Affinity Data by PubMed id=23648182

PubMed code 23648182

Found 6 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50491985 (CHEMBL2391620) Show SMILES Clc1cc2c(cc[nH]c2=O)cc1O[C@H]1CCNC1 \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi Curated by ChEMBL					Assay Description Inhibition of MEK1 (unknown origin) using ATP and ERK2 K54R as substrate after 60 to 80 mins by HTRF assay				Bioorg Med Chem Lett 23: 3620-6 (2013) Article DOI: 10.1016/j.bmcl.2013.04.003 BindingDB Entry DOI: 10.7270/Q20R9SBM
Sanofi Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM74351 (MLS001360529 \| SMR001223863 \| cid_3694944) Show SMILES CC1(O)CCN2C(=O)CCc3cccc1c23 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	1.81E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi Curated by ChEMBL					Assay Description Inhibition of MEK1 (unknown origin) using ATP and ERK2 K54R as substrate after 60 to 80 mins by HTRF assay				Bioorg Med Chem Lett 23: 3620-6 (2013) Article DOI: 10.1016/j.bmcl.2013.04.003 BindingDB Entry DOI: 10.7270/Q20R9SBM
Sanofi Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50234316 (CHEMBL2391621) Show SMILES COC(=O)c1c[nH]c2ncccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	3.94E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi Curated by ChEMBL					Assay Description Inhibition of MEK1 (unknown origin) using ATP and ERK2 K54R as substrate after 60 to 80 mins by HTRF assay				Bioorg Med Chem Lett 23: 3620-6 (2013) Article DOI: 10.1016/j.bmcl.2013.04.003 BindingDB Entry DOI: 10.7270/Q20R9SBM
Sanofi Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50491987 (CHEMBL2391618) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	1.57E+5	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi Curated by ChEMBL					Assay Description Inhibition of MEK1 (unknown origin) using ATP and ERK2 K54R as substrate after 60 to 80 mins by HTRF assay				Bioorg Med Chem Lett 23: 3620-6 (2013) Article DOI: 10.1016/j.bmcl.2013.04.003 BindingDB Entry DOI: 10.7270/Q20R9SBM
Sanofi Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50491984 (CHEMBL2391619) Show SMILES Nc1n[nH]c2cccc(C#N)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi Curated by ChEMBL					Assay Description Inhibition of MEK1 (unknown origin) using ATP and ERK2 K54R as substrate after 60 to 80 mins by HTRF assay				Bioorg Med Chem Lett 23: 3620-6 (2013) Article DOI: 10.1016/j.bmcl.2013.04.003 BindingDB Entry DOI: 10.7270/Q20R9SBM
Sanofi Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50491986 (CHEMBL2391615) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.91E+5	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi Curated by ChEMBL					Assay Description Inhibition of MEK1 (unknown origin) using ATP and ERK2 K54R as substrate after 60 to 80 mins by HTRF assay				Bioorg Med Chem Lett 23: 3620-6 (2013) Article DOI: 10.1016/j.bmcl.2013.04.003 BindingDB Entry DOI: 10.7270/Q20R9SBM
Sanofi Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%