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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50430022 (CHEMBL2144069) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet  | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of wild type CRAF (unknown origin) using biotinylated MEK as substrate and MgCl2 incubated for 20 mins prior to MgCl2 addition measured af... | J Med Chem 56: 1996-2015 (2013) Article DOI: 10.1021/jm301658d BindingDB Entry DOI: 10.7270/Q2DF6SJS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM50430022 (CHEMBL2144069) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 2.64E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of human recombinant N-terminus His-tagged BRAF expressed in Sf9 cells coexpressing CDC37 using biotinylated MEK as substrate and MgCl2 in... | J Med Chem 56: 1996-2015 (2013) Article DOI: 10.1021/jm301658d BindingDB Entry DOI: 10.7270/Q2DF6SJS | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50430021 (CHEMBL2335864) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 5.84E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of wild type CRAF (unknown origin) using biotinylated MEK as substrate and MgCl2 incubated for 20 mins prior to MgCl2 addition measured af... | J Med Chem 56: 1996-2015 (2013) Article DOI: 10.1021/jm301658d BindingDB Entry DOI: 10.7270/Q2DF6SJS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM50430021 (CHEMBL2335864) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of human recombinant N-terminus His-tagged BRAF expressed in Sf9 cells coexpressing CDC37 using biotinylated MEK as substrate and MgCl2 in... | J Med Chem 56: 1996-2015 (2013) Article DOI: 10.1021/jm301658d BindingDB Entry DOI: 10.7270/Q2DF6SJS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
