Affinity Data by PubMed id=2319562

PubMed code 2319562

Found 12 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Polyunsaturated fatty acid 5-lipoxygenase (Rattus norvegicus)	BDBM50015205 (4-Pentadeca-1,3,6,9-tetraenylsulfanyl-butyric acid...) Show SMILES CCCCC\C=C/C\C=C/C\C=C/C=C/SCCCC(=O)OC Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Molecular Therapeutics Inc. Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in rat RBL-1 cells				J Med Chem 33: 1163-70 (1990) BindingDB Entry DOI: 10.7270/Q2S75F9G
Molecular Therapeutics Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Rattus norvegicus)	BDBM50000540 (1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...) Show SMILES NC1=NN(CC1)c1cccc(c1)C(F)(F)F \|t:1\| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Molecular Therapeutics Inc. Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in rat RBL-1 cells				J Med Chem 33: 1163-70 (1990) BindingDB Entry DOI: 10.7270/Q2S75F9G
Molecular Therapeutics Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Rattus norvegicus)	BDBM50015209 (2-Pentadeca-1,3,6-trienylsulfanyl-benzoic acid met...) Show SMILES CCCCCCCC\C=C/C\C=C/C=C/Sc1ccccc1C(=O)OC Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Molecular Therapeutics Inc. Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in rat RBL-1 cells				J Med Chem 33: 1163-70 (1990) BindingDB Entry DOI: 10.7270/Q2S75F9G
Molecular Therapeutics Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Rattus norvegicus)	BDBM50015206 (4-Pentadeca-1,3-dien-6-ynylsulfanyl-butyric acid m...) Show SMILES CCCCCCCCC#CC\C=C/C=C/SCCCC(=O)OC Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	5.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Molecular Therapeutics Inc. Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in rat RBL-1 cells				J Med Chem 33: 1163-70 (1990) BindingDB Entry DOI: 10.7270/Q2S75F9G
Molecular Therapeutics Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50015203 (4-Pentadeca-1,3,6-trienylsulfanyl-butyric acid met...) Show SMILES CCCCCCCC\C=C/C\C=C/C=C/SCCCC(=O)OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Molecular Therapeutics Inc. Curated by ChEMBL					Assay Description Inhibitory activity against 5-lipoxygenase expressed from human polymorphonuclear cells				J Med Chem 33: 1163-70 (1990) BindingDB Entry DOI: 10.7270/Q2S75F9G
Molecular Therapeutics Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Rattus norvegicus)	BDBM50008999 (5-Methyl-2-[2-(naphthalen-2-yloxy)-ethyl]-2,4-dihy...) Show SMILES Cc1cc(=O)n(CCOc2ccc3ccccc3c2)[nH]1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Molecular Therapeutics Inc. Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in rat RBL-1 cells				J Med Chem 33: 1163-70 (1990) BindingDB Entry DOI: 10.7270/Q2S75F9G
Molecular Therapeutics Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Rattus norvegicus)	BDBM50015203 (4-Pentadeca-1,3,6-trienylsulfanyl-butyric acid met...) Show SMILES CCCCCCCC\C=C/C\C=C/C=C/SCCCC(=O)OC Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Molecular Therapeutics Inc. Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in rat RBL-1 cells				J Med Chem 33: 1163-70 (1990) BindingDB Entry DOI: 10.7270/Q2S75F9G
Molecular Therapeutics Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Rattus norvegicus)	BDBM50015204 (4-Pentadeca-1,3,6-trienylsulfanyl-butyric acid \| C...) Show SMILES CCCCCCCC\C=C/C\C=C/C=C/SCCCC(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	7.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Molecular Therapeutics Inc. Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in rat RBL-1 cells				J Med Chem 33: 1163-70 (1990) BindingDB Entry DOI: 10.7270/Q2S75F9G
Molecular Therapeutics Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Rattus norvegicus)	BDBM50015210 (3-Pentadeca-1,3,6-trienylsulfanyl-benzoic acid met...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	7.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Molecular Therapeutics Inc. Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in rat RBL-1 cells				J Med Chem 33: 1163-70 (1990) BindingDB Entry DOI: 10.7270/Q2S75F9G
Molecular Therapeutics Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Rattus norvegicus)	BDBM50015207 (3-Pentadeca-1,3-dien-6-ynylsulfanyl-benzoic acid m...) Show SMILES CCCCCCCCC#CC\C=C/C=C/Sc1cccc(c1)C(=O)OC Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Molecular Therapeutics Inc. Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in rat RBL-1 cells				J Med Chem 33: 1163-70 (1990) BindingDB Entry DOI: 10.7270/Q2S75F9G
Molecular Therapeutics Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Rattus norvegicus)	BDBM50015208 (4-Pentadeca-1,3,6-trienylsulfanyl-benzoic acid met...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.12E+4	n/a	n/a	n/a	n/a	n/a	n/a
Molecular Therapeutics Inc. Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in rat RBL-1 cells				J Med Chem 33: 1163-70 (1990) BindingDB Entry DOI: 10.7270/Q2S75F9G
Molecular Therapeutics Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Rattus norvegicus)	BDBM50015202 (4-Pentadeca-1,3-dienylsulfanyl-butyric acid methyl...) Show SMILES CCCCCCCCCCC\C=C/C=C/SCCCC(=O)OC Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Molecular Therapeutics Inc. Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in rat RBL-1 cells				J Med Chem 33: 1163-70 (1990) BindingDB Entry DOI: 10.7270/Q2S75F9G
Molecular Therapeutics Inc. Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%