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PubMed code 23999043

Compile data set for download or QSAR
Found 1 hit of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Matrix metalloproteinase-14


(Homo sapiens (Human))		BDBM50441081
PNG
(CHEMBL2430289)
Show SMILES N[C@@H](CCCCNC(=O)c1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc12)C(=O)N1CCC(CC1)(C(=O)NO)S(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1 |r|
Show InChI InChI=1S/C46H41F3N4O13S/c47-46(48,49)65-31-9-7-29(8-10-31)63-30-11-13-32(14-12-30)67(61,62)44(43(59)52-60)18-21-53(22-19-44)41(57)37(50)3-1-2-20-51-40(56)26-4-15-34-33(23-26)42(58)66-45(34)35-16-5-27(54)24-38(35)64-39-25-28(55)6-17-36(39)45/h4-17,23-25,37,54-55,60H,1-3,18-22,50H2,(H,51,56)(H,52,59)/t37-/m0/s1
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Mallinckrodt Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP14 using Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate by fluorescence plate reader analysis

Bioorg Med Chem Lett 23: 5566-70 (2013)


Article DOI: 10.1016/j.bmcl.2013.08.050
BindingDB Entry DOI: 10.7270/Q2ZP47JS
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%