Affinity Data by PubMed id=23899291

PubMed code 23899291

Found 3 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50439266 (CHEMBL2419471) Show SMILES CCCc1cc2ccnc(N)c2o1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.44E+4	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 expressed in HEK293 cells co-transfected with MD2 and sAP assessed as induction of NF-kappaB activity by reporter gene...				J Med Chem 56: 6871-85 (2013) Article DOI: 10.1021/jm400694d BindingDB Entry DOI: 10.7270/Q2FB54CK
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50439267 (CHEMBL2419475) Show SMILES CCCCc1cc2c(o1)c(N)nc1ccccc21 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 expressed in HEK293 cells co-transfected with MD2 and sAP assessed as induction of NF-kappaB activity by reporter gene...				J Med Chem 56: 6871-85 (2013) Article DOI: 10.1021/jm400694d BindingDB Entry DOI: 10.7270/Q2FB54CK
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50439265 (CHEMBL2419274) Show SMILES CCCCc1cc2ccnc(N)c2o1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.62E+4	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 expressed in HEK293 cells co-transfected with MD2 and sAP assessed as induction of NF-kappaB activity by reporter gene...				J Med Chem 56: 6871-85 (2013) Article DOI: 10.1021/jm400694d BindingDB Entry DOI: 10.7270/Q2FB54CK
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%