21-31-16-8-4-9-17-31/h3-11,14-19,24-25,29,32,34-36,38,47H,12-13,20-23,26-28,42H2,1-2H3,(H2,43,48)(H,44,51)(H,45,49)(H,46,50)/b25-24+/t34-,35+,36+,38+/m1/s1
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n/an/a 600n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of calmodulin-independent form of myosin light chain kinase isolated from chicken gizzard.

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015070
PNG
(CHEMBL426400 | benzyl 2-[1-{1-[1-(1-amino-2-hydrox...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccc(O)c(I)c1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C31H41IN6O9/c1-16(2)26(38-29(44)23(13-25(34)41)36-27(42)21(33)14-39)30(45)37-22(12-19-9-10-24(40)20(32)11-19)28(43)35-17(3)31(46)47-15-18-7-5-4-6-8-18/h4-11,16-17,21-23,26,39-40H,12-15,33H2,1-3H3,(H2,34,41)(H,35,43)(H,36,42)(H,37,45)(H,38,44)/t17-,21-,22-,23-,26-/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of chicken MLCK (myosin light chain kinase)

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015076
PNG
(CHEMBL367251 | benzyl 2-[1-{1-[1-(1-amino-2-hydrox...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C37H46N6O8/c1-22(2)32(43-35(48)30(19-31(39)45)41-33(46)28(38)20-44)36(49)42-29(18-24-14-16-27(17-15-24)26-12-8-5-9-13-26)34(47)40-23(3)37(50)51-21-25-10-6-4-7-11-25/h4-17,22-23,28-30,32,44H,18-21,38H2,1-3H3,(H2,39,45)(H,40,47)(H,41,46)(H,42,49)(H,43,48)/t23-,28-,29-,30-,32-/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of chicken MLCK (myosin light chain kinase)

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015045
PNG
(CHEMBL172826 | benzyl 2-[1-{1-[1-(1-amino-2-hydrox...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C35H44N6O8/c1-20(2)30(41-33(46)28(17-29(37)43)39-31(44)26(36)18-42)34(47)40-27(16-24-14-9-13-23-12-7-8-15-25(23)24)32(45)38-21(3)35(48)49-19-22-10-5-4-6-11-22/h4-15,20-21,26-28,30,42H,16-19,36H2,1-3H3,(H2,37,43)(H,38,45)(H,39,44)(H,40,47)(H,41,46)/t21-,26-,27-,28-,30-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of chicken MLCK (myosin light chain kinase)

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015045
PNG
(CHEMBL172826 | benzyl 2-[1-{1-[1-(1-amino-2-hydrox...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C35H44N6O8/c1-20(2)30(41-33(46)28(17-29(37)43)39-31(44)26(36)18-42)34(47)40-27(16-24-14-9-13-23-12-7-8-15-25(23)24)32(45)38-21(3)35(48)49-19-22-10-5-4-6-11-22/h4-15,20-21,26-28,30,42H,16-19,36H2,1-3H3,(H2,37,43)(H,38,45)(H,39,44)(H,40,47)(H,41,46)/t21-,26-,27-,28-,30-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of calmodulin-independent form of myosin light chain kinase isolated from chicken gizzard.

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015040
PNG
(CHEMBL172539 | benzyl 2-(1-{1-[1-(1-amino-2-hydrox...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C32H44N6O8/c1-19(2)14-24(37-31(44)26(16-27(34)40)36-28(41)23(33)17-39)30(43)38-25(15-21-10-6-4-7-11-21)29(42)35-20(3)32(45)46-18-22-12-8-5-9-13-22/h4-13,19-20,23-26,39H,14-18,33H2,1-3H3,(H2,34,40)(H,35,42)(H,36,41)(H,37,44)(H,38,43)/t20-,23-,24-,25-,26-/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of chicken MLCK (myosin light chain kinase)

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015046
PNG
(2-(2-Amino-3-hydroxy-propionylamino)-N1-[1-(1-benz...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccccc1)\C=C\C=C\c1ccccc1
Show InChI InChI=1S/C30H39N5O5/c1-20(2)27(35-29(39)25(18-26(32)37)34-28(38)24(31)19-36)30(40)33-23(17-22-14-7-4-8-15-22)16-10-9-13-21-11-5-3-6-12-21/h3-16,20,23-25,27,36H,17-19,31H2,1-2H3,(H2,32,37)(H,33,40)(H,34,38)(H,35,39)/b13-9+,16-10+/t23-,24+,25+,27+/m1/s1
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n/an/a 3.90E+3n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of calmodulin-independent form of myosin light chain kinase isolated from chicken gizzard.

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015050
PNG
(CHEMBL175384 | benzyl 2-(1-{1-[1-(1-amino-2-hydrox...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](N)CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C31H42N6O8/c1-18(2)26(37-29(42)24(15-25(33)39)35-27(40)22(32)16-38)30(43)36-23(14-20-10-6-4-7-11-20)28(41)34-19(3)31(44)45-17-21-12-8-5-9-13-21/h4-13,18-19,22-24,26,38H,14-17,32H2,1-3H3,(H2,33,39)(H,34,41)(H,35,40)(H,36,43)(H,37,42)/t19-,22+,23-,24-,26-/m0/s1
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n/an/a 5.00E+3n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of calmodulin-independent form of myosin light chain kinase isolated from chicken gizzard.

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015076
PNG
(CHEMBL367251 | benzyl 2-[1-{1-[1-(1-amino-2-hydrox...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C37H46N6O8/c1-22(2)32(43-35(48)30(19-31(39)45)41-33(46)28(38)20-44)36(49)42-29(18-24-14-16-27(17-15-24)26-12-8-5-9-13-26)34(47)40-23(3)37(50)51-21-25-10-6-4-7-11-25/h4-17,22-23,28-30,32,44H,18-21,38H2,1-3H3,(H2,39,45)(H,40,47)(H,41,46)(H,42,49)(H,43,48)/t23-,28-,29-,30-,32-/m0/s1
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n/an/a 5.00E+3n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of calmodulin-independent form of MLCK(myosin light chain kinase) from chicken gizzard

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015075
PNG
(CHEMBL172020 | benzyl 2-[1-{1-[1-(1-amino-2-hydrox...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C33H43N7O8/c1-18(2)28(40-31(45)26(14-27(35)42)38-29(43)23(34)16-41)32(46)39-25(13-21-15-36-24-12-8-7-11-22(21)24)30(44)37-19(3)33(47)48-17-20-9-5-4-6-10-20/h4-12,15,18-19,23,25-26,28,36,41H,13-14,16-17,34H2,1-3H3,(H2,35,42)(H,37,44)(H,38,43)(H,39,46)(H,40,45)/t19-,23-,25-,26-,28-/m0/s1
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n/an/a 6.00E+3n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of chicken MLCK (myosin light chain kinase)

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015048
PNG
(CHEMBL171961 | benzyl 2-(1-{1-[1-(1-amino-2-hydrox...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C37H46N6O8/c1-22(2)31(42-34(47)28(19-29(39)45)41-33(46)27(38)20-44)35(48)43-32(30(25-15-9-5-10-16-25)26-17-11-6-12-18-26)36(49)40-23(3)37(50)51-21-24-13-7-4-8-14-24/h4-18,22-23,27-28,30-32,44H,19-21,38H2,1-3H3,(H2,39,45)(H,40,49)(H,41,46)(H,42,47)(H,43,48)/t23-,27-,28-,31-,32-/m0/s1
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n/an/a 6.00E+3n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of chicken MLCK (myosin light chain kinase)

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015063
PNG
(CHEMBL172710 | benzyl 2-[1-{1-[1-(1-amino-2-hydrox...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1cc(I)c(O)c(I)c1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C31H40I2N6O9/c1-15(2)25(39-29(45)23(12-24(35)41)37-27(43)21(34)13-40)30(46)38-22(11-18-9-19(32)26(42)20(33)10-18)28(44)36-16(3)31(47)48-14-17-7-5-4-6-8-17/h4-10,15-16,21-23,25,40,42H,11-14,34H2,1-3H3,(H2,35,41)(H,36,44)(H,37,43)(H,38,46)(H,39,45)/t16-,21-,22-,23-,25-/m0/s1
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n/an/a 7.00E+3n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of chicken MLCK (myosin light chain kinase)

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015059
PNG
(CHEMBL426224 | benzyl 2-(1-{1-[1-(1-amino-2-sulfan...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C31H42N6O7S/c1-18(2)26(37-29(41)24(15-25(33)38)35-27(39)22(32)17-45)30(42)36-23(14-20-10-6-4-7-11-20)28(40)34-19(3)31(43)44-16-21-12-8-5-9-13-21/h4-13,18-19,22-24,26,45H,14-17,32H2,1-3H3,(H2,33,38)(H,34,40)(H,35,39)(H,36,42)(H,37,41)/t19-,22-,23-,24-,26-/m0/s1
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n/an/a 8.00E+3n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of chicken MLCK (myosin light chain kinase)

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015061
PNG
(2-(2-Amino-3-hydroxy-propionylamino)-N1-[1-(1-benz...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@H](CCCCc1ccccc1)Cc1ccccc1
Show InChI InChI=1S/C30H43N5O5/c1-20(2)27(35-29(39)25(18-26(32)37)34-28(38)24(31)19-36)30(40)33-23(17-22-14-7-4-8-15-22)16-10-9-13-21-11-5-3-6-12-21/h3-8,11-12,14-15,20,23-25,27,36H,9-10,13,16-19,31H2,1-2H3,(H2,32,37)(H,33,40)(H,34,38)(H,35,39)/t23-,24+,25+,27+/m1/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of calmodulin-independent form of myosin light chain kinase isolated from chicken gizzard.

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015084
PNG
(CHEMBL369018 | benzyl 2-(1-{1-[1-(1-amino-2-hydrox...)
Show SMILES CC(C)[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](N)CO)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C31H42N6O8/c1-18(2)26(37-29(42)24(15-25(33)39)35-27(40)22(32)16-38)30(43)36-23(14-20-10-6-4-7-11-20)28(41)34-19(3)31(44)45-17-21-12-8-5-9-13-21/h4-13,18-19,22-24,26,38H,14-17,32H2,1-3H3,(H2,33,39)(H,34,41)(H,35,40)(H,36,43)(H,37,42)/t19-,22-,23-,24-,26-/m1/s1
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Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of chicken MLCK (myosin light chain kinase)

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015058
PNG
(CHEMBL173179 | Ser-Asn-Val-Cha-Ala-OBzl)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC1CCCCC1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C31H48N6O8/c1-18(2)26(37-29(42)24(15-25(33)39)35-27(40)22(32)16-38)30(43)36-23(14-20-10-6-4-7-11-20)28(41)34-19(3)31(44)45-17-21-12-8-5-9-13-21/h5,8-9,12-13,18-20,22-24,26,38H,4,6-7,10-11,14-17,32H2,1-3H3,(H2,33,39)(H,34,41)(H,35,40)(H,36,43)(H,37,42)/t19-,22-,23-,24-,26-/m0/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of chicken MLCK (myosin light chain kinase)

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015071
PNG
(CHEMBL424374 | benzyl 2-[1-{1-[1-(1-amino-2-hydrox...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C35H44N6O8/c1-20(2)30(41-33(46)28(17-29(37)43)39-31(44)26(36)18-42)34(47)40-27(16-23-13-14-24-11-7-8-12-25(24)15-23)32(45)38-21(3)35(48)49-19-22-9-5-4-6-10-22/h4-15,20-21,26-28,30,42H,16-19,36H2,1-3H3,(H2,37,43)(H,38,45)(H,39,44)(H,40,47)(H,41,46)/t21-,26-,27-,28-,30-/m0/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of chicken MLCK (myosin light chain kinase)

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015050
PNG
(CHEMBL175384 | benzyl 2-(1-{1-[1-(1-amino-2-hydrox...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](N)CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C31H42N6O8/c1-18(2)26(37-29(42)24(15-25(33)39)35-27(40)22(32)16-38)30(43)36-23(14-20-10-6-4-7-11-20)28(41)34-19(3)31(44)45-17-21-12-8-5-9-13-21/h4-13,18-19,22-24,26,38H,14-17,32H2,1-3H3,(H2,33,39)(H,34,41)(H,35,40)(H,36,43)(H,37,42)/t19-,22+,23-,24-,26-/m0/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of calmodulin-independent form of myosin light chain kinase isolated from chicken gizzard.

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015064
PNG
(CHEMBL367267 | Ser-Asn-Val-Phe-Ala-NH-Bzl)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)NCc1ccccc1
Show InChI InChI=1S/C31H43N7O7/c1-18(2)26(38-30(44)24(15-25(33)40)36-28(42)22(32)17-39)31(45)37-23(14-20-10-6-4-7-11-20)29(43)35-19(3)27(41)34-16-21-12-8-5-9-13-21/h4-13,18-19,22-24,26,39H,14-17,32H2,1-3H3,(H2,33,40)(H,34,41)(H,35,43)(H,36,42)(H,37,45)(H,38,44)/t19-,22-,23-,24-,26-/m0/s1
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n/an/a 1.50E+4n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of chicken MLCK (myosin light chain kinase)

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015047
PNG
(CHEMBL173685 | Thr-Ser-Asn-Val-Phe-Ala-OBzl)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C35H49N7O10/c1-19(2)29(42-31(47)25(16-27(36)45)39-32(48)26(17-43)41-33(49)28(37)21(4)44)34(50)40-24(15-22-11-7-5-8-12-22)30(46)38-20(3)35(51)52-18-23-13-9-6-10-14-23/h5-14,19-21,24-26,28-29,43-44H,15-18,37H2,1-4H3,(H2,36,45)(H,38,46)(H,39,48)(H,40,50)(H,41,49)(H,42,47)/t20-,21+,24-,25-,26-,28-,29-/m0/s1
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n/an/a 1.50E+4n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of chicken MLCK (myosin light chain kinase)

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015041
PNG
(CHEMBL173144 | phenethyl 2-(1-{1-[1-(1-amino-2-hyd...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)OCCc1ccccc1
Show InChI InChI=1S/C32H44N6O8/c1-19(2)27(38-30(43)25(17-26(34)40)36-28(41)23(33)18-39)31(44)37-24(16-22-12-8-5-9-13-22)29(42)35-20(3)32(45)46-15-14-21-10-6-4-7-11-21/h4-13,19-20,23-25,27,39H,14-18,33H2,1-3H3,(H2,34,40)(H,35,42)(H,36,41)(H,37,44)(H,38,43)/t20-,23-,24-,25-,27-/m0/s1
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n/an/a 1.50E+4n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of chicken MLCK (myosin light chain kinase)

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015064
PNG
(CHEMBL367267 | Ser-Asn-Val-Phe-Ala-NH-Bzl)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)NCc1ccccc1
Show InChI InChI=1S/C31H43N7O7/c1-18(2)26(38-30(44)24(15-25(33)40)36-28(42)22(32)17-39)31(45)37-23(14-20-10-6-4-7-11-20)29(43)35-19(3)27(41)34-16-21-12-8-5-9-13-21/h4-13,18-19,22-24,26,39H,14-17,32H2,1-3H3,(H2,33,40)(H,34,41)(H,35,43)(H,36,42)(H,37,45)(H,38,44)/t19-,22-,23-,24-,26-/m0/s1
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n/an/a 1.60E+4n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of chicken MLCK (myosin light chain kinase)

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015052
PNG
(2-(2-Amino-3-hydroxy-propionylamino)-N1-[1-(1-benz...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccccc1)\C=C/[C@@H](C)COCc1ccccc1
Show InChI InChI=1S/C32H45N5O6/c1-21(2)29(37-31(41)27(17-28(34)39)36-30(40)26(33)18-38)32(42)35-25(16-23-10-6-4-7-11-23)15-14-22(3)19-43-20-24-12-8-5-9-13-24/h4-15,21-22,25-27,29,38H,16-20,33H2,1-3H3,(H2,34,39)(H,35,42)(H,36,40)(H,37,41)/b15-14-/t22-,25-,26+,27+,29+/m1/s1
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n/an/a 1.70E+4n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of calmodulin-independent form of myosin light chain kinase isolated from chicken gizzard.

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015065
PNG
(CHEMBL367967 | benzyl 2-(1-{1-[1-(1-amino-2-hydrox...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C30H41N5O7/c1-18(2)25(35-26(37)19(3)32-27(38)23(31)16-36)29(40)34-24(15-21-11-7-5-8-12-21)28(39)33-20(4)30(41)42-17-22-13-9-6-10-14-22/h5-14,18-20,23-25,36H,15-17,31H2,1-4H3,(H,32,38)(H,33,39)(H,34,40)(H,35,37)/t19-,20-,23-,24-,25-/m0/s1
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n/an/a 1.80E+4n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of calmodulin-independent form of myosin light chain kinase isolated from chicken gizzard.

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015074
PNG
(CHEMBL367517 | benzyl 2-(1-{1-[1-(1-amino-2-hydrox...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C32H44N6O8/c1-18(2)27(38-29(42)24(16-25(33)40)36-30(43)26(34)20(4)39)31(44)37-23(15-21-11-7-5-8-12-21)28(41)35-19(3)32(45)46-17-22-13-9-6-10-14-22/h5-14,18-20,23-24,26-27,39H,15-17,34H2,1-4H3,(H2,33,40)(H,35,41)(H,36,43)(H,37,44)(H,38,42)/t19-,20+,23-,24-,26-,27-/m0/s1
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n/an/a 1.80E+4n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of chicken MLCK (myosin light chain kinase)

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015077
PNG
(4-phenylbutyl 2-(1-{1-[1-(1-amino-2-hydroxyethylca...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)OCCCCc1ccccc1
Show InChI InChI=1S/C34H48N6O8/c1-21(2)29(40-32(45)27(19-28(36)42)38-30(43)25(35)20-41)33(46)39-26(18-24-15-8-5-9-16-24)31(44)37-22(3)34(47)48-17-11-10-14-23-12-6-4-7-13-23/h4-9,12-13,15-16,21-22,25-27,29,41H,10-11,14,17-20,35H2,1-3H3,(H2,36,42)(H,37,44)(H,38,43)(H,39,46)(H,40,45)/t22-,25-,26-,27-,29-/m0/s1
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n/an/a 1.90E+4n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of chicken MLCK (myosin light chain kinase)

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015060
PNG
(CHEMBL175048 | benzyl 2-[1-[1-[1-[1-amino-2-hydrox...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C31H42N6O8/c1-18(2)26(37-29(42)24(15-25(33)39)35-27(40)22(32)16-38)30(43)36-23(14-20-10-6-4-7-11-20)28(41)34-19(3)31(44)45-17-21-12-8-5-9-13-21/h4-13,18-19,22-24,26,38H,14-17,32H2,1-3H3,(H2,33,39)(H,34,41)(H,35,40)(H,36,43)(H,37,42)/t19-,22-,23-,24-,26-/m0/s1
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n/an/a 2.10E+4n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of calmodulin-independent form of myosin light chain kinase isolated from chicken gizzard.

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015044
PNG
(2-(2-Amino-3-hydroxy-propionylamino)-N1-[1-(1-benz...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccccc1)\C=C\[C@@H](C)COCc1ccccc1
Show InChI InChI=1S/C32H45N5O6/c1-21(2)29(37-31(41)27(17-28(34)39)36-30(40)26(33)18-38)32(42)35-25(16-23-10-6-4-7-11-23)15-14-22(3)19-43-20-24-12-8-5-9-13-24/h4-15,21-22,25-27,29,38H,16-20,33H2,1-3H3,(H2,34,39)(H,35,42)(H,36,40)(H,37,41)/b15-14+/t22-,25-,26+,27+,29+/m1/s1
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n/an/a 2.30E+4n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of calmodulin-independent form of myosin light chain kinase isolated from chicken gizzard.

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015057
PNG
(CHEMBL175509 | benzyl 2-(1-{1-[1-(1-amino-2-hydrox...)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](N)CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C32H45N5O7/c1-19(2)26(37-31(42)27(20(3)4)36-28(39)24(33)17-38)30(41)35-25(16-22-12-8-6-9-13-22)29(40)34-21(5)32(43)44-18-23-14-10-7-11-15-23/h6-15,19-21,24-27,38H,16-18,33H2,1-5H3,(H,34,40)(H,35,41)(H,36,39)(H,37,42)/t21-,24-,25-,26-,27-/m0/s1
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n/an/a 2.40E+4n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of calmodulin-independent form of myosin light chain kinase isolated from chicken gizzard.

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015060
PNG
(CHEMBL175048 | benzyl 2-[1-[1-[1-[1-amino-2-hydrox...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C31H42N6O8/c1-18(2)26(37-29(42)24(15-25(33)39)35-27(40)22(32)16-38)30(43)36-23(14-20-10-6-4-7-11-20)28(41)34-19(3)31(44)45-17-21-12-8-5-9-13-21/h4-13,18-19,22-24,26,38H,14-17,32H2,1-3H3,(H2,33,39)(H,34,41)(H,35,40)(H,36,43)(H,37,42)/t19-,22-,23-,24-,26-/m0/s1
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n/an/a 2.80E+4n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of MLCK myosin light chain kinase from chicken gizzard

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015069
PNG
(CHEMBL366612 | benzyl 2-(1-{1-[1-(1-amino-2-hydrox...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C31H42N6O8S/c1-19(31(44)45-18-21-11-7-4-8-12-21)34-29(42)24(15-20-9-5-3-6-10-20)37-28(41)23(13-14-46-2)35-30(43)25(16-26(33)39)36-27(40)22(32)17-38/h3-12,19,22-25,38H,13-18,32H2,1-2H3,(H2,33,39)(H,34,42)(H,35,43)(H,36,40)(H,37,41)/t19-,22-,23-,24-,25-/m0/s1
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n/an/a 3.00E+4n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of chicken MLCK (myosin light chain kinase)

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015056
PNG
(Ala-Thr-Ser-Asn-Val-Phe-Ala-OBzl | CHEMBL426949)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](C)N)[C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C38H54N8O11/c1-20(2)30(45-34(52)27(17-29(40)49)42-35(53)28(18-47)44-37(55)31(23(5)48)46-32(50)21(3)39)36(54)43-26(16-24-12-8-6-9-13-24)33(51)41-22(4)38(56)57-19-25-14-10-7-11-15-25/h6-15,20-23,26-28,30-31,47-48H,16-19,39H2,1-5H3,(H2,40,49)(H,41,51)(H,42,53)(H,43,54)(H,44,55)(H,45,52)(H,46,50)/t21-,22-,23+,26-,27-,28-,30-,31-/m0/s1
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n/an/a 3.10E+4n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of chicken MLCK (myosin light chain kinase)

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015062
PNG
(CHEMBL366854 | Ser-Asn-Val-CH=CH-Phe-Ala-O-Bzl)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)\C=C\[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C32H43N5O7/c1-20(2)26(36-31(42)27(17-28(34)39)37-30(41)25(33)18-38)15-14-24(16-22-10-6-4-7-11-22)29(40)35-21(3)32(43)44-19-23-12-8-5-9-13-23/h4-15,20-21,24-27,38H,16-19,33H2,1-3H3,(H2,34,39)(H,35,40)(H,36,42)(H,37,41)/b15-14+/t21-,24-,25-,26+,27-/m0/s1
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n/an/a 3.60E+4n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of calmodulin-independent form of myosin light chain kinase isolated from chicken gizzard.

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015068
PNG
(Arg-Ala-Thr-Ser-AsnVal-Phe-Ala-O-Benzyl | CHEMBL43...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)CCCNC(N)=N)[C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C44H66N12O12/c1-23(2)34(41(65)53-30(19-27-13-8-6-9-14-27)38(62)51-25(4)43(67)68-22-28-15-10-7-11-16-28)55-39(63)31(20-33(46)59)52-40(64)32(21-57)54-42(66)35(26(5)58)56-36(60)24(3)50-37(61)29(45)17-12-18-49-44(47)48/h6-11,13-16,23-26,29-32,34-35,57-58H,12,17-22,45H2,1-5H3,(H2,46,59)(H,50,61)(H,51,62)(H,52,64)(H,53,65)(H,54,66)(H,55,63)(H,56,60)(H4,47,48,49)/t24-,25-,26+,29-,30-,31-,32-,34-,35-/m0/s1
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n/an/a 3.80E+4n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of chicken MLCK (myosin light chain kinase)

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015053
PNG
(CHEMBL173631 | benzyl 2-(1-{1-[1-(1-amino-2-hydrox...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)OCc1ccccc1
Show InChI InChI=1S/C31H42N6O9/c1-18(2)26(37-29(43)23(14-25(33)40)34-27(41)21(32)15-38)30(44)35-22(13-19-9-5-3-6-10-19)28(42)36-24(16-39)31(45)46-17-20-11-7-4-8-12-20/h3-12,18,21-24,26,38-39H,13-17,32H2,1-2H3,(H2,33,40)(H,34,41)(H,35,44)(H,36,42)(H,37,43)/t21-,22-,23-,24-,26-/m0/s1
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n/an/a 4.30E+4n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of chicken MLCK (myosin light chain kinase)

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015054
PNG
(CHEMBL368968 | benzyl 2-[1-{1-[1-(1-amino-2-hydrox...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C31H42N6O9/c1-17(2)26(37-29(43)24(14-25(33)40)35-27(41)22(32)15-38)30(44)36-23(13-19-9-11-21(39)12-10-19)28(42)34-18(3)31(45)46-16-20-7-5-4-6-8-20/h4-12,17-18,22-24,26,38-39H,13-16,32H2,1-3H3,(H2,33,40)(H,34,42)(H,35,41)(H,36,44)(H,37,43)/t18-,22-,23-,24-,26-/m0/s1
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n/an/a 4.50E+4n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of chicken MLCK (myosin light chain kinase)

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015041
PNG
(CHEMBL173144 | phenethyl 2-(1-{1-[1-(1-amino-2-hyd...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)OCCc1ccccc1
Show InChI InChI=1S/C32H44N6O8/c1-19(2)27(38-30(43)25(17-26(34)40)36-28(41)23(33)18-39)31(44)37-24(16-22-12-8-5-9-13-22)29(42)35-20(3)32(45)46-15-14-21-10-6-4-7-11-21/h4-13,19-20,23-25,27,39H,14-18,33H2,1-3H3,(H2,34,40)(H,35,42)(H,36,41)(H,37,44)(H,38,43)/t20-,23-,24-,25-,27-/m0/s1
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n/an/a 5.00E+4n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of calmodulin-independent form of myosin light chain kinase isolated from chicken gizzard.

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015039
PNG
(CHEMBL368384 | benzyl 2-(1-{1-[1-(1-amino-2-hydrox...)
Show SMILES C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)OCc1ccccc1
Show InChI InChI=1S/C35H42N6O8/c1-22(35(48)49-21-25-15-9-4-10-16-25)38-32(45)27(17-23-11-5-2-6-12-23)40-33(46)28(18-24-13-7-3-8-14-24)41-34(47)29(19-30(37)43)39-31(44)26(36)20-42/h2-16,22,26-29,42H,17-21,36H2,1H3,(H2,37,43)(H,38,45)(H,39,44)(H,40,46)(H,41,47)/t22-,26-,27-,28-,29-/m0/s1
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n/an/a 5.00E+4n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of chicken MLCK (myosin light chain kinase)

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015072
PNG
(CHEMBL2371685 | benzyl 2-(1-{1-[2-carbamoyl-1-(4-h...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1C[C@H](O)CN1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C33H44N6O8/c1-19(2)28(39-31(44)26(16-27(34)41)37-29(42)24-15-23(40)17-35-24)32(45)38-25(14-21-10-6-4-7-11-21)30(43)36-20(3)33(46)47-18-22-12-8-5-9-13-22/h4-13,19-20,23-26,28,35,40H,14-18H2,1-3H3,(H2,34,41)(H,36,43)(H,37,42)(H,38,45)(H,39,44)/t20-,23-,24-,25-,26-,28-/m0/s1
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n/an/a 5.60E+4n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of chicken MLCK (myosin light chain kinase)

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015066
PNG
(CHEMBL172320 | benzyl 2-(1-{1-[1-(1-amino-2-hydrox...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C31H42N6O8/c1-18(2)26(37-29(42)24(15-25(33)39)35-27(40)22(32)16-38)30(43)36-23(14-20-10-6-4-7-11-20)28(41)34-19(3)31(44)45-17-21-12-8-5-9-13-21/h4-13,18-19,22-24,26,38H,14-17,32H2,1-3H3,(H2,33,39)(H,34,41)(H,35,40)(H,36,43)(H,37,42)/t19-,22+,23+,24+,26+/m1/s1
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n/an/a 6.40E+4n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of calmodulin-independent form of myosin light chain kinase isolated from chicken gizzard.

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015043
PNG
(CHEMBL172321 | benzyl 2-(1-{1-[1-(1-amino-2-hydrox...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C31H42N6O8/c1-18(2)26(37-29(42)24(15-25(33)39)35-27(40)22(32)16-38)30(43)36-23(14-20-10-6-4-7-11-20)28(41)34-19(3)31(44)45-17-21-12-8-5-9-13-21/h4-13,18-19,22-24,26,38H,14-17,32H2,1-3H3,(H2,33,39)(H,34,41)(H,35,40)(H,36,43)(H,37,42)/t19-,22-,23+,24-,26-/m0/s1
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n/an/a 7.50E+4n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of calmodulin-independent form of myosin light chain kinase isolated from chicken gizzard.

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015067
PNG
(CHEMBL425856 | benzyl 2-(1-{1-[1-(1-amino-3-methyl...)
Show SMILES CSCC[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C33H46N6O7S/c1-20(2)28(39-31(43)26(18-27(35)40)37-29(41)24(34)15-16-47-4)32(44)38-25(17-22-11-7-5-8-12-22)30(42)36-21(3)33(45)46-19-23-13-9-6-10-14-23/h5-14,20-21,24-26,28H,15-19,34H2,1-4H3,(H2,35,40)(H,36,42)(H,37,41)(H,38,44)(H,39,43)/t21-,24-,25-,26-,28-/m0/s1
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n/an/a 7.60E+4n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of chicken MLCK (myosin light chain kinase)

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015042
PNG
(CHEMBL177075 | benzyl 2-{1-[1-(1-amino-2-hydroxyet...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C28H37N5O7/c1-17(2)24(33-26(37)21(14-23(30)35)31-25(36)20(29)15-34)27(38)32-22(13-18-9-5-3-6-10-18)28(39)40-16-19-11-7-4-8-12-19/h3-12,17,20-22,24,34H,13-16,29H2,1-2H3,(H2,30,35)(H,31,36)(H,32,38)(H,33,37)/t20-,21-,22-,24-/m0/s1
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n/an/a 1.60E+5n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of chicken MLCK (myosin light chain kinase)

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015073
PNG
(CHEMBL174817 | butyl 2-(1-{1-[1-(1-amino-2-hydroxy...)
Show SMILES CCCCOC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(C)C
Show InChI InChI=1S/C28H44N6O8/c1-5-6-12-42-28(41)17(4)31-25(38)20(13-18-10-8-7-9-11-18)33-27(40)23(16(2)3)34-26(39)21(14-22(30)36)32-24(37)19(29)15-35/h7-11,16-17,19-21,23,35H,5-6,12-15,29H2,1-4H3,(H2,30,36)(H,31,38)(H,32,37)(H,33,40)(H,34,39)/t17-,19-,20-,21-,23-/m0/s1
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n/an/a 1.85E+5n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of calmodulin-independent form of myosin light chain kinase isolated from chicken gizzard.

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015049
PNG
(CHEMBL367462 | benzyl 2-(1-{1-[1-(1-amino-2-hydrox...)
Show SMILES CC(C)[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C31H42N6O8/c1-18(2)26(37-29(42)24(15-25(33)39)35-27(40)22(32)16-38)30(43)36-23(14-20-10-6-4-7-11-20)28(41)34-19(3)31(44)45-17-21-12-8-5-9-13-21/h4-13,18-19,22-24,26,38H,14-17,32H2,1-3H3,(H2,33,39)(H,34,41)(H,35,40)(H,36,43)(H,37,42)/t19-,22-,23-,24+,26+/m0/s1
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n/an/a 1.86E+5n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of calmodulin-independent form of myosin light chain kinase isolated from chicken gizzard.

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015085
PNG
(CHEMBL355810 | benzyl 2-(1-{1-[1-(1-amino-2-hydrox...)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C30H40N6O9/c1-17(30(44)45-16-20-11-7-4-8-12-20)33-27(41)22(13-19-9-5-3-6-10-19)35-29(43)25(18(2)38)36-28(42)23(14-24(32)39)34-26(40)21(31)15-37/h3-12,17-18,21-23,25,37-38H,13-16,31H2,1-2H3,(H2,32,39)(H,33,41)(H,34,40)(H,35,43)(H,36,42)/t17-,18+,21-,22-,23-,25-/m0/s1
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n/an/a 1.90E+5n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of calmodulin-independent form of myosin light chain kinase isolated from chicken gizzard.

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015055
PNG
(CHEMBL368723 | benzyl 2-{1-[1-(2-carbamoyl-1-tetra...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C33H44N6O7/c1-20(2)28(39-31(43)26(18-27(34)40)37-29(41)24-15-10-16-35-24)32(44)38-25(17-22-11-6-4-7-12-22)30(42)36-21(3)33(45)46-19-23-13-8-5-9-14-23/h4-9,11-14,20-21,24-26,28,35H,10,15-19H2,1-3H3,(H2,34,40)(H,36,42)(H,37,41)(H,38,44)(H,39,43)/t21-,24-,25-,26-,28-/m0/s1
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n/an/a 2.00E+5n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of chicken MLCK (myosin light chain kinase)

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015038
PNG
(CHEMBL176691 | Ser-Asn-Val-(CH2-NH)-Phe-Ala)
Show SMILES CC(C)[C@@H](CN[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO
Show InChI InChI=1S/C31H44N6O7/c1-19(2)26(37-30(42)25(15-27(33)39)36-28(40)23(32)17-38)16-34-24(14-21-10-6-4-7-11-21)29(41)35-20(3)31(43)44-18-22-12-8-5-9-13-22/h4-13,19-20,23-26,34,38H,14-18,32H2,1-3H3,(H2,33,39)(H,35,41)(H,36,40)(H,37,42)/t20-,23-,24-,25-,26+/m0/s1
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n/an/a 2.62E+5n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of calmodulin-independent form of myosin light chain kinase isolated from chicken gizzard.

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015082
PNG
(CHEMBL367080 | Ser-Asn-CH=CH-Val-Phe-Ala-NH-Bzl)
Show SMILES CC(C)[C@H](\C=C\[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)NCc1ccccc1
Show InChI InChI=1S/C32H44N6O6/c1-20(2)25(15-14-24(17-28(34)40)37-31(43)26(33)19-39)30(42)38-27(16-22-10-6-4-7-11-22)32(44)36-21(3)29(41)35-18-23-12-8-5-9-13-23/h4-15,20-21,24-27,39H,16-19,33H2,1-3H3,(H2,34,40)(H,35,41)(H,36,44)(H,37,43)(H,38,42)/b15-14+/t21-,24+,25-,26-,27-/m0/s1
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n/an/a 2.78E+5n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of calmodulin-independent form of myosin light chain kinase isolated from chicken gizzard.

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015051
PNG
(CHEMBL368725 | benzyl 2-(1-{1-[1-(1-amino-2-hydrox...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)C(C)(N)CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C32H44N6O8/c1-19(2)26(38-28(42)24(16-25(33)40)37-31(45)32(4,34)18-39)29(43)36-23(15-21-11-7-5-8-12-21)27(41)35-20(3)30(44)46-17-22-13-9-6-10-14-22/h5-14,19-20,23-24,26,39H,15-18,34H2,1-4H3,(H2,33,40)(H,35,41)(H,36,43)(H,37,45)(H,38,42)/t20-,23-,24-,26-,32?/m0/s1
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n/an/a 3.50E+5n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of chicken MLCK (myosin light chain kinase)

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015080
PNG
(CHEMBL176738 | benzyl 2-(1-{1-[1-(3,3-diamino-prop...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)CCC(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C32H45N7O7/c1-19(2)28(39-30(43)24(17-26(35)40)37-27(41)15-14-25(33)34)31(44)38-23(16-21-10-6-4-7-11-21)29(42)36-20(3)32(45)46-18-22-12-8-5-9-13-22/h4-13,19-20,23-25,28H,14-18,33-34H2,1-3H3,(H2,35,40)(H,36,42)(H,37,41)(H,38,44)(H,39,43)/t20-,23-,24-,28-/m0/s1
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n/an/a 4.00E+5n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of chicken MLCK (myosin light chain kinase)

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015079
PNG
(CHEMBL177581 | benzyl 2-{1-[1-(1-amino-2-hydroxyet...)
Show SMILES CC(C)[C@H](NC(=O)CNC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C29H39N5O7/c1-18(2)25(34-24(36)15-31-26(37)22(30)16-35)28(39)33-23(14-20-10-6-4-7-11-20)27(38)32-19(3)29(40)41-17-21-12-8-5-9-13-21/h4-13,18-19,22-23,25,35H,14-17,30H2,1-3H3,(H,31,37)(H,32,38)(H,33,39)(H,34,36)/t19-,22-,23-,25-/m0/s1
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n/an/a 4.50E+5n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of chicken MLCK (myosin light chain kinase)

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015078
PNG
(CHEMBL173663 | benzyl 2-[1-[1-[1-amino-2-carbamoyl...)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C28H37N5O6/c1-17(2)24(33-25(35)21(29)15-23(30)34)27(37)32-22(14-19-10-6-4-7-11-19)26(36)31-18(3)28(38)39-16-20-12-8-5-9-13-20/h4-13,17-18,21-22,24H,14-16,29H2,1-3H3,(H2,30,34)(H,31,36)(H,32,37)(H,33,35)/t18-,21-,22-,24-/m0/s1
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n/an/a 8.00E+5n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of myosin light chain kinase from chicken gizzard

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Gallus gallus (chicken))		BDBM50015083
PNG
(CHEMBL174940 | benzyl 2-[1-[1-amino-2-methyl-(1S)-...)
Show SMILES CC(C)[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C24H31N3O4/c1-16(2)21(25)23(29)27-20(14-18-10-6-4-7-11-18)22(28)26-17(3)24(30)31-15-19-12-8-5-9-13-19/h4-13,16-17,20-21H,14-15,25H2,1-3H3,(H,26,28)(H,27,29)/t17-,20-,21-/m0/s1
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n/an/a 1.00E+6n/an/an/an/an/an/a



Schering-Plough Research

Curated by ChEMBL


Assay Description
Inhibition of native form of myosin light chain kinase from chicken gizzard

J Med Chem 33: 964-72 (1990)


BindingDB Entry DOI: 10.7270/Q21N803V
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%