Affinity Data by PubMed id=2374147

PubMed code 2374147

Found 16 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Glutamate receptor ionotropic, NMDA 2C (Rattus norvegicus (Rat))	BDBM50015743 (Acetic acid 3-[1-(3,6-dihydro-2H-pyridin-1-yl)-cyc...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description Ability to displace [3H]- TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.				J Med Chem 33: 2211-5 (1990) BindingDB Entry DOI: 10.7270/Q2BZ6515
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C (Rattus norvegicus (Rat))	BDBM50015738 (3-[1-(3,6-Dihydro-2H-pyridin-1-yl)-cyclohexyl]-phe...) Show SMILES Oc1cccc(c1)C1(CCCCC1)N1CCC=CC1 \|c:18\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description Ability to displace [3H]-TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.				J Med Chem 33: 2211-5 (1990) BindingDB Entry DOI: 10.7270/Q2BZ6515
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C (Rattus norvegicus (Rat))	BDBM50015734 (1-(1-Thiophen-2-yl-cyclohexyl)-1,2,3,6-tetrahydro-...) Show SMILES C1CCC(CC1)(N1CCC=CC1)c1cccs1 \|c:10\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description Ability to displace [3H]-TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.				J Med Chem 33: 2211-5 (1990) BindingDB Entry DOI: 10.7270/Q2BZ6515
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C (Rattus norvegicus (Rat))	BDBM50015741 (1-[1-(3-Methoxy-phenyl)-cyclohexyl]-1,2,3,6-tetrah...) Show SMILES COc1cccc(c1)C1(CCCCC1)N1CCC=CC1 \|c:19\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	33	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description Ability to displace [3H]-TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.				J Med Chem 33: 2211-5 (1990) BindingDB Entry DOI: 10.7270/Q2BZ6515
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C (Rattus norvegicus (Rat))	BDBM50015732 (1-(1-Phenyl-cyclohexyl)-1,2,3,6-tetrahydro-pyridin...) Show SMILES C1CCC(CC1)(N1CCC=CC1)c1ccccc1 \|c:10\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	37	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description Ability to displace [3H]- TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.				J Med Chem 33: 2211-5 (1990) BindingDB Entry DOI: 10.7270/Q2BZ6515
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C (Rattus norvegicus (Rat))	BDBM50015733 (3-[1-(3,6-Dihydro-2H-pyridin-1-yl)-cyclohexyl]-ben...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	56	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description Ability to displace [3H]-TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.				J Med Chem 33: 2211-5 (1990) BindingDB Entry DOI: 10.7270/Q2BZ6515
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C (Rattus norvegicus (Rat))	BDBM50015735 (1-(1-m-Tolyl-cyclohexyl)-1,2,3,6-tetrahydro-pyridi...) Show SMILES Cc1cccc(c1)C1(CCCCC1)N1CCC=CC1 \|c:18\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	81	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description Ability to displace [3H]- TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.				J Med Chem 33: 2211-5 (1990) BindingDB Entry DOI: 10.7270/Q2BZ6515
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C (Rattus norvegicus (Rat))	BDBM50015744 (1-[1-(3-Methoxymethoxy-phenyl)-cyclohexyl]-1,2,3,6...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	92	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description Ability to displace [3H]- TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.				J Med Chem 33: 2211-5 (1990) BindingDB Entry DOI: 10.7270/Q2BZ6515
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C (Rattus norvegicus (Rat))	BDBM50015740 (1-[1-(3-Vinyl-phenyl)-cyclohexyl]-1,2,3,6-tetrahyd...) Show SMILES C=Cc1cccc(c1)C1(CCCCC1)N1CCC=CC1 \|c:19\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	114	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description Ability to displace [3H]- TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.				J Med Chem 33: 2211-5 (1990) BindingDB Entry DOI: 10.7270/Q2BZ6515
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C (Rattus norvegicus (Rat))	BDBM50015731 (1-[1-(3-Methylsulfanyl-phenyl)-cyclohexyl]-1,2,3,6...) Show SMILES CSc1cccc(c1)C1(CCCCC1)N1CCC=CC1 \|c:19\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	231	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description Ability to displace [3H]- TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.				J Med Chem 33: 2211-5 (1990) BindingDB Entry DOI: 10.7270/Q2BZ6515
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C (Rattus norvegicus (Rat))	BDBM50015736 (1-[1-(3-Fluoro-phenyl)-cyclohexyl]-1,2,3,6-tetrahy...) Show SMILES Fc1cccc(c1)C1(CCCCC1)N1CCC=CC1 \|c:18\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	281	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description Ability to displace [3H]- TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.				J Med Chem 33: 2211-5 (1990) BindingDB Entry DOI: 10.7270/Q2BZ6515
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C (Rattus norvegicus (Rat))	BDBM50015739 (3-[1-(3,6-Dihydro-2H-pyridin-1-yl)-cyclohexyl]-ben...) Show SMILES O=Cc1cccc(c1)C1(CCCCC1)N1CCC=CC1 \|c:19\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	324	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description Ability to displace [3H]- TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.				J Med Chem 33: 2211-5 (1990) BindingDB Entry DOI: 10.7270/Q2BZ6515
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C (Rattus norvegicus (Rat))	BDBM50015730 (1-[1-(3-Trifluoromethyl-phenyl)-cyclohexyl]-1,2,3,...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	422	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description Ability to displace [3H]- TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.				J Med Chem 33: 2211-5 (1990) BindingDB Entry DOI: 10.7270/Q2BZ6515
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C (Rattus norvegicus (Rat))	BDBM50015742 (1-[1-(3-[1,3]Dioxolan-2-yl-phenyl)-cyclohexyl]-1,2...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	601	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description Ability to displace [3H]-TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.				J Med Chem 33: 2211-5 (1990) BindingDB Entry DOI: 10.7270/Q2BZ6515
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C (Rattus norvegicus (Rat))	BDBM50015745 (1-[1-(3-Benzyloxy-phenyl)-cyclohexyl]-1,2,3,6-tetr...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	733	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description Ability to displace [3H]-TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.				J Med Chem 33: 2211-5 (1990) BindingDB Entry DOI: 10.7270/Q2BZ6515
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C (Rattus norvegicus (Rat))	BDBM50015737 (1-[1-(3,5-Dimethoxy-phenyl)-cyclohexyl]-1,2,3,6-te...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	8.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description Ability to displace [3H]-TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.				J Med Chem 33: 2211-5 (1990) BindingDB Entry DOI: 10.7270/Q2BZ6515
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%