Affinity Data by PubMed id=23137448

PubMed code 23137448

Found 16 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50392674 (CHEMBL2153834) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ G. d'Annunzio Curated by ChEMBL					Assay Description Binding affinity to PPARalpha LBD after 2 hrs by TR-FRET analysis				Eur J Med Chem 58: 317-22 (2012) Article DOI: 10.1016/j.ejmech.2012.10.019 BindingDB Entry DOI: 10.7270/Q2CR5VG4
Universit£ G. d'Annunzio Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50392675 (CHEMBL2153835) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ G. d'Annunzio Curated by ChEMBL					Assay Description Antagonist activity at PPARalpha expressed in HEK293 cells co-expressing GAL4 assessed as inhibition of GW7647-induced transactivation activity after...				Eur J Med Chem 58: 317-22 (2012) Article DOI: 10.1016/j.ejmech.2012.10.019 BindingDB Entry DOI: 10.7270/Q2CR5VG4
Universit£ G. d'Annunzio Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50392677 (CHEMBL2153837) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ G. d'Annunzio Curated by ChEMBL					Assay Description Binding affinity to PPARalpha LBD after 2 hrs by TR-FRET analysis				Eur J Med Chem 58: 317-22 (2012) Article DOI: 10.1016/j.ejmech.2012.10.019 BindingDB Entry DOI: 10.7270/Q2CR5VG4
Universit£ G. d'Annunzio Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50392677 (CHEMBL2153837) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ G. d'Annunzio Curated by ChEMBL					Assay Description Antagonist activity at PPARalpha expressed in HEK293 cells co-expressing GAL4 assessed as inhibition of GW7647-induced transactivation activity after...				Eur J Med Chem 58: 317-22 (2012) Article DOI: 10.1016/j.ejmech.2012.10.019 BindingDB Entry DOI: 10.7270/Q2CR5VG4
Universit£ G. d'Annunzio Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50392675 (CHEMBL2153835) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	890	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ G. d'Annunzio Curated by ChEMBL					Assay Description Binding affinity to PPARalpha LBD after 2 hrs by TR-FRET analysis				Eur J Med Chem 58: 317-22 (2012) Article DOI: 10.1016/j.ejmech.2012.10.019 BindingDB Entry DOI: 10.7270/Q2CR5VG4
Universit£ G. d'Annunzio Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50392679 (CHEMBL2153839) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ G. d'Annunzio Curated by ChEMBL					Assay Description Antagonist activity at PPARalpha expressed in HEK293 cells co-expressing GAL4 assessed as inhibition of GW7647-induced transactivation activity after...				Eur J Med Chem 58: 317-22 (2012) Article DOI: 10.1016/j.ejmech.2012.10.019 BindingDB Entry DOI: 10.7270/Q2CR5VG4
Universit£ G. d'Annunzio Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50392679 (CHEMBL2153839) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	950	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ G. d'Annunzio Curated by ChEMBL					Assay Description Binding affinity to PPARalpha LBD after 2 hrs by TR-FRET analysis				Eur J Med Chem 58: 317-22 (2012) Article DOI: 10.1016/j.ejmech.2012.10.019 BindingDB Entry DOI: 10.7270/Q2CR5VG4
Universit£ G. d'Annunzio Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50392678 (CHEMBL2153838) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ G. d'Annunzio Curated by ChEMBL					Assay Description Antagonist activity at PPARalpha expressed in HEK293 cells co-expressing GAL4 assessed as inhibition of GW7647-induced transactivation activity after...				Eur J Med Chem 58: 317-22 (2012) Article DOI: 10.1016/j.ejmech.2012.10.019 BindingDB Entry DOI: 10.7270/Q2CR5VG4
Universit£ G. d'Annunzio Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50392674 (CHEMBL2153834) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.87E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ G. d'Annunzio Curated by ChEMBL					Assay Description Antagonist activity at PPARalpha expressed in HEK293 cells co-expressing GAL4 assessed as inhibition of GW7647-induced transactivation activity after...				Eur J Med Chem 58: 317-22 (2012) Article DOI: 10.1016/j.ejmech.2012.10.019 BindingDB Entry DOI: 10.7270/Q2CR5VG4
Universit£ G. d'Annunzio Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50392676 (CHEMBL2153836) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.65E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ G. d'Annunzio Curated by ChEMBL					Assay Description Antagonist activity at PPARalpha expressed in HEK293 cells co-expressing GAL4 assessed as inhibition of GW7647-induced transactivation activity after...				Eur J Med Chem 58: 317-22 (2012) Article DOI: 10.1016/j.ejmech.2012.10.019 BindingDB Entry DOI: 10.7270/Q2CR5VG4
Universit£ G. d'Annunzio Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50392680 (CHEMBL2153842) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.85E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ G. d'Annunzio Curated by ChEMBL					Assay Description Antagonist activity at PPARalpha expressed in HEK293 cells co-expressing GAL4 assessed as inhibition of GW7647-induced transactivation activity after...				Eur J Med Chem 58: 317-22 (2012) Article DOI: 10.1016/j.ejmech.2012.10.019 BindingDB Entry DOI: 10.7270/Q2CR5VG4
Universit£ G. d'Annunzio Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50392672 (CHEMBL2153840) Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)NS(C)(=O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.07E+4	n/a	n/a	n/a	n/a
Universit£ G. d'Annunzio Curated by ChEMBL					Assay Description Transactivation of PPARalpha expressed in HEK293A cells co-expressing GAL4 after 16 to 18 hrs by luciferase reporter gene assay				Eur J Med Chem 58: 317-22 (2012) Article DOI: 10.1016/j.ejmech.2012.10.019 BindingDB Entry DOI: 10.7270/Q2CR5VG4
Universit£ G. d'Annunzio Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50099491 (2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a
Universit£ G. d'Annunzio Curated by ChEMBL					Assay Description Transactivation of PPARalpha expressed in HEK293A cells co-expressing GAL4 after 16 to 18 hrs by luciferase reporter gene assay				Eur J Med Chem 58: 317-22 (2012) Article DOI: 10.1016/j.ejmech.2012.10.019 BindingDB Entry DOI: 10.7270/Q2CR5VG4
Universit£ G. d'Annunzio Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM28699 (2-(4-chlorophenoxy)-2-methylpropanoic acid \| CHEMB...) Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	5.50E+4	n/a	n/a	n/a	n/a
Universit£ G. d'Annunzio Curated by ChEMBL					Assay Description Transactivation of PPARalpha expressed in HEK293A cells co-expressing GAL4 after 16 to 18 hrs by luciferase reporter gene assay				Eur J Med Chem 58: 317-22 (2012) Article DOI: 10.1016/j.ejmech.2012.10.019 BindingDB Entry DOI: 10.7270/Q2CR5VG4
Universit£ G. d'Annunzio Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50392671 (CHEMBL2153833) Show SMILES CCOc1ccc2nc(SC(C)C(=O)NS(C)(=O)=O)sc2c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.59E+3	n/a	n/a	n/a	n/a
Universit£ G. d'Annunzio Curated by ChEMBL					Assay Description Transactivation of PPARalpha expressed in HEK293A cells co-expressing GAL4 after 16 to 18 hrs by luciferase reporter gene assay				Eur J Med Chem 58: 317-22 (2012) Article DOI: 10.1016/j.ejmech.2012.10.019 BindingDB Entry DOI: 10.7270/Q2CR5VG4
Universit£ G. d'Annunzio Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50392673 (CHEMBL2153843) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.10E+3	n/a	n/a	n/a	n/a
Universit£ G. d'Annunzio Curated by ChEMBL					Assay Description Transactivation of PPARalpha expressed in HEK293A cells co-expressing GAL4 after 16 to 18 hrs by luciferase reporter gene assay				Eur J Med Chem 58: 317-22 (2012) Article DOI: 10.1016/j.ejmech.2012.10.019 BindingDB Entry DOI: 10.7270/Q2CR5VG4
Universit£ G. d'Annunzio Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%