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PubMed code 23414839

Compile data set for download or QSAR
Found 27 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50401370
PNG
(CHEMBL2205821)
Show SMILES OC12C3C4C5C3C(C3C5CC4C13)N2CCCCc1ccccc1 |TLB:6:7:4.3:9,8:7:5.2:12,4:5:7.11:12,1:11:4.3:9,10:11:5.2:12,3:2:7.11:12,THB:5:4:7.11:9,2:3:7.11:9,13:12:5.2:7.11|
Show InChI InChI=1S/C21H25NO/c23-21-18-13-10-12-14-15(13)19(21)17(14)20(16(12)18)22(21)9-5-4-8-11-6-2-1-3-7-11/h1-3,6-7,12-20,23H,4-5,8-10H2
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 8.91n/an/an/an/an/an/an/an/a



Northeast Ohio Medical University (NEOMED)

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma-1 receptor in guinea pig brain

Bioorg Med Chem Lett 23: 1707-11 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.069
BindingDB Entry DOI: 10.7270/Q2G73G3N
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50305342
PNG
(4-(3'-Fluorophenethyl)-4-azahexacyclo[5.4.1.02,6.0...)
Show SMILES OC12C3C4C5C3C(C3C5CC4C13)N2CCc1cccc(F)c1 |TLB:1:11:4.3:9,6:7:4.3:9,THB:2:3:9:7.11,5:4:9:7.11|
Show InChI InChI=1S/C19H20FNO/c20-9-3-1-2-8(6-9)4-5-21-18-14-10-7-11-13-12(10)15(18)17(13)19(21,22)16(11)14/h1-3,6,10-18,22H,4-5,7H2
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 10n/an/an/an/an/an/an/an/a



Northeast Ohio Medical University (NEOMED)

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma-1 receptor in guinea pig brain

Bioorg Med Chem Lett 23: 1707-11 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.069
BindingDB Entry DOI: 10.7270/Q2G73G3N
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50430257
PNG
(CHEMBL2332492)
Show SMILES OC12C3C4C5C3C(C3C5CC4C13)N2CCc1ccc(Cl)c(Cl)c1 |TLB:6:7:4.3:9,8:7:5.2:12,4:5:7.11:12,1:11:4.3:9,10:11:5.2:12,3:2:7.11:12,THB:5:4:7.11:9,2:3:7.11:9|
Show InChI InChI=1S/C19H19Cl2NO/c20-10-2-1-7(5-11(10)21)3-4-22-18-14-8-6-9-13-12(8)15(18)17(13)19(22,23)16(9)14/h1-2,5,8-9,12-18,23H,3-4,6H2
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 10n/an/an/an/an/an/an/an/a



Northeast Ohio Medical University (NEOMED)

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma-1 receptor in guinea pig brain

Bioorg Med Chem Lett 23: 1707-11 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.069
BindingDB Entry DOI: 10.7270/Q2G73G3N
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50430259
PNG
(CHEMBL2332494)
Show SMILES OC12C3C4C5C3C(C3C5CC4C13)N2CCc1ccc(Br)cc1 |TLB:6:7:4.3:9,8:7:5.2:12,4:5:7.11:12,1:11:4.3:9,10:11:5.2:12,3:2:7.11:12,THB:5:4:7.11:9,2:3:7.11:9|
Show InChI InChI=1S/C19H20BrNO/c20-9-3-1-8(2-4-9)5-6-21-18-14-10-7-11-13-12(10)15(18)17(13)19(21,22)16(11)14/h1-4,10-18,22H,5-7H2
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 10n/an/an/an/an/an/an/an/a



Northeast Ohio Medical University (NEOMED)

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma-1 receptor in guinea pig brain

Bioorg Med Chem Lett 23: 1707-11 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.069
BindingDB Entry DOI: 10.7270/Q2G73G3N
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50288953
PNG
(11'N-(3-bromobenzyl)spiro[dihydro[1,3]dioxolane-2,...)
Show SMILES Brc1cccc(CNC2C3C4C5C3C3(OCCO3)C3C5CC4C23)c1 |TLB:13:18:11.10:20,8:22:11.10:20,THB:12:11:18.22:20,9:10:18.22:20|
Show InChI InChI=1S/C20H22BrNO2/c21-10-3-1-2-9(6-10)8-22-19-15-11-7-12-14-13(11)16(19)18(14)20(17(12)15)23-4-5-24-20/h1-3,6,11-19,22H,4-5,7-8H2
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 17n/an/an/an/an/an/an/an/a



Northeast Ohio Medical University (NEOMED)

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma-1 receptor in guinea pig brain

Bioorg Med Chem Lett 23: 1707-11 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.069
BindingDB Entry DOI: 10.7270/Q2G73G3N
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50401377
PNG
(CHEMBL2205835)
Show SMILES OC12C3C4C5C3C(C3C5CC4C13)N2CCc1ccccc1 |TLB:6:7:4.3:9,8:7:5.2:12,4:5:7.11:12,1:11:4.3:9,10:11:5.2:12,3:2:7.11:12,THB:5:4:7.11:9,2:3:7.11:9,13:12:5.2:7.11|
Show InChI InChI=1S/C19H21NO/c21-19-16-11-8-10-12-13(11)17(19)15(12)18(14(10)16)20(19)7-6-9-4-2-1-3-5-9/h1-5,10-18,21H,6-8H2
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 20n/an/an/an/an/an/an/an/a



Northeast Ohio Medical University (NEOMED)

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma-1 receptor in guinea pig brain

Bioorg Med Chem Lett 23: 1707-11 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.069
BindingDB Entry DOI: 10.7270/Q2G73G3N
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50401372
PNG
(CHEMBL2205819)
Show SMILES OC12C3C4C5C3C(C3C5CC4C13)N2CCCc1ccccc1 |TLB:6:7:4.3:9,8:7:5.2:12,4:5:7.11:12,1:11:4.3:9,10:11:5.2:12,3:2:7.11:12,THB:5:4:7.11:9,2:3:7.11:9,13:12:5.2:7.11|
Show InChI InChI=1S/C20H23NO/c22-20-17-12-9-11-13-14(12)18(20)16(13)19(15(11)17)21(20)8-4-7-10-5-2-1-3-6-10/h1-3,5-6,11-19,22H,4,7-9H2
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 20.9n/an/an/an/an/an/an/an/a



Northeast Ohio Medical University (NEOMED)

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma-1 receptor in guinea pig brain

Bioorg Med Chem Lett 23: 1707-11 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.069
BindingDB Entry DOI: 10.7270/Q2G73G3N
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50430258
PNG
(CHEMBL2332493)
Show SMILES OC12C3C4C5C3C(C3C5CC4C13)N2CCc1cccc(Cl)c1 |TLB:6:7:4.3:9,8:7:5.2:12,4:5:7.11:12,1:11:4.3:9,10:11:5.2:12,3:2:7.11:12,THB:5:4:7.11:9,2:3:7.11:9|
Show InChI InChI=1S/C19H20ClNO/c20-9-3-1-2-8(6-9)4-5-21-18-14-10-7-11-13-12(10)15(18)17(13)19(21,22)16(11)14/h1-3,6,10-18,22H,4-5,7H2
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 20.9n/an/an/an/an/an/an/an/a



Northeast Ohio Medical University (NEOMED)

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma-1 receptor in guinea pig brain

Bioorg Med Chem Lett 23: 1707-11 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.069
BindingDB Entry DOI: 10.7270/Q2G73G3N
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50288955
PNG
(11'N-benzylspiro[dihydro[1,3]dioxolane-2,8'-pentac...)
Show SMILES C(NC1C2C3C4C2C2(OCCO2)C2C4CC3C12)c1ccccc1 |TLB:7:12:5.4:14,2:16:5.4:14,THB:6:5:12.16:14,3:4:12.16:14|
Show InChI InChI=1S/C20H23NO2/c1-2-4-10(5-3-1)9-21-19-15-11-8-12-14-13(11)16(19)18(14)20(17(12)15)22-6-7-23-20/h1-5,11-19,21H,6-9H2
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 67.6n/an/an/an/an/an/an/an/a



Northeast Ohio Medical University (NEOMED)

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma-1 receptor in guinea pig brain

Bioorg Med Chem Lett 23: 1707-11 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.069
BindingDB Entry DOI: 10.7270/Q2G73G3N
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50288949
PNG
(11'N-(4-iodomobenzyl)spiro[dihydro[1,3]dioxolane-2...)
Show SMILES Ic1ccc(CNC2C3C4C5C3C3(OCCO3)C3C5CC4C23)cc1 |TLB:12:17:10.9:19,7:21:10.9:19,THB:11:10:17.21:19,8:9:17.21:19|
Show InChI InChI=1S/C20H22INO2/c21-10-3-1-9(2-4-10)8-22-19-15-11-7-12-14-13(11)16(19)18(14)20(17(12)15)23-5-6-24-20/h1-4,11-19,22H,5-8H2
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 72.4n/an/an/an/an/an/an/an/a



Northeast Ohio Medical University (NEOMED)

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma-1 receptor in guinea pig brain

Bioorg Med Chem Lett 23: 1707-11 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.069
BindingDB Entry DOI: 10.7270/Q2G73G3N
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50430268
PNG
(CHEMBL2332502)
Show SMILES OC12C3C4C5C3C(C3C5CC4C13)N2Cc1ccc(I)cc1 |TLB:6:7:4.3:9,8:7:5.2:12,4:5:7.11:12,1:11:4.3:9,10:11:5.2:12,3:2:7.11:12,THB:5:4:7.11:9,2:3:7.11:9|
Show InChI InChI=1S/C18H18INO/c19-8-3-1-7(2-4-8)6-20-17-13-9-5-10-12-11(9)14(17)16(12)18(20,21)15(10)13/h1-4,9-17,21H,5-6H2
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 81.3n/an/an/an/an/an/an/an/a



Northeast Ohio Medical University (NEOMED)

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma-1 receptor in guinea pig brain

Bioorg Med Chem Lett 23: 1707-11 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.069
BindingDB Entry DOI: 10.7270/Q2G73G3N
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50430269
PNG
(CHEMBL2332504)
Show SMILES OC12C3C4C5C3C(C3C5CC4C13)N2Cc1ccc(Br)cc1 |TLB:6:7:4.3:9,8:7:5.2:12,4:5:7.11:12,1:11:4.3:9,10:11:5.2:12,3:2:7.11:12,THB:5:4:7.11:9,2:3:7.11:9|
Show InChI InChI=1S/C18H18BrNO/c19-8-3-1-7(2-4-8)6-20-17-13-9-5-10-12-11(9)14(17)16(12)18(20,21)15(10)13/h1-4,9-17,21H,5-6H2
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 85.1n/an/an/an/an/an/an/an/a



Northeast Ohio Medical University (NEOMED)

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma-1 receptor in guinea pig brain

Bioorg Med Chem Lett 23: 1707-11 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.069
BindingDB Entry DOI: 10.7270/Q2G73G3N
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50430261
PNG
(CHEMBL2332496)
Show SMILES Cc1cccc(CN2C3C4C5C6C4C2(O)C2C6CC5C32)c1 |TLB:8:19:10.11:17,13:15:10.11:17,THB:18:19:9.12:7,9:10:19.15:17,10:9:19.15:7,12:11:19.15:17,16:15:9.12:7,11:12:19.15:7|
Show InChI InChI=1S/C19H21NO/c1-8-3-2-4-9(5-8)7-20-18-14-10-6-11-13-12(10)15(18)17(13)19(20,21)16(11)14/h2-5,10-18,21H,6-7H2,1H3
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 97.7n/an/an/an/an/an/an/an/a



Northeast Ohio Medical University (NEOMED)

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma-1 receptor in guinea pig brain

Bioorg Med Chem Lett 23: 1707-11 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.069
BindingDB Entry DOI: 10.7270/Q2G73G3N
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50401382
PNG
(CHEMBL2205825)
Show SMILES COc1ccc(CN2C3C4C5C6C4C2(O)C2C6CC5C32)cc1 |TLB:8:19:10.11:17,13:15:10.11:17,THB:9:10:19.15:17,18:19:9.12:7,10:9:19.15:7,12:11:19.15:17,16:15:9.12:7,11:12:19.15:7,6:7:9.12:19.15|
Show InChI InChI=1S/C19H21NO2/c1-22-9-4-2-8(3-5-9)7-20-18-14-10-6-11-13-12(10)15(18)17(13)19(20,21)16(11)14/h2-5,10-18,21H,6-7H2,1H3
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 102n/an/an/an/an/an/an/an/a



Northeast Ohio Medical University (NEOMED)

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma-1 receptor in guinea pig brain

Bioorg Med Chem Lett 23: 1707-11 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.069
BindingDB Entry DOI: 10.7270/Q2G73G3N
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50288954
PNG
(11-benzyl-11-azahexacyclo[5.4.1.02,6.03,10.04,8.09...)
Show SMILES OC12C3C4C5C3C(C3C5CC4C13)N2Cc1ccccc1 |TLB:3:2:12:11.7,4:5:12:11.7,10:11:12:2.5,8:7:12:2.5,THB:13:12:11.7:2.5|
Show InChI InChI=1S/C18H19NO/c20-18-15-10-6-9-11-12(10)16(18)14(11)17(13(9)15)19(18)7-8-4-2-1-3-5-8/h1-5,9-17,20H,6-7H2
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 102n/an/an/an/an/an/an/an/a



Northeast Ohio Medical University (NEOMED)

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma-1 receptor in guinea pig brain

Bioorg Med Chem Lett 23: 1707-11 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.069
BindingDB Entry DOI: 10.7270/Q2G73G3N
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50430266
PNG
(CHEMBL2332501)
Show SMILES OC12C3C4C5C3C(C3C5CC4C13)N2Cc1ccc(F)cc1 |TLB:6:7:4.3:9,8:7:5.2:12,4:5:7.11:12,1:11:4.3:9,10:11:5.2:12,3:2:7.11:12,THB:5:4:7.11:9,2:3:7.11:9|
Show InChI InChI=1S/C18H18FNO/c19-8-3-1-7(2-4-8)6-20-17-13-9-5-10-12-11(9)14(17)16(12)18(20,21)15(10)13/h1-4,9-17,21H,5-6H2
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 107n/an/an/an/an/an/an/an/a



Northeast Ohio Medical University (NEOMED)

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma-1 receptor in guinea pig brain

Bioorg Med Chem Lett 23: 1707-11 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.069
BindingDB Entry DOI: 10.7270/Q2G73G3N
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50288950
PNG
(11'N-(3-iodobenzyl)spiro[dihydro[1,3]dioxolane-2,8...)
Show SMILES Ic1cccc(CNC2C3C4C5C3C3(OCCO3)C3C5CC4C23)c1 |TLB:13:18:11.10:20,8:22:11.10:20,THB:12:11:18.22:20,9:10:18.22:20|
Show InChI InChI=1S/C20H22INO2/c21-10-3-1-2-9(6-10)8-22-19-15-11-7-12-14-13(11)16(19)18(14)20(17(12)15)23-4-5-24-20/h1-3,6,11-19,22H,4-5,7-8H2
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 123n/an/an/an/an/an/an/an/a



Northeast Ohio Medical University (NEOMED)

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma-1 receptor in guinea pig brain

Bioorg Med Chem Lett 23: 1707-11 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.069
BindingDB Entry DOI: 10.7270/Q2G73G3N
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50305343
PNG
(4-(3'-Fluorophenyl)methyl-4-azahexacyclo[5.4.1.02,...)
Show SMILES OC12C3C4C5C3C(C3C5CC4C13)N2Cc1cccc(F)c1 |TLB:1:11:4.3:9,6:7:4.3:9,THB:2:3:9:7.11,5:4:9:7.11|
Show InChI InChI=1S/C18H18FNO/c19-8-3-1-2-7(4-8)6-20-17-13-9-5-10-12-11(9)14(17)16(12)18(20,21)15(10)13/h1-4,9-17,21H,5-6H2
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 151n/an/an/an/an/an/an/an/a



Northeast Ohio Medical University (NEOMED)

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma-1 receptor in guinea pig brain

Bioorg Med Chem Lett 23: 1707-11 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.069
BindingDB Entry DOI: 10.7270/Q2G73G3N
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50430267
PNG
(CHEMBL2332503)
Show SMILES OC12C3C4C5C3C(C3C5CC4C13)N2Cc1cccc(I)c1 |TLB:6:7:4.3:9,8:7:5.2:12,4:5:7.11:12,1:11:4.3:9,10:11:5.2:12,3:2:7.11:12,THB:5:4:7.11:9,2:3:7.11:9|
Show InChI InChI=1S/C18H18INO/c19-8-3-1-2-7(4-8)6-20-17-13-9-5-10-12-11(9)14(17)16(12)18(20,21)15(10)13/h1-4,9-17,21H,5-6H2
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 169n/an/an/an/an/an/an/an/a



Northeast Ohio Medical University (NEOMED)

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma-1 receptor in guinea pig brain

Bioorg Med Chem Lett 23: 1707-11 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.069
BindingDB Entry DOI: 10.7270/Q2G73G3N
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50430265
PNG
(CHEMBL2332499)
Show SMILES OC12C3C4C5C3C(C3C5CC4C13)N2Cc1ccccc1F |TLB:6:7:4.3:9,8:7:5.2:12,4:5:7.11:12,1:11:4.3:9,10:11:5.2:12,3:2:7.11:12,THB:5:4:7.11:9,2:3:7.11:9|
Show InChI InChI=1S/C18H18FNO/c19-10-4-2-1-3-7(10)6-20-17-13-8-5-9-12-11(8)14(17)16(12)18(20,21)15(9)13/h1-4,8-9,11-17,21H,5-6H2
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 181n/an/an/an/an/an/an/an/a



Northeast Ohio Medical University (NEOMED)

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma-1 receptor in guinea pig brain

Bioorg Med Chem Lett 23: 1707-11 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.069
BindingDB Entry DOI: 10.7270/Q2G73G3N
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50430260
PNG
(CHEMBL2332495)
Show SMILES OC12C3C4C5C3C(C3C5CC4C13)N2Cc1cccc(Cl)c1 |TLB:6:7:4.3:9,8:7:5.2:12,4:5:7.11:12,1:11:4.3:9,10:11:5.2:12,3:2:7.11:12,THB:5:4:7.11:9,2:3:7.11:9|
Show InChI InChI=1S/C18H18ClNO/c19-8-3-1-2-7(4-8)6-20-17-13-9-5-10-12-11(9)14(17)16(12)18(20,21)15(10)13/h1-4,9-17,21H,5-6H2
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 186n/an/an/an/an/an/an/an/a



Northeast Ohio Medical University (NEOMED)

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma-1 receptor in guinea pig brain

Bioorg Med Chem Lett 23: 1707-11 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.069
BindingDB Entry DOI: 10.7270/Q2G73G3N
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50430264
PNG
(CHEMBL2332500)
Show SMILES OC12C3C4C5C3C(C3C5CC4C13)N2Cc1ccc(F)c(F)c1 |TLB:6:7:4.3:9,8:7:5.2:12,4:5:7.11:12,1:11:4.3:9,10:11:5.2:12,3:2:7.11:12,THB:5:4:7.11:9,2:3:7.11:9|
Show InChI InChI=1S/C18H17F2NO/c19-9-2-1-6(3-10(9)20)5-21-17-13-7-4-8-12-11(7)14(17)16(12)18(21,22)15(8)13/h1-3,7-8,11-17,22H,4-5H2
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 199n/an/an/an/an/an/an/an/a



Northeast Ohio Medical University (NEOMED)

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma-1 receptor in guinea pig brain

Bioorg Med Chem Lett 23: 1707-11 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.069
BindingDB Entry DOI: 10.7270/Q2G73G3N
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50288952
PNG
(11-(3-bromobenzyl)-11-azahexacyclo[5.4.1.02,6.03,1...)
Show SMILES OC12C3C4C5C3C(C3C5CC4C13)N2Cc1cccc(Br)c1 |TLB:3:2:12:11.7,4:5:12:11.7,10:11:12:2.5,8:7:12:2.5|
Show InChI InChI=1S/C18H18BrNO/c19-8-3-1-2-7(4-8)6-20-17-13-9-5-10-12-11(9)14(17)16(12)18(20,21)15(10)13/h1-4,9-17,21H,5-6H2
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 208n/an/an/an/an/an/an/an/a



Northeast Ohio Medical University (NEOMED)

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma-1 receptor in guinea pig brain

Bioorg Med Chem Lett 23: 1707-11 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.069
BindingDB Entry DOI: 10.7270/Q2G73G3N
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50430263
PNG
(CHEMBL2332497)
Show SMILES OC12C3C4C5C3C(C3C5CC4C13)N2Cc1cccc(c1)C(F)(F)F |TLB:6:7:4.3:9,8:7:5.2:12,4:5:7.11:12,1:11:4.3:9,10:11:5.2:12,3:2:7.11:12,THB:5:4:7.11:9,2:3:7.11:9|
Show InChI InChI=1S/C19H18F3NO/c20-19(21,22)8-3-1-2-7(4-8)6-23-17-13-9-5-10-12-11(9)14(17)16(12)18(23,24)15(10)13/h1-4,9-17,24H,5-6H2
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 269n/an/an/an/an/an/an/an/a



Northeast Ohio Medical University (NEOMED)

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma-1 receptor in guinea pig brain

Bioorg Med Chem Lett 23: 1707-11 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.069
BindingDB Entry DOI: 10.7270/Q2G73G3N
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50430262
PNG
(CHEMBL2332498)
Show SMILES OC12C3C4C5C3C(C3C5CC4C13)N2Cc1cccc(c1)[N+]([O-])=O |TLB:6:7:4.3:9,8:7:5.2:12,4:5:7.11:12,1:11:4.3:9,10:11:5.2:12,3:2:7.11:12,THB:5:4:7.11:9,2:3:7.11:9|
Show InChI InChI=1S/C18H18N2O3/c21-18-15-10-5-9-11-12(10)16(18)14(11)17(13(9)15)19(18)6-7-2-1-3-8(4-7)20(22)23/h1-4,9-17,21H,5-6H2
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 1.09E+3n/an/an/an/an/an/an/an/a



Northeast Ohio Medical University (NEOMED)

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma-1 receptor in guinea pig brain

Bioorg Med Chem Lett 23: 1707-11 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.069
BindingDB Entry DOI: 10.7270/Q2G73G3N
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM50430255
PNG
(CHEMBL240981)
Show SMILES C(Cc1ccccc1)NC12OC3C4C5C(C14)C1CC5C3C21 |THB:13:12:10:20.19,14:15:10:20.19,16:20:10:15.12,18:19:10:15.12|
Show InChI InChI=1S/C19H21NO/c1-2-4-9(5-3-1)6-7-20-19-16-11-8-10-12-13(11)17(19)15(12)18(21-19)14(10)16/h1-5,10-18,20H,6-8H2
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n/an/a 1.54E+3n/an/an/an/an/an/a



Northeast Ohio Medical University (NEOMED)

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma-1 receptor in rat liver homogenate

Bioorg Med Chem Lett 23: 1707-11 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.069
BindingDB Entry DOI: 10.7270/Q2G73G3N
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM50430256
PNG
(CHEMBL391409 | NPGI-01)
Show SMILES C(NC12OC3C4C5C(C14)C1CC5C3C21)c1ccccc1 |THB:6:5:3:13.12,7:8:3:13.12,9:13:3:8.5,11:12:3:8.5|
Show InChI InChI=1S/C18H19NO/c1-2-4-8(5-3-1)7-19-18-15-10-6-9-11-12(10)16(18)14(11)17(20-18)13(9)15/h1-5,9-17,19H,6-7H2
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n/an/a 1.78E+3n/an/an/an/an/an/a



Northeast Ohio Medical University (NEOMED)

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma-1 receptor in rat liver homogenate

Bioorg Med Chem Lett 23: 1707-11 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.069
BindingDB Entry DOI: 10.7270/Q2G73G3N
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%