Found 72 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436720
(CHEMBL2401963)Show SMILES CC[C@H]1N(C2CCCC2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1 |r| Show InChI InChI=1S/C23H26N6O/c1-3-18-22(30)27(2)19-15-25-23(26-21(19)29(18)17-11-7-8-12-17)28-14-13-24-20(28)16-9-5-4-6-10-16/h4-6,9-10,13-15,17-18H,3,7-8,11-12H2,1-2H3/t18-/m1/s1 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436742
(CHEMBL2402081)Show SMILES CC[C@H]1N(c2ccn(C)n2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 |r| Show InChI InChI=1S/C22H21FN8O/c1-4-16-21(32)29(3)17-13-25-22(26-20(17)31(16)18-9-11-28(2)27-18)30-12-10-24-19(30)14-5-7-15(23)8-6-14/h5-13,16H,4H2,1-3H3/t16-/m1/s1 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50436720
(CHEMBL2401963)Show SMILES CC[C@H]1N(C2CCCC2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1 |r| Show InChI InChI=1S/C23H26N6O/c1-3-18-22(30)27(2)19-15-25-23(26-21(19)29(18)17-11-7-8-12-17)28-14-13-24-20(28)16-9-5-4-6-10-16/h4-6,9-10,13-15,17-18H,3,7-8,11-12H2,1-2H3/t18-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436746
(CHEMBL2401971)Show SMILES CC[C@H]1N([C@H]2CCOC2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1 |r| Show InChI InChI=1S/C22H24N6O2/c1-3-17-21(29)26(2)18-13-24-22(25-20(18)28(17)16-9-12-30-14-16)27-11-10-23-19(27)15-7-5-4-6-8-15/h4-8,10-11,13,16-17H,3,9,12,14H2,1-2H3/t16-,17+/m0/s1 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436734
(CHEMBL2402079)Show SMILES CCC1N(c2ccn[nH]2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 Show InChI InChI=1S/C21H19FN8O/c1-3-15-20(31)28(2)16-12-24-21(26-19(16)30(15)17-8-9-25-27-17)29-11-10-23-18(29)13-4-6-14(22)7-5-13/h4-12,15H,3H2,1-2H3,(H,25,27) | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436749
(CHEMBL2401966)Show SMILES CC[C@H]1N(CCC(F)(F)F)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1 |r| Show InChI InChI=1S/C21H21F3N6O/c1-3-15-19(31)28(2)16-13-26-20(27-18(16)29(15)11-9-21(22,23)24)30-12-10-25-17(30)14-7-5-4-6-8-14/h4-8,10,12-13,15H,3,9,11H2,1-2H3/t15-/m1/s1 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436727
(CHEMBL2402078)Show SMILES CC[C@H]1N(c2cn[nH]c2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 |r| Show InChI InChI=1S/C21H19FN8O/c1-3-16-20(31)28(2)17-12-24-21(27-19(17)30(16)15-10-25-26-11-15)29-9-8-23-18(29)13-4-6-14(22)7-5-13/h4-12,16H,3H2,1-2H3,(H,25,26)/t16-/m1/s1 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436726
(CHEMBL2401969)Show SMILES CC[C@H]1N(C2CC(F)(F)C2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 |r| Show InChI InChI=1S/C22H21F3N6O/c1-3-16-20(32)29(2)17-12-27-21(28-19(17)31(16)15-10-22(24,25)11-15)30-9-8-26-18(30)13-4-6-14(23)7-5-13/h4-9,12,15-16H,3,10-11H2,1-2H3/t16-/m1/s1 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436747
(CHEMBL2401968)Show SMILES CCC1N(C2CCC(F)(F)C2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 Show InChI InChI=1S/C23H23F3N6O/c1-3-17-21(33)30(2)18-13-28-22(29-20(18)32(17)16-8-9-23(25,26)12-16)31-11-10-27-19(31)14-4-6-15(24)7-5-14/h4-7,10-11,13,16-17H,3,8-9,12H2,1-2H3 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436738
(CHEMBL2401975)Show SMILES CCC1N(c2ccc(F)cc2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 Show InChI InChI=1S/C24H20F2N6O/c1-3-19-23(33)30(2)20-14-28-24(29-22(20)32(19)18-10-8-17(26)9-11-18)31-13-12-27-21(31)15-4-6-16(25)7-5-15/h4-14,19H,3H2,1-2H3 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436737
(CHEMBL2401974)Show SMILES CCC1N(c2ccccc2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1 Show InChI InChI=1S/C24H22N6O/c1-3-19-23(31)28(2)20-16-26-24(27-22(20)30(19)18-12-8-5-9-13-18)29-15-14-25-21(29)17-10-6-4-7-11-17/h4-16,19H,3H2,1-2H3 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436735
(CHEMBL2402080)Show SMILES CC[C@H]1N(c2cnn(C)c2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 |r| Show InChI InChI=1S/C22H21FN8O/c1-4-17-21(32)29(3)18-12-25-22(27-20(18)31(17)16-11-26-28(2)13-16)30-10-9-24-19(30)14-5-7-15(23)8-6-14/h5-13,17H,4H2,1-3H3/t17-/m1/s1 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436745
(CHEMBL2401972)Show SMILES CC[C@H]1N([C@@H]2CCOC2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1 |r| Show InChI InChI=1S/C22H24N6O2/c1-3-17-21(29)26(2)18-13-24-22(25-20(18)28(17)16-9-12-30-14-16)27-11-10-23-19(27)15-7-5-4-6-8-15/h4-8,10-11,13,16-17H,3,9,12,14H2,1-2H3/t16-,17-/m1/s1 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436744
(CHEMBL2401965)Show SMILES CC[C@H]1N(C(C)C)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1 |r| Show InChI InChI=1S/C21H24N6O/c1-5-16-20(28)25(4)17-13-23-21(24-19(17)27(16)14(2)3)26-12-11-22-18(26)15-9-7-6-8-10-15/h6-14,16H,5H2,1-4H3/t16-/m1/s1 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436730
(CHEMBL2401959)Show SMILES CCC1(C)N(CCC(F)(F)F)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 Show InChI InChI=1S/C22H22F4N6O/c1-4-21(2)19(33)30(3)16-13-28-20(29-18(16)32(21)11-9-22(24,25)26)31-12-10-27-17(31)14-5-7-15(23)8-6-14/h5-8,10,12-13H,4,9,11H2,1-3H3 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436731
(CHEMBL2402076)Show SMILES CCC1N(c2ccc(cc2)C#N)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 Show InChI InChI=1S/C25H20FN7O/c1-3-20-24(34)31(2)21-15-29-25(30-23(21)33(20)19-10-4-16(14-27)5-11-19)32-13-12-28-22(32)17-6-8-18(26)9-7-17/h4-13,15,20H,3H2,1-2H3 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436729
(CHEMBL2401973)Show SMILES CC[C@H]1N([C@H]2CCOC2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 |r| Show InChI InChI=1S/C22H23FN6O2/c1-3-17-21(30)27(2)18-12-25-22(26-20(18)29(17)16-8-11-31-13-16)28-10-9-24-19(28)14-4-6-15(23)7-5-14/h4-7,9-10,12,16-17H,3,8,11,13H2,1-2H3/t16-,17+/m0/s1 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436748
(CHEMBL2402083)Show SMILES CC[C@H]1N(C2CCOCC2)c2nc(ncc2N(C)C1=O)-c1c[nH]nc1-c1nccs1 |r| Show InChI InChI=1S/C20H23N7O2S/c1-3-14-20(28)26(2)15-11-22-17(13-10-23-25-16(13)19-21-6-9-30-19)24-18(15)27(14)12-4-7-29-8-5-12/h6,9-12,14H,3-5,7-8H2,1-2H3,(H,23,25)/t14-/m1/s1 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436741
(CHEMBL2402084)Show SMILES CC[C@H]1N([C@H]2CCOC2)c2nc(ncc2N(C)C1=O)-c1c[nH]nc1-c1nccs1 |r| Show InChI InChI=1S/C19H21N7O2S/c1-3-13-19(27)25(2)14-9-21-16(23-17(14)26(13)11-4-6-28-10-11)12-8-22-24-15(12)18-20-5-7-29-18/h5,7-9,11,13H,3-4,6,10H2,1-2H3,(H,22,24)/t11-,13+/m0/s1 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436732
(CHEMBL2401967)Show SMILES CC[C@H]1N(CCC(F)(F)F)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 |r| Show InChI InChI=1S/C21H20F4N6O/c1-3-15-19(32)29(2)16-12-27-20(28-18(16)30(15)10-8-21(23,24)25)31-11-9-26-17(31)13-4-6-14(22)7-5-13/h4-7,9,11-12,15H,3,8,10H2,1-2H3/t15-/m1/s1 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436728
(CHEMBL2402077)Show SMILES CC[C@H]1N(c2cncnc2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1 |r| Show InChI InChI=1S/C22H20N8O/c1-3-17-21(31)28(2)18-13-26-22(27-20(18)30(17)16-11-23-14-24-12-16)29-10-9-25-19(29)15-7-5-4-6-8-15/h4-14,17H,3H2,1-2H3/t17-/m1/s1 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436721
(CHEMBL2401964)Show SMILES CC[C@H]1N(C(C)C)c2nc(ncc2N(C)C1=O)-c1c[nH]nc1-c1nccs1 |r| Show InChI InChI=1S/C18H21N7OS/c1-5-12-18(26)24(4)13-9-20-15(22-16(13)25(12)10(2)3)11-8-21-23-14(11)17-19-6-7-27-17/h6-10,12H,5H2,1-4H3,(H,21,23)/t12-/m1/s1 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436736
(CHEMBL2402085)Show SMILES CC[C@H]1N(c2cn[nH]c2)c2nc(ncc2N(C)C1=O)-c1c[nH]nc1-c1nccs1 |r| Show InChI InChI=1S/C18H17N9OS/c1-3-12-18(28)26(2)13-9-20-15(24-16(13)27(12)10-6-21-22-7-10)11-8-23-25-14(11)17-19-4-5-29-17/h4-9,12H,3H2,1-2H3,(H,21,22)(H,23,25)/t12-/m1/s1 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 92 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436743
(CHEMBL2401956)Show SMILES CC[C@H]1N(c2cnn(C)c2)c2nc(ncc2N(C)C1=O)-c1c[nH]nc1-c1ccc(F)cc1F |r| Show InChI InChI=1S/C22H20F2N8O/c1-4-17-22(33)31(3)18-10-25-20(28-21(18)32(17)13-8-27-30(2)11-13)15-9-26-29-19(15)14-6-5-12(23)7-16(14)24/h5-11,17H,4H2,1-3H3,(H,26,29)/t17-/m1/s1 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 103 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436733
(CHEMBL2401958)Show SMILES CN1C(=O)C(CC(F)(F)F)N(CCC(F)(F)F)c2nc(ncc12)-n1ccnc1-c1ccc(F)cc1 Show InChI InChI=1S/C21H17F7N6O/c1-32-15-11-30-19(34-9-7-29-16(34)12-2-4-13(22)5-3-12)31-17(15)33(8-6-20(23,24)25)14(18(32)35)10-21(26,27)28/h2-5,7,9,11,14H,6,8,10H2,1H3 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436740
(CHEMBL2402086)Show SMILES CCC1N(c2cnn(C)c2)c2nc(ncc2N(C)C1=O)-c1c[nH]nc1-c1nccs1 Show InChI InChI=1S/C19H19N9OS/c1-4-13-19(29)27(3)14-9-21-16(12-8-22-25-15(12)18-20-5-6-30-18)24-17(14)28(13)11-7-23-26(2)10-11/h5-10,13H,4H2,1-3H3,(H,22,25) | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436739
(CHEMBL2401957)Show SMILES CCC1N(c2cnn(C)c2)c2nc(ncc2N(C)C1=O)-c1c[nH]nc1-c1ccccn1 Show InChI InChI=1S/C21H21N9O/c1-4-16-21(31)29(3)17-11-23-19(26-20(17)30(16)13-9-25-28(2)12-13)14-10-24-27-18(14)15-7-5-6-8-22-15/h5-12,16H,4H2,1-3H3,(H,24,27) | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 168 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50436748
(CHEMBL2402083)Show SMILES CC[C@H]1N(C2CCOCC2)c2nc(ncc2N(C)C1=O)-c1c[nH]nc1-c1nccs1 |r| Show InChI InChI=1S/C20H23N7O2S/c1-3-14-20(28)26(2)15-11-22-17(13-10-23-25-16(13)19-21-6-9-30-19)24-18(15)27(14)12-4-7-29-8-5-12/h6,9-12,14H,3-5,7-8H2,1-2H3,(H,23,25)/t14-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50436749
(CHEMBL2401966)Show SMILES CC[C@H]1N(CCC(F)(F)F)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1 |r| Show InChI InChI=1S/C21H21F3N6O/c1-3-15-19(31)28(2)16-13-26-20(27-18(16)29(15)11-9-21(22,23)24)30-12-10-25-17(30)14-7-5-4-6-8-14/h4-8,10,12-13,15H,3,9,11H2,1-2H3/t15-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50436747
(CHEMBL2401968)Show SMILES CCC1N(C2CCC(F)(F)C2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 Show InChI InChI=1S/C23H23F3N6O/c1-3-17-21(33)30(2)18-13-28-22(29-20(18)32(17)16-8-9-23(25,26)12-16)31-11-10-27-19(31)14-4-6-15(24)7-5-14/h4-7,10-11,13,16-17H,3,8-9,12H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50436746
(CHEMBL2401971)Show SMILES CC[C@H]1N([C@H]2CCOC2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1 |r| Show InChI InChI=1S/C22H24N6O2/c1-3-17-21(29)26(2)18-13-24-22(25-20(18)28(17)16-9-12-30-14-16)27-11-10-23-19(27)15-7-5-4-6-8-15/h4-8,10-11,13,16-17H,3,9,12,14H2,1-2H3/t16-,17+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50436745
(CHEMBL2401972)Show SMILES CC[C@H]1N([C@@H]2CCOC2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1 |r| Show InChI InChI=1S/C22H24N6O2/c1-3-17-21(29)26(2)18-13-24-22(25-20(18)28(17)16-9-12-30-14-16)27-11-10-23-19(27)15-7-5-4-6-8-15/h4-8,10-11,13,16-17H,3,9,12,14H2,1-2H3/t16-,17-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 480 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436742
(CHEMBL2402081)Show SMILES CC[C@H]1N(c2ccn(C)n2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 |r| Show InChI InChI=1S/C22H21FN8O/c1-4-16-21(32)29(3)17-13-25-22(26-20(17)31(16)18-9-11-28(2)27-18)30-12-10-24-19(30)14-5-7-15(23)8-6-14/h5-13,16H,4H2,1-3H3/t16-/m1/s1 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 480 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of Plk2 (unknown origin) transfected in HEK293 cells assessed as inhibition of alpha-synuclein phosphorylation at ser129 after 2 hrs by EL... |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436724
(CHEMBL2402082)Show SMILES CC[C@H]1N(c2ccnn2C)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 |r| Show InChI InChI=1S/C22H21FN8O/c1-4-16-21(32)28(2)17-13-25-22(27-20(17)31(16)18-9-10-26-29(18)3)30-12-11-24-19(30)14-5-7-15(23)8-6-14/h5-13,16H,4H2,1-3H3/t16-/m1/s1 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 532 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436734
(CHEMBL2402079)Show SMILES CCC1N(c2ccn[nH]2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 Show InChI InChI=1S/C21H19FN8O/c1-3-15-20(31)28(2)16-12-24-21(26-19(16)30(15)17-8-9-25-27-17)29-11-10-23-18(29)13-4-6-14(22)7-5-13/h4-12,15H,3H2,1-2H3,(H,25,27) | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 740 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of Plk2 (unknown origin) transfected in HEK293 cells assessed as inhibition of alpha-synuclein phosphorylation at ser129 after 2 hrs by EL... |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50436721
(CHEMBL2401964)Show SMILES CC[C@H]1N(C(C)C)c2nc(ncc2N(C)C1=O)-c1c[nH]nc1-c1nccs1 |r| Show InChI InChI=1S/C18H21N7OS/c1-5-12-18(26)24(4)13-9-20-15(22-16(13)25(12)10(2)3)11-8-21-23-14(11)17-19-6-7-27-17/h6-10,12H,5H2,1-4H3,(H,21,23)/t12-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 770 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436735
(CHEMBL2402080)Show SMILES CC[C@H]1N(c2cnn(C)c2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 |r| Show InChI InChI=1S/C22H21FN8O/c1-4-17-21(32)29(3)18-12-25-22(27-20(18)31(17)16-11-26-28(2)13-16)30-10-9-24-19(30)14-5-7-15(23)8-6-14/h5-13,17H,4H2,1-3H3/t17-/m1/s1 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 780 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of Plk2 (unknown origin) transfected in HEK293 cells assessed as inhibition of alpha-synuclein phosphorylation at ser129 after 2 hrs by EL... |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50436744
(CHEMBL2401965)Show SMILES CC[C@H]1N(C(C)C)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1 |r| Show InChI InChI=1S/C21H24N6O/c1-5-16-20(28)25(4)17-13-23-21(24-19(17)27(16)14(2)3)26-12-11-22-18(26)15-9-7-6-8-10-15/h6-14,16H,5H2,1-4H3/t16-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 870 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436722
(CHEMBL2401970)Show SMILES CC[C@H]1N(C2COC2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 |r| Show InChI InChI=1S/C21H21FN6O2/c1-3-16-20(29)26(2)17-10-24-21(25-19(17)28(16)15-11-30-12-15)27-9-8-23-18(27)13-4-6-14(22)7-5-13/h4-10,15-16H,3,11-12H2,1-2H3/t16-/m1/s1 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.04E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436725
(CHEMBL2401960)Show SMILES CC(C)N1c2nc(ncc2N(C)C(=O)C11CCC1)-n1ccnc1-c1ccc(F)cc1 Show InChI InChI=1S/C22H23FN6O/c1-14(2)29-19-17(27(3)20(30)22(29)9-4-10-22)13-25-21(26-19)28-12-11-24-18(28)15-5-7-16(23)8-6-15/h5-8,11-14H,4,9-10H2,1-3H3 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.15E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50436743
(CHEMBL2401956)Show SMILES CC[C@H]1N(c2cnn(C)c2)c2nc(ncc2N(C)C1=O)-c1c[nH]nc1-c1ccc(F)cc1F |r| Show InChI InChI=1S/C22H20F2N8O/c1-4-17-22(33)31(3)18-10-25-20(28-21(18)32(17)13-8-27-30(2)11-13)15-9-26-29-19(15)14-6-5-12(23)7-16(14)24/h5-11,17H,4H2,1-3H3,(H,26,29)/t17-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50436742
(CHEMBL2402081)Show SMILES CC[C@H]1N(c2ccn(C)n2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 |r| Show InChI InChI=1S/C22H21FN8O/c1-4-16-21(32)29(3)17-13-25-22(26-20(17)31(16)18-9-11-28(2)27-18)30-12-10-24-19(30)14-5-7-15(23)8-6-14/h5-13,16H,4H2,1-3H3/t16-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.35E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50436741
(CHEMBL2402084)Show SMILES CC[C@H]1N([C@H]2CCOC2)c2nc(ncc2N(C)C1=O)-c1c[nH]nc1-c1nccs1 |r| Show InChI InChI=1S/C19H21N7O2S/c1-3-13-19(27)25(2)14-9-21-16(23-17(14)26(13)11-4-6-28-10-11)12-8-22-24-15(12)18-20-5-7-29-18/h5,7-9,11,13H,3-4,6,10H2,1-2H3,(H,22,24)/t11-,13+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.41E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50436739
(CHEMBL2401957)Show SMILES CCC1N(c2cnn(C)c2)c2nc(ncc2N(C)C1=O)-c1c[nH]nc1-c1ccccn1 Show InChI InChI=1S/C21H21N9O/c1-4-16-21(31)29(3)17-11-23-19(26-20(17)30(16)13-9-25-28(2)12-13)14-10-24-27-18(14)15-7-5-6-8-22-15/h5-12,16H,4H2,1-3H3,(H,24,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.82E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50436740
(CHEMBL2402086)Show SMILES CCC1N(c2cnn(C)c2)c2nc(ncc2N(C)C1=O)-c1c[nH]nc1-c1nccs1 Show InChI InChI=1S/C19H19N9OS/c1-4-13-19(29)27(3)14-9-21-16(12-8-22-25-15(12)18-20-5-6-30-18)24-17(14)28(13)11-7-23-26(2)10-11/h5-10,13H,4H2,1-3H3,(H,22,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.82E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436727
(CHEMBL2402078)Show SMILES CC[C@H]1N(c2cn[nH]c2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 |r| Show InChI InChI=1S/C21H19FN8O/c1-3-16-20(31)28(2)17-12-24-21(27-19(17)30(16)15-10-25-26-11-15)29-9-8-23-18(29)13-4-6-14(22)7-5-13/h4-12,16H,3H2,1-2H3,(H,25,26)/t16-/m1/s1 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.87E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of Plk2 (unknown origin) transfected in HEK293 cells assessed as inhibition of alpha-synuclein phosphorylation at ser129 after 2 hrs by EL... |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436729
(CHEMBL2401973)Show SMILES CC[C@H]1N([C@H]2CCOC2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 |r| Show InChI InChI=1S/C22H23FN6O2/c1-3-17-21(30)27(2)18-12-25-22(26-20(18)29(17)16-8-11-31-13-16)28-10-9-24-19(28)14-4-6-15(23)7-5-14/h4-7,9-10,12,16-17H,3,8,11,13H2,1-2H3/t16-,17+/m0/s1 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of Plk2 (unknown origin) transfected in HEK293 cells assessed as inhibition of alpha-synuclein phosphorylation at ser129 after 2 hrs by EL... |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50436738
(CHEMBL2401975)Show SMILES CCC1N(c2ccc(F)cc2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 Show InChI InChI=1S/C24H20F2N6O/c1-3-19-23(33)30(2)20-14-28-24(29-22(20)32(19)18-10-8-17(26)9-11-18)31-13-12-27-21(31)15-4-6-16(25)7-5-15/h4-14,19H,3H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.34E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436732
(CHEMBL2401967)Show SMILES CC[C@H]1N(CCC(F)(F)F)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 |r| Show InChI InChI=1S/C21H20F4N6O/c1-3-15-19(32)29(2)16-12-27-20(28-18(16)30(15)10-8-21(23,24)25)31-11-9-26-17(31)13-4-6-14(22)7-5-13/h4-7,9,11-12,15H,3,8,10H2,1-2H3/t15-/m1/s1 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.56E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of Plk2 (unknown origin) transfected in HEK293 cells assessed as inhibition of alpha-synuclein phosphorylation at ser129 after 2 hrs by EL... |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436723
(CHEMBL2401961)Show SMILES CC(C)N1c2nc(ncc2N(C)C(=O)C1(C)C)-n1ccnc1-c1ccc(F)cc1 Show InChI InChI=1S/C21H23FN6O/c1-13(2)28-18-16(26(5)19(29)21(28,3)4)12-24-20(25-18)27-11-10-23-17(27)14-6-8-15(22)9-7-14/h6-13H,1-5H3 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.71E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50436737
(CHEMBL2401974)Show SMILES CCC1N(c2ccccc2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1 Show InChI InChI=1S/C24H22N6O/c1-3-19-23(31)28(2)20-16-26-24(27-22(20)30(19)18-12-8-5-9-13-18)29-15-14-25-21(29)17-10-6-4-7-11-17/h4-16,19H,3H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.83E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436748
(CHEMBL2402083)Show SMILES CC[C@H]1N(C2CCOCC2)c2nc(ncc2N(C)C1=O)-c1c[nH]nc1-c1nccs1 |r| Show InChI InChI=1S/C20H23N7O2S/c1-3-14-20(28)26(2)15-11-22-17(13-10-23-25-16(13)19-21-6-9-30-19)24-18(15)27(14)12-4-7-29-8-5-12/h6,9-12,14H,3-5,7-8H2,1-2H3,(H,23,25)/t14-/m1/s1 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.99E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of Plk2 (unknown origin) transfected in HEK293 cells assessed as inhibition of alpha-synuclein phosphorylation at ser129 after 2 hrs by EL... |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50436736
(CHEMBL2402085)Show SMILES CC[C@H]1N(c2cn[nH]c2)c2nc(ncc2N(C)C1=O)-c1c[nH]nc1-c1nccs1 |r| Show InChI InChI=1S/C18H17N9OS/c1-3-12-18(28)26(2)13-9-20-15(24-16(13)27(12)10-6-21-22-7-10)11-8-23-25-14(11)17-19-4-5-29-17/h4-9,12H,3H2,1-2H3,(H,21,22)(H,23,25)/t12-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436741
(CHEMBL2402084)Show SMILES CC[C@H]1N([C@H]2CCOC2)c2nc(ncc2N(C)C1=O)-c1c[nH]nc1-c1nccs1 |r| Show InChI InChI=1S/C19H21N7O2S/c1-3-13-19(27)25(2)14-9-21-16(23-17(14)26(13)11-4-6-28-10-11)12-8-22-24-15(12)18-20-5-7-29-18/h5,7-9,11,13H,3-4,6,10H2,1-2H3,(H,22,24)/t11-,13+/m0/s1 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.19E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of Plk2 (unknown origin) transfected in HEK293 cells assessed as inhibition of alpha-synuclein phosphorylation at ser129 after 2 hrs by EL... |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50436735
(CHEMBL2402080)Show SMILES CC[C@H]1N(c2cnn(C)c2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 |r| Show InChI InChI=1S/C22H21FN8O/c1-4-17-21(32)29(3)18-12-25-22(27-20(18)31(17)16-11-26-28(2)13-16)30-10-9-24-19(30)14-5-7-15(23)8-6-14/h5-13,17H,4H2,1-3H3/t17-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.29E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50436734
(CHEMBL2402079)Show SMILES CCC1N(c2ccn[nH]2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 Show InChI InChI=1S/C21H19FN8O/c1-3-15-20(31)28(2)16-12-24-21(26-19(16)30(15)17-8-9-25-27-17)29-11-10-23-18(29)13-4-6-14(22)7-5-13/h4-12,15H,3H2,1-2H3,(H,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.42E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50436733
(CHEMBL2401958)Show SMILES CN1C(=O)C(CC(F)(F)F)N(CCC(F)(F)F)c2nc(ncc12)-n1ccnc1-c1ccc(F)cc1 Show InChI InChI=1S/C21H17F7N6O/c1-32-15-11-30-19(34-9-7-29-16(34)12-2-4-13(22)5-3-12)31-17(15)33(8-6-20(23,24)25)14(18(32)35)10-21(26,27)28/h2-5,7,9,11,14H,6,8,10H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50436732
(CHEMBL2401967)Show SMILES CC[C@H]1N(CCC(F)(F)F)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 |r| Show InChI InChI=1S/C21H20F4N6O/c1-3-15-19(32)29(2)16-12-27-20(28-18(16)30(15)10-8-21(23,24)25)31-11-9-26-17(31)13-4-6-14(22)7-5-13/h4-7,9,11-12,15H,3,8,10H2,1-2H3/t15-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.55E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50436731
(CHEMBL2402076)Show SMILES CCC1N(c2ccc(cc2)C#N)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 Show InChI InChI=1S/C25H20FN7O/c1-3-20-24(34)31(2)21-15-29-25(30-23(21)33(20)19-10-4-16(14-27)5-11-19)32-13-12-28-22(32)17-6-8-18(26)9-7-17/h4-13,15,20H,3H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.76E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436728
(CHEMBL2402077)Show SMILES CC[C@H]1N(c2cncnc2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1 |r| Show InChI InChI=1S/C22H20N8O/c1-3-17-21(31)28(2)18-13-26-22(27-20(18)30(17)16-11-23-14-24-12-16)29-10-9-25-19(29)15-7-5-4-6-8-15/h4-14,17H,3H2,1-2H3/t17-/m1/s1 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.87E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of Plk2 (unknown origin) transfected in HEK293 cells assessed as inhibition of alpha-synuclein phosphorylation at ser129 after 2 hrs by EL... |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human)) | BDBM50436736
(CHEMBL2402085)Show SMILES CC[C@H]1N(c2cn[nH]c2)c2nc(ncc2N(C)C1=O)-c1c[nH]nc1-c1nccs1 |r| Show InChI InChI=1S/C18H17N9OS/c1-3-12-18(28)26(2)13-9-20-15(24-16(13)27(12)10-6-21-22-7-10)11-8-23-25-14(11)17-19-4-5-29-17/h4-9,12H,3H2,1-2H3,(H,21,22)(H,23,25)/t12-/m1/s1 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.82E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of Plk2 (unknown origin) transfected in HEK293 cells assessed as inhibition of alpha-synuclein phosphorylation at ser129 after 2 hrs by EL... |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50436730
(CHEMBL2401959)Show SMILES CCC1(C)N(CCC(F)(F)F)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 Show InChI InChI=1S/C22H22F4N6O/c1-4-21(2)19(33)30(3)16-13-28-20(29-18(16)32(21)11-9-22(24,25)26)31-12-10-27-17(31)14-5-7-15(23)8-6-14/h5-8,10,12-13H,4,9,11H2,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50436729
(CHEMBL2401973)Show SMILES CC[C@H]1N([C@H]2CCOC2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 |r| Show InChI InChI=1S/C22H23FN6O2/c1-3-17-21(30)27(2)18-12-25-22(26-20(18)29(17)16-8-11-31-13-16)28-10-9-24-19(28)14-4-6-15(23)7-5-14/h4-7,9-10,12,16-17H,3,8,11,13H2,1-2H3/t16-,17+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.53E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50436728
(CHEMBL2402077)Show SMILES CC[C@H]1N(c2cncnc2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1 |r| Show InChI InChI=1S/C22H20N8O/c1-3-17-21(31)28(2)18-13-26-22(27-20(18)30(17)16-11-23-14-24-12-16)29-10-9-25-19(29)15-7-5-4-6-8-15/h4-14,17H,3H2,1-2H3/t17-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.76E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50436727
(CHEMBL2402078)Show SMILES CC[C@H]1N(c2cn[nH]c2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 |r| Show InChI InChI=1S/C21H19FN8O/c1-3-16-20(31)28(2)17-12-24-21(27-19(17)30(16)15-10-25-26-11-15)29-9-8-23-18(29)13-4-6-14(22)7-5-13/h4-12,16H,3H2,1-2H3,(H,25,26)/t16-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.67E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50436726
(CHEMBL2401969)Show SMILES CC[C@H]1N(C2CC(F)(F)C2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 |r| Show InChI InChI=1S/C22H21F3N6O/c1-3-16-20(32)29(2)17-12-27-21(28-19(17)31(16)15-10-22(24,25)11-15)30-9-8-26-18(30)13-4-6-14(23)7-5-13/h4-9,12,15-16H,3,10-11H2,1-2H3/t16-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.39E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK3
(Homo sapiens (Human)) | BDBM50436721
(CHEMBL2401964)Show SMILES CC[C@H]1N(C(C)C)c2nc(ncc2N(C)C1=O)-c1c[nH]nc1-c1nccs1 |r| Show InChI InChI=1S/C18H21N7OS/c1-5-12-18(26)24(4)13-9-20-15(22-16(13)25(12)10(2)3)11-8-21-23-14(11)17-19-6-7-27-17/h6-10,12H,5H2,1-4H3,(H,21,23)/t12-/m1/s1 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.24E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk3 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 15 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50436725
(CHEMBL2401960)Show SMILES CC(C)N1c2nc(ncc2N(C)C(=O)C11CCC1)-n1ccnc1-c1ccc(F)cc1 Show InChI InChI=1S/C22H23FN6O/c1-14(2)29-19-17(27(3)20(30)22(29)9-4-10-22)13-25-21(26-19)28-12-11-24-18(28)15-5-7-16(23)8-6-15/h5-8,11-14H,4,9-10H2,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.53E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50436724
(CHEMBL2402082)Show SMILES CC[C@H]1N(c2ccnn2C)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 |r| Show InChI InChI=1S/C22H21FN8O/c1-4-16-21(32)28(2)17-13-25-22(27-20(17)31(16)18-9-10-26-29(18)3)30-12-11-24-19(30)14-5-7-15(23)8-6-14/h5-13,16H,4H2,1-3H3/t16-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.88E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50436722
(CHEMBL2401970)Show SMILES CC[C@H]1N(C2COC2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 |r| Show InChI InChI=1S/C21H21FN6O2/c1-3-16-20(29)26(2)17-10-24-21(25-19(17)28(16)15-11-30-12-15)27-9-8-23-18(27)13-4-6-14(22)7-5-13/h4-10,15-16H,3,11-12H2,1-2H3/t16-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK3
(Homo sapiens (Human)) | BDBM50436720
(CHEMBL2401963)Show SMILES CC[C@H]1N(C2CCCC2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1 |r| Show InChI InChI=1S/C23H26N6O/c1-3-18-22(30)27(2)19-15-25-23(26-21(19)29(18)17-11-7-8-12-17)28-14-13-24-20(28)16-9-5-4-6-10-16/h4-6,9-10,13-15,17-18H,3,7-8,11-12H2,1-2H3/t18-/m1/s1 | PDB
NCI pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk3 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 15 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50436723
(CHEMBL2401961)Show SMILES CC(C)N1c2nc(ncc2N(C)C(=O)C1(C)C)-n1ccnc1-c1ccc(F)cc1 Show InChI InChI=1S/C21H23FN6O/c1-13(2)28-18-16(26(5)19(29)21(28,3)4)12-24-20(25-18)27-11-10-23-17(27)14-6-8-15(22)9-7-14/h6-13H,1-5H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Elan Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 23: 2743-9 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M |
More data for this
Ligand-Target Pair | |
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